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STPNSHPGANSPCPIKRRRARRGSGELLREEILDATTDLLLETGHAKDVSIRAVAKRVGVTPPSIYLHFA DKDALLDAVCARYFEKLDQQMQRVAAGQPSTIDVLRAQGLAYVEFATHTPELYRLATMAEGRPGSDVDIT LNSSAFQHMRATIEKLMDEGIYPPGDATTWALELWTAAHGVAAMLIAKPYLPWGDTHEFADRVLRAVCSG HIVSGIIGNDVTPSEAVARLKGLADAPN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5177 | - | - | 100% (239) | regulatory protein, TetR |
| M. smegmatis MC2 155 | MSMEG_5307 | - | 3e-11 | 38.94% (113) | TetR-family protein transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_3425 | - | 6e-09 | 29.19% (161) | TetR-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3076c | - | 6e-08 | 28.08% (146) | AsnC family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2132 | - | 2e-87 | 69.68% (221) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv3050c | - | 6e-08 | 28.08% (146) | AsnC family transcriptional regulator |
| M. leprae Br4923 | MLBr_01733 | - | 4e-07 | 26.90% (145) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1288 | - | 4e-61 | 52.86% (210) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4304 | - | 2e-76 | 67.31% (208) | TetR family transcriptional regulator |
| M. avium 104 | MAV_4494 | - | 3e-07 | 28.79% (198) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_1893 | - | 1e-07 | 27.94% (204) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY |
| M. ulcerans Agy99 | MUL_0990 | - | 9e-76 | 66.83% (208) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4572 | - | 7e-77 | 63.18% (220) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2132|M.gilvum_PYR-GCK -----------------------------------MSEHGV------RRR
Mvan_4572|M.vanbaalenii_PYR-1 --------------------------------MADVSAPRQ------RRH
MSMEG_5177|M.smegmatis_MC2_155 -------------------------------MSTPNSHPGANSPCPIKRR
MMAR_4304|M.marinum_M -----------------------------------MSMGRL------RRA
MUL_0990|M.ulcerans_Agy99 ----------------------------------------M------RRA
MAB_1288|M.abscessus_ATCC_1997 -----------------------------------MT----------RRQ
MAV_4494|M.avium_104 ---------------------------------MAAQPEPPTAAGRQRAG
TH_1893|M.thermoresistible__bu ---------------------------------VNTQMSAGPGGAPGART
Mb3076c|M.bovis_AF2122/97 -----------------------------MVRIPRPHPSAKPGVKVDARS
Rv3050c|M.tuberculosis_H37Rv -----------------------------MVRIPRPHPSAKPGVKVDARS
MLBr_01733|M.leprae_Br4923 MTRRSIHTRKPLKWSGCAGQHVRSGKVFDVGRISLSYPSMKPGVKIDARS
Mflv_2132|M.gilvum_PYR-GCK RAPRGAGEHLRDEILDAATELLLESGDEKAVSVRSVAERVGVTPPSLYLH
Mvan_4572|M.vanbaalenii_PYR-1 RAPRGAGEQLRAEILDAATDLLLETGDEKAVSIRSVAQRVGVTPPSIYLH
MSMEG_5177|M.smegmatis_MC2_155 RARRGSGELLREEILDATTDLLLETGHAKDVSIRAVAKRVGVTPPSIYLH
MMAR_4304|M.marinum_M RAPRGSGDLLRHEILDAATELLLQTRQARAVSIRSVAERVGVTPPSIYLH
MUL_0990|M.ulcerans_Agy99 RAPRGSGDLLRHEILDAATELLLQTRQARAVSIRSVAERVGVTSPSIYLH
MAB_1288|M.abscessus_ATCC_1997 RASRGSGDRLRDEIIDAAIALVLETKELRAPSIREVARKIGVTPPSIYLH
MAV_4494|M.avium_104 RPAARPAKLSREGIIDGALTFLDREG-WDALTINALATQLGTKGPSLYNH
TH_1893|M.thermoresistible__bu KSPARAGRLSRDTIVNAALTFLDREG-WDALTINALATQLGTKGPSLYNH
Mb3076c|M.bovis_AF2122/97 ERWREHRKKVRNEIVDAAFRAIDRLG--PELSVRQIAEEAGTAKPKIYRH
Rv3050c|M.tuberculosis_H37Rv ERWREHRKKVRNEIVDAAFRAIDRLG--PELSVRQIAEEAGTAKPKIYRH
MLBr_01733|M.leprae_Br4923 ERWREHRKKVRGEIVDAAFRALDRLG--PEVSVREIAEEAGTAKPKIYRH
. * *::.: : . ::. :* . *. *.:* *
Mflv_2132|M.gilvum_PYR-GCK FADKNALLDAVCGRYFEKLDEQMQ-AVAAACPSTIEVLRAQGLAYVRFAL
Mvan_4572|M.vanbaalenii_PYR-1 FVDKTALLDAVCGRYFEKLDEEMQ-EVAGAAATALDVLRAQGMAYVRFAL
MSMEG_5177|M.smegmatis_MC2_155 FADKDALLDAVCARYFEKLDQQMQ-RVAAGQPSTIDVLRAQGLAYVEFAT
MMAR_4304|M.marinum_M FQDKDALLDAVCARYLARLDEEME-RAAMGHTCVVEVLRAQGLAYVRFAL
MUL_0990|M.ulcerans_Agy99 FQDKDALLDAVCARYLARLDEEME-RAAMGHTCVVEVLRAQGLAYVRFAL
MAB_1288|M.abscessus_ATCC_1997 FADKDELMDAVCGQYFQRLNDKMV-EAARGDITALERLHAQGMAYVRFAI
MAV_4494|M.avium_104 VDSLEDLRRAVRIRVIDDIITMLN-RVGEGR-ARDDAVLVMAGAYRSYAH
TH_1893|M.thermoresistible__bu VQSLDDLRRSVRMRVVDDIIGMLN-AAGQGR-TRDDAVLAMASAYRSYAH
Mb3076c|M.bovis_AF2122/97 FTDKSDLLEAIGMRLRDMLWAAIFPSLDLATDSAREVIRRSVEEYVNLVD
Rv3050c|M.tuberculosis_H37Rv FTDKSDLLEAIGMRLRDMLWAAIFPSLDLATDSAREVIRRSVEEYVNLVD
MLBr_01733|M.leprae_Br4923 FTDKSDLFEAIGIRLRDMLWAAIFPAIDLATDSAREIIRRSVDEYVSLVD
. . * :: : : : . : : * .
