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VSGMTGHEADVVVVGAGLSGLIAARTLLGAGLTPLILEADTRVGGRILTEDLGGLPMELGAQWIGDTHHR MFALAAELGVETYPQFDDGETTYELAGTGVLRGNEFHDRFAGELAELEKVLRRLDGLATEVDPATPWTAP HAAEWDAITAGAWYDAQGLSPVARTLLEICTVGILAVPTVEVSFLHLLFTIQTCGVTSELFAESEGGAQT TRFVGGTAEIPKRLAAMLTEHLVLDAPVQLIEHGSDSVTVHCRGGRTARGRRIIVAVSPMLAGRIMYDPP LSGYRDQLTQRMPNSAAMKAFFVYDEPFWRADGLNGQLISDVGPARMSNDTCIRGDDRGVILLFLEGEQA RTHGHWSEEERRAALTAELVRHFGERAAHPQLYVDGEWGSRQWTRGCYNANCGPLVWTTYGAALAEPIGP IHWASTDTATEWSAYMEGAVQAGERAAAEVIEALTK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5578 | - | - | 100% (456) | amine oxidase (flavin-containing) |
| M. vanbaalenii PYR-1 | Mvan_1178 | - | 5e-72 | 36.64% (453) | amine oxidase |
| M. vanbaalenii PYR-1 | Mvan_1866 | - | 6e-66 | 35.25% (451) | amine oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 3e-70 | 36.40% (445) | flavin-containing monoamine oxidase |
| M. gilvum PYR-GCK | Mflv_1230 | - | 0.0 | 89.58% (451) | amine oxidase (flavin-containing) |
| M. tuberculosis H37Rv | Rv3170 | aofH | 3e-70 | 36.40% (445) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | MLBr_01044 | hemY | 3e-06 | 40.85% (71) | protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_2659 | - | 2e-63 | 33.03% (445) | putative flavin-containing monoamine oxidase AofH |
| M. marinum M | MMAR_1389 | aofH | 2e-72 | 37.00% (446) | flavin-containing monoamine oxidase AofH (amine oxidase) |
| M. avium 104 | MAV_4062 | - | 2e-70 | 37.00% (446) | putative flavin-containing monoamine oxidase AofH |
| M. smegmatis MC2 155 | MSMEG_2035 | - | 4e-71 | 36.02% (447) | amine oxidase |
| M. thermoresistible (build 8) | TH_2921 | - | 2e-96 | 44.86% (457) | PUTATIVE putative flavin-containing monoamine oxidase AofH_1 |
| M. ulcerans Agy99 | MUL_2487 | aofH | 1e-71 | 36.77% (446) | flavin-containing monoamine oxidase AofH (amine oxidase) |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5578|M.vanbaalenii_PYR-1 MSG-----MTGHEADVVVVGAGLSGLIAARTLLGAG---LTPLILEADTR
Mflv_1230|M.gilvum_PYR-GCK --------MARDEADVLIVGAGISGLIAARTVLAAG---LTPLVVEADTR
TH_2921|M.thermoresistible__bu ---------------VVVVGAGLAGLTAARTLRRAG---VDVVVLEARDR
