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NTTAATLSGRTALVTGSTSGLGAGIAEALADAGAHVVITGRTRARGEQVVTQIESQGGRAVFVPVDFAAG PGTITDLVVTATEALGGRLDILVNNVATLVQPAPTADVTAEEITTAFGVSVATPFLLTGLIAPAMVQRGD GAIVNIGSISGIIGAAGSALYGATKASVHLLTKAWAAEYGPSGVRVNAVAPGPIATERTREFGDAIAPVL ARVPSHRMSTVAEVASAVVFLAGPEAANIHGTILSVDGGATAVRDEPAAVTKLGNHPHPG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0325 | - | - | 100% (271) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4593 | - | 3e-77 | 61.42% (254) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_1212 | - | 2e-40 | 41.94% (248) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0950c | - | 2e-32 | 37.35% (249) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1825 | - | 4e-34 | 38.55% (249) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv0927c | - | 2e-32 | 37.35% (249) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 2e-20 | 29.27% (246) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0827 | - | 7e-31 | 38.28% (256) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_0629 | - | 4e-59 | 44.94% (247) | dehydrogenase |
| M. avium 104 | MAV_1046 | - | 2e-33 | 37.75% (249) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5204 | - | 3e-78 | 59.68% (253) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3898 | - | 3e-37 | 39.36% (249) | PUTATIVE short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_4442 | - | 1e-32 | 37.35% (249) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0325|M.vanbaalenii_PYR-1 MNTTAAT-----------LSGRTALVTGSTSGLGAGIAEALADAGAHVVI
MSMEG_5204|M.smegmatis_MC2_155 MNNHSTR-----------LEGRTALVTGATGGLGVAIASSLAANGAHVVI
MMAR_0629|M.marinum_M ------------------MAGLTALITGATSGIGRATAHGLAELGATVLV
MAV_1046|M.avium_104 MILDRFR-----------LDDKVAVITGAGRGLGAAIAVAFAEAGADVLI
MUL_4442|M.ulcerans_Agy99 MILDRFR-----------LDDQVAVITGGGRGFGAAIALAFAEAGADVVI
Mb0950c|M.bovis_AF2122/97 MILDMFR-----------LDDKVAVITGGGRGLGAAIALAFAQAGADVLI
Rv0927c|M.tuberculosis_H37Rv MILDMFR-----------LDDKVAVITGGGRGLGAAIALAFAQAGADVLI
Mflv_1825|M.gilvum_PYR-GCK MILDRFR-----------LDDQVAVVTGAGRGLGAAMALAFAEAGADVLI
TH_3898|M.thermoresistible__bu VILDRFR-----------LDDRVAVVTGAGRGLGAAMAVAFAEAGADVLI
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MAB_0827|M.abscessus_ATCC_1997 MTSPLK--------------SRRAFVTGGSRGIGAGIVRRLAEDGARVVF
. .:**. *:* . . :. * * .
Mvan_0325|M.vanbaalenii_PYR-1 TGRTRARGEQ-VVTQIESQGGRAVFVPVDFAAGPGTITDLVVTATEALGG
MSMEG_5204|M.smegmatis_MC2_155 TGRDAARGDA-VVAGIRSAGGRVDLVAADLAAGEDEVRRLARRAVEVAGG
MMAR_0629|M.marinum_M SGRDEARGRE-VVDEVTARGGRGIFLAAELRDVTG-VRNLATAAADAGAG
MAV_1046|M.avium_104 ASRTESQLEA-VAEQVRAAGRRAHVVAADLAHPES-TAELAGRAVEAFG-
MUL_4442|M.ulcerans_Agy99 ASRTQSQLDE-VADTVRSIGRRAHVVAADLAHPEA-TAELAGQAVEAFG-
Mb0950c|M.bovis_AF2122/97 ASRTSSELDA-VAEQIRAAGRRAHTVAADLAHPEV-TAQLAGQAVGAFG-
Rv0927c|M.tuberculosis_H37Rv ASRTSSELDA-VAEQIRAAGRRAHTVAADLAHPEV-TAQLAGQAVGAFG-
Mflv_1825|M.gilvum_PYR-GCK AARTQSQLEA-VAEQIAGTGRRAHIVVADLARPED-TAGLAAQAVEAFG-
TH_3898|M.thermoresistible__bu SARTQAQLEE-VAAQIAATGRRAHVVAADLAHPEA-TAELAGAAVEAFG-
MLBr_01807|M.leprae_Br4923 THRASVVP------------DWFFGVECDVTDNDA-IGAAFKAVEEHQG-
MAB_0827|M.abscessus_ATCC_1997 TYSSSVQQAADVVDDINEDGGWARAVKADVADPDQ-LGAAIGQAAEELG-
: : :. . .
Mvan_0325|M.vanbaalenii_PYR-1 RLDILVNNVATLVQPAPTADVTAEEITTAFGVSVATPFLLTGLIAPAMVQ
MSMEG_5204|M.smegmatis_MC2_155 HIDILVNNAGLWGMPEATSAVSEPDLLASFRTNVIAPFLLTGALAPAMAE
MMAR_0629|M.marinum_M KVDILINSAGAFPF-GPTADTSPDDFDAVFALNVRAPYFLVGALAPTMAK
MAV_1046|M.avium_104 KLDIVVNNVG-GTMPNTLLTTSTKDLKDAFTFNVATAHALTVAAVPLMLE
MUL_4442|M.ulcerans_Agy99 RLDIVVNNVG-GTMPNTLLTTSTKDLKDAFTFNVATAHALTVAAVPLMLE
Mb0950c|M.bovis_AF2122/97 KLDIVVNNVG-GTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLE
Rv0927c|M.tuberculosis_H37Rv KLDIVVNNVG-GTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLE
Mflv_1825|M.gilvum_PYR-GCK RLDIVVNNVG-GTMPNALLNTSTKDMRDAFTFNVATAHALTTAAVPLMLE
TH_3898|M.thermoresistible__bu KLDIVVNNVG-GTMPGPLLNTSAKEMRDAFTFNVGTAHALTTAAVPLMLK
MLBr_01807|M.leprae_Br4923 PVEVLVANAG-ITSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIK
MAB_0827|M.abscessus_ATCC_1997 GLDILVNNAG-ILSIGDVDTATLADFDEIVAVNVRAVFAGIKAASPHLTE
::::: ... : :: . .: . : :
Mvan_0325|M.vanbaalenii_PYR-1 R-GDGAIVNIGSISGIIGAAGSALYGATKASVHLLTKAWAAEYGPSGVRV
MSMEG_5204|M.smegmatis_MC2_155 R-GHGAVVNVGSITGFIGGDRAALYSSTKAAVHSLTKSWAVEYGPQGVRV
MMAR_0629|M.marinum_M R-GRGSIVNVTTMVAEFGAAGTGLYGASKAAIALLTKSWAAEYGPSGVRV
MAV_1046|M.avium_104 HSGGGNIINITSTMGRLAGRGFAAYGTAKAALSHYTRLTALDLCPR-IRV
MUL_4442|M.ulcerans_Agy99 HSGGGGIINITSTMGRVAGRGFAAYGTAKVALAHYTRLAALDLCPR-IRV
Mb0950c|M.bovis_AF2122/97 HSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR-VRV
Rv0927c|M.tuberculosis_H37Rv HSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPR-VRV
Mflv_1825|M.gilvum_PYR-GCK HSGGGSIINITSTMGRVAGRGFAAYGTAKAALAHYTRLSALDLAPR-IRV
TH_3898|M.thermoresistible__bu HSGGGSIINITSTMGRLAGRGFAAYGTAKAALAHYTRLAALDLAPR-IRV
MLBr_01807|M.leprae_Br4923 QRFGRYIFMGSVVG-LSGVPGQANYAASKSGLIGMARSLARELGSRSITA
MAB_0827|M.abscessus_ATCC_1997 G--GRIVTIGSINGDSSPTANLSLYSMTKAAVAGLTRGLAREFGPRGITI
: . *. :* .: :: * : . :
Mvan_0325|M.vanbaalenii_PYR-1 NAVAPGPIAT---ERTREFGDAIAPVLARVPSHRMSTVAEVASAVVFLAG
MSMEG_5204|M.smegmatis_MC2_155 NAVAPGPIAT---ERVLEAADHVSGVLARIPSRRMSTPEEVAAAVVFLAG
MMAR_0629|M.marinum_M NAVSPGPTRT---EGTVEMGEALDQLAAAAPAGRPADPTEIASTIVYLAS
MAV_1046|M.avium_104 NAIAPGSILTSALDVVASNDELRAPMEKATPLRRLGDPVDIASAAVYLAS
MUL_4442|M.ulcerans_Agy99 NAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLAS
Mb0950c|M.bovis_AF2122/97 NAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLAS
Rv0927c|M.tuberculosis_H37Rv NAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLAS
Mflv_1825|M.gilvum_PYR-GCK NAIAPGSILTSALEIVASNDDLRDPMEKATPMKRLGDPLDIAAAAVYLAS
TH_3898|M.thermoresistible__bu NAIAPGSILTSALDVVASNDELRTPMEQATPLRRLGEPADIAAAAVYLAS
MLBr_01807|M.leprae_Br4923 NVVAPGFIDT--EMTRAMDSKYQEAALQAIPLGRIGAVEEIAGAVSFLAS
MAB_0827|M.abscessus_ATCC_1997 NNVQPGPIGT--DMN-PEDGQLADILRPNIAVGRYGQPRDIASLVSYLVS
* : ** * . . * . ::*. :*..
Mvan_0325|M.vanbaalenii_PYR-1 PEAANIHGTILSVDGGATAVRDEPAAVTKLGNHPHPG
MSMEG_5204|M.smegmatis_MC2_155 DEAANIHGAILSVDGGWAAA-----------------
MMAR_0629|M.marinum_M DAASFIHGAVVPVDGGRAAV-----------------
MAV_1046|M.avium_104 PAGEFLTGKTLEVDGGLTYPNLDIPVPDL--------
MUL_4442|M.ulcerans_Agy99 PAGSFLTGKTLEVDGGLTHPNLDIPVPDL--------
Mb0950c|M.bovis_AF2122/97 PAGSFLTGKTLEVDGGLTFPNLDLPIPDL--------
Rv0927c|M.tuberculosis_H37Rv PAGSFLTGKTLEVDGGLTFPNLDLPIPDL--------
Mflv_1825|M.gilvum_PYR-GCK PAGSYLTGKTLEVDGGITFPNLELPIPDL--------
TH_3898|M.thermoresistible__bu PAGSYLTGKVLEVDGGLTRPNLDMPIPDL--------
MLBr_01807|M.leprae_Br4923 EDAGYISGAVIPVDGGLGMGH----------------
MAB_0827|M.abscessus_ATCC_1997 DEAWYITGTAINIDGGFTA------------------
. : * : :***