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LALTRRQFTLGLGAVAATPLLTSCGGGGDTTRGHVVVVGAGMSGLAAARRLTDAGVPVTVVEARSRIGGR TWTDTSLGLPVDLGAAWIHGSQGNPLTGLAAQAGARTVETNFDDVVVLDGGRAVDPAAVEEVSRDWMGVL DEIEPMTADAAPDVSLADGLVWAGADLEDPLMQWMVSAAIGAEYAADPEELALRWFGHEGEFDGPDLILP GGYRQLIDHLARDLDIRLDAEVTRIAYDDVGVTVETAQEVLRADRVIVTVPLGVLKAGVIVFDPPLPQAK RAAVERLGFGLLDKVVLVFDEPFWTEAFDIHSDMLGIAGGAQPVSDLVNGLRFTDVPLLVGLRGGANARA READSDQQTVGEVLAALRAPDPVGVFVTRWAADPYARGSYSFLAVGSSPADQQALAEPVADRVAFAGEAT HPEFFATVHGAYLSGLREADRILR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4388 | - | - | 100% (445) | amine oxidase |
| M. vanbaalenii PYR-1 | Mvan_1178 | - | 3e-28 | 29.69% (448) | amine oxidase |
| M. vanbaalenii PYR-1 | Mvan_5578 | - | 8e-27 | 28.79% (455) | amine oxidase (flavin-containing) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 9e-22 | 29.58% (453) | flavin-containing monoamine oxidase |
| M. gilvum PYR-GCK | Mflv_2278 | - | 0.0 | 73.78% (431) | amine oxidase |
| M. tuberculosis H37Rv | Rv3170 | aofH | 1e-21 | 29.58% (453) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | MLBr_00062 | gltD | 6e-05 | 62.86% (35) | glutamate synthase subunit beta |
| M. abscessus ATCC 19977 | MAB_2659 | - | 2e-24 | 26.67% (450) | putative flavin-containing monoamine oxidase AofH |
| M. marinum M | MMAR_1387 | - | 7e-61 | 35.81% (472) | monoamine oxidase |
| M. avium 104 | MAV_4062 | - | 6e-21 | 27.87% (445) | putative flavin-containing monoamine oxidase AofH |
| M. smegmatis MC2 155 | MSMEG_2035 | - | 7e-22 | 27.21% (452) | amine oxidase |
| M. thermoresistible (build 8) | TH_0685 | - | 1e-23 | 32.02% (456) | PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE |
| M. ulcerans Agy99 | MUL_2489 | - | 2e-60 | 37.24% (427) | monoamine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_4388|M.vanbaalenii_PYR-1 -MLALTRRQFT-------------LGLGAVAATPLLTSCG--GGGDTTRG
Mflv_2278|M.gilvum_PYR-GCK -----------------------------MATAPLLASCGNGGGGRDTRE
MMAR_1387|M.marinum_M -MSRVPRRKFLAATAGLSCGAAAGLGAGCASDHAARSSAPATPVDKTDTR
MUL_2489|M.ulcerans_Agy99 --MRVESR--------------------------SPAERPATPADKTDTR
MSMEG_2035|M.smegmatis_MC2_155 -------------------------------------------MSIPTSA
TH_0685|M.thermoresistible__bu ------------------------------------------------VV
Mb3195|M.bovis_AF2122/97 ------------------------------------------MTNPPWTV
Rv3170|M.tuberculosis_H37Rv ------------------------------------------MTNPPWTV
MAV_4062|M.avium_104 ------------------------------------------MSGPPRIV
MAB_2659|M.abscessus_ATCC_1997 ------------------------------------MSRSVDNAVEAASV
MLBr_00062|M.leprae_Br4923 MADPAGFLKYTQRELPRRRPVPLRLRDWKELYEEFDKETLRNQASRCMDC
Mvan_4388|M.vanbaalenii_PYR-1 HVVVVGAGMSGLAAARRLTDAGVPVTVVEARSRIGGRTWTDTSLG--LPV
