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SPNSTRLTGRTALVTGSTGGLGVTIAHALAADGAVVVVTGRDVARGESVVAGIRADGASAHFVAADLGGA DEQAIDGLAQRAAEAASAGIDILVNNAAKLLLPEPTATLSAGEVAEAFTVNVVAPMLLTGRLASAMAARG SGSVVNIGSITGLRGTAGSAVYDATKASVHSLTRSWAAEYGPSGVRVNAVAPGPIATERAAEFAEHIAPA LARVPSRRMSTPQEVAAAVVFLASDDAANIQGAVLSVDGGWAAT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4593 | - | - | 100% (255) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0325 | - | 3e-77 | 61.42% (254) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_1212 | - | 7e-43 | 43.15% (248) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2788c | fabG | 7e-34 | 36.80% (250) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_0296 | - | 2e-33 | 39.85% (261) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2766c | fabG | 7e-34 | 36.80% (250) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 3e-25 | 33.06% (242) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0827 | - | 2e-31 | 38.00% (250) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0629 | - | 5e-55 | 47.37% (247) | dehydrogenase |
| M. avium 104 | MAV_3655 | fabG | 4e-34 | 39.20% (250) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. smegmatis MC2 155 | MSMEG_5204 | - | 3e-87 | 65.35% (254) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_2488 | - | 2e-42 | 44.88% (254) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2173 | fabG | 6e-33 | 36.80% (250) | 3-ketoacyl-(acyl-carrier-protein) reductase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01807|M.leprae_Br4923 -------MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVA
MAB_0827|M.abscessus_ATCC_1997 -------MTSPLK--------------SRRAFVTGGSRGIGAGIVRRLAE
Mb2788c|M.bovis_AF2122/97 -------MTSLDLT-------------GRTAIITGASRGIGLAIAQQLAA
Rv2766c|M.tuberculosis_H37Rv -------MTSLDLT-------------GRTAIITGASRGIGLAIAQQLAA
MUL_2173|M.ulcerans_Agy99 -------MTSLDLT-------------GRTAIITGASRGIGLAIAQRLAG
MAV_3655|M.avium_104 -------MTSQDLT-------------GRTAIITGASRGIGLAIAQQLAA
Mvan_4593|M.vanbaalenii_PYR-1 MSPNSTRLT------------------GRTALVTGSTGGLGVTIAHALAA
MSMEG_5204|M.smegmatis_MC2_155 MNNHSTRLE------------------GRTALVTGATGGLGVAIASSLAA
MMAR_0629|M.marinum_M -------MA------------------GLTALITGATSGIGRATAHGLAE
TH_2488|M.thermoresistible__bu -----MEFQ------------------GLHVLVTGGTGGIGLACARAFAE
Mflv_0296|M.gilvum_PYR-GCK ---MDMGLS------------------GKRALVTGSSSGLGRAIAESLAA
: . ::**.. *:* . :.
MLBr_01807|M.leprae_Br4923 DGHRVAVTHRASVVP------------DWFFGVECDVTDNDAIG---AAF
MAB_0827|M.abscessus_ATCC_1997 DGARVVFTYSSSVQQAADVVDDINEDGGWARAVKADVADPDQLG---AAI
Mb2788c|M.bovis_AF2122/97 AGAHVVLTARRQEAADEAAAQVG----DRALGVGAHAVDEDAAR---RCV
Rv2766c|M.tuberculosis_H37Rv AGAHVVLTARRQEAADEAAAQVG----DRALGVGAHAVDEDAAR---RCV
MUL_2173|M.ulcerans_Agy99 AGANVVLTARKQESADAAAAEVG----ERAVGVGAHAVDEEAAR---GCV
MAV_3655|M.avium_104 AGANVVLTARKQEAADEAAAQVG----PQALGVGAHAVDEDAAR---QCV
Mvan_4593|M.vanbaalenii_PYR-1 DGAVVVVTGRDVARGESVVAGIRAD-GASAHFVAADLGGADEQAIDGLAQ
MSMEG_5204|M.smegmatis_MC2_155 NGAHVVITGRDAARGDAVVAGIRSA-GGRVDLVAADLA-AGEDEVRRLAR
MMAR_0629|M.marinum_M LGATVLVSGRDEARGREVVDEVTAR-GGRGIFLAAELR--DVTGVRNLAT
TH_2488|M.thermoresistible__bu AGAEVTVTGRDAGRG----AAAAGA-HPRLRFIRGDLA--DLASVQNLIR
Mflv_0296|M.gilvum_PYR-GCK EGASVVVHGRDEVRTGAVADGIRAR-GGDAWAAVGDLATEGGAG------
* * . .
MLBr_01807|M.leprae_Br4923 KAVEEHQGPVEVLVANAG-ITSDMLIMRMSEEQFQKVIDVNLTGVFRVAK
MAB_0827|M.abscessus_ATCC_1997 GQAAEELGGLDILVNNAG-ILSIGDVDTATLADFDEIVAVNVRAVFAGIK
Mb2788c|M.bovis_AF2122/97 DLTLERFGSVDILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTS
Rv2766c|M.tuberculosis_H37Rv DLTLERFGSVDILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTS
MUL_2173|M.ulcerans_Agy99 DLALERFGSVDILINNAGTNPAYGPLIEQDHARFTKIFDVNLWAPLMWTS
MAV_3655|M.avium_104 QLTLERFGSVDILVNNAGTNPAYGPLIEQDHARFAKIFDVNLWAPLLWTS
Mvan_4593|M.vanbaalenii_PYR-1 RAAEAASAGIDILVNNAAKLLLPEPTATLSAGEVAEAFTVNVVAPMLLTG
MSMEG_5204|M.smegmatis_MC2_155 RAVEVAGGHIDILVNNAGLWGMPEATSAVSEPDLLASFRTNVIAPFLLTG
MMAR_0629|M.marinum_M AAADAGAGKVDILINSAGAFPF-GPTADTSPDDFDAVFALNVRAPYFLVG
TH_2488|M.thermoresistible__bu -YADA----VDVLVNNAASFPG-ALTVEQDAESFTRTFATNVTGTYFLTA
Mflv_0296|M.gilvum_PYR-GCK -AVAAAAGEVDILVNNAGVYDG-LAWSDLAPRQWQSIYEVNVVSGVRMIE
. :::*: .*. *: .
MLBr_01807|M.leprae_Br4923 LASRNMIKQRFGRYIFMGSVVG-LSGVPGQANYAASKSGLIGMARSLARE
MAB_0827|M.abscessus_ATCC_1997 AASPHLTEG--GRIVTIGSINGDSSPTANLSLYSMTKAAVAGLTRGLARE
Mb2788c|M.bovis_AF2122/97 LVVTAWMGEHGGAVVNTASIGG-MHQSPAMGMYNATKAALIHVTKQLALE
Rv2766c|M.tuberculosis_H37Rv LVVTAWMGEHGGAVVNTASIGG-MHQSPAMGMYNATKAALIHVTKQLALE
MUL_2173|M.ulcerans_Agy99 LVVKAWMGEHGGVVINTASIGG-MHQSPAMGMYNATNAALIHVTKQLALE
MAV_3655|M.avium_104 LAVKSWMGEHGGSIVNTASIGG-LHQSPAMGMYNATKAALIHVTKQLALE
Mvan_4593|M.vanbaalenii_PYR-1 RLASAMAARGSGSVVNIGSITG-LRGTAGSAVYDATKASVHSLTRSWAAE
MSMEG_5204|M.smegmatis_MC2_155 ALAPAMAERGHGAVVNVGSITG-FIGGDRAALYSSTKAAVHSLTKSWAVE
MMAR_0629|M.marinum_M ALAPTMAKRGRGSIVNVTTMVA-EFGAAGTGLYGASKAAIALLTKSWAAE
TH_2488|M.thermoresistible__bu GLIPGMLARGRGSIVNITSMVA-TKAVPGASVYSSSKAAVESLTRSWAVE
Mflv_0296|M.gilvum_PYR-GCK YLVPGMRQRGWGRIIQIGGGLA-LQPAADQPHYNATLAARHNLTVSLARE
* : . * : :. :: * *
MLBr_01807|M.leprae_Br4923 LGSRSITANVVAPGFIDTEMTR---------AMDSKYQEAALQAIPLG--
MAB_0827|M.abscessus_ATCC_1997 FGPRGITINNVQPGPIGTDMN----------PEDGQLADILRPNIAVG--
