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MATAPLLASCGNGGGGRDTRERVVVVGAGMAGLSAARRLADNGVSVAVVEARQRIGGRTWTDTSLGVPID LGGAWIHGPEGNPLTDLVEQVGARTVATDFEDAVVLQNGVVVNPASVDAADREWDRILGEVASMTEDAAP GESLADGLAETGADLSDPLLQWCVAGSIGSEYAADPDELSLRWFGNEGEFDGPDLILSGGYGQLIDYLSR DLTIRLGREVTRISHDATGVRVETAREVFEADRVIVTVPLGVLKAGVITFDPPLPDAKRDAIRRLGFGLL NKVVLRFDEPFWTEEFDADTDMFGMAGQDQPVSDLVNGLRFTDIPVLIGLRGGANARARESESDQQTADE VVTALRAPTPSGVIVTRWAQDPFARGSYSFLAVGSSPDDQDALAAPVADRVAFAGEATHRDFFATVHGAY LSGLREADRILESGV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2278 | - | - | 100% (435) | amine oxidase |
| M. gilvum PYR-GCK | Mflv_4501 | - | 2e-22 | 29.24% (448) | amine oxidase |
| M. gilvum PYR-GCK | Mflv_1230 | - | 5e-17 | 24.29% (457) | amine oxidase (flavin-containing) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 6e-19 | 27.43% (452) | flavin-containing monoamine oxidase |
| M. tuberculosis H37Rv | Rv3170 | aofH | 6e-19 | 27.43% (452) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | MLBr_00092 | glf | 4e-05 | 28.48% (165) | putative UDP-galactopyranose mutase |
| M. abscessus ATCC 19977 | MAB_2659 | - | 5e-24 | 26.72% (464) | putative flavin-containing monoamine oxidase AofH |
| M. marinum M | MMAR_1387 | - | 2e-66 | 38.33% (420) | monoamine oxidase |
| M. avium 104 | MAV_4062 | - | 4e-21 | 28.73% (456) | putative flavin-containing monoamine oxidase AofH |
| M. smegmatis MC2 155 | MSMEG_2035 | - | 3e-17 | 28.99% (307) | amine oxidase |
| M. thermoresistible (build 8) | TH_2921 | - | 5e-23 | 28.79% (462) | PUTATIVE putative flavin-containing monoamine oxidase AofH_1 |
| M. ulcerans Agy99 | MUL_2489 | - | 8e-66 | 38.33% (420) | monoamine oxidase |
| M. vanbaalenii PYR-1 | Mvan_4388 | - | 0.0 | 73.78% (431) | amine oxidase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2278|M.gilvum_PYR-GCK ----------------------------MATAPLLASCGNGGGGRDTRER
Mvan_4388|M.vanbaalenii_PYR-1 MLALTRRQFT-------------LGLGAVAATPLLTSCG--GGGDTTRGH
MMAR_1387|M.marinum_M MSRVPRRKFLAATAGLSCGAAAGLGAGCASDHAARSSAPATPVDKTDTRS
MUL_2489|M.ulcerans_Agy99 -MRVESR--------------------------SPAERPATPADKTDTRS
Mb3195|M.bovis_AF2122/97 -----------------------------------MT------NPPWTVD
