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MRVESRSPAERPATPADKTDTRSILVIGAGMAGLGAARALADAGWPVRLIEARDRVGGRVNTVRDWDVPL EMGASWIHGTTDNPLVELAGQVEARLAPTDYDTPAKLAVDPRLEPISYDDDTWRRLVAQARRDVDDGSLA AALDAQAPRDDLSDRERAELAYYVNTVIEDEYAADADQLSATTYDQGTYSSGPQVVITSGYDALPRRLAD GLPIVFGTKVDSIVHKDDSVLVRAAGRTFQGPAAIVTAPLGVLKAGAITFDPPLPNDHRRAIAALGFGVL SKSYFRFDRRTWDADNAFYQFLGPPGSMWSQWLTLPAAAGPIVLALNAGHRGRHVESCSPSELMSGALPV ARQLFGKDIAPAEVRSSGWSTDPLALGSYSFHAPGSGLDDRRQLQEPISDRLYLAGEAVGVDNPATVHGA LISGRSAAAELMRQLQ
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2489 | - | - | 100% (436) | monoamine oxidase |
| M. ulcerans Agy99 | MUL_1281 | aofH_1 | 5e-21 | 26.80% (444) | flavin-containing monoamine oxidase AofH_1 |
| M. ulcerans Agy99 | MUL_2487 | aofH | 6e-16 | 23.65% (444) | flavin-containing monoamine oxidase AofH (amine oxidase) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 9e-20 | 27.35% (457) | flavin-containing monoamine oxidase |
| M. gilvum PYR-GCK | Mflv_2278 | - | 1e-65 | 38.33% (420) | amine oxidase |
| M. tuberculosis H37Rv | Rv3170 | aofH | 9e-20 | 27.35% (457) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2659 | - | 2e-18 | 23.88% (448) | putative flavin-containing monoamine oxidase AofH |
| M. marinum M | MMAR_1387 | - | 0.0 | 97.88% (425) | monoamine oxidase |
| M. avium 104 | MAV_4062 | - | 2e-19 | 27.33% (450) | putative flavin-containing monoamine oxidase AofH |
| M. smegmatis MC2 155 | MSMEG_2035 | - | 1e-19 | 27.21% (452) | amine oxidase |
| M. thermoresistible (build 8) | TH_2921 | - | 7e-20 | 27.09% (454) | PUTATIVE putative flavin-containing monoamine oxidase AofH_1 |
| M. vanbaalenii PYR-1 | Mvan_4388 | - | 3e-60 | 37.24% (427) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3195|M.bovis_AF2122/97 -----------------------------------MT------NPPWTVD
Rv3170|M.tuberculosis_H37Rv -----------------------------------MT------NPPWTVD
MAV_4062|M.avium_104 -----------------------------------MS------GPPRIVD
MSMEG_2035|M.smegmatis_MC2_155 -----------------------------------MS------IPT-SAD
MAB_2659|M.abscessus_ATCC_1997 -----------------------------------MSRSVDNAVEAASVD
TH_2921|M.thermoresistible__bu --------------------------------------------------
MUL_2489|M.ulcerans_Agy99 -MRVESR--------------------------SPAERPATPADKTDTRS
MMAR_1387|M.marinum_M MSRVPRRKFLAATAGLSCGAAAGLGAGCASDHAARSSAPATPVDKTDTRS
Mflv_2278|M.gilvum_PYR-GCK ----------------------------MATAPLLASCGNGGGGRDTRER
Mvan_4388|M.vanbaalenii_PYR-1 MLALTRRQFTLG-------------LGAVAATPLLTSCG--GGGDTTRGH
Mb3195|M.bovis_AF2122/97 VVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGGRSLTGRVAGVP----
Rv3170|M.tuberculosis_H37Rv VVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGGRSLTGRVAGVP----
MAV_4062|M.avium_104 VVVVGAGFAGLAAARELNRQGHDVVVFEGRDRVGGRSFTGSVAGLP----
MSMEG_2035|M.smegmatis_MC2_155 VVVVGAGFAGLTAARRLVQLGYDVVVLEGRDRVGGRSSTATIAGVP----
MAB_2659|M.abscessus_ATCC_1997 VVIVGAGFAGLSAADRLVNMGVSVLVIDARERVGGRSFTGEVAGVK----
TH_2921|M.thermoresistible__bu VVVVGAGLAGLTAARTLRRAGVDVVVLEARDRVGGRTLNHFLEHGPDPEN
MUL_2489|M.ulcerans_Agy99 ILVIGAGMAGLGAARALADAGWPVRLIEARDRVGGRVNTVRDWDVP----
MMAR_1387|M.marinum_M ILVIGAGMAGLGAARALADAGWPVRLIEARDRVGGRVNTVRDWGVP----
Mflv_2278|M.gilvum_PYR-GCK VVVVGAGMAGLSAARRLADNGVSVAVVEARQRIGGRTWTDTSLGVP----
Mvan_4388|M.vanbaalenii_PYR-1 VVVVGAGMSGLAAARRLTDAGVPVTVVEARSRIGGRTWTDTSLGLP----
::::***::** ** * * * :.:.*.*:*** .