Mflv_2278|M.gilvum_PYR-GCK RVVVVGAGMAGLSAARRLADNGVSVAVVEARQRIGGRTWTDTSLG--VPI
MMAR_1387|M.marinum_M SILVIGAGMAGLGAARALADAGWPVRLIEARDRVGGRVNTVRDWG--VPL
MUL_2489|M.ulcerans_Agy99 SILVIGAGMAGLGAARALADAGWPVRLIEARDRVGGRVNTVRDWD--VPL
MSMEG_2035|M.smegmatis_MC2_155 DVVVVGAGFAGLTAARRLVQLGYDVVVLEGRDRVGGRSSTATIAG--VPV
TH_0685|M.thermoresistible__bu DVVVVGAGFAGLTAARELTGLGYEVVVFEGRDRVGGRSYTATLAG--VPV
Mb3195|M.bovis_AF2122/97 DVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGGRSLTGRVAG--VPA
Rv3170|M.tuberculosis_H37Rv DVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGGRSLTGRVAG--VPA
MAV_4062|M.avium_104 DVVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGGRSFTGSVAG--LPA
MAB_2659|M.abscessus_ATCC_1997 DVVIVGAGFAGLSAADRLVNMGVSVLVIDARERVGGRSFTGEVAG--VKV
MLBr_00062|M.leprae_Br4923 GIPFCHNGCPLGNLIPEWNDLVRRGRWHDAVERLHATNNFPDVTGRLCPA
: . * . :. .*: . .
Mvan_4388|M.vanbaalenii_PYR-1 DLGAAWIHGSQGNPLTGLAAQAGARTVETNFDDVVVLDGG----------
Mflv_2278|M.gilvum_PYR-GCK DLGGAWIHGPEGNPLTDLVEQVGARTVATDFEDAVVLQNG----------
MMAR_1387|M.marinum_M EMGASWIHGTTDNPLVELAGQVEARLAPTDYDTPAKLAVD----------
MUL_2489|M.ulcerans_Agy99 EMGASWIHGTTDNPLVELAGQVEARLAPTDYDTPAKLAVD----------
MSMEG_2035|M.smegmatis_MC2_155 DLGGTFVG-PTQDAVLGLAAELGCATVPTYNRGKNLIRWHGRVRSYRSTI
TH_0685|M.thermoresistible__bu DLGATFVG-PGQTAVTGLAAELGCPTVGTYHQGNNLILWRGRLKSYRSTI
Mb3195|M.bovis_AF2122/97 DMGGSFIG-PTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARSYRGTI
Rv3170|M.tuberculosis_H37Rv DMGGSFIG-PTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARSYRGTI
MAV_4062|M.avium_104 DLGGTFVG-PTQDAVLALAAELEVPTTPTHHEGKNLIHWRGWTHAYHGTI
MAB_2659|M.abscessus_ATCC_1997 DLGATWVA-KRHTAIRDLMDRLGCSLTPQYDEGVNLLWMAGKRKTWTGTL
MLBr_00062|M.leprae_Br4923 PCESACVLGINQDPVT--IKQIELEIIDKAFDEGWVQPLPPQQLTGKTVA
.: : .: .
Mvan_4388|M.vanbaalenii_PYR-1 RAVDPAAVEEVSRDWMGVLDEIEPMTADAAPDVSLADGLVWAG-ADLED-
Mflv_2278|M.gilvum_PYR-GCK VVVNPASVDAADREWDRILGEVASMTEDAAPGESLADGLAETG-ADLSD-
MMAR_1387|M.marinum_M PRLEPISYDDDT--WRRLVAQARRDVDDGSLAAALDAQAPRDDLSDRER-
MUL_2489|M.ulcerans_Agy99 PRLEPISYDDDT--WRRLVAQARRDVDDGSLAAALDAQAPRDDLSDRER-
MSMEG_2035|M.smegmatis_MC2_155 PRLSIIELLDVSRIQWRFERLFRHVDVAEPWNGSLAHKLDQYSMERWLRY
TH_0685|M.thermoresistible__bu PTLSILELLDVSRIQWRFERLCRQIPVGEPWRAPAAHRLDTMSLDRWLRS
Mb3195|M.bovis_AF2122/97 PKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLGEWLRL
Rv3170|M.tuberculosis_H37Rv PKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLGEWLRL
MAV_4062|M.avium_104 PKLSLTGLLDIGRLRWQFDRIARSIPLAAPWEARRAAELDGLSLGGWLRS
MAB_2659|M.abscessus_ATCC_1997 PTVDPVDLEDLGRITIEMGKLLETINVDAAWKSPNADQLDSISFGEWLSQ
MLBr_00062|M.leprae_Br4923 VVGSGPAGLAAAQQLTRAGHRVTVFERDDRIGGLLRYGIPEFKMEKRFLE
.
