For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGGRSLTGRVAGVPADMGGSFIGPTQDAV LALATELGIPTTPTHRDGRNVIQWRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARR ARELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLDVKNGAQQDR VPGGTQQIAQAAAAQLGARVLLNAAVRRIDRHGAGVTVTSDQGQAEAGFVIVAIPPAHRVAIEFDPPLPP EYQQLAHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFITFDVSPHADGPGILMGFVDARGFDSL PIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHWAST ETADEWTGYFDGAVRSGQRAAAEVAALL
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3195 | aofH | - | 100% (448) | flavin-containing monoamine oxidase |
M. bovis AF2122 / 97 | Mb3888c | gltD | 3e-07 | 68.57% (35) | glutamate synthase subunit beta |
M. bovis AF2122 / 97 | Mb1467 | - | 6e-05 | 50.00% (54) | dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. gilvum PYR-GCK | Mflv_4501 | - | 1e-169 | 65.14% (436) | amine oxidase |
M. tuberculosis H37Rv | Rv3170 | aofH | 0.0 | 100.00% (448) | flavin-containing monoamine oxidase |
M. leprae Br4923 | MLBr_00062 | gltD | 2e-07 | 68.57% (35) | glutamate synthase subunit beta |
M. abscessus ATCC 19977 | MAB_2659 | - | 1e-117 | 47.74% (442) | putative flavin-containing monoamine oxidase AofH |
M. marinum M | MMAR_1389 | aofH | 0.0 | 80.36% (448) | flavin-containing monoamine oxidase AofH (amine oxidase) |
M. avium 104 | MAV_4062 | - | 0.0 | 80.36% (448) | putative flavin-containing monoamine oxidase AofH |
M. smegmatis MC2 155 | MSMEG_2035 | - | 1e-171 | 65.17% (445) | amine oxidase |
M. thermoresistible (build 8) | TH_0685 | - | 1e-168 | 65.62% (445) | PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE |
M. ulcerans Agy99 | MUL_2487 | aofH | 0.0 | 79.02% (448) | flavin-containing monoamine oxidase AofH (amine oxidase) |
M. vanbaalenii PYR-1 | Mvan_1866 | - | 1e-167 | 65.90% (437) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment Mb3195|M.bovis_AF2122/97 ------MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGG Rv3170|M.tuberculosis_H37Rv ------MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGG MMAR_1389|M.marinum_M ------MTNPSWIVDVVIVGAGFAGLAAARDLARQGHDVLVLEGRDRVGG MUL_2487|M.ulcerans_Agy99 ------MTNPSWIVDVVIVGAGFAGLAAARDLARQGHDVLVLEGRDRVGG MAV_4062|M.avium_104 ------MSGPPRIVDVVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGG MSMEG_2035|M.smegmatis_MC2_155 -------MSIPTSADVVVVGAGFAGLTAARRLVQLGYDVVVLEGRDRVGG TH_0685|M.thermoresistible__bu ------------VVDVVVVGAGFAGLTAARELTGLGYEVVVFEGRDRVGG Mflv_4501|M.gilvum_PYR-GCK ------------MAEVVVVGAGFAGLAAARELSRLGRDVVVVEGRDRVGG Mvan_1866|M.vanbaalenii_PYR-1 ------------MADVVVVGAGFAGLSAARELTRLGHEVVVVEGRDRVGG MAB_2659|M.abscessus_ATCC_1997 MSRSVDNAVEAASVDVVIVGAGFAGLSAADRLVNMGVSVLVIDARERVGG MLBr_00062|M.leprae_Br4923 --------MADPAGFLKYTQRELPRRRPVPLRLRDWKELYEEFDKETLRN : . :. .. .: :: : . Mb3195|M.bovis_AF2122/97 RSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIP-TTPTHRDGRNVIQ Rv3170|M.tuberculosis_H37Rv RSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIP-TTPTHRDGRNVIQ MMAR_1389|M.marinum_M RSFTGSIAGLPADMGGSFVGPTQDAVLALAAELGVP-TVPTFHDGKNVIR MUL_2487|M.ulcerans_Agy99 RSFTGSIAGLPADMGGSFVGPSQDAVLALAAELGVP-TVPTFHDGKNVIR MAV_4062|M.avium_104 RSFTGSVAGLPADLGGTFVGPTQDAVLALAAELEVP-TTPTHHEGKNLIH MSMEG_2035|M.smegmatis_MC2_155 RSSTATIAGVPVDLGGTFVGPTQDAVLGLAAELGCA-TVPTYNRGKNLIR TH_0685|M.thermoresistible__bu RSYTATLAGVPVDLGATFVGPGQTAVTGLAAELGCP-TVGTYHQGNNLIL Mflv_4501|M.gilvum_PYR-GCK RSYTGSVGGVPVDFGATFVGPTQDAVLALAAELGVE-SVPTYGEGKNLIR Mvan_1866|M.vanbaalenii_PYR-1 RSYTGTIAGVPVDLGATFVGPTQDAVLKLADELGCE-REPTFGRGKNLIR MAB_2659|M.abscessus_ATCC_1997 RSFTGEVAGVKVDLGATWVAKRHTAIRDLMDRLGCS-LTPQYDEGVNLLW MLBr_00062|M.leprae_Br4923 QASRCMDCGIPFCHNGCPLGNLIPEWNDLVRRGRWHDAVERLHATNNFPD :: *: .. :. * . *. Mb3195|M.bovis_AF2122/97 WRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARR-AR Rv3170|M.tuberculosis_H37Rv WRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARR-AR MMAR_1389|M.marinum_M WRGGVRPYSGTIPRLSLTGLLDIARLRWQFERLARSIPISAPWAANR-AA MUL_2487|M.ulcerans_Agy99 WRGGVRPYSGTIPRLSLTGLLDIARLRWQFERLARSIPISAPWAANR-AA MAV_4062|M.avium_104 WRGWTHAYHGTIPKLSLTGLLDIGRLRWQFDRIARSIPLAAPWEARR-AA MSMEG_2035|M.smegmatis_MC2_155 WHGRVRSYRSTIPRLSIIELLDVSRIQWRFERLFRHVDVAEPWNGSL-AH TH_0685|M.thermoresistible__bu WRGRLKSYRSTIPTLSILELLDVSRIQWRFERLCRQIPVGEPWRAPA-AH Mflv_4501|M.gilvum_PYR-GCK WRGRVRSYRSTIPRLSILELLDVSRIQWRFDRISKRVPVDQPWASPL-AG Mvan_1866|M.vanbaalenii_PYR-1 WRGSVRSYRSTVPRLSIIELLDVSRIQWRFERVCRKVSVDQPWRSPV-AA MAB_2659|M.abscessus_ATCC_1997 