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M. bovis AF2122 / 97 Mb3195 (aofH)

annotation: flavin-containing monoamine oxidase
coordinates: 3495756 - 3497102
length: 448

VTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGGRSLTGRVAGVPADMGGSFIGPTQDAV
LALATELGIPTTPTHRDGRNVIQWRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARR
ARELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLDVKNGAQQDR
VPGGTQQIAQAAAAQLGARVLLNAAVRRIDRHGAGVTVTSDQGQAEAGFVIVAIPPAHRVAIEFDPPLPP
EYQQLAHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFITFDVSPHADGPGILMGFVDARGFDSL
PIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHWAST
ETADEWTGYFDGAVRSGQRAAAEVAALL
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3195aofH-100% (448)flavin-containing monoamine oxidase
M. bovis AF2122 / 97Mb3888cgltD3e-0768.57% (35) glutamate synthase subunit beta
M. bovis AF2122 / 97Mb1467-6e-0550.00% (54) dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_4501-1e-16965.14% (436) amine oxidase
M. tuberculosis H37RvRv3170aofH0.0100.00% (448) flavin-containing monoamine oxidase
M. leprae Br4923MLBr_00062gltD2e-0768.57% (35) glutamate synthase subunit beta
M. abscessus ATCC 19977MAB_2659-1e-11747.74% (442) putative flavin-containing monoamine oxidase AofH
M. marinum MMMAR_1389aofH0.080.36% (448) flavin-containing monoamine oxidase AofH (amine oxidase)
M. avium 104MAV_4062-0.080.36% (448) putative flavin-containing monoamine oxidase AofH
M. smegmatis MC2 155MSMEG_2035-1e-17165.17% (445) amine oxidase
M. thermoresistible (build 8)TH_0685-1e-16865.62% (445) PROBABLE FLAVIN-CONTAINING MONOAMINE OXIDASE AOFH (AMINE
M. ulcerans Agy99MUL_2487aofH0.079.02% (448) flavin-containing monoamine oxidase AofH (amine oxidase)
M. vanbaalenii PYR-1Mvan_1866-1e-16765.90% (437) amine oxidase

CLUSTAL 2.0.9 multiple sequence alignment


Mb3195|M.bovis_AF2122/97            ------MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGG
Rv3170|M.tuberculosis_H37Rv         ------MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGG
MMAR_1389|M.marinum_M               ------MTNPSWIVDVVIVGAGFAGLAAARDLARQGHDVLVLEGRDRVGG
MUL_2487|M.ulcerans_Agy99           ------MTNPSWIVDVVIVGAGFAGLAAARDLARQGHDVLVLEGRDRVGG
MAV_4062|M.avium_104                ------MSGPPRIVDVVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGG
MSMEG_2035|M.smegmatis_MC2_155      -------MSIPTSADVVVVGAGFAGLTAARRLVQLGYDVVVLEGRDRVGG
TH_0685|M.thermoresistible__bu      ------------VVDVVVVGAGFAGLTAARELTGLGYEVVVFEGRDRVGG
Mflv_4501|M.gilvum_PYR-GCK          ------------MAEVVVVGAGFAGLAAARELSRLGRDVVVVEGRDRVGG
Mvan_1866|M.vanbaalenii_PYR-1       ------------MADVVVVGAGFAGLSAARELTRLGHEVVVVEGRDRVGG
MAB_2659|M.abscessus_ATCC_1997      MSRSVDNAVEAASVDVVIVGAGFAGLSAADRLVNMGVSVLVIDARERVGG
MLBr_00062|M.leprae_Br4923          --------MADPAGFLKYTQRELPRRRPVPLRLRDWKELYEEFDKETLRN
                                                   :  .   :.   ..        .:     :: : .

Mb3195|M.bovis_AF2122/97            RSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIP-TTPTHRDGRNVIQ
Rv3170|M.tuberculosis_H37Rv         RSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIP-TTPTHRDGRNVIQ
MMAR_1389|M.marinum_M               RSFTGSIAGLPADMGGSFVGPTQDAVLALAAELGVP-TVPTFHDGKNVIR
MUL_2487|M.ulcerans_Agy99           RSFTGSIAGLPADMGGSFVGPSQDAVLALAAELGVP-TVPTFHDGKNVIR
MAV_4062|M.avium_104                RSFTGSVAGLPADLGGTFVGPTQDAVLALAAELEVP-TTPTHHEGKNLIH
MSMEG_2035|M.smegmatis_MC2_155      RSSTATIAGVPVDLGGTFVGPTQDAVLGLAAELGCA-TVPTYNRGKNLIR
TH_0685|M.thermoresistible__bu      RSYTATLAGVPVDLGATFVGPGQTAVTGLAAELGCP-TVGTYHQGNNLIL
Mflv_4501|M.gilvum_PYR-GCK          RSYTGSVGGVPVDFGATFVGPTQDAVLALAAELGVE-SVPTYGEGKNLIR
Mvan_1866|M.vanbaalenii_PYR-1       RSYTGTIAGVPVDLGATFVGPTQDAVLKLADELGCE-REPTFGRGKNLIR
MAB_2659|M.abscessus_ATCC_1997      RSFTGEVAGVKVDLGATWVAKRHTAIRDLMDRLGCS-LTPQYDEGVNLLW
MLBr_00062|M.leprae_Br4923          QASRCMDCGIPFCHNGCPLGNLIPEWNDLVRRGRWHDAVERLHATNNFPD
                                    ::      *:    ..  :.        *  .              *.  

Mb3195|M.bovis_AF2122/97            WRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARR-AR
Rv3170|M.tuberculosis_H37Rv         WRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARR-AR
MMAR_1389|M.marinum_M               WRGGVRPYSGTIPRLSLTGLLDIARLRWQFERLARSIPISAPWAANR-AA
MUL_2487|M.ulcerans_Agy99           WRGGVRPYSGTIPRLSLTGLLDIARLRWQFERLARSIPISAPWAANR-AA
MAV_4062|M.avium_104                WRGWTHAYHGTIPKLSLTGLLDIGRLRWQFDRIARSIPLAAPWEARR-AA
MSMEG_2035|M.smegmatis_MC2_155      WHGRVRSYRSTIPRLSIIELLDVSRIQWRFERLFRHVDVAEPWNGSL-AH
TH_0685|M.thermoresistible__bu      WRGRLKSYRSTIPTLSILELLDVSRIQWRFERLCRQIPVGEPWRAPA-AH
Mflv_4501|M.gilvum_PYR-GCK          WRGRVRSYRSTIPRLSILELLDVSRIQWRFDRISKRVPVDQPWASPL-AG
Mvan_1866|M.vanbaalenii_PYR-1       WRGSVRSYRSTVPRLSIIELLDVSRIQWRFERVCRKVSVDQPWRSPV-AA
MAB_2659|M.abscessus_ATCC_1997      MAGKRKTWTGTLPTVDPVDLEDLGRITIEMGKLLETINVDAAWKSPN-AD
MLBr_00062|M.leprae_Br4923          VTGRLCPAPCESACVLGINQDPVTIKQIELEIIDK--AFDEGWVQPLPPQ
                                      *   .     . :       :     .:  : .   .   *     . 

Mb3195|M.bovis_AF2122/97            ELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVS---MLHAARY
Rv3170|M.tuberculosis_H37Rv         ELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVS---MLHAARY
MMAR_1389|M.marinum_M               DLDGVSLRQWLRSVRASASSHDLMAIMTRVTWGCEPDDVS---MLHAARY
MUL_2487|M.ulcerans_Agy99           DLDGVSLRQWLRSVRASASSHDLMAIMTRVTWECEPDDVS---MLHAARS
MAV_4062|M.avium_104                ELDGLSLGGWLRSVRATASSHALLAMVARVTWGCEPDEVS---MLHAARY
MSMEG_2035|M.smegmatis_MC2_155      KLDQYSMERWLRYVHANASTRNLMAIMSRVTWGAEPDQVS---MLHAVRY
TH_0685|M.thermoresistible__bu      RLDTMSLDRWLRSVYASASTRDLMAIMARVTWGCEPHQVS---MLHAARY
Mflv_4501|M.gilvum_PYR-GCK          QLDDISLDAWLRSVHAGASTRDLMAIMARVTWGAEPGDVS---MLHAVRY
Mvan_1866|M.vanbaalenii_PYR-1       ELDAVSLDGWLRSVHAGASTRDLMAIVARVTWGAEPDAVS---MLHAVRY
MAB_2659|M.abscessus_ATCC_1997      QLDSISFGEWLSQQQAVTSTNALMYIVTRVQWGCSPLDVS---LLHVLRY
MLBr_00062|M.leprae_Br4923          QLTGKTVAVVGSGPAGLAAAQQLTRAGHRVTVFERDDRIGGLLRYGIPEF
                                     *   :.        . :::. *     **        :.        . 

Mb3195|M.bovis_AF2122/97            VRAAGGLDR---LLDVKNGAQQDRVPGGTQQIAQAAAAQLG---------
Rv3170|M.tuberculosis_H37Rv         VRAAGGLDR---LLDVKNGAQQDRVPGGTQQIAQAAAAQLG---------
MMAR_1389|M.marinum_M               VRAAGGLDR---LLDVENGAQQELIPGGTQQIAELAAAELG---------
MUL_2487|M.ulcerans_Agy99           VRAAGGLDR---LLDVENGAQQELIPGGTQQIAELAAAELG---------
MAV_4062|M.avium_104                AHAAGGLDR---LLDVEDGAQQDRFPGGTQQIAAAAAAELG---------
MSMEG_2035|M.smegmatis_MC2_155      VKAAGGLTR---LLDVEGGAQQDRLVEGTQQIALRMADELG---------
TH_0685|M.thermoresistible__bu      VKAAGGLGR---MLDVEGGAQQDRFPAGTQQIAQRMAEELDGAEPG----
Mflv_4501|M.gilvum_PYR-GCK          VNAAGGLNR---MLDVEGGAQQDRFPAGTQKIADLMAAELG---------
Mvan_1866|M.vanbaalenii_PYR-1       VKAAGGLSR---MLDVKGGAQQDRFLAGTQQIALRMAEQLG---------
MAB_2659|M.abscessus_ATCC_1997      VQAVGGLDH---MLAVEHGQQEYRVTETTQEIAKRLAAQIG---------
MLBr_00062|M.leprae_Br4923          KMEKRFLERRLDQLRAEGTEFRSGVNVGVDITADQLCADFDAVVLAGGAA
                                          * :    * .:    .  .   .:  *   . ::.         

Mb3195|M.bovis_AF2122/97            ARVLLNAAVRRIDRHGAG-VTVTSDQG-QAEAGFVIVAIPPAHRVAIEFD
Rv3170|M.tuberculosis_H37Rv         ARVLLNAAVRRIDRHGAG-VTVTSDQG-QAEAGFVIVAIPPAHRVAIEFD
MMAR_1389|M.marinum_M               THVVLDAPVRRIDRHGAG-VTVTSDQG-QAEAGFVIVAIPPAHRAAIEFN
MUL_2487|M.ulcerans_Agy99           IHVVLDAPVRRIDRHGAG-VTVTSDQG-QAEAGFVIVAIPPAHRAAIEFN
MAV_4062|M.avium_104                ARVVLGAPVRRIERHGAG-VTVRTDLG-DTEAGFVIVAIPPAHRAAIEFA
MSMEG_2035|M.smegmatis_MC2_155      QRIALDAPVQRIERHSGGDIGVTFTTG-HVRARAVVIAIAPQHRGDIEFD
TH_0685|M.thermoresistible__bu      SRVRLGAPVRRITRNPDGTVTVHTGSGDGVTAGAVVVAVPPAHRDAIEFD
Mflv_4501|M.gilvum_PYR-GCK          DRVVVGAPVRRITRNPDRTVTVTTAGA-EYQAGAVIVAVPPEHRSGIEFD
Mvan_1866|M.vanbaalenii_PYR-1       DRVVLGAPVRRIARHPDHSLTVGTDRA-EYTAAAVVVAIPPAHRGAVEFD
MAB_2659|M.abscessus_ATCC_1997      DQIVLNTRVRQISQDDNG-VTVSTDSG-VINAKYAIVTAAPEHRAYIEYQ
MLBr_00062|M.leprae_Br4923          TWRELPIPGRELDGVHQAMEFLPWVNR-VQEGDDVLGDDGQPPITAKDKK
                                        :    :.:         :         .  .:           :  

Mb3195|M.bovis_AF2122/97            PPLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFIT
Rv3170|M.tuberculosis_H37Rv         PPLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASGYSGQALSDEAPVFIT
MMAR_1389|M.marinum_M               PPLPTGYQELADNWPQGRLSKAYAAYSTPFWRINGFTGQSLSDIGPVFIT
MUL_2487|M.ulcerans_Agy99           PPLPTGYQELADNWPQGRLSKAYAAYSTPFWRINGFTGQSLSDMGPVFIT
MAV_4062|M.avium_104                PPLPAEYEQLARHWPQGRLSKAYAAYSTPFWRADGFSGQALSDEGPVFIT
MSMEG_2035|M.smegmatis_MC2_155      PPLPPEYTELAARWPQGRLSKAYAAYDRPFWRANGCSGEALSDEGPVFIT
TH_0685|M.thermoresistible__bu      PALPPRHTALPGHWPQGMLSKAYAAYDTPFWRADGRSGEALSDDGPVFIT
Mflv_4501|M.gilvum_PYR-GCK          PPLPAEHRELSRHWPQGRLSKAYAAYETPFWRADGHSGESLSDEGPVFIT
Mvan_1866|M.vanbaalenii_PYR-1       PPLPADYGELNRHWPQGHLSKAYAAYQTPFWRTNGCSGEALSDEGPVFIT
MAB_2659|M.abscessus_ATCC_1997      PALPAKIEGLTTSFPMGALSKAFVAYDKPFWRAEGLSGEALTDTAPVFIT
MLBr_00062|M.leprae_Br4923          VVIIGGGDTGADCLGAVHRQGAIHVHQLEIMPRPPDARAASTPWPTYPLM
                                      :                . *  .:.  :      :  : :   .  : 

Mb3195|M.bovis_AF2122/97            FDVSPHADGPGILMGFVDARGFDSLPI----------EERRRDALRCFAS
Rv3170|M.tuberculosis_H37Rv         FDVSPHADGPGILMGFVDARGFDSLPI----------EERRRDALRCFAS
MMAR_1389|M.marinum_M               FDASPHDDGPGILMGFVDAREFDSLSA----------DQRRDRTLRCFAS
MUL_2487|M.ulcerans_Agy99           FDASPHDDAPGILMGFVDAREFDSLSA----------DQRRDRTLRCFAS
MAV_4062|M.avium_104                FDVSPHPDGPGILMGFVDARAFDSLPA----------DQRRRDALRCFAT
MSMEG_2035|M.smegmatis_MC2_155      FDVSPGDEGPGILLGFTDARTFDALPP----------EQRRQRALGGFAT
TH_0685|M.thermoresistible__bu      FDVSPDENGPGILLGFTDARTFDPLSP----------DRRRDKALHGFAK
Mflv_4501|M.gilvum_PYR-GCK          FDCSPGDDGPGVLLGFTDPRSFDPLPG----------EQRREIALAGFSA
Mvan_1866|M.vanbaalenii_PYR-1       FDCSPGDGGPGVLLGFTDARTFDPLPP----------EQRREVALAGFTA
MAB_2659|M.abscessus_ATCC_1997      FDVSPSDDGPGILMVFCTARVYDGFGP----------EVRRKLVLKQLVD
MLBr_00062|M.leprae_Br4923          YRVSPAHEEGGERVFSVNTEEFVGKNGRVHALKAHEVTMQDGRFVKVENS
                                    :  **     *  :    .. :                 :    :     

Mb3195|M.bovis_AF2122/97            LFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPI
Rv3170|M.tuberculosis_H37Rv         LFGDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPI
MMAR_1389|M.marinum_M               LFGDDALEPLDYVDYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPI
MUL_2487|M.ulcerans_Agy99           LFGDDALEPLDYADYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPI
MAV_4062|M.avium_104                LFGDDALKPLDYVDHRWGAEEFAPGGPTAAVPPGSWTRFGRWLREPVGPI
MSMEG_2035|M.smegmatis_MC2_155      FFGDAARDPIDYLDHCWGTEAFAPGGPTAAVPPEAWTAYGPWLRKPIDGI
TH_0685|M.thermoresistible__bu      LFGDAALKPIDYLDFCWGCDDFAPGGPTAAVPPGSWTEFGPWLREPVDQI
Mflv_4501|M.gilvum_PYR-GCK          LFGAAAAHPIDYVDHCWGAEPFSPGGPTAAVPPGAWTAHGRWLRAPVDGI
Mvan_1866|M.vanbaalenii_PYR-1       LFGEAASRPLDYLDHCWGAETFAPGGPTAAVPPGAWTAHGRWLRAPVDGI
MAB_2659|M.abscessus_ATCC_1997      LYGEQANTPIDYIDHCWGTEPFAAGGPHPAAPPFASVNYGEALREPHGRI
MLBr_00062|M.leprae_Br4923          VFELEADLVLLAMGFVGPEKPGLLTDLGVKFTDRGNVARGADFDTSVPGV
                                    .:   *   :   ..    .     .     .  . .  *  :  .   :

Mb3195|M.bovis_AF2122/97            HWASTETADEWTGYFDGAVRSGQRAAAEVAALL-----------------
Rv3170|M.tuberculosis_H37Rv         HWASTETADEWTGYFDGAVRSGQRAAAEVAALL-----------------
MMAR_1389|M.marinum_M               HWAGTETADEWTGYFDGAVRSGQRAAAEVAALL-----------------
MUL_2487|M.ulcerans_Agy99           HWAGTETADEWTGYFDGAVRAGQRAAAEVAALL-----------------
MAV_4062|M.avium_104                HWAGTETADEWTGFLDGAIRSGRRAAAEVTALL-----------------
MSMEG_2035|M.smegmatis_MC2_155      HWAGTETADVWTGFLDGAVRSGQRAATEVAEALKSSAAAG----------
TH_0685|M.thermoresistible__bu      YWAGTETADQWTGFLDGAVRSGQRAAAEVHRRLSSGG-------------
Mflv_4501|M.gilvum_PYR-GCK          FWAGTETADSWTGFLDGAVRSGLRAADEAHRELARA--------------
Mvan_1866|M.vanbaalenii_PYR-1       FWAGTETADRWTGFLDGAVRSGLRAATDVHQELTRRS-------------
MAB_2659|M.abscessus_ATCC_1997      HWAGTETAGEWVGTMNGAILMGLHTADQIAQQLGVTGEVSK---------
MLBr_00062|M.leprae_Br4923          FVAG--DMGRGQSLIVWAIAEGRAAAAAVDRFLMGATALPAPVKPSSLPL
                                    . *.    .   . :  *:  *  :*      *                 

Mb3195|M.bovis_AF2122/97            -
Rv3170|M.tuberculosis_H37Rv         -
MMAR_1389|M.marinum_M               -
MUL_2487|M.ulcerans_Agy99           -
MAV_4062|M.avium_104                -
MSMEG_2035|M.smegmatis_MC2_155      -
TH_0685|M.thermoresistible__bu      -
Mflv_4501|M.gilvum_PYR-GCK          -
Mvan_1866|M.vanbaalenii_PYR-1       -
MAB_2659|M.abscessus_ATCC_1997      -
MLBr_00062|M.leprae_Br4923          Q