Mb3195|M.bovis_AF2122/97 MT------NPPWTVDVVVVGAGFAGLAAARELTRQG---HEVLVFEGRDR
Rv3170|M.tuberculosis_H37Rv MT------NPPWTVDVVVVGAGFAGLAAARELTRQG---HEVLVFEGRDR
MAV_4062|M.avium_104 MS------GPPRIVDVVVVGAGFAGLAAARELNRQG---HDVVVFEGRDR
MMAR_1389|M.marinum_M MT------NPSWIVDVVIVGAGFAGLAAARDLARQG---HDVLVLEGRDR
MUL_2487|M.ulcerans_Agy99 MT------NPSWIVDVVIVGAGFAGLAAARDLARQG---HDVLVLEGRDR
MSMEG_2035|M.smegmatis_MC2_155 MS------IPT-SADVVVVGAGFAGLTAARRLVQLG---YDVVVLEGRDR
MAB_2659|M.abscessus_ATCC_1997 MSRSVDNAVEAASVDVVIVGAGFAGLSAADRLVNMG---VSVLVIDARER
MLBr_01044|M.leprae_Br4923 ----------MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDR
:**.*::** ** : :.: *
Mvan_5578|M.vanbaalenii_PYR-1 VGGRILTEDLGGLP-------MELGAQWIGDTHHRMFALAAELGVETYP-
Mflv_1230|M.gilvum_PYR-GCK VGGRVLTEELAGLP-------MELGAQWIGDTHHRMFALAAELGVETYP-
TH_2921|M.thermoresistible__bu VGGRTLNHFLEHGPDPENDAVVELGGQWIGPGHQRIRALIDELGLSTFD-
Mb3195|M.bovis_AF2122/97 VGGRSLTGRVAGVP-------ADMGGSFIGPTQDAVLALATELGIPTTP-
Rv3170|M.tuberculosis_H37Rv VGGRSLTGRVAGVP-------ADMGGSFIGPTQDAVLALATELGIPTTP-
MAV_4062|M.avium_104 VGGRSFTGSVAGLP-------ADLGGTFVGPTQDAVLALAAELEVPTTP-
MMAR_1389|M.marinum_M VGGRSFTGSIAGLP-------ADMGGSFVGPTQDAVLALAAELGVPTVP-
MUL_2487|M.ulcerans_Agy99 VGGRSFTGSIAGLP-------ADMGGSFVGPSQDAVLALAAELGVPTVP-
MSMEG_2035|M.smegmatis_MC2_155 VGGRSSTATIAGVP-------VDLGGTFVGPTQDAVLGLAAELGCATVP-
MAB_2659|M.abscessus_ATCC_1997 VGGRSFTGEVAGVK-------VDLGATWVAKRHTAIRDLMDRLGCSLTP-
MLBr_01044|M.leprae_Br4923 LGGVLRTECVGGQP-------MDLGAEAFLLRRPEVPALLAELGLSERQR
:** . : ::*. . : : * .*
Mvan_5578|M.vanbaalenii_PYR-1 QFDDGETTYELAGTGVLRGNEFHDRFAGELAELEKVL--RRLDGLATEVD
Mflv_1230|M.gilvum_PYR-GCK QYDDGETSYELAGTGVLRGNDFHERFAGELAELEKVL--RRLDELAAEVC
TH_2921|M.thermoresistible__bu TYDRGAKLWEHNGRVRRYTGEIPRANPLHLADLQIAL--TRLERMARRID
Mb3195|M.bovis_AF2122/97 THRDGRNVIQWRGSARSYRGTIPKLSLTGLIDIGRLR--WQFERIARGVP
Rv3170|M.tuberculosis_H37Rv THRDGRNVIQWRGSARSYRGTIPKLSLTGLIDIGRLR--WQFERIARGVP
MAV_4062|M.avium_104 THHEGKNLIHWRGWTHAYHGTIPKLSLTGLLDIGRLR--WQFDRIARSIP
MMAR_1389|M.marinum_M TFHDGKNVIRWRGGVRPYSGTIPRLSLTGLLDIARLR--WQFERLARSIP
