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SMGRLRRARAPRGSGDLLRHEILDAATELLLQTRQARAVSIRSVAERVGVTPPSIYLHFQDKDALLDAVC ARYLARLDEEMERAAMGHTCVVEVLRAQGLAYVRFALQTPELYRLATMGEWRSGSNVDSALDSSAFRHMC ASVQAMMDEGIYRADDPTTIALELWTAAHGVAALLIAKPHLPFGDVAAFADRVLGAVLCGHMVAGLVGPQ ATSRDLMDWVVQHRPSEESRV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4304 | - | - | 100% (232) | TetR family transcriptional regulator |
| M. marinum M | MMAR_4906 | - | 2e-09 | 31.01% (158) | transcriptional regulator |
| M. marinum M | MMAR_1249 | - | 4e-08 | 32.52% (163) | transcriptional regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0672c | - | 7e-09 | 27.32% (205) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2132 | - | 2e-76 | 63.35% (221) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0653c | - | 7e-09 | 27.32% (205) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_01733 | - | 2e-06 | 31.19% (109) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_1288 | - | 4e-55 | 52.24% (201) | TetR family transcriptional regulator |
| M. avium 104 | MAV_4851 | - | 3e-07 | 40.24% (82) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_5177 | - | 2e-76 | 67.31% (208) | regulatory protein, TetR |
| M. thermoresistible (build 8) | TH_4347 | - | 1e-08 | 26.14% (176) | PUTATIVE transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_0990 | - | 1e-127 | 99.56% (227) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4572 | - | 8e-72 | 59.73% (221) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4304|M.marinum_M -----------------------------------MSMGRL------RRA
MUL_0990|M.ulcerans_Agy99 ----------------------------------------M------RRA
Mflv_2132|M.gilvum_PYR-GCK -----------------------------------MSEHGV------RRR
Mvan_4572|M.vanbaalenii_PYR-1 --------------------------------MADVSAPRQ------RRH
MSMEG_5177|M.smegmatis_MC2_155 -------------------------------MSTPNSHPGANSPCPIKRR
MAB_1288|M.abscessus_ATCC_1997 -----------------------------------MT----------RRQ
Mb0672c|M.bovis_AF2122/97 --------------------------------------------------
Rv0653c|M.tuberculosis_H37Rv --------------------------------------------------
TH_4347|M.thermoresistible__bu --------------------------------------------------
MAV_4851|M.avium_104 -------------------------------MSIAAGQQPGRPAGPTRRT
MLBr_01733|M.leprae_Br4923 MTRRSIHTRKPLKWSGCAGQHVRSGKVFDVGRISLSYPSMKPGVKIDARS
MMAR_4304|M.marinum_M RAPRGSGDLLRHEILDAATELLLQTRQARAVSIRSVAERVGVTPPSIYLH
MUL_0990|M.ulcerans_Agy99 RAPRGSGDLLRHEILDAATELLLQTRQARAVSIRSVAERVGVTSPSIYLH
Mflv_2132|M.gilvum_PYR-GCK RAPRGAGEHLRDEILDAATELLLESGDEKAVSVRSVAERVGVTPPSLYLH
Mvan_4572|M.vanbaalenii_PYR-1 RAPRGAGEQLRAEILDAATDLLLETGDEKAVSIRSVAQRVGVTPPSIYLH
MSMEG_5177|M.smegmatis_MC2_155 RARRGSGELLREEILDATTDLLLETGHAKDVSIRAVAKRVGVTPPSIYLH
MAB_1288|M.abscessus_ATCC_1997 RASRGSGDRLRDEIIDAAIALVLETKELRAPSIREVARKIGVTPPSIYLH
Mb0672c|M.bovis_AF2122/97 ---MTSQTGVRDELLHAGVRLLDDHG-PDALQTRKVAAAAGTSTMAVYTH
Rv0653c|M.tuberculosis_H37Rv ---MTSQTGVRDELLHAGVRLLDDHG-PDALQTRKVAAAAGTSTMAVYTH
TH_4347|M.thermoresistible__bu ----VTADDIREKLVDAGVRLLERDG-VQALSARNLAAEAGTSTMAVYTR
MAV_4851|M.avium_104 TAPRKRGDDTRARIIDETVRCIIEEG-FAAATAKHVAERAGVTWGVIQYH
MLBr_01733|M.leprae_Br4923 ERWREHRKKVRGEIVDAAFRALDRLG--PEVSVREIAEEAGTAKPKIYRH
* .::. : : :* *.: : :
MMAR_4304|M.marinum_M FQDKDALLDAVCARY-LARLDEEMERAAMGHTCVVEVLRAQGLAYVRFAL
MUL_0990|M.ulcerans_Agy99 FQDKDALLDAVCARY-LARLDEEMERAAMGHTCVVEVLRAQGLAYVRFAL
Mflv_2132|M.gilvum_PYR-GCK FADKNALLDAVCGRY-FEKLDEQMQAVAAACPSTIEVLRAQGLAYVRFAL
Mvan_4572|M.vanbaalenii_PYR-1 FVDKTALLDAVCGRY-FEKLDEEMQEVAGAAATALDVLRAQGMAYVRFAL
MSMEG_5177|M.smegmatis_MC2_155 FADKDALLDAVCARY-FEKLDQQMQRVAAGQPSTIDVLRAQGLAYVEFAT
MAB_1288|M.abscessus_ATCC_1997 FADKDELMDAVCGQY-FQRLNDKMVEAARGDITALERLHAQGMAYVRFAI
Mb0672c|M.bovis_AF2122/97 FGGMRGLIAAIAEEG-LRQFDVALT-VPQTADPVADLL-AIGTAYRRYAI
Rv0653c|M.tuberculosis_H37Rv FGGMRGLIAAIAEEG-LRQFDVALT-VPQTADPVADLL-AIGTAYRRYAI
TH_4347|M.thermoresistible__bu FGGMPGVLEAVAGEI-FARFADALTQIPQTGDPVADFL-LMGAAYREYAL
MAV_4851|M.avium_104 FGDRNGLLMAVVDDG-VARLVESLSSADVSELPLRQRVEVVIDTAWSCYS
MLBr_01733|M.leprae_Br4923 FTDKSDLFEAIGIRLRDMLWAAIFPAIDLATDSAREIIRRSVDEYVSLVD
* . :: *: : : :
MMAR_4304|M.marinum_M QTPELYRLATMGEWRSGSN------------VDSALDSSAFRHMCASVQA
MUL_0990|M.ulcerans_Agy99 QTPELYRLATMGEWRSGSN------------VDSALDSSAFRHMCASVQA
Mflv_2132|M.gilvum_PYR-GCK QTPELYRIATMGHGNPGSG------------VDLTLNSAAFVHMRASVEA
Mvan_4572|M.vanbaalenii_PYR-1 KNPVLYRIAMMGPGSPGSD------------VDVALNSSAFGHLLMSVQA
MSMEG_5177|M.smegmatis_MC2_155 HTPELYRLATMAEGRPGSD------------VDITLNSSAFQHMRATIEK
MAB_1288|M.abscessus_ATCC_1997 ATPLMYRLATVTQ--PEGE------------LDETMASAAFAHLHNGVKE
Mb0672c|M.bovis_AF2122/97 ERPHMYRLMFGSTSAHGIN-VPARDVLTLKVAEIEHQHPSFAHVVRAVHR
Rv0653c|M.tuberculosis_H37Rv ERPHMYRLMFGSTSAHGIN-VPARDVLTLKVAEIEHQHPSFAHVVRAVHR
TH_4347|M.thermoresistible__bu THPQRYLLMFGTATPASIAGSRADLTATGEVSDRTEWAASFEALRTMVRR
MAV_4851|M.avium_104 SPTSMAAFEILHATRGALG------------DSSRRHLLDMNAAIGQLGR
MLBr_01733|M.leprae_Br4923 KHPNVLRVFIQGRFSAQSEAT---------VRTLDEGREITLTMAEMFNN
. . .
MMAR_4304|M.marinum_M MMDEGIYR-------ADDPTTIALELWTAAHGVAALLIAKPHLPFGDVAA
MUL_0990|M.ulcerans_Agy99 MMDEGIYR-------ADDPTTIALELWTAAHGVAALLIAKPHLPFGDVAA
Mflv_2132|M.gilvum_PYR-GCK LIAEGVYP-------PGDPTVFALELWTCAHGIAAQLISRPYLPWGDVEQ
Mvan_4572|M.vanbaalenii_PYR-1 LIAEGVYP-------QADPTMLALELWTAVHGIAAMLISRPYLPWGGAEE
MSMEG_5177|M.smegmatis_MC2_155 LMDEGIYP-------PGDATTWALELWTAAHGVAAMLIAKPYLPWGDTHE
MAB_1288|M.abscessus_ATCC_1997 LVTEGLYP-------EGDTVAMALQLWVAAHGVASMLVTKPHLPWGDPEE
Mb0672c|M.bovis_AF2122/97 CLLAGRFATALGADDDTAIVATAAQFWSQIHGFVMLELAG---FYGDRGA
Rv0653c|M.tuberculosis_H37Rv CLLAGRFATALGADDDTAIVATAAQFWSQIHGFVMLELAG---FYGDRGA
TH_4347|M.thermoresistible__bu MIAAGRIR-------DDGEAAIAGRLWSLIHGEVMLELAG---FFGAEGH
MAV_4851|M.avium_104 LITT-----------DPANAGVAEVIWATLRGVVLAQMVIG--------T
MLBr_01733|M.leprae_Br4923 ELREMELN------RAASELAAFAAFGSVASATEWWLGPEPDSPRRMPRE
: : .
MMAR_4304|M.marinum_M FADRVLGAVLCGHMVAGLVGPQATSRDLMDWVVQHRPSEESRV
MUL_0990|M.ulcerans_Agy99 FADRVLGAVLCGHMVAGLVGPQATSRDLMDWVVQHRPSEESRV
Mflv_2132|M.gilvum_PYR-GCK FADRVLRAVCIGHMVSVAIGPDENAMDTVNWLKEVVDERRRR-
Mvan_4572|M.vanbaalenii_PYR-1 FADRLMRAVCCGQALSVAIRPDESPREIMTWLKEVVDERQRG-
MSMEG_5177|M.smegmatis_MC2_155 FADRVLRAVCSGHIVSGIIGNDVTPSEAVARLKGLADAPN---
MAB_1288|M.abscessus_ATCC_1997 FASEVLRAACLGQAVS-----DIDLTEVLPRQK----------
Mb0672c|M.bovis_AF2122/97 AVEPVLAAMTVNLLVALGDSPERAQCSLRAEQTQKNTLGRAT-
Rv0653c|M.tuberculosis_H37Rv AVEPVLAAMTVNLLVALGDSPERAQCSLRAEQTQKNTLGRAT-
TH_4347|M.thermoresistible__bu GLTKILTPMTVDMLVGLGDDRARVEASL---TTAAEAHGR---
MAV_4851|M.avium_104 TVDWSLERRALIDMVTRVLQ-----------------------
MLBr_01733|M.leprae_Br4923 QFVAHLTIIMMAVIVGTAETLGISMNPDRPIHDAVPLDRSAS-
: :