MAGKRKTWTGTLPTVDPVDLEDLGRITIEMGKLLETINVDAAWKSPN-AD MLBr_00062|M.leprae_Br4923 VTGRLCPAPCESACVLGINQDPVTIKQIELEIIDK--AFDEGWVQPLPPQ * . . : : .: : . . * . Mb3195|M.bovis_AF2122/97 ELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVS---MLHAARY Rv3170|M.tuberculosis_H37Rv ELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVS---MLHAARY MMAR_1389|M.marinum_M DLDGVSLRQWLRSVRASASSHDLMAIMTRVTWGCEPDDVS---MLHAARY MUL_2487|M.ulcerans_Agy99 DLDGVSLRQWLRSVRASASSHDLMAIMTRVTWECEPDDVS---MLHAARS MAV_4062|M.avium_104 ELDGLSLGGWLRSVRATASSHALLAMVARVTWGCEPDEVS---MLHAARY MSMEG_2035|M.smegmatis_MC2_155 KLDQYSMERWLRYVHANASTRNLMAIMSRVTWGAEPDQVS---MLHAVRY TH_0685|M.thermoresistible__bu RLDTMSLDRWLRSVYASASTRDLMAIMARVTWGCEPHQVS---MLHAARY Mflv_4501|M.gilvum_PYR-GCK QLDDISLDAWLRSVHAGASTRDLMAIMARVTWGAEPGDVS---MLHAVRY Mvan_1866|M.vanbaalenii_PYR-1 ELDAVSLDGWLRSVHAGASTRDLMAIVARVTWGAEPDAVS---MLHAVRY MAB_2659|M.abscessus_ATCC_1997 QLDSISFGEWLSQQQAVTSTNALMYIVTRVQWGCSPLDVS---LLHVLRY MLBr_00062|M.leprae_Br4923 QLTGKTVAVVGSGPAGLAAAQQLTRAGHRVTVFERDDRIGGLLRYGIPEF * :. . :::. * ** :. . Mb3195|M.bovis_AF2122/97 VRAAGGLDR---LLDVKNGAQQDRVPGGTQQIAQAAAAQLG--------- Rv3170|M.tuberculosis_H37Rv VRAAGGLDR---LLDVKNGAQQDRVPGGTQQIAQAAAAQLG--------- MMAR_1389|M.marinum_M VRAAGGLDR---LLDVENGAQQELIPGGTQQIAELAAAELG--------- MUL_2487|M.ulcerans_Agy99 VRAAGGLDR---LLDVENGAQQELIPGGTQQIAELAAAELG--------- MAV_4062|M.avium_104 AHAAGGLDR---LLDVEDGAQQDRFPGGTQQIAAAAAAELG--------- MSMEG_2035|M.smegmatis_MC2_155 VKAAGGLTR---LLDVEGGAQQDRLVEGTQQIALRMADELG--------- TH_0685|M.thermoresistible__bu VKAAGGLGR---MLDVEGGAQQDRFPAGTQQIAQRMAEELDGAEPG---- Mflv_4501|M.gilvum_PYR-GCK VNAAGGLNR---MLDVEGGAQQDRFPAGTQKIADLMAAELG--------- Mvan_1866|M.vanbaalenii_PYR-1 VKAAGGLSR---MLDVKGGAQQDRFLAGTQQIALRMAEQLG--------- MAB_2659|M.abscessus_ATCC_1997 VQAVGGLDH---MLAVEHGQQEYRVTETTQEIAKRLAAQIG--------- MLBr_00062|M.leprae_Br4923 KMEKRFLERRLDQLRAEGTEFRSGVNVGVDITADQLCADFDAVVLAGGAA * : * .: . . .: * . ::. Mb3195|M.bovis_AF2122/97 ARVLLNAAVRRIDRHGAG-VTVTSDQG-QAEAGFVIVAIPPAHRVAIEFD Rv3170|M.tuberculosis_H37Rv ARVLLNAAVRRIDRHGAG-VTVTSDQG-QAEAGFVIVAIPPAHRVAIEFD MMAR_1389|M.marinum_M THVVLDAPVRRIDRHGAG-VTVTSDQG-QAEAGFVIVAIPPAHRAAIEFN MUL_2487|M.ulcerans_Agy99 IHVVLDAPVRRIDRHGAG-VTVTSDQG-QAEAGFVIVAIPPAHRAAIEFN