Mb3195|M.bovis_AF2122/97 ---ADMGGSFIG-PTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARSY
Rv3170|M.tuberculosis_H37Rv ---ADMGGSFIG-PTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARSY
MAV_4062|M.avium_104 ---ADLGGTFVG-PTQDAVLALAAELEVPTTPTHHEGKNLIHWRGWTHAY
MSMEG_2035|M.smegmatis_MC2_155 ---VDLGGTFVG-PTQDAVLGLAAELGCATVPTYNRGKNLIRWHGRVRSY
MAB_2659|M.abscessus_ATCC_1997 ---VDLGATWVA-KRHTAIRDLMDRLGCSLTPQYDEGVNLLWMAGKRKTW
TH_2921|M.thermoresistible__bu DAVVELGGQWIG-PGHQRIRALIDELGLSTFDTYDRGAKLWEHNGRVRRY
MUL_2489|M.ulcerans_Agy99 ---LEMGASWIHGTTDNPLVELAGQVEARLAPTDYDTPAKLAVD------
MMAR_1387|M.marinum_M ---LEMGASWIHGTTDNPLVELAGQVEARLAPTDYDTPAKLAVD------
Mflv_2278|M.gilvum_PYR-GCK ---IDLGGAWIHGPEGNPLTDLVEQVGARTVATDFEDAVVLQNG------
Mvan_4388|M.vanbaalenii_PYR-1 ---VDLGAAWIHGSQGNPLTGLAAQAGARTVETNFDDVVVLDGG------
::*. :: : * .
Mb3195|M.bovis_AF2122/97 RGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLGE
Rv3170|M.tuberculosis_H37Rv RGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLGE
MAV_4062|M.avium_104 HGTIPKLSLTGLLDIGRLRWQFDRIARSIPLAAPWEARRAAELDGLSLGG
MSMEG_2035|M.smegmatis_MC2_155 RSTIPRLSIIELLDVSRIQWRFERLFRHVDVAEPWNGSLAHKLDQYSMER
MAB_2659|M.abscessus_ATCC_1997 TGTLPTVDPVDLEDLGRITIEMGKLLETINVDAAWKSPNADQLDSISFGE
TH_2921|M.thermoresistible__bu TGEIPRANPLHLADLQIALTRLERMARRIDPAAPWAAPRAAQWDRQTVAG
MUL_2489|M.ulcerans_Agy99 ----PRLEPISYDDDT--WRRLVAQARRDVDDGSLAAALDAQAPRDDLSD
MMAR_1387|M.marinum_M ----PRLEPISYDDDT--WRRLVAQARRDVDDGSLAAALDAQAPRDDLSD
Mflv_2278|M.gilvum_PYR-GCK ----VVVNPASVDAADREWDRILGEVASMTEDAAPGESLADGLAETG-AD
Mvan_4388|M.vanbaalenii_PYR-1 ----RAVDPAAVEEVSRDWMGVLDEIEPMTADAAPDVSLADGLVWAG-AD
. . .
Mb3195|M.bovis_AF2122/97 WLRLVRATSSSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLD
Rv3170|M.tuberculosis_H37Rv WLRLVRATSSSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLD
MAV_4062|M.avium_104 WLRSVRATASSHALLAMVARVTWGCEPDEVSMLHAARYAHAAGGLDRLLD
MSMEG_2035|M.smegmatis_MC2_155 WLRYVHANASTRNLMAIMSRVTWGAEPDQVSMLHAVRYVKAAGGLTRLLD
MAB_2659|M.abscessus_ATCC_1997 WLSQQQAVTSTNALMYIVTRVQWGCSPLDVSLLHVLRYVQAVGGLDHMLA
TH_2921|M.thermoresistible__bu WIDRHVRTAVGRAFIELVCEAVWAADAADLSLLHLLTYTSSNQGLSQLIT
MUL_2489|M.ulcerans_Agy99 RER-----AELAYYVNTVIEDEYAADADQLSATTYDQGTYSSG-------
MMAR_1387|M.marinum_M RER-----AELAYYVNTVIEDEYAADADQLSATTYDQGTYSSG-------
Mflv_2278|M.gilvum_PYR-GCK LSD-----PLLQWCVAGSIGSEYAADPDELSLRWFGNEGEFDG-------
Mvan_4388|M.vanbaalenii_PYR-1 LED-----PLMQWMVSAAIGAEYAADPEELALRWFGHEGEFDG-------
. : :.... :::
Mb3195|M.bovis_AF2122/97 VKNGAQQDRVPGGTQQIAQAAAAQLGARVLLNAAVRRIDRHGAG-VTVTS
Rv3170|M.tuberculosis_H37Rv VKNGAQQDRVPGGTQQIAQAAAAQLGARVLLNAAVRRIDRHGAG-VTVTS
MAV_4062|M.avium_104 VEDGAQQDRFPGGTQQIAAAAAAELGARVVLGAPVRRIERHGAG-VTVRT
MSMEG_2035|M.smegmatis_MC2_155 VEGGAQQDRLVEGTQQIALRMADELGQRIALDAPVQRIERHSGGDIGVTF
MAB_2659|M.abscessus_ATCC_1997 VEHGQQEYRVTETTQEIAKRLAAQIGDQIVLNTRVRQISQDDNG-VTVST
TH_2921|M.thermoresistible__bu TRGGAQQSRIIGGAQQISTAMADELGDAVRLGAPVREIR-TRDG-VQVVA
MUL_2489|M.ulcerans_Agy99 -----PQVVITSGYDALPRRLADGL--PIVFGTKVDSIVHKDDS-VLVRA
MMAR_1387|M.marinum_M -----PQVVITSGYDALPRRLADGL--PIVFGTKVDSIVHKDDS-VLVRA
Mflv_2278|M.gilvum_PYR-GCK -----PDLILSGGYGQLIDYLSRDL--TIRLGREVTRISHDATG-VRVET
Mvan_4388|M.vanbaalenii_PYR-1 -----PDLILPGGYRQLIDHLARDL--DIRLDAEVTRIAYDDVG-VTVET
: . : : : : :. * * . : *
Mb3195|M.bovis_AF2122/97 DQGQAEAGFVIVAIPP--AHRVAIEFDPPLPPEYQQLAHHWPQGRLSKAY
Rv3170|M.tuberculosis_H37Rv DQGQAEAGFVIVAIPP--AHRVAIEFDPPLPPEYQQLAHHWPQGRLSKAY
MAV_4062|M.avium_104 DLGDTEAGFVIVAIPP--AHRAAIEFAPPLPAEYEQLARHWPQGRLSKAY
MSMEG_2035|M.smegmatis_MC2_155 TTGHVRARAVVIAIAP--QHRGDIEFDPPLPPEYTELAARWPQGRLSKAY
MAB_2659|M.abscessus_ATCC_1997 DSGVINAKYAIVTAAP--EHRAYIEYQPALPAKIEGLTTSFPMGALSKAF
TH_2921|M.thermoresistible__bu DTATVRAERVVVAMSP--TLAGRLHYDEPLPADRDQLTQRMPNGSVVKCM
MUL_2489|M.ulcerans_Agy99 AGRTFQGPAAIVTAPLGVLKAGAITFDPPLPNDHRRAIAALGFGVLSKSY
MMAR_1387|M.marinum_M ADRTFQGPAAIVTAPLGVLKAGAITFDPPLPDDHRRAIAALGFGVLSKSY
Mflv_2278|M.gilvum_PYR-GCK AREVFEADRVIVTVPLGVLKAGVITFDPPLPDAKRDAIRRLGFGLLNKVV
Mvan_4388|M.vanbaalenii_PYR-1 AQEVLRADRVIVTVPLGVLKAGVIVFDPPLPQAKRAAVERLGFGLLDKVV
.. .::: . : : .** * : *
Mb3195|M.bovis_AF2122/97 AAYSTP----FWRASGYSGQALSDEAPVFITFDVSPHADGPGILMGFVD-
Rv3170|M.tuberculosis_H37Rv AAYSTP----FWRASGYSGQALSDEAPVFITFDVSPHADGPGILMGFVD-
MAV_4062|M.avium_104 AAYSTP----FWRADGFSGQALSDEGPVFITFDVSPHPDGPGILMGFVD-
MSMEG_2035|M.smegmatis_MC2_155 AAYDRP----FWRANGCSGEALSDEGPVFITFDVSPGDEGPGILLGFTD-
MAB_2659|M.abscessus_ATCC_1997 VAYDKP----FWRAEGLSGEALTDTAPVFITFDVSPSDDGPGILMVFCT-
TH_2921|M.thermoresistible__bu AIYDEP----FWRADGLSGQGVGFTGPVKVFFDNSPPSGRPGVLLGFLEG
MUL_2489|M.ulcerans_Agy99 FRFDR----RTWDADNAFYQFLGPPGSMWSQWLTLPAAAGP-IVLALNAG
MMAR_1387|M.marinum_M FRFER----RTWDADNAFYQFLGPPGSMWSQWLTLPAAAGP-IVLAFNAG
Mflv_2278|M.gilvum_PYR-GCK LRFDEPFWTEEFDADTDMFGMAGQDQPVSDLVNGLRFTDIP-VLIGLRGG
Mvan_4388|M.vanbaalenii_PYR-1 LVFDEPFWTEAFDIHSDMLGIAGGAQPVSDLVNGLRFTDVP-LLVGLRGG
:. : .: * ::: :
Mb3195|M.bovis_AF2122/97 --ARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGG
Rv3170|M.tuberculosis_H37Rv --ARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPGG
MAV_4062|M.avium_104 --ARAFDSLPADQRRRDALRCFATLFGDDALKPLDYVDHRWGAEEFAPGG
MSMEG_2035|M.smegmatis_MC2_155 --ARTFDALPPEQRRQRALGGFATFFGDAARDPIDYLDHCWGTEAFAPGG
MAB_2659|M.abscessus_ATCC_1997 --ARVYDGFGPEVRRKLVLKQLVDLYGEQANTPIDYIDHCWGTEPFAAGG
TH_2921|M.thermoresistible__bu SQARELGRADTRTRREAVIGCFARMFGPRAARPVDYVEKVWAADQWTRGC
MUL_2489|M.ulcerans_Agy99 HRGRHVESCSPSELMSGALPVARQLFGKDIA-PAEVRSSGWSTDPLALGS
MMAR_1387|M.marinum_M RRGRHVESYSPSELMSGALPVARQLFGNDIA-PAEVRSSGWSTDPLALGS
Mflv_2278|M.gilvum_PYR-GCK ANARARESESDQQTADEVVTALRAPT------PSGVIVTRWAQDPFARGS
Mvan_4388|M.vanbaalenii_PYR-1 ANARAREADSDQQTVGEVLAALRAPD------PVGVFVTRWAADPYARGS
.* .: * *. : : *
Mb3195|M.bovis_AF2122/97 PTAAVPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRAA
Rv3170|M.tuberculosis_H37Rv PTAAVPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRAA
MAV_4062|M.avium_104 PTAAVPPGSWTRFGRWLREPVGPIHWAGTETADEWTGFLDGAIRSGRRAA
MSMEG_2035|M.smegmatis_MC2_155 PTAAVPPEAWTAYGPWLRKPIDGIHWAGTETADVWTGFLDGAVRSGQRAA
MAB_2659|M.abscessus_ATCC_1997 PHPAAPPFASVNYGEALREPHGRIHWAGTETAGEWVGTMNGAILMGLHTA
TH_2921|M.thermoresistible__bu YGAFLPPNTWTQVGPALRRAVGPIHWAGAETAVRSMGYMDGAVASGERAA
MUL_2489|M.ulcerans_Agy99 YSFHAPGSGLDDRRQLQEPISDRLYLAGEAVGVDNPATVHGALISGRSAA
MMAR_1387|M.marinum_M YSFHAPGSGLDDRRQLQEPISDRLYLAGEAVGVDNPATVHGALISGRSAA
Mflv_2278|M.gilvum_PYR-GCK YSFLAVGSSPDDQDALAAPVADRVAFAGEATHRDFFATVHGAYLSGLREA
Mvan_4388|M.vanbaalenii_PYR-1 YSFLAVGSSPADQQALAEPVADRVAFAGEATHPEFFATVHGAYLSGLREA
. : *. . . ..** * *
Mb3195|M.bovis_AF2122/97 AEVAALL--------
Rv3170|M.tuberculosis_H37Rv AEVAALL--------
MAV_4062|M.avium_104 AEVTALL--------
MSMEG_2035|M.smegmatis_MC2_155 TEVAEALKSSAAAG-
MAB_2659|M.abscessus_ATCC_1997 DQIAQQLGVTGEVSK
TH_2921|M.thermoresistible__bu AEVLTALGSGA----
MUL_2489|M.ulcerans_Agy99 AELMRQLQ-------
MMAR_1387|M.marinum_M AELMRQLQ-------
Mflv_2278|M.gilvum_PYR-GCK DRILESGV-------
Mvan_4388|M.vanbaalenii_PYR-1 DRILR----------
.: