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ELTGQTALITGGTAGIGLACAQLMAREGADVVITGRDPGRGEAAAASDPRLRFLRCDLADRTSIESLVQQ APPVDILVNNAASFPGAMTVDQDAATFQRTFDTNVGGTYFLTAAVVPAMLLRGRGAIVNVTSMVAWKGVP GASVYSASKAAVESLTRTWAAEFAPHVRVNSVAPGPTDTEGVVAEWGDTNDELGRALPLGRTATPGEIAQ AVLFLASPRAGFVTGSVLHADGGGTAI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1212 | - | - | 100% (238) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_4593 | - | 6e-43 | 43.15% (248) | short-chain dehydrogenase/reductase SDR |
| M. vanbaalenii PYR-1 | Mvan_0325 | - | 1e-40 | 41.94% (248) | short-chain dehydrogenase/reductase SDR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2788c | fabG | 3e-37 | 37.92% (240) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. gilvum PYR-GCK | Mflv_2424 | - | 3e-31 | 35.12% (242) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv2766c | fabG | 3e-37 | 37.92% (240) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. leprae Br4923 | MLBr_01807 | fabG1 | 1e-26 | 32.77% (235) | 3-oxoacyl- |
| M. abscessus ATCC 19977 | MAB_0607 | - | 6e-36 | 37.50% (240) | short chain dehydrogenase |
| M. marinum M | MMAR_0629 | - | 1e-51 | 46.75% (246) | dehydrogenase |
| M. avium 104 | MAV_3655 | fabG | 4e-37 | 38.49% (239) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. smegmatis MC2 155 | MSMEG_1689 | - | 6e-92 | 70.83% (240) | 3-oxoacyl- |
| M. thermoresistible (build 8) | TH_2488 | - | 2e-93 | 69.04% (239) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_2173 | fabG | 7e-36 | 36.67% (240) | 3-ketoacyl-(acyl-carrier-protein) reductase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1212|M.vanbaalenii_PYR-1 ----------------MELTGQTALITGGTAGIGLACAQLMAREGADVVI
MSMEG_1689|M.smegmatis_MC2_155 ----------------MQLSGYHALVTGGTAGIGRACADLLAREGARVTI
TH_2488|M.thermoresistible__bu ----------------MEFQGLHVLVTGGTGGIGLACARAFAEAGAEVTV
MMAR_0629|M.marinum_M ------------------MAGLTALITGATSGIGRATAHGLAELGATVLV
Mflv_2424|M.gilvum_PYR-GCK ---------MAITASDILLTGRVAVVTGGGAGIGRGIAQGLAAFGASVAI
MAB_0607|M.abscessus_ATCC_1997 ----------MRTPYDLGLEGRVVLVTGGVRGVGAGISQVFADQGATVVT
Mb2788c|M.bovis_AF2122/97 -------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVL
Rv2766c|M.tuberculosis_H37Rv -------------MTSLDLTGRTAIITGASRGIGLAIAQQLAAAGAHVVL