Mvan_4388|M.vanbaalenii_PYR-1 ----PLMQWMVSAAIGAEYAADPEELALRWFGHEGEFDG-----------
Mflv_2278|M.gilvum_PYR-GCK ----PLLQWCVAGSIGSEYAADPDELSLRWFGNEGEFDG-----------
MMAR_1387|M.marinum_M ----AELAYYVNTVIEDEYAADADQLSATTYDQGTYSSG-----------
MUL_2489|M.ulcerans_Agy99 ----AELAYYVNTVIEDEYAADADQLSATTYDQGTYSSG-----------
MSMEG_2035|M.smegmatis_MC2_155 VHANASTRNLMAIMSRVTWGAEPDQVSMLHAVRYVKAAGGLTRLLDVEGG
TH_0685|M.thermoresistible__bu VYASASTRDLMAIMARVTWGCEPHQVSMLHAARYVKAAGGLGRMLDVEGG
Mb3195|M.bovis_AF2122/97 VRATSSSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLDVKNG
Rv3170|M.tuberculosis_H37Rv VRATSSSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLDVKNG
MAV_4062|M.avium_104 VRATASSHALLAMVARVTWGCEPDEVSMLHAARYAHAAGGLDRLLDVEDG
MAB_2659|M.abscessus_ATCC_1997 QQAVTSTNALMYIVTRVQWGCSPLDVSLLHVLRYVQAVGGLDHMLAVEHG
MLBr_00062|M.leprae_Br4923 RRLDQLRAEGTEFRSGVNVGVDITADQLCADFDAVVLAGGAATWRELPIP
. . *
Mvan_4388|M.vanbaalenii_PYR-1 -PDLILPGGYRQLIDHLARDLD-------IRLDAEVTRIAYDDVGVTVET
Mflv_2278|M.gilvum_PYR-GCK -PDLILSGGYGQLIDYLSRDLT-------IRLGREVTRISHDATGVRVET
MMAR_1387|M.marinum_M -PQVVITSGYDALPRRLADGLP-------IVFGTKVDSIVHKDDSVLVRA
MUL_2489|M.ulcerans_Agy99 -PQVVITSGYDALPRRLADGLP-------IVFGTKVDSIVHKDDSVLVRA
MSMEG_2035|M.smegmatis_MC2_155 AQQDRLVEGTQQIALRMADELG-----QRIALDAPVQRIERHSGGDIGVT
TH_0685|M.thermoresistible__bu AQQDRFPAGTQQIAQRMAEELDGAEPGSRVRLGAPVRRITRNPDGTVTVH
Mb3195|M.bovis_AF2122/97 AQQDRVPGGTQQIAQAAAAQLG-----ARVLLNAAVRRIDRHGAG-VTVT
Rv3170|M.tuberculosis_H37Rv AQQDRVPGGTQQIAQAAAAQLG-----ARVLLNAAVRRIDRHGAG-VTVT
MAV_4062|M.avium_104 AQQDRFPGGTQQIAAAAAAELG-----ARVVLGAPVRRIERHGAG-VTVR
MAB_2659|M.abscessus_ATCC_1997 QQEYRVTETTQEIAKRLAAQIG-----DQIVLNTRVRQISQDDNG-VTVS
MLBr_00062|M.leprae_Br4923 GRELDGVHQAMEFLPWVNRVQE-----GDDVLGDDGQPPITAKDKKVVII
: : :.
Mvan_4388|M.vanbaalenii_PYR-1 AQEVLRADRVIVTVPLGVLKAGVIVFDPPLPQAKRAAVERLGFGLLDKVV
Mflv_2278|M.gilvum_PYR-GCK AREVFEADRVIVTVPLGVLKAGVITFDPPLPDAKRDAIRRLGFGLLNKVV
MMAR_1387|M.marinum_M ADRTFQGPAAIVTAPLGVLKAGAITFDPPLPDDHRRAIAALGFGVLSKSY
MUL_2489|M.ulcerans_Agy99 AGRTFQGPAAIVTAPLGVLKAGAITFDPPLPNDHRRAIAALGFGVLSKSY
MSMEG_2035|M.smegmatis_MC2_155 FTTG-HVRARAVVIAIAPQHRGDIEFDPPLPPEYTELAARWPQGRLSKAY
TH_0685|M.thermoresistible__bu TGSGDGVTAGAVVVAVPPAHRDAIEFDPALPPRHTALPGHWPQGMLSKAY
Mb3195|M.bovis_AF2122/97 SDQG-QAEAGFVIVAIPPAHRVAIEFDPPLPPEYQQLAHHWPQGRLSKAY
Rv3170|M.tuberculosis_H37Rv SDQG-QAEAGFVIVAIPPAHRVAIEFDPPLPPEYQQLAHHWPQGRLSKAY
MAV_4062|M.avium_104 TDLG-DTEAGFVIVAIPPAHRAAIEFAPPLPAEYEQLARHWPQGRLSKAY
MAB_2659|M.abscessus_ATCC_1997 TDSG-VINAKYAIVTAAPEHRAYIEYQPALPAKIEGLTTSFPMGALSKAF
MLBr_00062|M.leprae_Br4923 GGGDTGADCLGAVHRQGAIHVHQLEIMPRPPDARAASTPWPTYPLMYRVS
. : : * * : :
Mvan_4388|M.vanbaalenii_PYR-1 LVFDEPFWTEAFDIHSDMLGIAGGAQPVSDLVNGLRFTDVPLLVGLRGGA
Mflv_2278|M.gilvum_PYR-GCK LRFDEPFWTEEFDADTDMFGMAGQDQPVSDLVNGLRFTDIPVLIGLRGGA
MMAR_1387|M.marinum_M FRFER----RTWDADNAFYQFLGPPGSMWSQWLTLPAAAGPIVLAFNAGR
MUL_2489|M.ulcerans_Agy99 FRFDR----RTWDADNAFYQFLGPPGSMWSQWLTLPAAAGPIVLALNAGH
MSMEG_2035|M.smegmatis_MC2_155 AAYDRP----FWRANGCSGEALSDEGPVFITFDVSPGDEGPGILLG--FT
TH_0685|M.thermoresistible__bu AAYDTP----FWRADGRSGEALSDDGPVFITFDVSPDENGPGILLG--FT
Mb3195|M.bovis_AF2122/97 AAYSTP----FWRASGYSGQALSDEAPVFITFDVSPHADGPGILMG--FV
Rv3170|M.tuberculosis_H37Rv AAYSTP----FWRASGYSGQALSDEAPVFITFDVSPHADGPGILMG--FV
MAV_4062|M.avium_104 AAYSTP----FWRADGFSGQALSDEGPVFITFDVSPHPDGPGILMG--FV
MAB_2659|M.abscessus_ATCC_1997 VAYDKP----FWRAEGLSGEALTDTAPVFITFDVSPSDDGPGILMV--FC
MLBr_00062|M.leprae_Br4923 PAHEEG---GERVFSVNTEEFVGKNGRVHALKAHEVTMQD---------G
.. :
Mvan_4388|M.vanbaalenii_PYR-1 NARAREADSDQQTVGEVLAALRAPD------PVGVFVTRWAADPYARGS-
Mflv_2278|M.gilvum_PYR-GCK NARARESESDQQTADEVVTALRAPT------PSGVIVTRWAQDPFARGS-
MMAR_1387|M.marinum_M RGRHVESYSPSELMSGALPVARQLFGNDIA-PAEVRSSGWSTDPLALGS-
MUL_2489|M.ulcerans_Agy99 RGRHVESCSPSELMSGALPVARQLFGKDIA-PAEVRSSGWSTDPLALGS-
MSMEG_2035|M.smegmatis_MC2_155 DARTFDALPPEQRRQRALGGFATFFGDAARDPIDYLDHCWGTEAFAPGG-
TH_0685|M.thermoresistible__bu DARTFDPLSPDRRRDKALHGFAKLFGDAALKPIDYLDFCWGCDDFAPGG-
Mb3195|M.bovis_AF2122/97 DARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGG-
Rv3170|M.tuberculosis_H37Rv DARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGG-
MAV_4062|M.avium_104 DARAFDSLPADQRRRDALRCFATLFGDDALKPLDYVDHRWGAEEFAPGG-
MAB_2659|M.abscessus_ATCC_1997 TARVYDGFGPEVRRKLVLKQLVDLYGEQANTPIDYIDHCWGTEPFAAGG-
MLBr_00062|M.leprae_Br4923 RFVKVENSVFELEADLVLLAMGFVGPEKPGLLTDLGVKFTDRGNVARGAD
: . .: * *.
Mvan_4388|M.vanbaalenii_PYR-1 YSFLAVGSSPADQQALAEPVADRVAFAGEATHPEFFATVHGAYLSGLREA
Mflv_2278|M.gilvum_PYR-GCK YSFLAVGSSPDDQDALAAPVADRVAFAGEATHRDFFATVHGAYLSGLREA
MMAR_1387|M.marinum_M YSFHAPGSGLDDRRQLQEPISDRLYLAGEAVGVDNPATVHGALISGRSAA
MUL_2489|M.ulcerans_Agy99 YSFHAPGSGLDDRRQLQEPISDRLYLAGEAVGVDNPATVHGALISGRSAA
MSMEG_2035|M.smegmatis_MC2_155 PTAAVPPEAWTAYGPWLRKPIDGIHWAGTETADVWTGFLDGAVRSGQRAA
TH_0685|M.thermoresistible__bu PTAAVPPGSWTEFGPWLREPVDQIYWAGTETADQWTGFLDGAVRSGQRAA
Mb3195|M.bovis_AF2122/97 PTAAVPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRAA
Rv3170|M.tuberculosis_H37Rv PTAAVPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRAA
MAV_4062|M.avium_104 PTAAVPPGSWTRFGRWLREPVGPIHWAGTETADEWTGFLDGAIRSGRRAA
MAB_2659|M.abscessus_ATCC_1997 PHPAAPPFASVNYGEALREPHGRIHWAGTETAGEWVGTMNGAILMGLHTA
MLBr_00062|M.leprae_Br4923 FDTSVPGVFVAGDMGRGQSLIVWAIAEGRAAAAAVDRFLMGATALPAPVK
. . . . **
Mvan_4388|M.vanbaalenii_PYR-1 DRILR----------
Mflv_2278|M.gilvum_PYR-GCK DRILESGV-------
MMAR_1387|M.marinum_M AELMRQLQ-------
MUL_2489|M.ulcerans_Agy99 AELMRQLQ-------
MSMEG_2035|M.smegmatis_MC2_155 TEVAEALKSSAAAG-
TH_0685|M.thermoresistible__bu AEVHRRLSSGG----
Mb3195|M.bovis_AF2122/97 AEVAALL--------
Rv3170|M.tuberculosis_H37Rv AEVAALL--------
MAV_4062|M.avium_104 AEVTALL--------
MAB_2659|M.abscessus_ATCC_1997 DQIAQQLGVTGEVSK
MLBr_00062|M.leprae_Br4923 PSSLPLQ--------