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DSFESDKPGADQDLNDQHNVISYPGHTEDMADKPRDEMAQYVGRGLLEGKRALISGGDSGIGRAVAVAFA KEGADVAIAYLDEHDDATHTASLVERTGRRCLRLPGDLSEVEQCRAIVSRTAGALGGIDIVVNNVAYQRP TEKFTDISDEQWRHTFAVNIDSFFYVTKAALEYLPDGGAIINTASINGLRGNKTLIDYSATKGAVIALTY ALAQSLTERRIRVNCVAPGPVWTPLIPATMDAERVESFGEQAPYNRAAQPDEIAPSYVFFAADQLSSYYT GEVLAPIGGETLPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1782 | - | - | 100% (295) | oxidoreductase, short chain dehydrogenase/reductase family protein |
| M. smegmatis MC2 155 | MSMEG_6626 | - | 5e-35 | 36.61% (254) | short-chain dehydrogenase/reductase SDR |
| M. smegmatis MC2 155 | MSMEG_3604 | - | 1e-28 | 33.33% (249) | sorbitol utilization protein SOU2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3589c | - | 3e-30 | 33.73% (252) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1963 | - | 1e-124 | 78.55% (275) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv3559c | - | 2e-30 | 33.73% (252) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 5e-17 | 29.80% (245) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0598 | - | 6e-29 | 33.33% (249) | short chain dehydrogenase |
| M. marinum M | MMAR_4765 | - | 3e-31 | 35.11% (262) | short chain dehydrogenase |
| M. avium 104 | MAV_0886 | - | 6e-32 | 34.48% (261) | short-chain dehydrogenase/reductase SDR |
| M. thermoresistible (build 8) | TH_3969 | - | 5e-69 | 47.58% (269) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0336 | - | 5e-32 | 35.11% (262) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_4753 | - | 1e-119 | 75.55% (274) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4765|M.marinum_M --------------------------------------------------
MUL_0336|M.ulcerans_Agy99 --------------------------------------------------
MAV_0886|M.avium_104 --------------------------------------------------
Mb3589c|M.bovis_AF2122/97 --------------------------------------------------
Rv3559c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0598|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1963|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4753|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1782|M.smegmatis_MC2_155 --------------------------------------------------
TH_3969|M.thermoresistible__bu --------------------------------------------------
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
MMAR_4765|M.marinum_M --------------------------------------------------
MUL_0336|M.ulcerans_Agy99 --------------------------------------------------
MAV_0886|M.avium_104 --------------------------------------------------
Mb3589c|M.bovis_AF2122/97 --------------------------------------------------
Rv3559c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0598|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1963|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4753|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1782|M.smegmatis_MC2_155 --------------------------------------------------
TH_3969|M.thermoresistible__bu --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
MMAR_4765|M.marinum_M --------------------------------------------------
MUL_0336|M.ulcerans_Agy99 --------------------------------------------------
MAV_0886|M.avium_104 --------------------------------------------------
Mb3589c|M.bovis_AF2122/97 --------------------------------------------------
Rv3559c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0598|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1963|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4753|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_1782|M.smegmatis_MC2_155 --------------------------------------------------
TH_3969|M.thermoresistible__bu --------------------------------------------------
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
MMAR_4765|M.marinum_M --------------------------------------------------
MUL_0336|M.ulcerans_Agy99 --------------------------------------------------
MAV_0886|M.avium_104 --------------------------------------------------
Mb3589c|M.bovis_AF2122/97 ---------------------------------------------MNLSV
Rv3559c|M.tuberculosis_H37Rv ---------------------------------------------MNLSV
MAB_0598|M.abscessus_ATCC_1997 ---------------------------------------------MNLAE
Mflv_1963|M.gilvum_PYR-GCK -----------------------MTDDVTPDA-VIPYPGETQDMSDRPRD
Mvan_4753|M.vanbaalenii_PYR-1 -----------------------MSDDVTPEG-VIPYPGQTADMTPQPRD
MSMEG_1782|M.smegmatis_MC2_155 -------------MDSFESDKPGADQDLNDQHNVISYPGHTEDMADKPRD
TH_3969|M.thermoresistible__bu -----------------------MGFPEQQQQ----VPGRQSAMDPVPDC
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
MMAR_4765|M.marinum_M ------MVDELAGKIAIVTGGA-SGIGRATVARFIAEGARVVIADVEE--
MUL_0336|M.ulcerans_Agy99 ------MVDELAGKIAIVTGGA-SGIGRATVARFIAEGARVVIADVEE--
MAV_0886|M.avium_104 ------MVNELAGKVAIVTGGA-SGIGRGIVERFVAEGARVVIADIET--
Mb3589c|M.bovis_AF2122/97 APKEIAGHGLLDGKVVVVTAAAGTGIGSATARRALAEGADVVISDHHERR
Rv3559c|M.tuberculosis_H37Rv APKEIAGHGLLDGKVVVVTAAAGTGIGSATARRALAEGADVVISDHHERR
MAB_0598|M.abscessus_ATCC_1997 APTEIEGHGLLKGKAVVVTAAAGTGIGSSTARRALVEGADVVVSDYHERR
Mflv_1963|M.gilvum_PYR-GCK DMRDYVGRGLLDGKKALITGGD-SGIGRAVAVAFAKEGADVAIAYLNETS
Mvan_4753|M.vanbaalenii_PYR-1 EMRDYTGTGLLSGKRALITGGD-SGIGRAVAIAFAKEGADVAIAYLEEQA
MSMEG_1782|M.smegmatis_MC2_155 EMAQYVGRGLLEGKRALISGGD-SGIGRAVAVAFAKEGADVAIAYLDEHD
TH_3969|M.thermoresistible__bu GESSYRGSGKLTGKRAVITGGD-SGIGRAVAIAYAREGADVLVSYLNEDD
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAA-RGIGAAIAEVVARDGARVVAIDVES--
* .* .:::.. *** . . :** * .
MMAR_4765|M.marinum_M --ERGESLAAALGADAMFCRTDVSQPEQVAAVVAAAVENFG-GLHVMVNN
MUL_0336|M.ulcerans_Agy99 --ERGESLAAALGADAMFCRTDVSQPEQVAAVVAAAVDNFG-GLHVMVNN
MAV_0886|M.avium_104 --ERGERLAAELGGEAVFRRTDVSDIEQVGALVAAAVEKFG-GLHVMVNN
Mb3589c|M.bovis_AF2122/97 LGETAAELSALGLGRVEHVVCDVTSTAQVDALIDSTTARMG-RLDVLVNN
Rv3559c|M.tuberculosis_H37Rv LGETAAELSALGLGRVEHVVCDVTSTAQVDALIDSTTARMG-RLDVLVNN
MAB_0598|M.abscessus_ATCC_1997 LTETRDELAALGLGKVAAVVCDVTSTEAVDALITESVAALG-RIDVLVNN
Mflv_1963|M.gilvum_PYR-GCK DAAHTVSLIEAQGRPGLELPGDLAEPGHCRSIVEQTVKEFG-GLDIVVNN
Mvan_4753|M.vanbaalenii_PYR-1 DAAHTVSLIEAAGQRGIQLPGDLADPSHCRGVVAETVKQLG-GLDIVVNN
MSMEG_1782|M.smegmatis_MC2_155 DATHTASLVERTGRRCLRLPGDLSEVEQCRAIVSRTAGALG-GIDIVVNN
TH_3969|M.thermoresistible__bu DAAEVAQLVTDAGRRCVLVPGDLSDPAHCRSVIDRAVSEFD-GLDVLVVN
MLBr_02565|M.leprae_Br4923 --AAEALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNN
*:: : . .::* *
MMAR_4765|M.marinum_M AGVSGVMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAAH-GGGSI
MUL_0336|M.ulcerans_Agy99 AGVSGAMHRRFLDDDLADFHRVMAVNVLGVMAGTRDAARHMAAH-GGGSI
MAV_0886|M.avium_104 AGISSPLRR-LLDDDLADFHRVMGVNVLGVMAGTRDAARHMADN-GGGAI
Mb3589c|M.bovis_AF2122/97 AGLGGQTPVADMTDD--EWDRVLDVSLTSVFRATRAALRYFRDAPHGGVI
Rv3559c|M.tuberculosis_H37Rv AGLGGQTPVADMTDD--EWDRVLDVSLTSVFRATRAALRYFRDAPHGGVI
MAB_0598|M.abscessus_ATCC_1997 AGLGGETPVADMTDD--QWDRVLDVTLTSTFRATRAALRYFREAGHGGVI
Mflv_1963|M.gilvum_PYR-GCK VAFQSPADDLTEISD-EQWRRTFAVNIDSFFHVTKAALSHLPDG---SAI
Mvan_4753|M.vanbaalenii_PYR-1 VAFQSPVSDLAEISD-EQWRRTFAVNIDSFFHVTKAALQHLPDG---SAI
MSMEG_1782|M.smegmatis_MC2_155 VAYQRPTEKFTDISD-EQWRHTFAVNIDSFFYVTKAALEYLPDG---GAI
TH_3969|M.thermoresistible__bu HAHQMTHPTLEEISD-EEWDYTFRLNIGAYFHLVKAALPHLKPG---ASI
MLBr_02565|M.leprae_Br4923 AGITRDKLLANMDDC--RWDAVLEVNLLAPQRLTEGLVGNGSIS-KGGRV
. . : .: :.: . .. . :
MMAR_4765|M.marinum_M VNLTSIGGIQAGGGVMTYRASKAAVIQFTKSAAIELAHYEIRVNAIAPGN
MUL_0336|M.ulcerans_Agy99 VNLTSIGGIQAGGGVMTYRASKGAVIQFTKSAAIELAHYEIRVNAIAPGN
MAV_0886|M.avium_104 INLTSIGGIQAGGGVMTYRASKAAVIQFTKAAAIELARYDIRVNAIAPGN
Mb3589c|M.bovis_AF2122/97 VNNASVLGWRAQHSQSHYAAAKAGVMALTRCSAIEAAEYGVRINAVSPSI
Rv3559c|M.tuberculosis_H37Rv VNNASVLGWRAQHSQSHYAAAKAGVMALTRCSAIEAAEYGVRINAVSPSI
MAB_0598|M.abscessus_ATCC_1997 VNNASVLGWRAQYGQSHYAAAKAGVMALTRCSAIEAVEHGVRVNAVAPSI
Mflv_1963|M.gilvum_PYR-GCK INTASINGLRGNKSLIDYSATKGAVIALTYSLAQSLAQRRIRVNCVAPGP
Mvan_4753|M.vanbaalenii_PYR-1 INTGSINGLRGNKTLIDYSATKGAVIALTYSLAQSLADRNIRVNCVAPGP
MSMEG_1782|M.smegmatis_MC2_155 INTASINGLRGNKTLIDYSATKGAVIALTYALAQSLTERRIRVNCVAPGP
TH_3969|M.thermoresistible__bu IGSSSVNSDMPSPTLAPYAATKAAIANFSASLAQMLGDKGIRVNSVAPGP
MLBr_02565|M.leprae_Br4923 IVLSSMAGIAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGF
: *: . * ::*..: :: . * : :*.::*.
MMAR_4765|M.marinum_M IPTPLLASSAAGMDQEQVERFTAQIRQTMREDRPLKREGTPEDIAEAALY
MUL_0336|M.ulcerans_Agy99 IPTPLLASSAAGLDQEQVERFTAQIRQTMREDRPLKREGTPEDIAEAALY
MAV_0886|M.avium_104 IPTPILGKSAGDMDPEQRERFEARIREGMREDRPLKREGTPDDVAEAALY
Mb3589c|M.bovis_AF2122/97 ARHKFLDKTAS-----------AELLDRLVAGEAFGRAAEPWEVAATIAF
Rv3559c|M.tuberculosis_H37Rv ARHKFLDKTAS-----------AELLDRLAAGEAFGRAAEPWEVAATIAF
MAB_0598|M.abscessus_ATCC_1997 ARHKFLDKVTS-----------SDLLDKLSSDEAFGRAAEPWEVAATIAF
Mflv_1963|M.gilvum_PYR-GCK VWTPLIPATMD-----------ADKVESFGGQVPMGRAAQPDEIAPSYVF
Mvan_4753|M.vanbaalenii_PYR-1 VWTPLIPATMD-----------AEKTASFGEHVPMGRAAQPDEIAPSYVF
MSMEG_1782|M.smegmatis_MC2_155 VWTPLIPATMD-----------AERVESFGEQAPYNRAAQPDEIAPSYVF
TH_3969|M.thermoresistible__bu IWTPLIPSTMP-----------PEKVARFGDDTPLGRAGQPAELAGAYVL
MLBr_02565|M.leprae_Br4923 IETQMTAAIPL------------ATREVGRRLNSLLQGGLPVDVAETIAY
: . : . * ::* :
MMAR_4765|M.marinum_M FAG-ERSRYVTGTVLPVDGGTVAGKVIRRSR--
MUL_0336|M.ulcerans_Agy99 FAG-ERSRYVTGTVLPVDGGTVAGKVIRRSR--
MAV_0886|M.avium_104 FAT-ERSRYVTGTVLPVDGGTSAGKAMRSKRQG
Mb3589c|M.bovis_AF2122/97 LAS-DYSSYLTGEVISVSCQHP-----------
Rv3559c|M.tuberculosis_H37Rv LAS-DYSSYLTGEVISVSCQHP-----------
MAB_0598|M.abscessus_ATCC_1997 LAS-DYSSYLTGEVISVSSQRA-----------
Mflv_1963|M.gilvum_PYR-GCK FAASQMSSYYSGEVLAPIGGETLPG--------
Mvan_4753|M.vanbaalenii_PYR-1 FAASRMSSYYSGEVLAPIGGETLPV--------
MSMEG_1782|M.smegmatis_MC2_155 FAADQLSSYYTGEVLAPIGGETLPG--------
TH_3969|M.thermoresistible__bu LAADEGS-YISGARIAVTGGRPIL---------
MLBr_02565|M.leprae_Br4923 FAI-PASNAVTGNVIRVCGQAMLGA--------
:* * :* :