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DMGLSGKRALVTGSSSGLGRAIAESLAAEGASVVVHGRDEVRTGAVADGIRARGGDAWAAVGDLATEGGA GAVAAAAGEVDILVNNAGVYDGLAWSDLAPRQWQSIYEVNVVSGVRMIEYLVPGMRQRGWGRIIQIGGGL ALQPAADQPHYNATLAARHNLTVSLARELAGTGVTSNTVAPGAILTEPVREMTYRVAAQRGWGPTWEDVE KAAATTWFPNDIGRFGRPEEVAAAVAFLAGVHAGYISGADLRVDGGAIRSVA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0296 | - | - | 100% (263) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_2469 | - | 2e-29 | 31.66% (259) | short-chain dehydrogenase/reductase SDR |
| M. gilvum PYR-GCK | Mflv_0943 | - | 1e-27 | 32.45% (265) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1963c | - | 4e-24 | 30.77% (260) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv1928c | - | 4e-24 | 30.77% (260) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 1e-25 | 35.08% (248) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_4665c | - | 1e-31 | 32.07% (237) | putative short-chain dehydrogenase/reductase |
| M. marinum M | MMAR_1568 | - | 2e-33 | 34.34% (265) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_2438 | - | 3e-33 | 35.32% (269) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_0600 | - | 9e-39 | 35.47% (265) | dehydrogenase |
| M. thermoresistible (build 8) | TH_3893 | - | 5e-61 | 49.08% (271) | PUTATIVE putative short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 6e-28 | 35.71% (252) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_0398 | - | 1e-42 | 37.84% (259) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0296|M.gilvum_PYR-GCK --------------MDMGLSGKRALVTGSSSGLGRAIAESLAAEGASVVV
TH_3893|M.thermoresistible__bu --------------MDFDLNGKRALVTGSSSGIGAGIVETLAAEGVSVVV
MSMEG_0600|M.smegmatis_MC2_155 --------------MNIDLTGKTALVTGSTQGIGLAIAETLARSGARVAI
Mvan_0398|M.vanbaalenii_PYR-1 --------------MKIDLTGKTALVTGSTQGIGLAIARSLAASGARVAV
MAB_4665c|M.abscessus_ATCC_199 -------------------------------------MRQLAASGARAVV
MMAR_1568|M.marinum_M --------------MDLGFSGSKAVVTGGSKGMGLAIAETLAAEGASVAV
MAV_2438|M.avium_104 --------------MDLGLAGSTAVVTGGSKGMGLAVAETLAAEGAKVAV
Mb1963c|M.bovis_AF2122/97 ----------MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAI
Rv1928c|M.tuberculosis_H37Rv ----------MSVLDLFDLHGKRALITGASTGIGKRVALAYVEAGAQVAI
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
MUL_0315|M.ulcerans_Agy99 ---------MRPD-SSPSWCTITSVVTGGASGIGLAIARRLSADGTDVAT
* ..
Mflv_0296|M.gilvum_PYR-GCK HGRDEVRTGAVADGIRAR-GGDAWAAVGDLATEGGAGAVAAAAG----EV
TH_3893|M.thermoresistible__bu HGRNAERAEAVADRIRAD-GGTAATAVGDLATEDGAAQVADTAAAAFSGI
MSMEG_0600|M.smegmatis_MC2_155 NGRTASRVDETVAQLG---DLDVVGVAADVATQKGTEALLEQLP----SV
Mvan_0398|M.vanbaalenii_PYR-1 NGRSRDRVDEAVATL----DGDVVGVAADVADAAGAQALAAELP----HI
MAB_4665c|M.abscessus_ATCC_199 NGRSQERVDAAVAEVGLQ-HGSVSGVAADVSTADGVERLLKQLP----EV
MMAR_1568|M.marinum_M IARGKRALDSAVERLSQAGAPDAVAISADMADAASITSAFAAVSERWGQL
MAV_2438|M.avium_104 MARGRHALDAAVALLREAGAPDAVGVSVDMADAESIADGFAAVAQRWGRL
Mb1963c|M.bovis_AF2122/97 AARHLDALEKLADEIG-TSGGKVVPVCCDVSQHQQVTSMLDQVTAELGGI
Rv1928c|M.tuberculosis_H37Rv AARHLDALEKLADEIG-TSGGKVVPVCCDVSQHQQVTSMLDQVTAELGGI
MLBr_01807|M.leprae_Br4923 THRAS------------VVPDWFFGVECDVTDNDAIGAAFKAVEEHQGPV
MUL_0315|M.ulcerans_Agy99 LDLK--------------TPDGGLAFSADVTNRSQVDAALAAIRQRLGPV
*:: :
Mflv_0296|M.gilvum_PYR-GCK DILVNNAGVYDG---LAWSDLAPRQWQSIYEVNVVSGVRMIEYLVPGMRQ
TH_3893|M.thermoresistible__bu DILVNNAGGSSETGIQSWFALPVSEWGVTYQRNVMSAGYLIHALVPAMKE
MSMEG_0600|M.smegmatis_MC2_155 DILVNNLGIFGA---EPAREITDEQWRKYFDVNVLAAVRLIRSYLPGMIE
Mvan_0398|M.vanbaalenii_PYR-1 DILVNNLGIFGA---VPAREITDDQWRSYFEVNVLAAARLIRHYLPGMVD
MAB_4665c|M.abscessus_ATCC_199 DILINNLGIFGA---TPAREITDEQWRNYFEVNVLSAVRLIRAYLPAMIG
MMAR_1568|M.marinum_M NCLVHTIGPGDG----YFEELDDAAWDAAFTLGTMSGVRAIRAALPLLRA
MAV_2438|M.avium_104 NSLVHTIGPGDG----DFEELDDTGWDEAFALGTMSAVRSIRNALPLLRA
Mb1963c|M.bovis_AF2122/97 DIAVCNAGIITV---TPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVK
Rv1928c|M.tuberculosis_H37Rv DIAVCNAGIITV---TPMLDMPLEEFQRLQNTNVTGVFLTAQAAAKAMVK
MLBr_01807|M.leprae_Br4923 EVLVANAGITSD---MLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIK
MUL_0315|M.ulcerans_Agy99 TILVNAAGLDGF---KRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVA
: * : : . . . :
Mflv_0296|M.gilvum_PYR-GCK RGWGRIIQIGGGLA---LQPAADQPHYNATLAARHNLTVSLARELAGTGV
TH_3893|M.thermoresistible__bu SGWGRIIQIASAAG---IIPTSGQPDYGPSKAAMINMSMGLSKALAGTGI
MSMEG_0600|M.smegmatis_MC2_155 KGWGRAIQIASDSA---IVIPEEMIHYGVSKTALLAVSRGFAKDAAGTGV
Mvan_0398|M.vanbaalenii_PYR-1 RGWGRVLQIASDSA---IVIPEEMIHYGVSKTALLALSRGFAKDASGTGV
MAB_4665c|M.abscessus_ATCC_199 AGWGRIIQIASDSA---IVIPQEMIHYGVSKTALLGVTRGFAKDAAGSGV
MMAR_1568|M.marinum_M ADWARVVTLSAHSI---QRQNPRLVAYTASKAALSSVTKNLSKSLAKEGI
MAV_2438|M.avium_104 ADWGRIVTFAAHSI---QRQNPRIVAYTASKAALASITKNLSKSLAAEGI
Mb1963c|M.bovis_AF2122/97 QGQGGVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHKI
Rv1928c|M.tuberculosis_H37Rv QGQGGVIINTASMSGHIINVPQQVSHYCASKAAVIHLTKAMAVELAPHKI
MLBr_01807|M.leprae_Br4923 QRFGRYIFMGSVVG---LSGVPGQANYAASKSGLIGMARSLARELGSRSI
MUL_0315|M.ulcerans_Agy99 AGWGRIVNISSSST---HSGTPYMTHYVAAKSAVNGLTKALALEYGPSGI
. : . * : :. :: :: . :
Mflv_0296|M.gilvum_PYR-GCK TSNTVAPGAILTEPVREMTYRVAAQRGWGPTWEDVEKAAATTWFPN--DI
TH_3893|M.thermoresistible__bu TVNTVMPGMIMTEGLRDFLRTFADHRGWG---DDLDKAADYILKGTGQTV
MSMEG_0600|M.smegmatis_MC2_155 TVNSVIAGPTHTAGVEDFVYQLVDK---SLPWDEAQREFMRKHRPQ-SLL
Mvan_0398|M.vanbaalenii_PYR-1 TVNSVIAGPTHTAGVEDFVYQLVDK---SLPWEQAQREFMRLHRPQ-SLI
MAB_4665c|M.abscessus_ATCC_199 TINSVIAGPTHTAGVEDFVYQLVDK---SLPWDEAQREFMKRHRPQ-SLV
MMAR_1568|M.marinum_M LVNCVCPGTIVTASFTEQLKDLLAADGLDATNPYDVMAWIDKYFHQPCDL
MAV_2438|M.avium_104 LVNCVCPGTIVTASFTEALKGVLAADGLDATDPVDVMTWIDDNFHQPCDL
Mb1963c|M.bovis_AF2122/97 RVNSVSPGYILTELVEPYTEY-------------------QPLWEPKIPL
Rv1928c|M.tuberculosis_H37Rv RVNSVSPGYILTELVEPYTEY-------------------QPLWEPKIPL
MLBr_01807|M.leprae_Br4923 TANVVAPGFIDTEMTRAMDSK------------------YQEAALQAIPL
MUL_0315|M.ulcerans_Agy99 TVNAVPPGFIDTPMLRNAAAQGHLG--------------DIEQNIARTPV
* * .* * :
Mflv_0296|M.gilvum_PYR-GCK GRFGRPEEVAAAVAFLAGVHAGYISGADLRVDGGAIRSVA-
TH_3893|M.thermoresistible__bu HRIGQVSDVAYAVAFLASPRADFLNGINLHLDGGATQSIY-
MSMEG_0600|M.smegmatis_MC2_155 QRLIEPEEIANMVAYLASPLASATTGGALRVDGGYVDAILP
Mvan_0398|M.vanbaalenii_PYR-1 ERLIEPEEIANMVTYLASPLASATTGGALRVDGGYVDAILP
MAB_4665c|M.abscessus_ATCC_199 QRLIEPAEIANLVVYLSSPLASATTGAAVRADGGYVDSILP
MMAR_1568|M.marinum_M GRAGLPEEVASITAYLVSRRNGYVTGATVNADGGSDFI---
MAV_2438|M.avium_104 GRAGLPEEVASITVYLASRRNGYVTGAMVNVDGGSDFI---
Mb1963c|M.bovis_AF2122/97 GRLGRPEELAGLYLYLASEASSYMTGSDIVIDGGYTCP---
Rv1928c|M.tuberculosis_H37Rv GRLGRPEELAGLYLYLASEASSYMTGSDIVIDGGYTCP---
MLBr_01807|M.leprae_Br4923 GRIGAVEEIAGAVSFLASEDAGYISGAVIPVDGGLGMGH--
MUL_0315|M.ulcerans_Agy99 RRIGKPEDIAAACAFLVSEEAGYITGQILGVNGGRNT----
* ::* :* . . .* : :**