Mflv_2132|M.gilvum_PYR-GCK QTPELYRIATMGHGNPGSGVDLTLNSAAFVHMRASVEALIAEGVYPPGDP
Mvan_4572|M.vanbaalenii_PYR-1 KNPVLYRIAMMGPGSPGSDVDVALNSSAFGHLLMSVQALIAEGVYPQADP
MSMEG_5177|M.smegmatis_MC2_155 HTPELYRLATMAEGRPGSDVDITLNSSAFQHMRATIEKLMDEGIYPPGDA
MMAR_4304|M.marinum_M QTPELYRLATMGEWRSGSNVDSALDSSAFRHMCASVQAMMDEGIYRADDP
MUL_0990|M.ulcerans_Agy99 QTPELYRLATMGEWRSGSNVDSALDSSAFRHMCASVQAMMDEGIYRADDP
MAB_1288|M.abscessus_ATCC_1997 ATPLMYRLATVTQ--PEGELDETMASAAFAHLHNGVKELVTEGLYPEGDT
MAV_4494|M.avium_104 HHPGRY---SAFTRMPLGGDDPEYTAATRGAAAPVISVLSSYGLDGE-EA
TH_1893|M.thermoresistible__bu HHPGRY---SAFTRMPLGGDDPEFSAAARAAAGPVIAVLGSYGLEGE-EA
Mb3076c|M.bovis_AF2122/97 QHPNVLRVFIQGRSAKQSEATVRTLNEGREITLAMAEMFNNELREMELNR
Rv3050c|M.tuberculosis_H37Rv QHPNVLRVFIQGRSAKQSEATVRTLNEGREITLAMAEMFNNELREMELNR
MLBr_01733|M.leprae_Br4923 KHPNVLRVFIQGRFSAQSEATVRTLDEGREITLTMAEMFNNELREMELNR
* . : :
Mflv_2132|M.gilvum_PYR-GCK TVFALELWTCAHGIAAQLISRPYLPWGDVEQFADRVLRAVCIGHMVSVAI
Mvan_4572|M.vanbaalenii_PYR-1 TMLALELWTAVHGIAAMLISRPYLPWGGAEEFADRLMRAVCCGQALSVAI
MSMEG_5177|M.smegmatis_MC2_155 TTWALELWTAAHGVAAMLIAKPYLPWGDTHEFADRVLRAVCSGHIVSGII
MMAR_4304|M.marinum_M TTIALELWTAAHGVAALLIAKPHLPFGDVAAFADRVLGAVLCGHMVAGLV
MUL_0990|M.ulcerans_Agy99 TTIALELWTAAHGVAALLIAKPHLPFGDVAAFADRVLGAVLCGHMVAGLV
MAB_1288|M.abscessus_ATCC_1997 VAMALQLWVAAHGVASMLVTKPHLPWGDPEEFASEVLRAACLGQAVS---
MAV_4494|M.avium_104 FHAALEFWSALHGFVLLEMTGVMDDIDTDALFSDMVLRLAAGLERRTAHG
TH_1893|M.thermoresistible__bu FYAALEFWSALHGFVLLEMTGVMDDVDSDKVFTDMVLRLAAGMEKRS---
Mb3076c|M.bovis_AF2122/97 AALELAAFAAFGSAASATEWWLGPEPDSPRRMPREQFVAHLTTIMMGVIV
Rv3050c|M.tuberculosis_H37Rv AALELAAFAAFGSAASATEWWLGPEPDSPRRMPREQFVAHLTTIMMGVIV
MLBr_01733|M.leprae_Br4923 AASELAAFAAFGSVASATEWWLGPEPDSPRRMPREQFVAHLTIIMMAVIV
* : . . . . :. :
Mflv_2132|M.gilvum_PYR-GCK GPDENAMDTVNWLKEVVDERRRR----
Mvan_4572|M.vanbaalenii_PYR-1 RPDESPREIMTWLKEVVDERQRG----
MSMEG_5177|M.smegmatis_MC2_155 GNDVTPSEAVARLKGLADAPN------
MMAR_4304|M.marinum_M GPQATSRDLMDWVVQHRPSEESRV---
MUL_0990|M.ulcerans_Agy99 GPQATSRDLMDWVVQHRPSEESRV---
MAB_1288|M.abscessus_ATCC_1997 --DIDLTEVLPRQK-------------
MAV_4494|M.avium_104 ---------------------------
TH_1893|M.thermoresistible__bu ---------------------------
Mb3076c|M.bovis_AF2122/97 GTAEALGIAVDPDQPIHDAVPNNPAVR
Rv3050c|M.tuberculosis_H37Rv GTAEALGIAVDPDQPIHDAVPNNPAVR
MLBr_01733|M.leprae_Br4923 GTAETLGISMNPDRPIHDAVPLDRSAS