MUL_2487|M.ulcerans_Agy99 TFHDGKNVIRWRGGVRPYSGTIPRLSLTGLLDIARLR--WQFERLARSIP
MSMEG_2035|M.smegmatis_MC2_155 TYNRGKNLIRWHGRVRSYRSTIPRLSIIELLDVSRIQ--WRFERLFRHVD
MAB_2659|M.abscessus_ATCC_1997 QYDEGVNLLWMAGKRKTWTGTLPTVDPVDLEDLGRIT--IEMGKLLETIN
MLBr_01044|M.leprae_Br4923 ATTDARPLIYSQQRLHSLPPDTVAGIPSSATSVAGLVDDATVARIGAEAV
. .: . :
Mvan_5578|M.vanbaalenii_PYR-1 PATPWTAPHAAEWDAITAGAWYDAQGLSPVARTLLEICT----VGILAVP
Mflv_1230|M.gilvum_PYR-GCK AATPWTAPHAAEWDAITAGAWYDAQGLSPVARTLLEICT----VGILAVP
TH_2921|M.thermoresistible__bu PAAPWAAPRAAQWDRQTVAGWIDRHVRTAVGRAFIELVC----EAVWAAD
Mb3195|M.bovis_AF2122/97 VAAPWDARRARELDDVSLGEWLRLVRATSSSRNLMAIMT----RVTWGCE
Rv3170|M.tuberculosis_H37Rv VAAPWDARRARELDDVSLGEWLRLVRATSSSRNLMAIMT----RVTWGCE
MAV_4062|M.avium_104 LAAPWEARRAAELDGLSLGGWLRSVRATASSHALLAMVA----RVTWGCE
MMAR_1389|M.marinum_M ISAPWAANRAADLDGVSLRQWLRSVRASASSHDLMAIMT----RVTWGCE
MUL_2487|M.ulcerans_Agy99 ISAPWAANRAADLDGVSLRQWLRSVRASASSHDLMAIMT----RVTWECE
MSMEG_2035|M.smegmatis_MC2_155 VAEPWNGSLAHKLDQYSMERWLRYVHANASTRNLMAIMS----RVTWGAE
MAB_2659|M.abscessus_ATCC_1997 VDAAWKSPNADQLDSISFGEWLSQQQAVTSTNALMYIVT----RVQWGCS
MLBr_01044|M.leprae_Br4923 RPLSWEPGSDPAMAELVADRFGEQAVARLVDPLLGGVYAGSAATIGLRAG
.* : : :
Mvan_5578|M.vanbaalenii_PYR-1 TVEVSFLHLLFTIQTCGVTSELFAESEGGAQTTRFVGGTAEIPKRLAAML
Mflv_1230|M.gilvum_PYR-GCK TVEVSFLHLLFTIQTCGVTAELFAESEGGAQTTRFVGGTAEIPKRLAALI
TH_2921|M.thermoresistible__bu AADLSLLHLLTYTSSNQGLSQLIT-TRGGAQQSRIIGGAQQISTAMADEL
Mb3195|M.bovis_AF2122/97 PDDVSMLHAARYVRAAGGLDRLLD-VKNGAQQDRVPGGTQQIAQAAAAQL
Rv3170|M.tuberculosis_H37Rv PDDVSMLHAARYVRAAGGLDRLLD-VKNGAQQDRVPGGTQQIAQAAAAQL
MAV_4062|M.avium_104 PDEVSMLHAARYAHAAGGLDRLLD-VEDGAQQDRFPGGTQQIAAAAAAEL
MMAR_1389|M.marinum_M PDDVSMLHAARYVRAAGGLDRLLD-VENGAQQELIPGGTQQIAELAAAEL
MUL_2487|M.ulcerans_Agy99 PDDVSMLHAARSVRAAGGLDRLLD-VENGAQQELIPGGTQQIAELAAAEL
MSMEG_2035|M.smegmatis_MC2_155 PDQVSMLHAVRYVKAAGGLTRLLD-VEGGAQQDRLVEGTQQIALRMADEL
MAB_2659|M.abscessus_ATCC_1997 PLDVSLLHVLRYVQAVGGLDHMLA-VEHGQQEYRVTETTQEIAKRLAAQI
MLBr_01044|M.leprae_Br4923 APSVAAALDCGATSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDELVRRS
. .:: . : * . : .
Mvan_5578|M.vanbaalenii_PYR-1 TEHLVLDAPVQLIEHGSDSVTVHCRGGRTARGRRIIVAVSPMLAGRIMYD
Mflv_1230|M.gilvum_PYR-GCK SEHIVLDSPVQLIEHRADSVTLHCRGGRTAQGRRVIVAVSPTLAGRIMYD
TH_2921|M.thermoresistible__bu GDAVRLGAPVREIRTR-DGVQVVADT-ATVRAERVVVAMSPTLAGRLHYD
Mb3195|M.bovis_AF2122/97 GARVLLNAAVRRIDRHGAG-VTVTSDQGQAEAGFVIVAIPPAHRVAIEFD
Rv3170|M.tuberculosis_H37Rv GARVLLNAAVRRIDRHGAG-VTVTSDQGQAEAGFVIVAIPPAHRVAIEFD
MAV_4062|M.avium_104 GARVVLGAPVRRIERHGAG-VTVRTDLGDTEAGFVIVAIPPAHRAAIEFA
MMAR_1389|M.marinum_M GTHVVLDAPVRRIDRHGAG-VTVTSDQGQAEAGFVIVAIPPAHRAAIEFN
MUL_2487|M.ulcerans_Agy99 GIHVVLDAPVRRIDRHGAG-VTVTSDQGQAEAGFVIVAIPPAHRAAIEFN
MSMEG_2035|M.smegmatis_MC2_155 GQRIALDAPVQRIERHSGGDIGVTFTTGHVRARAVVIAIAPQHRGDIEFD
MAB_2659|M.abscessus_ATCC_1997 GDQIVLNTRVRQISQDDNG-VTVSTDSGVINAKYAIVTAAPEHRAYIEYQ
MLBr_01044|M.leprae_Br4923 -RLQWVAATVVGLDRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLLQQ
: : * : . . ::: .. :
Mvan_5578|M.vanbaalenii_PYR-1 PPLSGYRDQLTQRMPNSAAMKAFFVYDEPFWRADG---LNGQLISDVGPA
Mflv_1230|M.gilvum_PYR-GCK PPLSGYRDQLTQRMPNSAAMKAFFVYDEPFWRADG---LNGQLISDIGPA
TH_2921|M.thermoresistible__bu EPLPADRDQLTQRMPNGSVVKCMAIYDEPFWRADG---LSGQGVGFTGPV
Mb3195|M.bovis_AF2122/97 PPLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASG---YSGQALSDEAPV
Rv3170|M.tuberculosis_H37Rv PPLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASG---YSGQALSDEAPV
MAV_4062|M.avium_104 PPLPAEYEQLARHWPQGRLSKAYAAYSTPFWRADG---FSGQALSDEGPV
MMAR_1389|M.marinum_M PPLPTGYQELADNWPQGRLSKAYAAYSTPFWRING---FTGQSLSDIGPV
MUL_2487|M.ulcerans_Agy99 PPLPTGYQELADNWPQGRLSKAYAAYSTPFWRING---FTGQSLSDMGPV
MSMEG_2035|M.smegmatis_MC2_155 PPLPPEYTELAARWPQGRLSKAYAAYDRPFWRANG---CSGEALSDEGPV
MAB_2659|M.abscessus_ATCC_1997 PALPAKIEGLTTSFPMGALSKAFVAYDKPFWRAEG---LSGEALTDTAPV
MLBr_01044|M.leprae_Br4923 IAPRTVAAASRIVSASSAVVALSVPRDTTFPQNSGVLVASGERLRAKAVT
. . . . .* : .* .*: : . .