MUL_2173|M.ulcerans_Agy99 -------------MTSLDLTGRTAIITGASRGIGLAIAQRLAGAGANVVL
MAV_3655|M.avium_104 -------------MTSQDLTGRTAIITGASRGIGLAIAQQLAAAGANVVL
MLBr_01807|M.leprae_Br4923 MTDAAAKVSAAPGRGKPAFVSRSILVTGGNRGIGLAVARRLVADGHRVAV
: . ::**. *:* . : :. * *
Mvan_1212|M.vanbaalenii_PYR-1 TGRDPGRG---EAAAASD-PRLRFLRCDLADRTSIESLVQQAP-----PV
MSMEG_1689|M.smegmatis_MC2_155 TGRDADRG---AAAAAELGDNVRFVQADLSDLQSVKALAEQCD-----TA
TH_2488|M.thermoresistible__bu TGRDAGRG---AAAAGAH-PRLRFIRGDLADLASVQNLIRYAD-----AV
MMAR_0629|M.marinum_M SGRDEARGREVVDEVTARGGRGIFLAAELRDVTGVRNLATAAADAGAGKV
Mflv_2424|M.gilvum_PYR-GCK WERDPDTC-----AAAAAAIGGLGLEVDVRDAAAVDTALDRTERELG-TV
MAB_0607|M.abscessus_ATCC_1997 CARRPGDA-----PYEFHSC-------DVRDEESVDTLIGAIVAAHG-RL
Mb2788c|M.bovis_AF2122/97 TARRQEAAD---EAAAQVGDRALGVGAHAVDEDAARRCVDLTLERFG-SV
Rv2766c|M.tuberculosis_H37Rv TARRQEAAD---EAAAQVGDRALGVGAHAVDEDAARRCVDLTLERFG-SV
MUL_2173|M.ulcerans_Agy99 TARKQESAD---AAAAEVGERAVGVGAHAVDEEAARGCVDLALERFG-SV
MAV_3655|M.avium_104 TARKQEAAD---EAAAQVGPQALGVGAHAVDEDAARQCVQLTLERFG-SV
MLBr_01807|M.leprae_Br4923 THR-----------ASVVPDWFFGVECDVTDNDAIGAAFKAVEEHQG-PV
* . * .
Mvan_1212|M.vanbaalenii_PYR-1 DILVNNAAS-FPGAMTVDQDAATFQRTFDTNVGGTYFLTAAVVPAMLLR-
MSMEG_1689|M.smegmatis_MC2_155 DIVVNNAAS-FPGALTVEQDIASYERTFDTNVRGTYFLVAQLAPGMFAR-
TH_2488|M.thermoresistible__bu DVLVNNAAS-FPGALTVEQDAESFTRTFATNVTGTYFLTAGLIPGMLAR-
MMAR_0629|M.marinum_M DILINSAGA-FPFGPTADTSPDDFDAVFALNVRAPYFLVGALAPTMAKR-
Mflv_2424|M.gilvum_PYR-GCK SILVNNAGG-TFNSPLLDTSENGWDALYRSNLRHVLLCTQRVARRLVAAE
MAB_0607|M.abscessus_ATCC_1997 DAVVNNAGG-APFALAADASHNFHRKIIELNLLSALLVSQRANAVMQKQD
Mb2788c|M.bovis_AF2122/97 DILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGE-
Rv2766c|M.tuberculosis_H37Rv DILINNAGTNPAYGPLLEQDHARFAKIFDVNLWAPLMWTSLVVTAWMGE-
MUL_2173|M.ulcerans_Agy99 DILINNAGTNPAYGPLIEQDHARFTKIFDVNLWAPLMWTSLVVKAWMGE-
MAV_3655|M.avium_104 DILVNNAGTNPAYGPLIEQDHARFAKIFDVNLWAPLLWTSLAVKSWMGE-
MLBr_01807|M.leprae_Br4923 EVLVANAGI-TSDMLIMRMSEEQFQKVIDVNLTGVFRVAKLASRNMIKQ-
. :: .*. . *:
Mvan_1212|M.vanbaalenii_PYR-1 GRGAIVNVTSMVAWKGVPGASVYSASKAAVESLTRTWAAEFAPH-VRVNS
MSMEG_1689|M.smegmatis_MC2_155 GRGSIVNVTSMVASKGVAGASTYSASKAAVESLTRTWAAEFGPRGVRVNS
TH_2488|M.thermoresistible__bu GRGSIVNITSMVATKAVPGASVYSSSKAAVESLTRSWAVEFAAHGIRVNA
MMAR_0629|M.marinum_M GRGSIVNVTTMVAEFGAAGTGLYGASKAAIALLTKSWAAEYGPSGVRVNA
Mflv_2424|M.gilvum_PYR-GCK QTGSVINVTSIEGSRAAPGYAAYAAAKAGVVNYTKTASFELAPYGIRVNG
MAB_0607|M.abscessus_ATCC_1997 GGGTIVNITSVSAGRPSPGTAAYGAAKAGLESLTRSLAVEWAPK-VRVNA
Mb2788c|M.bovis_AF2122/97 HGGAVVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-IRVNA
Rv2766c|M.tuberculosis_H37Rv HGGAVVNTASIGGMHQSPAMGMYNATKAALIHVTKQLALELSPR-IRVNA
MUL_2173|M.ulcerans_Agy99 HGGVVINTASIGGMHQSPAMGMYNATNAALIHVTKQLALELSPR-VRVNA
MAV_3655|M.avium_104 HGGSIVNTASIGGLHQSPAMGMYNATKAALIHVTKQLALELSPR-VRVNA
MLBr_01807|M.leprae_Br4923 RFGRYIFMGSVVGLSGVPGQANYAASKSGLIGMARSLARELGSRSITANV
* : :: . .. . * ::::.: :: : * .. : .*
Mvan_1212|M.vanbaalenii_PYR-1 VAPGPTDTEGVVAEWG---DTNDELGRALPLGRTATPGEIAQAVLFLASP
MSMEG_1689|M.smegmatis_MC2_155 VAPGPTRTEGVEAEWG---DTNEQLGKALPLGRTAQPEEIAHAVLFLCSP
TH_2488|M.thermoresistible__bu VAPGPTSTDGVATEWG---ETNEALGRALPIGRTADPDEIAQAVVFLASS
MMAR_0629|M.marinum_M VSPGPTRTEG-TVEMG---EALDQLAAAAPAGRPADPTEIASTIVYLASD
Mflv_2424|M.gilvum_PYR-GCK LAPDLTMTEGLQKLAFGELSGTVAR--MVPMRRAGHVDEMASAAVFLASD
MAB_0607|M.abscessus_ATCC_1997 LAAGMIRTE-LSEMHYGDEDGIAAVGATVPLGRLANPDEIGWTAAFLASP
Mb2788c|M.bovis_AF2122/97 ICPGVVRTRLAEALWK---DHEDPLAATIALGRIGEPADIASAVAFLVSD
Rv2766c|M.tuberculosis_H37Rv ICPGVVRTRLAEALWK---DHEDPLAATIALGRIGEPADIASAVAFLVSD
MUL_2173|M.ulcerans_Agy99 ICPGVVRTKLAEALWK---DHEDPLAANIALGRIGEPVDVAEAVGFLVSD
MAV_3655|M.avium_104 IAPGVVRTRLAEALWK---DHEDPLSSSIALGRIGEPIDVAAAVAFLVSD
MLBr_01807|M.leprae_Br4923 VAPGFIDTEMTRAMDS---KYQEAALQAIPLGRIGAVEEIAGAVSFLASE
:... * . . * . ::. : :* *
Mvan_1212|M.vanbaalenii_PYR-1 RAGFVTGSVLHADGGGTAI------------------
MSMEG_1689|M.smegmatis_MC2_155 RASFITGSTLHADGGGAAV------------------
TH_2488|M.thermoresistible__bu RASFITGAVLHVDGGGIAV------------------
MMAR_0629|M.marinum_M AASFIHGAVVPVDGGRAAV------------------
Mflv_2424|M.gilvum_PYR-GCK MASYITGQTIHVDGGTEAAGGWYFHPDNGAPTLGPA-
MAB_0607|M.abscessus_ATCC_1997 LSSYVTGSVLTVHGGGERP-AFLDAANVNSNENGEKE
Mb2788c|M.bovis_AF2122/97 AASWITGETMIIDGGLLLGNALGFRAAPSTEH-----
Rv2766c|M.tuberculosis_H37Rv AASWITGETMIIDGGLLLGNALGFRAAPSTEH-----
MUL_2173|M.ulcerans_Agy99 AASWITGETMVIDGGLLLGSAAGFQSRPGSAS-----
MAV_3655|M.avium_104 AASWITGETLVIDGGTVLGAAQGFRSAPTPS------
MLBr_01807|M.leprae_Br4923 DAGYISGAVIPVDGGLGMGH-----------------
:.:: * .: .**