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AGLTALITGATSGIGRATAHGLAELGATVLVSGRDEARGREVVDEVTARGGRGIFLAAELRDVTGVRNLA TAAADAGAGKVDILINSAGAFPFGPTADTSPDDFDAVFALNVRAPYFLVGALAPTMAKRGRGSIVNVTTM VAEFGAAGTGLYGASKAAIALLTKSWAAEYGPSGVRVNAVSPGPTRTEGTVEMGEALDQLAAAAPAGRPA DPTEIASTIVYLASDAASFIHGAVVPVDGGRAAV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0629 | - | - | 100% (245) | dehydrogenase |
| M. marinum M | MMAR_4756 | - | 8e-33 | 37.14% (245) | oxidoreductase |
| M. marinum M | MMAR_4581 | - | 2e-32 | 37.34% (241) | short-chain type dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0950c | - | 6e-32 | 37.34% (241) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1235 | - | 2e-33 | 33.20% (244) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0927c | - | 6e-32 | 37.34% (241) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_00862 | ephD | 1e-21 | 35.96% (178) | short chain dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0833 | - | 3e-33 | 34.29% (245) | Short-chain dehydrogenase/reductase |
| M. avium 104 | MAV_1832 | - | 2e-33 | 37.29% (236) | 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5383 | - | 5e-62 | 50.42% (240) | dehydrogenase/reductase SDR family protein member 4 |
| M. thermoresistible (build 8) | TH_2488 | - | 8e-54 | 48.78% (246) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0327 | - | 3e-33 | 36.73% (245) | oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_0325 | - | 3e-59 | 44.94% (247) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0629|M.marinum_M --------------------------------------------------
MSMEG_5383|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0325|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1235|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_0327|M.ulcerans_Agy99 --------------------------------------------------
MAV_1832|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 MPATQSIHKVPHQFVESPDGVRLAIYQSGQPEGPAIVLVHGFPDSHVLWD
MMAR_0629|M.marinum_M --------------------------------------------------
MSMEG_5383|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0325|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1235|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_0327|M.ulcerans_Agy99 --------------------------------------------------
MAV_1832|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 GVVPLLAKRFRIVRYDNRGVGQSSVPKPVSAYTMTRFADDFAAVIDELSP
MMAR_0629|M.marinum_M --------------------------------------------------
MSMEG_5383|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0325|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1235|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_0327|M.ulcerans_Agy99 --------------------------------------------------
MAV_1832|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DRPVHVLAHDWGSVGVWEYLSRSGASDRVASFTSVSGPSQDQLVDYILSG
MMAR_0629|M.marinum_M --------------------------------------------------
MSMEG_5383|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0325|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1235|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_0327|M.ulcerans_Agy99 --------------------------------------------------
MAV_1832|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LRRPWRPRTFARAVSQLFRLTYMVLFSIPVLVPMVLWIALSSATIRRTMV
MMAR_0629|M.marinum_M --------------------------------------------------
MSMEG_5383|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0325|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1235|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_0327|M.ulcerans_Agy99 --------------------------------------------------
MAV_1832|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 DNISTDQIHHSATLARDAAHSVKTYPANYFRAFSGRRRGKGVPVVNVPVQ
MMAR_0629|M.marinum_M --------------------------------------------------
MSMEG_5383|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0325|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2488|M.thermoresistible__bu --------------------------------------------------
Mb0950c|M.bovis_AF2122/97 --------------------------------------------------
Rv0927c|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_1235|M.gilvum_PYR-GCK --------------------------------------------------
MAB_0833|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_0327|M.ulcerans_Agy99 --------------------------------------------------
MAV_1832|M.avium_104 --------------------------------------------------
MLBr_00862|M.leprae_Br4923 LIVNTMDRYVRPYGYDATARWVPRLWRRDIKAGHFSPMSHPQVMAAAVHD
MMAR_0629|M.marinum_M -----------------------MAGLT--ALITGATSGIGRATAHGLAE
MSMEG_5383|M.smegmatis_MC2_155 -----------------MSHTEESAAPRGWALVTGSTSGIGRETALLLAR
Mvan_0325|M.vanbaalenii_PYR-1 -----------------MNTTAATLSGR-TALVTGSTSGLGAGIAEALAD
TH_2488|M.thermoresistible__bu ---------------------MEFQGLH--VLVTGGTGGIGLACARAFAE
Mb0950c|M.bovis_AF2122/97 ------------------MILDMFRLDDKVAVITGGGRGLGAAIALAFAQ
Rv0927c|M.tuberculosis_H37Rv ------------------MILDMFRLDDKVAVITGGGRGLGAAIALAFAQ
Mflv_1235|M.gilvum_PYR-GCK ---------------------MFTSLQGRSAAVTGGSKGIGRGIAETFAR
MAB_0833|M.abscessus_ATCC_1997 --------------MNRETFSRLFDLTGRTAIVTGGTRGIGRALAEGYAC
MUL_0327|M.ulcerans_Agy99 ----------------MAIDPADVLLNGRVAVVTGAGSGIGRGVAAGLAA
MAV_1832|M.avium_104 -----------------------MNFTSKVAVVTGAASGIGEATAKRLAE
MLBr_00862|M.leprae_Br4923 LADLVDGKQPSRALLRAQVGRSRDTFGDTLVSVTGAGSGIGRETALALAR
. :**. *:* * *
MMAR_0629|M.marinum_M LGATVLVSGRDEARGREVVDEVTARGGRGIFLAAELRDVTG-VRNLATAA
MSMEG_5383|M.smegmatis_MC2_155 DGYSVIVSGRDEARAGEVVDRITTDGGTALALTADLSDTAA-VRTLATDA
Mvan_0325|M.vanbaalenii_PYR-1 AGAHVVITGRTRARGEQVVTQIESQGGRAVFVPVDFAAGPGTITDLVVTA
TH_2488|M.thermoresistible__bu AGAEVTVTGRDAGRGAAAAGAHP----RLRFIRGDLADLAS-VQNLIR--
Mb0950c|M.bovis_AF2122/97 AGADVLIASRTSSELDAVAEQIRAAGRRAHTVAADLAHPEV--TAQLAGQ
Rv0927c|M.tuberculosis_H37Rv AGADVLIASRTSSELDAVAEQIRAAGRRAHTVAADLAHPEV--TAQLAGQ
Mflv_1235|M.gilvum_PYR-GCK AGINVVITARTQDDIDATVADLAGLAGTVTGVAADVTSPED--CRRVVET
MAB_0833|M.abscessus_ATCC_1997 AGANVVVASRKPEACTEAVERLRSLGARALGVPTHTGDIHS--LEELVRA
MUL_0327|M.ulcerans_Agy99 FGASMAIWERDPQTCAQAAAELGGLG-----IATDVRSGDQ--VDAALQR
MAV_1832|M.avium_104 DGAKVVVADINEDGGERVVAEIAERGGEAAFLRTDISIEED--VNSLIDF
MLBr_00862|M.leprae_Br4923 RGAEVVVSDIDEAAAKNTAAQIVASGGVAYAYALDVSDAAA--VEAFAEQ
* : : .. .
MMAR_0629|M.marinum_M ADAGAGKVDILINSAG-AFPFGPTADTSPDDFDAVFALNVRAPYFLVGAL
MSMEG_5383|M.smegmatis_MC2_155 LEVAGGVIDVLVNNAG-GGTFAATEDTTDDMFDVAFKVHVKGPFILTAAL
Mvan_0325|M.vanbaalenii_PYR-1 TEALGGRLDILVNNVATLVQPAPTADVTAEEITTAFGVSVATPFLLTGLI
TH_2488|M.thermoresistible__bu ---YADAVDVLVNNAA-SFPGALTVEQDAESFTRTFATNVTGTYFLTAGL
Mb0950c|M.bovis_AF2122/97 AVGAFGKLDIVVNNVG-GTMPNTLLSTSTKDLADAFAFNVGTAHALTVAA
Rv0927c|M.tuberculosis_H37Rv AVGAFGKLDIVVNNVG-GTMPNTLLSTSTKDLADAFAFNVGTAHALTVAA
Mflv_1235|M.gilvum_PYR-GCK AIERHGGLDIVCPNAG-IFPSGRIADLTPDDIEQVLGVNFKGTVYIVQAA
MAB_0833|M.abscessus_ATCC_1997 TAEEFGGIDIVVNNAA-NALTEPVGAFTVDGWDKSFGVNLRGPVFLVQAA
MUL_0327|M.ulcerans_Agy99 TQAELGAVTILVNNVG-GVFWSPLLQTSEKGWDALYRSNLGHVLLCTQRV
MAV_1832|M.avium_104 AVSTYGGLHLAHNNAAVAHTPTPLHELSTDVFDTVTGIGLRGTFFCMRAE
MLBr_00862|M.leprae_Br4923 VSAKHGVPDIVVNNAG-IGQAGRFLDTPPEEFDRVLAVNLGGVVNCCRAF
. : ... . .
MMAR_0629|M.marinum_M APTMAKRG-RGSIVNVTTMVAEFGAAGTGLYGASKAAIALLTKSWAAEYG
MSMEG_5383|M.smegmatis_MC2_155 APLMAQRG-GGAIVNVGSISADLAASGVAIFQASKAALDMLTKSWTAEYG
Mvan_0325|M.vanbaalenii_PYR-1 APAMVQRG-DGAIVNIGSISGIIGAAGSALYGATKASVHLLTKAWAAEYG
TH_2488|M.thermoresistible__bu IPGMLARG-RGSIVNITSMVATKAVPGASVYSSSKAAVESLTRSWAVEFA
Mb0950c|M.bovis_AF2122/97 VPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLC
Rv0927c|M.tuberculosis_H37Rv VPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLC
Mflv_1235|M.gilvum_PYR-GCK LDALTASGHGRVIITSSITGPITGFPGWSHYGASKAAQLGFLRTAAIELA
MAB_0833|M.abscessus_ATCC_1997 LPHLVASPHAAVLNVVSVGAFMFG-QGVSMYSAAKAALVSYTRSAAAELA
MUL_0327|M.ulcerans_Agy99 ARRLVAAGLPGSIMAITSIEGVRAAPGYAAYAAAKAGVVNYTKTTALELA
MAV_1832|M.avium_104 IAHMIGHG-GGAIVNTASGAALKAAAGMHAYVATKHGIVGLTRNAGLDYA
MLBr_00862|M.leprae_Br4923 GQRLVERGTGGHIVNVSSMAAYAPLQSLSAYCTSKAATYMFSDCLRAELD
: : . : ::* . :
MMAR_0629|M.marinum_M PSGVRVNAVSPGPTRT---------EGT-VEMG--EALDQLAAAAPAGRP
MSMEG_5383|M.smegmatis_MC2_155 PRGVRVNTVNPGFVIT---------PAN-EAFR--DGYGPFVETVPARRG
Mvan_0325|M.vanbaalenii_PYR-1 PSGVRVNAVAPGPIAT---------ERT-REFG--DAIAPVLARVPSHRM
TH_2488|M.thermoresistible__bu AHGIRVNAVAPGPTST---------DGVATEWG--ETNEALGRALPIGRT
Mb0950c|M.bovis_AF2122/97 PR-VRVNAIAPGSILT---------SALEVVAANDELRAPMEQATPLRRL
Rv0927c|M.tuberculosis_H37Rv PR-VRVNAIAPGSILT---------SALEVVAANDELRAPMEQATPLRRL
Mflv_1235|M.gilvum_PYR-GCK PKKITVNAVLPGNILT---------EGLVEMGQ--SYIDQMAAAVPAGKL
MAB_0833|M.abscessus_ATCC_1997 SRGVRVNALAPGAIDT---------DMVRKTPP--AEVERMANTNHLKRL
MUL_0327|M.ulcerans_Agy99 HHGIRVNAIAPDITMT---------EGLAQLGG-AAALERIGSLVPLGRP
MAV_1832|M.avium_104 RNGIRVNAVAPGSIKT---------PQMASFPQ--EMQDEWERIIPMGRM
MLBr_00862|M.leprae_Br4923 AVGVGLTTICPGVIDTNIIQSTRIDTPTAKQERVRDRRGQLDMMFRLRRY
: :.:: *. * :
MMAR_0629|M.marinum_M ADPTEIASTIVYLASDAASFIHGAVVPVDGGRAAV---------------
MSMEG_5383|M.smegmatis_MC2_155 AEPEEVAEVIRFLISPAASYIQGAAIAVDGGRTAVLPM------------
Mvan_0325|M.vanbaalenii_PYR-1 STVAEVASAVVFLAGPEAANIHGTILSVDGGATAVRDEPAAVTKLGNHPH
TH_2488|M.thermoresistible__bu ADPDEIAQAVVFLASSRASFITGAVLHVDGGGIAV---------------
Mb0950c|M.bovis_AF2122/97 GDPVDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL------
Rv0927c|M.tuberculosis_H37Rv GDPVDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL------
Mflv_1235|M.gilvum_PYR-GCK GEVADIGNAALFFATDEAAYITGQSLVVDGGQILPESPEALADL------
MAB_0833|M.abscessus_ATCC_1997 GLPDEMVGTALLLTSDAGSYITGQTIIADGGLVAR---------------
MUL_0327|M.ulcerans_Agy99 GDVDEIASVAVFLASDMARYVTGQTIHVDGGTHAAAGWYRDPQTGEYRLG
MAV_1832|M.avium_104 GRPEEVADVVAFLLSDAASFITATTVEIDGAYLQSSK-------------
MLBr_00862|M.leprae_Br4923 GPDKVADTILSAIKKNKPIRPVAPEAYALYGISRVLPQVLRSTARIRVI-
. : . .
MMAR_0629|M.marinum_M --
MSMEG_5383|M.smegmatis_MC2_155 --
Mvan_0325|M.vanbaalenii_PYR-1 PG
TH_2488|M.thermoresistible__bu --
Mb0950c|M.bovis_AF2122/97 --
Rv0927c|M.tuberculosis_H37Rv --
Mflv_1235|M.gilvum_PYR-GCK --
MAB_0833|M.abscessus_ATCC_1997 --
MUL_0327|M.ulcerans_Agy99 PG
MAV_1832|M.avium_104 --
MLBr_00862|M.leprae_Br4923 --