MAV_4062|M.avium_104 ARVVLGAPVRRIERHGAG-VTVRTDLG-DTEAGFVIVAIPPAHRAAIEFA MSMEG_2035|M.smegmatis_MC2_155 QRIALDAPVQRIERHSGGDIGVTFTTG-HVRARAVVIAIAPQHRGDIEFD TH_0685|M.thermoresistible__bu SRVRLGAPVRRITRNPDGTVTVHTGSGDGVTAGAVVVAVPPAHRDAIEFD Mflv_4501|M.gilvum_PYR-GCK DRVVVGAPVRRITRNPDRTVTVTTAGA-EYQAGAVIVAVPPEHRSGIEFD Mvan_1866|M.vanbaalenii_PYR-1 DRVVLGAPVRRIARHPDHSLTVGTDRA-EYTAAAVVVAIPPAHRGAVEFD MAB_2659|M.abscessus_ATCC_1997 DQIVLNTRVRQISQDDNG-VTVSTDSG-VINAKYAIVTAAPEHRAYIEYQ MLBr_00062|M.leprae_Br4923 TWRELPIPGRELDGVHQAMEFLPWVNR-VQEGDDVLGDDGQPPITAKDKK : :.: : . .: : Mb3195|M.bovis_AF2122/97 PPLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFIT Rv3170|M.tuberculosis_H37Rv PPLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFIT MMAR_1389|M.marinum_M PPLPTGYQELADNWPQGRLSKAYAAYSTPFWRINGFTGQSLSDIGPVFIT MUL_2487|M.ulcerans_Agy99 PPLPTGYQELADNWPQGRLSKAYAAYSTPFWRINGFTGQSLSDMGPVFIT MAV_4062|M.avium_104 PPLPAEYEQLARHWPQGRLSKAYAAYSTPFWRADGFSGQALSDEGPVFIT MSMEG_2035|M.smegmatis_MC2_155 PPLPPEYTELAARWPQGRLSKAYAAYDRPFWRANGCSGEALSDEGPVFIT TH_0685|M.thermoresistible__bu PALPPRHTALPGHWPQGMLSKAYAAYDTPFWRADGRSGEALSDDGPVFIT Mflv_4501|M.gilvum_PYR-GCK PPLPAEHRELSRHWPQGRLSKAYAAYETPFWRADGHSGESLSDEGPVFIT Mvan_1866|M.vanbaalenii_PYR-1 PPLPADYGELNRHWPQGHLSKAYAAYQTPFWRTNGCSGEALSDEGPVFIT MAB_2659|M.abscessus_ATCC_1997 PALPAKIEGLTTSFPMGALSKAFVAYDKPFWRAEGLSGEALTDTAPVFIT MLBr_00062|M.leprae_Br4923 VVIIGGGDTGADCLGAVHRQGAIHVHQLEIMPRPPDARAASTPWPTYPLM : . * .:. : : : : . : Mb3195|M.bovis_AF2122/97 FDVSPHADGPGILMGFVDARGFDSLPI----------EERRRDALRCFAS Rv3170|M.tuberculosis_H37Rv FDVSPHADGPGILMGFVDARGFDSLPI----------EERRRDALRCFAS MMAR_1389|M.marinum_M FDASPHDDGPGILMGFVDAREFDSLSA----------DQRRDRTLRCFAS MUL_2487|M.ulcerans_Agy99 FDASPHDDAPGILMGFVDAREFDSLSA----------DQRRDRTLRCFAS MAV_4062|M.avium_104 FDVSPHPDGPGILMGFVDARAFDSLPA----------DQRRRDALRCFAT MSMEG_2035|M.smegmatis_MC2_155 FDVSPGDEGPGILLGFTDARTFDALPP----------EQRRQRALGGFAT TH_0685|M.thermoresistible__bu FDVSPDENGPGILLGFTDARTFDPLSP----------DRRRDKALHGFAK Mflv_4501|M.gilvum_PYR-GCK FDCSPGDDGPGVLLGFTDPRSFDPLPG----------EQRREIALAGFSA Mvan_1866|M.vanbaalenii_PYR-1 FDCSPGDGGPGVLLGFTDARTFDPLPP----------EQRREVALAGFTA MAB_2659|M.abscessus_ATCC_1997 FDVSPSDDGPGILMVFCTARVYDGFGP----------EVRRKLVLKQLVD MLBr_00062|M.leprae_Br4923 YRVSPAHEEGGERVFSVNTEEFVGKNGRVHALKAHEVTMQDGRFVKVENS : ** * : .. : : : Mb3195|M.bovis_AF2122/97 LFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPI Rv3170|M.tuberculosis_H37Rv LFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPI MMAR_1389|M.marinum_M LFGDDALEPLDYVDYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPI MUL_2487|M.ulcerans_Agy99 LFGDDALEPLDYADYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPI MAV_4062|M.avium_104 LFGDDALKPLDYVDHRWGAEEFAPGGPTAAVPPGSWTRFGRWLREPVGPI MSMEG_2035|M.smegmatis_MC2_155 FFGDAARDPIDYLDHCWGTEAFAPGGPTAAVPPEAWTAYGPWLRKPIDGI TH_0685|M.thermoresistible__bu LFGDAALKPIDYLDFCWGCDDFAPGGPTAAVPPGSWTEFGPWLREPVDQI Mflv_4501|M.gilvum_PYR-GCK LFGAAAAHPIDYVDHCWGAEPFSPGGPTAAVPPGAWTAHGRWLRAPVDGI Mvan_1866|M.vanbaalenii_PYR-1 LFGEAASRPLDYLDHCWGAETFAPGGPTAAVPPGAWTAHGRWLRAPVDGI MAB_2659|M.abscessus_ATCC_1997 LYGEQANTPIDYIDHCWGTEPFAAGGPHPAAPPFASVNYGEALREPHGRI MLBr_00062|M.leprae_Br4923 VFELEADLVLLAMGFVGPEKPGLLTDLGVKFTDRGNVARGADFDTSVPGV .: * : .. . . . . . * : . : Mb3195|M.bovis_AF2122/97 HWASTETADEWTGYFDGAVRSGQRAAAEVAALL----------------- Rv3170|M.tuberculosis_H37Rv HWASTETADEWTGYFDGAVRSGQRAAAEVAALL----------------- MMAR_1389|M.marinum_M HWAGTETADEWTGYFDGAVRSGQRAAAEVAALL----------------- MUL_2487|M.ulcerans_Agy99 HWAGTETADEWTGYFDGAVRAGQRAAAEVAALL----------------- MAV_4062|M.avium_104 HWAGTETADEWTGFLDGAIRSGRRAAAEVTALL----------------- MSMEG_2035|M.smegmatis_MC2_155 HWAGTETADVWTGFLDGAVRSGQRAATEVAEALKSSAAAG---------- TH_0685|M.thermoresistible__bu YWAGTETADQWTGFLDGAVRSGQRAAAEVHRRLSSGG------------- Mflv_4501|M.gilvum_PYR-GCK FWAGTETADSWTGFLDGAVRSGLRAADEAHRELARA-------------- Mvan_1866|M.vanbaalenii_PYR-1 FWAGTETADRWTGFLDGAVRSGLRAATDVHQELTRRS------------- MAB_2659|M.abscessus_ATCC_1997 HWAGTETAGEWVGTMNGAILMGLHTADQIAQQLGVTGEVSK--------- MLBr_00062|M.leprae_Br4923 FVAG--DMGRGQSLIVWAIAEGRAAAAAVDRFLMGATALPAPVKPSSLPL . *. . . : *: * :* * Mb3195|M.bovis_AF2122/97 - Rv3170|M.tuberculosis_H37Rv - MMAR_1389|M.marinum_M - MUL_2487|M.ulcerans_Agy99 - MAV_4062|M.avium_104 - MSMEG_2035|M.smegmatis_MC2_155 - TH_0685|M.thermoresistible__bu - Mflv_4501|M.gilvum_PYR-GCK - Mvan_1866|M.vanbaalenii_PYR-1 - MAB_2659|M.abscessus_ATCC_1997 - MLBr_00062|M.leprae_Br4923 Q