Mvan_5578|M.vanbaalenii_PYR-1 RMSNDTCIRGDDRGVILLFLEGEQARTHGHWSEEERRAALTAELVRHFGE
Mflv_1230|M.gilvum_PYR-GCK RMSNDTCIQGDDHGVILLFLEGEQARTHGHWSEEERREALTAELVRHFGD
TH_2921|M.thermoresistible__bu KVFFDNSPPSGRPGVLLGFLEGSQARELGRADTRTRREAVIGCFARMFGP
Mb3195|M.bovis_AF2122/97 FITFDVSPHADGPGILMGFVD---ARGFDSLPIEERRRDALRCFASLFGD
Rv3170|M.tuberculosis_H37Rv FITFDVSPHADGPGILMGFVD---ARGFDSLPIEERRRDALRCFASLFGD
MAV_4062|M.avium_104 FITFDVSPHPDGPGILMGFVD---ARAFDSLPADQRRRDALRCFATLFGD
MMAR_1389|M.marinum_M FITFDASPHDDGPGILMGFVD---AREFDSLSADQRRDRTLRCFASLFGD
MUL_2487|M.ulcerans_Agy99 FITFDASPHDDAPGILMGFVD---AREFDSLSADQRRDRTLRCFASLFGD
MSMEG_2035|M.smegmatis_MC2_155 FITFDVSPGDEGPGILLGFTD---ARTFDALPPEQRRQRALGGFATFFGD
MAB_2659|M.abscessus_ATCC_1997 FITFDVSPSDDGPGILMVFCT---ARVYDGFGPEVRRKLVLKQLVDLYGE
MLBr_01044|M.leprae_Br4923 LSSRKWGLQGDTQLVRLSFGKFG-DQVASTASDDELLAWAVSDLAAVF-D
. : : * : . :. :
Mvan_5578|M.vanbaalenii_PYR-1 RAAHPQLYVDGEWGSRQWTRGCYNANCGPLVWTTYGAALAEPIGPIHWAS
Mflv_1230|M.gilvum_PYR-GCK RAARPSHYIDGEWGSRQWTRGCYNANCGPLVWTTYGAALAEPIGVIHWAS
TH_2921|M.thermoresistible__bu RAARPVDYVEKVWAADQWTRGCYGAFLPPNTWTQVGPALRRAVGPIHWAG
Mb3195|M.bovis_AF2122/97 EALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHWAS
Rv3170|M.tuberculosis_H37Rv EALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHWAS
MAV_4062|M.avium_104 DALKPLDYVDHRWGAEEFAPGGPTAAVPPGSWTRFGRWLREPVGPIHWAG
MMAR_1389|M.marinum_M DALEPLDYVDYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPIHWAG
MUL_2487|M.ulcerans_Agy99 DALEPLDYADYCWGTEQFAPGGPTAAVPPGSWTRYGQLLRKPVGPIHWAG
MSMEG_2035|M.smegmatis_MC2_155 AARDPIDYLDHCWGTEAFAPGGPTAAVPPEAWTAYGPWLRKPIDGIHWAG
MAB_2659|M.abscessus_ATCC_1997 QANTPIDYIDHCWGTEPFAAGGPHPAAPPFASVNYGEALREPHGRIHWAG
MLBr_01044|M.leprae_Br4923 VTVDPVDVCVQRWIDAMPQYGPGHADLVAEVRAGLPPTLVVAGSHMDGIG
: * * * . . . * . . :. .
Mvan_5578|M.vanbaalenii_PYR-1 TDTATEWSAYMEGAVQAGERAAAEVIEALTK------
Mflv_1230|M.gilvum_PYR-GCK TDTAVEWSAYMEGAVEAGERAAREVIDALVSQRDR--
TH_2921|M.thermoresistible__bu AETAVRSMGYMDGAVASGERAAAEVLTALGSGA----
Mb3195|M.bovis_AF2122/97 TETADEWTGYFDGAVRSGQRAAAEVAALL--------
Rv3170|M.tuberculosis_H37Rv TETADEWTGYFDGAVRSGQRAAAEVAALL--------
MAV_4062|M.avium_104 TETADEWTGFLDGAIRSGRRAAAEVTALL--------
MMAR_1389|M.marinum_M TETADEWTGYFDGAVRSGQRAAAEVAALL--------
MUL_2487|M.ulcerans_Agy99 TETADEWTGYFDGAVRAGQRAAAEVAALL--------
MSMEG_2035|M.smegmatis_MC2_155 TETADVWTGFLDGAVRSGQRAATEVAEALKSSAAAG-
MAB_2659|M.abscessus_ATCC_1997 TETAGEWVGTMNGAILMGLHTADQIAQQLGVTGEVSK
MLBr_01044|M.leprae_Br4923 VPACISAAGRAIEALQAEVAR----------------
. :. . *: