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SRVPRRKFLAATAGLSCGAAAGLGAGCASDHAARSSAPATPVDKTDTRSILVIGAGMAGLGAARALADAG WPVRLIEARDRVGGRVNTVRDWGVPLEMGASWIHGTTDNPLVELAGQVEARLAPTDYDTPAKLAVDPRLE PISYDDDTWRRLVAQARRDVDDGSLAAALDAQAPRDDLSDRERAELAYYVNTVIEDEYAADADQLSATTY DQGTYSSGPQVVITSGYDALPRRLADGLPIVFGTKVDSIVHKDDSVLVRAADRTFQGPAAIVTAPLGVLK AGAITFDPPLPDDHRRAIAALGFGVLSKSYFRFERRTWDADNAFYQFLGPPGSMWSQWLTLPAAAGPIVL AFNAGRRGRHVESYSPSELMSGALPVARQLFGNDIAPAEVRSSGWSTDPLALGSYSFHAPGSGLDDRRQL QEPISDRLYLAGEAVGVDNPATVHGALISGRSAAAELMRQLQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1387 | - | - | 100% (463) | monoamine oxidase |
| M. marinum M | MMAR_3362 | aofH_1 | 1e-19 | 26.58% (444) | flavin-containing monoamine oxidase AofH_1 |
| M. marinum M | MMAR_1389 | aofH | 3e-18 | 25.39% (445) | flavin-containing monoamine oxidase AofH (amine oxidase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 2e-21 | 27.69% (455) | flavin-containing monoamine oxidase |
| M. gilvum PYR-GCK | Mflv_2278 | - | 2e-66 | 38.33% (420) | amine oxidase |
| M. tuberculosis H37Rv | Rv3170 | aofH | 2e-21 | 27.69% (455) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2659 | - | 5e-19 | 23.88% (448) | putative flavin-containing monoamine oxidase AofH |
| M. avium 104 | MAV_4062 | - | 1e-20 | 27.56% (450) | putative flavin-containing monoamine oxidase AofH |
| M. smegmatis MC2 155 | MSMEG_2035 | - | 6e-21 | 26.83% (451) | amine oxidase |
| M. thermoresistible (build 8) | TH_0685 | - | 2e-20 | 26.07% (468) | PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE |
| M. ulcerans Agy99 | MUL_2489 | - | 0.0 | 97.88% (425) | monoamine oxidase |
| M. vanbaalenii PYR-1 | Mvan_4388 | - | 7e-61 | 35.81% (472) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2035|M.smegmatis_MC2_155 ------------------------------------------MSIPTSAD
TH_0685|M.thermoresistible__bu -----------------------------------------------VVD
Mb3195|M.bovis_AF2122/97 -----------------------------------------MTNPPWTVD
Rv3170|M.tuberculosis_H37Rv -----------------------------------------MTNPPWTVD
MAV_4062|M.avium_104 -----------------------------------------MSGPPRIVD
MAB_2659|M.abscessus_ATCC_1997 -----------------------------------MSRSVDNAVEAASVD
MMAR_1387|M.marinum_M MSRVPRRKFLAATAGLSCGAAAGLGAGCASDHAARSSAPATPVDKTDTRS
MUL_2489|M.ulcerans_Agy99 -MRVESR--------------------------SPAERPATPADKTDTRS
Mflv_2278|M.gilvum_PYR-GCK ----------------------------MATAPLLASCGNGGGGRDTRER
Mvan_4388|M.vanbaalenii_PYR-1 MLALTRRQFTLG-------------LGAVAATPLLTSCG--GGGDTTRGH
MSMEG_2035|M.smegmatis_MC2_155 VVVVGAGFAGLTAARRLVQLGYDVVVLEGRDRVGGRSSTATIAGVPVDLG
TH_0685|M.thermoresistible__bu VVVVGAGFAGLTAARELTGLGYEVVVFEGRDRVGGRSYTATLAGVPVDLG
Mb3195|M.bovis_AF2122/97 VVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGGRSLTGRVAGVPADMG
Rv3170|M.tuberculosis_H37Rv VVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGGRSLTGRVAGVPADMG
MAV_4062|M.avium_104 VVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGGRSFTGSVAGLPADLG
MAB_2659|M.abscessus_ATCC_1997 VVIVGAGFAGLSAADRLVNMGVSVLVIDARERVGGRSFTGEVAGVKVDLG
MMAR_1387|M.marinum_M ILVIGAGMAGLGAARALADAGWPVRLIEARDRVGGRVNTVRDWGVPLEMG
MUL_2489|M.ulcerans_Agy99 ILVIGAGMAGLGAARALADAGWPVRLIEARDRVGGRVNTVRDWDVPLEMG
Mflv_2278|M.gilvum_PYR-GCK VVVVGAGMAGLSAARRLADNGVSVAVVEARQRIGGRTWTDTSLGVPIDLG
Mvan_4388|M.vanbaalenii_PYR-1 VVVVGAGMSGLAAARRLTDAGVPVTVVEARSRIGGRTWTDTSLGLPVDLG
::::***::** ** * * * :.:.*.*:*** * .: ::*
MSMEG_2035|M.smegmatis_MC2_155 GTFVG-PTQDAVLGLAAELGCATVPTYNRGKNLIRWHGRVRSYRSTIPRL
TH_0685|M.thermoresistible__bu ATFVG-PGQTAVTGLAAELGCPTVGTYHQGNNLILWRGRLKSYRSTIPTL
Mb3195|M.bovis_AF2122/97 GSFIG-PTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARSYRGTIPKL
Rv3170|M.tuberculosis_H37Rv GSFIG-PTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARSYRGTIPKL
MAV_4062|M.avium_104 GTFVG-PTQDAVLALAAELEVPTTPTHHEGKNLIHWRGWTHAYHGTIPKL
MAB_2659|M.abscessus_ATCC_1997 ATWVA-KRHTAIRDLMDRLGCSLTPQYDEGVNLLWMAGKRKTWTGTLPTV
MMAR_1387|M.marinum_M ASWIHGTTDNPLVELAGQVEARLAPTDYDTPAKLAVD----------PRL
MUL_2489|M.ulcerans_Agy99 ASWIHGTTDNPLVELAGQVEARLAPTDYDTPAKLAVD----------PRL
Mflv_2278|M.gilvum_PYR-GCK GAWIHGPEGNPLTDLVEQVGARTVATDFEDAVVLQNG----------VVV
Mvan_4388|M.vanbaalenii_PYR-1 AAWIHGSQGNPLTGLAAQAGARTVETNFDDVVVLDGG----------RAV
.::: .: * . . : :
MSMEG_2035|M.smegmatis_MC2_155 SIIELLDVSRIQWRFERLFRHVDVAEPWNGSLAHKLDQYSMERWLRYVHA
TH_0685|M.thermoresistible__bu SILELLDVSRIQWRFERLCRQIPVGEPWRAPAAHRLDTMSLDRWLRSVYA
Mb3195|M.bovis_AF2122/97 SLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLGEWLRLVRA
Rv3170|M.tuberculosis_H37Rv SLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLGEWLRLVRA
MAV_4062|M.avium_104 SLTGLLDIGRLRWQFDRIARSIPLAAPWEARRAAELDGLSLGGWLRSVRA
MAB_2659|M.abscessus_ATCC_1997 DPVDLEDLGRITIEMGKLLETINVDAAWKSPNADQLDSISFGEWLSQQQA
MMAR_1387|M.marinum_M EPISYDDDT--WRRLVAQARRDVDDGSLAAALDAQAPRDDLSDRER----
MUL_2489|M.ulcerans_Agy99 EPISYDDDT--WRRLVAQARRDVDDGSLAAALDAQAPRDDLSDRER----
Mflv_2278|M.gilvum_PYR-GCK NPASVDAADREWDRILGEVASMTEDAAPGESLADGLAETG-ADLSD----
Mvan_4388|M.vanbaalenii_PYR-1 DPAAVEEVSRDWMGVLDEIEPMTADAAPDVSLADGLVWAG-ADLED----
. . . .
MSMEG_2035|M.smegmatis_MC2_155 NASTRNLMAIMSRVTWGAEPDQVSMLHAVRYVKAAGGLTRLLDVEGGAQQ
TH_0685|M.thermoresistible__bu SASTRDLMAIMARVTWGCEPHQVSMLHAARYVKAAGGLGRMLDVEGGAQQ
Mb3195|M.bovis_AF2122/97 TSSSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLDVKNGAQQ
Rv3170|M.tuberculosis_H37Rv TSSSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLDVKNGAQQ
MAV_4062|M.avium_104 TASSHALLAMVARVTWGCEPDEVSMLHAARYAHAAGGLDRLLDVEDGAQQ
MAB_2659|M.abscessus_ATCC_1997 VTSTNALMYIVTRVQWGCSPLDVSLLHVLRYVQAVGGLDHMLAVEHGQQE
MMAR_1387|M.marinum_M -AELAYYVNTVIEDEYAADADQLSATTYDQGTYSSG------------PQ
MUL_2489|M.ulcerans_Agy99 -AELAYYVNTVIEDEYAADADQLSATTYDQGTYSSG------------PQ
Mflv_2278|M.gilvum_PYR-GCK -PLLQWCVAGSIGSEYAADPDELSLRWFGNEGEFDG------------PD
Mvan_4388|M.vanbaalenii_PYR-1 -PLMQWMVSAAIGAEYAADPEELALRWFGHEGEFDG------------PD
. : :.... ::: . * :
MSMEG_2035|M.smegmatis_MC2_155 DRLVEGTQQIALRMADELG-----QRIALDAPVQRIERHSGGDIGVTFTT
TH_0685|M.thermoresistible__bu DRFPAGTQQIAQRMAEELDGAEPGSRVRLGAPVRRITRNPDGTVTVHTGS
Mb3195|M.bovis_AF2122/97 DRVPGGTQQIAQAAAAQLG-----ARVLLNAAVRRIDRHGAG-VTVTSDQ
Rv3170|M.tuberculosis_H37Rv DRVPGGTQQIAQAAAAQLG-----ARVLLNAAVRRIDRHGAG-VTVTSDQ
MAV_4062|M.avium_104 DRFPGGTQQIAAAAAAELG-----ARVVLGAPVRRIERHGAG-VTVRTDL
MAB_2659|M.abscessus_ATCC_1997 YRVTETTQEIAKRLAAQIG-----DQIVLNTRVRQISQDDNG-VTVSTDS
MMAR_1387|M.marinum_M VVITSGYDALPRRLADGLP-------IVFGTKVDSIVHKDDSVLVRAADR
MUL_2489|M.ulcerans_Agy99 VVITSGYDALPRRLADGLP-------IVFGTKVDSIVHKDDSVLVRAAGR
Mflv_2278|M.gilvum_PYR-GCK LILSGGYGQLIDYLSRDLT-------IRLGREVTRISHDATGVRVETARE
Mvan_4388|M.vanbaalenii_PYR-1 LILPGGYRQLIDHLARDLD-------IRLDAEVTRIAYDDVGVTVETAQE
. : : : : :. * * . .
MSMEG_2035|M.smegmatis_MC2_155 G-HVRARAVVIAIAPQHRGDIEFDPPLPPEYTELAARWPQGRLSKAYAAY
TH_0685|M.thermoresistible__bu GDGVTAGAVVVAVPPAHRDAIEFDPALPPRHTALPGHWPQGMLSKAYAAY
Mb3195|M.bovis_AF2122/97 G-QAEAGFVIVAIPPAHRVAIEFDPPLPPEYQQLAHHWPQGRLSKAYAAY
Rv3170|M.tuberculosis_H37Rv G-QAEAGFVIVAIPPAHRVAIEFDPPLPPEYQQLAHHWPQGRLSKAYAAY
MAV_4062|M.avium_104 G-DTEAGFVIVAIPPAHRAAIEFAPPLPAEYEQLARHWPQGRLSKAYAAY
MAB_2659|M.abscessus_ATCC_1997 G-VINAKYAIVTAAPEHRAYIEYQPALPAKIEGLTTSFPMGALSKAFVAY
MMAR_1387|M.marinum_M TFQGPAAIVTAPLGVLKAGAITFDPPLPDDHRRAIAALGFGVLSKSYFRF
MUL_2489|M.ulcerans_Agy99 TFQGPAAIVTAPLGVLKAGAITFDPPLPNDHRRAIAALGFGVLSKSYFRF
Mflv_2278|M.gilvum_PYR-GCK VFEADRVIVTVPLGVLKAGVITFDPPLPDAKRDAIRRLGFGLLNKVVLRF
Mvan_4388|M.vanbaalenii_PYR-1 VLRADRVIVTVPLGVLKAGVIVFDPPLPQAKRAAVERLGFGLLDKVVLVF
. . : * : *.** * *.* :
MSMEG_2035|M.smegmatis_MC2_155 DRP----FWRANGCSGEALSDEGPVFITFDVSPGDEGPGILLG--FTDAR
TH_0685|M.thermoresistible__bu DTP----FWRADGRSGEALSDDGPVFITFDVSPDENGPGILLG--FTDAR
Mb3195|M.bovis_AF2122/97 STP----FWRASGYSGQALSDEAPVFITFDVSPHADGPGILMG--FVDAR
Rv3170|M.tuberculosis_H37Rv STP----FWRASGYSGQALSDEAPVFITFDVSPHADGPGILMG--FVDAR
MAV_4062|M.avium_104 STP----FWRADGFSGQALSDEGPVFITFDVSPHPDGPGILMG--FVDAR
MAB_2659|M.abscessus_ATCC_1997 DKP----FWRAEGLSGEALTDTAPVFITFDVSPSDDGPGILMV--FCTAR
MMAR_1387|M.marinum_M ER----RTWDADNAFYQFLGPPGSMWSQWLTLPAAAGPIVLAFNAGRRGR
MUL_2489|M.ulcerans_Agy99 DR----RTWDADNAFYQFLGPPGSMWSQWLTLPAAAGPIVLALNAGHRGR
Mflv_2278|M.gilvum_PYR-GCK DEPFWTEEFDADTDMFGMAGQDQPVSDLVNGLRFTDIPVLIGLRGGANAR
Mvan_4388|M.vanbaalenii_PYR-1 DEPFWTEAFDIHSDMLGIAGGAQPVSDLVNGLRFTDVPLLVGLRGGANAR
. : .: * :: .*
MSMEG_2035|M.smegmatis_MC2_155 TFDALPPEQRRQRALGGFATFFGDAARDPIDYLDHCWGTEAFAPGGPTAA
TH_0685|M.thermoresistible__bu TFDPLSPDRRRDKALHGFAKLFGDAALKPIDYLDFCWGCDDFAPGGPTAA
Mb3195|M.bovis_AF2122/97 GFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGGPTAA
Rv3170|M.tuberculosis_H37Rv GFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGGPTAA
MAV_4062|M.avium_104 AFDSLPADQRRRDALRCFATLFGDDALKPLDYVDHRWGAEEFAPGGPTAA
MAB_2659|M.abscessus_ATCC_1997 VYDGFGPEVRRKLVLKQLVDLYGEQANTPIDYIDHCWGTEPFAAGGPHPA
MMAR_1387|M.marinum_M HVESYSPSELMSGALPVARQLFGNDIA-PAEVRSSGWSTDPLALGSYSFH
MUL_2489|M.ulcerans_Agy99 HVESCSPSELMSGALPVARQLFGKDIA-PAEVRSSGWSTDPLALGSYSFH
Mflv_2278|M.gilvum_PYR-GCK ARESESDQQTADEVVTALRAPT------PSGVIVTRWAQDPFARGSYSFL
Mvan_4388|M.vanbaalenii_PYR-1 AREADSDQQTVGEVLAALRAPD------PVGVFVTRWAADPYARGSYSFL
: . .: * *. : * *.
MSMEG_2035|M.smegmatis_MC2_155 VPPEAWTAYGPWLRKPIDGIHWAGTETADVWTGFLDGAVRSGQRAATEVA
TH_0685|M.thermoresistible__bu VPPGSWTEFGPWLREPVDQIYWAGTETADQWTGFLDGAVRSGQRAAAEVH
Mb3195|M.bovis_AF2122/97 VPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRAAAEVA
Rv3170|M.tuberculosis_H37Rv VPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRAAAEVA
MAV_4062|M.avium_104 VPPGSWTRFGRWLREPVGPIHWAGTETADEWTGFLDGAIRSGRRAAAEVT
MAB_2659|M.abscessus_ATCC_1997 APPFASVNYGEALREPHGRIHWAGTETAGEWVGTMNGAILMGLHTADQIA
MMAR_1387|M.marinum_M APGSGLDDRRQLQEPISDRLYLAGEAVGVDNPATVHGALISGRSAAAELM
MUL_2489|M.ulcerans_Agy99 APGSGLDDRRQLQEPISDRLYLAGEAVGVDNPATVHGALISGRSAAAELM
Mflv_2278|M.gilvum_PYR-GCK AVGSSPDDQDALAAPVADRVAFAGEATHRDFFATVHGAYLSGLREADRIL
Mvan_4388|M.vanbaalenii_PYR-1 AVGSSPADQQALAEPVADRVAFAGEATHPEFFATVHGAYLSGLREADRIL
. . . : *. . . ..** * * .:
MSMEG_2035|M.smegmatis_MC2_155 EALKSSAAAG-
TH_0685|M.thermoresistible__bu RRLSSGG----
Mb3195|M.bovis_AF2122/97 ALL--------
Rv3170|M.tuberculosis_H37Rv ALL--------
MAV_4062|M.avium_104 ALL--------
MAB_2659|M.abscessus_ATCC_1997 QQLGVTGEVSK
MMAR_1387|M.marinum_M RQLQ-------
MUL_2489|M.ulcerans_Agy99 RQLQ-------
Mflv_2278|M.gilvum_PYR-GCK ESGV-------
Mvan_4388|M.vanbaalenii_PYR-1 R----------