Mb2788c|M.bovis_AF2122/97 LSPR-IRVNAICPGVVRTRLAE---------ALWKDHEDPLAATIALG--
Rv2766c|M.tuberculosis_H37Rv LSPR-IRVNAICPGVVRTRLAE---------ALWKDHEDPLAATIALG--
MUL_2173|M.ulcerans_Agy99 LSPR-VRVNAICPGVVRTKLAE---------ALWKDHEDPLAANIALG--
MAV_3655|M.avium_104 LSPR-VRVNAIAPGVVRTRLAE---------ALWKDHEDPLSSSIALG--
Mvan_4593|M.vanbaalenii_PYR-1 YGPSGVRVNAVAPGPIATER----------AAEFAEHIAPALARVPS---
MSMEG_5204|M.smegmatis_MC2_155 YGPQGVRVNAVAPGPIATER----------VLEAADHVSGVLARIPS---
MMAR_0629|M.marinum_M YGPSGVRVNAVSPGPTRTEG----------TVEMGEALDQLAAAAPA---
TH_2488|M.thermoresistible__bu FAAHGIRVNAVAPGPTSTDGV---------ATEWGETNEALGRALPI---
Mflv_0296|M.gilvum_PYR-GCK LAGTGVTSNTVAPGAILTEPVREMTYRVAAQRGWGPTWEDVEKAAATTWF
. : * : ** * .
MLBr_01807|M.leprae_Br4923 -----RIGAVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH-------
MAB_0827|M.abscessus_ATCC_1997 -----RYGQPRDIASLVSYLVSDEAWYITGTAINIDGGFTA---------
Mb2788c|M.bovis_AF2122/97 -----RIGEPADIASAVAFLVSDAASWITGETMIIDGGLLLGNALGFRAA
Rv2766c|M.tuberculosis_H37Rv -----RIGEPADIASAVAFLVSDAASWITGETMIIDGGLLLGNALGFRAA
MUL_2173|M.ulcerans_Agy99 -----RIGEPVDVAEAVGFLVSDAASWITGETMVIDGGLLLGSAAGFQSR
MAV_3655|M.avium_104 -----RIGEPIDVAAAVAFLVSDAASWITGETLVIDGGTVLGAAQGFRSA
Mvan_4593|M.vanbaalenii_PYR-1 ----RRMSTPQEVAAAVVFLASDDAANIQGAVLSVDGGWAAT--------
MSMEG_5204|M.smegmatis_MC2_155 ----RRMSTPEEVAAAVVFLAGDEAANIHGAILSVDGGWAAA--------
MMAR_0629|M.marinum_M ----GRPADPTEIASTIVYLASDAASFIHGAVVPVDGGRAAV--------
TH_2488|M.thermoresistible__bu ----GRTADPDEIAQAVVFLASSRASFITGAVLHVDGGGIAV--------
Mflv_0296|M.gilvum_PYR-GCK PNDIGRFGRPEEVAAAVAFLAGVHAGYISGADLRVDGGAIRSVA------
* . ::* : :*.. * * * : :***
MLBr_01807|M.leprae_Br4923 -----
MAB_0827|M.abscessus_ATCC_1997 -----
Mb2788c|M.bovis_AF2122/97 PSTEH
Rv2766c|M.tuberculosis_H37Rv PSTEH
MUL_2173|M.ulcerans_Agy99 PGSAS
MAV_3655|M.avium_104 PTPS-
Mvan_4593|M.vanbaalenii_PYR-1 -----
MSMEG_5204|M.smegmatis_MC2_155 -----
MMAR_0629|M.marinum_M -----
TH_2488|M.thermoresistible__bu -----
Mflv_0296|M.gilvum_PYR-GCK -----