Rv3170|M.tuberculosis_H37Rv -----------------------------------MT------NPPWTVD
MAV_4062|M.avium_104 -----------------------------------MS------GPPRIVD
MSMEG_2035|M.smegmatis_MC2_155 -----------------------------------MS------IPT-SAD
MAB_2659|M.abscessus_ATCC_1997 -----------------------------------MSRSVDNAVEAASVD
TH_2921|M.thermoresistible__bu --------------------------------------------------
MLBr_00092|M.leprae_Br4923 --------------------------------------------MTVSFD
Mflv_2278|M.gilvum_PYR-GCK VVVVGAGMAGLSAARRLA-DNGVSVAVVEARQRIGGRTWTDTSLGVP---
Mvan_4388|M.vanbaalenii_PYR-1 VVVVGAGMSGLAAARRLT-DAGVPVTVVEARSRIGGRTWTDTSLGLP---
MMAR_1387|M.marinum_M ILVIGAGMAGLGAARALA-DAGWPVRLIEARDRVGGRVNTVRDWGVP---
MUL_2489|M.ulcerans_Agy99 ILVIGAGMAGLGAARALA-DAGWPVRLIEARDRVGGRVNTVRDWDVP---
Mb3195|M.bovis_AF2122/97 VVVVGAGFAGLAAARELT-RQGHEVLVFEGRDRVGGRSLTGRVAGVP---
Rv3170|M.tuberculosis_H37Rv VVVVGAGFAGLAAARELT-RQGHEVLVFEGRDRVGGRSLTGRVAGVP---
MAV_4062|M.avium_104 VVVVGAGFAGLAAARELN-RQGHDVVVFEGRDRVGGRSFTGSVAGLP---
MSMEG_2035|M.smegmatis_MC2_155 VVVVGAGFAGLTAARRLV-QLGYDVVVLEGRDRVGGRSSTATIAGVP---
MAB_2659|M.abscessus_ATCC_1997 VVIVGAGFAGLSAADRLV-NMGVSVLVIDARERVGGRSFTGEVAGVK---
TH_2921|M.thermoresistible__bu VVVVGAGLAGLTAARTLR-RAGVDVVVLEARDRVGGRTLNHFLEHGPDPE
MLBr_00092|M.leprae_Br4923 LFVVGSGFFGLTIAERVATQLGKRVLIVEKRPHIGGNAYSEAEPQTG---
:.::*:*: ** * : * * :.: * ::**. .
Mflv_2278|M.gilvum_PYR-GCK ----IDLGGAWIHGPEGNPLTDLVEQVGARTVATDFEDAVVLQNG-----
Mvan_4388|M.vanbaalenii_PYR-1 ----VDLGAAWIHGSQGNPLTGLAAQAGARTVETNFDDVVVLDGG-----
MMAR_1387|M.marinum_M ----LEMGASWIHGTTDNPLVELAGQVEARLAPTDYDTPAKLAVD-----
MUL_2489|M.ulcerans_Agy99 ----LEMGASWIHGTTDNPLVELAGQVEARLAPTDYDTPAKLAVD-----
Mb3195|M.bovis_AF2122/97 ----ADMGGSFIG-PTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARS
Rv3170|M.tuberculosis_H37Rv ----ADMGGSFIG-PTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARS
MAV_4062|M.avium_104 ----ADLGGTFVG-PTQDAVLALAAELEVPTTPTHHEGKNLIHWRGWTHA
MSMEG_2035|M.smegmatis_MC2_155 ----VDLGGTFVG-PTQDAVLGLAAELGCATVPTYNRGKNLIRWHGRVRS
MAB_2659|M.abscessus_ATCC_1997 ----VDLGATWVA-KRHTAIRDLMDRLGCSLTPQYDEGVNLLWMAGKRKT
TH_2921|M.thermoresistible__bu NDAVVELGGQWIG-PGHQRIRALIDELGLSTFDTYDRGAKLWEHNGRVRR
MLBr_00092|M.leprae_Br4923 ----IEVHKYGAHLFHTSSKRVWDYVRQFTEFTDYRHRVFAVHNG-----
::
Mflv_2278|M.gilvum_PYR-GCK -----VVVNPASVDAADREWDRILGEVASMTEDAAPGESLADGLAETG-A
Mvan_4388|M.vanbaalenii_PYR-1 -----RAVDPAAVEEVSRDWMGVLDEIEPMTADAAPDVSLADGLVWAG-A
MMAR_1387|M.marinum_M -----PRLEPISYDDDT--WRRLVAQARRDVDDGSLAAALDAQAPRDDLS
MUL_2489|M.ulcerans_Agy99 -----PRLEPISYDDDT--WRRLVAQARRDVDDGSLAAALDAQAPRDDLS
Mb3195|M.bovis_AF2122/97 YRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLG
Rv3170|M.tuberculosis_H37Rv YRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLG
MAV_4062|M.avium_104 YHGTIPKLSLTGLLDIGRLRWQFDRIARSIPLAAPWEARRAAELDGLSLG
MSMEG_2035|M.smegmatis_MC2_155 YRSTIPRLSIIELLDVSRIQWRFERLFRHVDVAEPWNGSLAHKLDQYSME
MAB_2659|M.abscessus_ATCC_1997 WTGTLPTVDPVDLEDLGRITIEMGKLLETINVDAAWKSPNADQLDSISFG
TH_2921|M.thermoresistible__bu YTGEIPRANPLHLADLQIALTRLERMARRIDPAAPWAAPRAAQWDRQTVA
MLBr_00092|M.leprae_Br4923 ----QVYQFPMGLGLVSQFFGRYFTPDEARQLIAEQAS-EIDTADAKTLE
Mflv_2278|M.gilvum_PYR-GCK DLSD-----PLLQWCVAGSIGSEYAADPDELSLRWFGNEGEFDG------
Mvan_4388|M.vanbaalenii_PYR-1 DLED-----PLMQWMVSAAIGAEYAADPEELALRWFGHEGEFDG------
MMAR_1387|M.marinum_M DRER-----AELAYYVNTVIEDEYAADADQLSATTYDQGTYSSG------
MUL_2489|M.ulcerans_Agy99 DRER-----AELAYYVNTVIEDEYAADADQLSATTYDQGTYSSG------
Mb3195|M.bovis_AF2122/97 EWLRLVRATSSSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLL
Rv3170|M.tuberculosis_H37Rv EWLRLVRATSSSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLL
MAV_4062|M.avium_104 GWLRSVRATASSHALLAMVARVTWGCEPDEVSMLHAARYAHAAGGLDRLL
MSMEG_2035|M.smegmatis_MC2_155 RWLRYVHANASTRNLMAIMSRVTWGAEPDQVSMLHAVRYVKAAGGLTRLL
MAB_2659|M.abscessus_ATCC_1997 EWLSQQQAVTSTNALMYIVTRVQWGCSPLDVSLLHVLRYVQAVGGLDHML
TH_2921|M.thermoresistible__bu GWIDRHVRTAVGRAFIELVCEAVWAADAADLSLLHLLTYTSSNQGLSQLI
MLBr_00092|M.leprae_Br4923 EKAISLIGRPLYEAFVKGYTAKQWQTDPAELPAAVISR------------
. : : .. ::.
Mflv_2278|M.gilvum_PYR-GCK ------PDLILSGGYGQLIDYLSRDL--TIRLGREVTRISHDATG-VRVE
Mvan_4388|M.vanbaalenii_PYR-1 ------PDLILPGGYRQLIDHLARDL--DIRLDAEVTRIAYDDVG-VTVE
MMAR_1387|M.marinum_M ------PQVVITSGYDALPRRLADGL--PIVFGTKVDSIVHKDDS-VLVR
MUL_2489|M.ulcerans_Agy99 ------PQVVITSGYDALPRRLADGL--PIVFGTKVDSIVHKDDS-VLVR
Mb3195|M.bovis_AF2122/97 DVKNGAQQDRVPGGTQQIAQAAAAQLGARVLLNAAVRRIDRHGAG-VTVT
Rv3170|M.tuberculosis_H37Rv DVKNGAQQDRVPGGTQQIAQAAAAQLGARVLLNAAVRRIDRHGAG-VTVT
MAV_4062|M.avium_104 DVEDGAQQDRFPGGTQQIAAAAAAELGARVVLGAPVRRIERHGAG-VTVR
MSMEG_2035|M.smegmatis_MC2_155 DVEGGAQQDRLVEGTQQIALRMADELGQRIALDAPVQRIERHSGGDIGVT
MAB_2659|M.abscessus_ATCC_1997 AVEHGQQEYRVTETTQEIAKRLAAQIGDQIVLNTRVRQISQDDNG-VTVS
TH_2921|M.thermoresistible__bu TTRGGAQQSRIIGGAQQISTAMADELGDAVRLGAPVREIR-TRDG-VQVV
MLBr_00092|M.leprae_Br4923 ----------LPVRYTFDNRYFSDIYEGLPVDGYTAWCTKMADDDRIEVR
. : . . . : *
Mflv_2278|M.gilvum_PYR-GCK TAREVFEADRVIVTVPLGVLKAGVITFDPPLPDAKRDAIRRLGFGLLNKV
Mvan_4388|M.vanbaalenii_PYR-1 TAQEVLRADRVIVTVPLGVLKAGVIVFDPPLPQAKRAAVERLGFGLLDKV
MMAR_1387|M.marinum_M AADRTFQGPAAIVTAPLGVLKAGAITFDPPLPDDHRRAIAALGFGVLSKS
MUL_2489|M.ulcerans_Agy99 AAGRTFQGPAAIVTAPLGVLKAGAITFDPPLPNDHRRAIAALGFGVLSKS
Mb3195|M.bovis_AF2122/97 SDQGQAEAGFVIVAIPP--AHRVAIEFDPPLPPEYQQLAHHWPQGRLSKA
Rv3170|M.tuberculosis_H37Rv SDQGQAEAGFVIVAIPP--AHRVAIEFDPPLPPEYQQLAHHWPQGRLSKA
MAV_4062|M.avium_104 TDLGDTEAGFVIVAIPP--AHRAAIEFAPPLPAEYEQLARHWPQGRLSKA
MSMEG_2035|M.smegmatis_MC2_155 FTTGHVRARAVVIAIAP--QHRGDIEFDPPLPPEYTELAARWPQGRLSKA
MAB_2659|M.abscessus_ATCC_1997 TDSGVINAKYAIVTAAP--EHRAYIEYQPALPAKIEGLTTSFPMGALSKA
TH_2921|M.thermoresistible__bu ADTATVRAERVVVAMSP--TLAGRLHYDEPLPADRDQLTQRMPNGSVVKC
MLBr_00092|M.leprae_Br4923 FGTDWFDVADQLRADSLG----APVVYTGPLDRYFDYAAGRLGWRTLDFE
: : . : : .* :
Mflv_2278|M.gilvum_PYR-GCK VLRFDEPFWTEEFDADTDMFGMAGQDQPVSDLVNGLRFTDIP-VLIGLRG
Mvan_4388|M.vanbaalenii_PYR-1 VLVFDEPFWTEAFDIHSDMLGIAGGAQPVSDLVNGLRFTDVP-LLVGLRG
MMAR_1387|M.marinum_M YFRFER----RTWDADNAFYQFLGPPGSMWSQWLTLPAAAGP-IVLAFNA
MUL_2489|M.ulcerans_Agy99 YFRFDR----RTWDADNAFYQFLGPPGSMWSQWLTLPAAAGP-IVLALNA
Mb3195|M.bovis_AF2122/97 YAAYSTP----FWRASGYSGQALSDEAPVFITFDVSPHADGPGILMGFVD
Rv3170|M.tuberculosis_H37Rv YAAYSTP----FWRASGYSGQALSDEAPVFITFDVSPHADGPGILMGFVD
MAV_4062|M.avium_104 YAAYSTP----FWRADGFSGQALSDEGPVFITFDVSPHPDGPGILMGFVD
MSMEG_2035|M.smegmatis_MC2_155 YAAYDRP----FWRANGCSGEALSDEGPVFITFDVSPGDEGPGILLGFTD
MAB_2659|M.abscessus_ATCC_1997 FVAYDKP----FWRAEGLSGEALTDTAPVFITFDVSPSDDGPGILMVFCT
TH_2921|M.thermoresistible__bu MAIYDEP----FWRADGLSGQGVGFTGPVKVFFDNSPPSGRPGVLLGFLE
MLBr_00092|M.leprae_Br4923 VEVLPIG---DFQGTPVMNYSDLDVPFTRIHEFRHFHRERHYPIDKTVIM
. : .
Mflv_2278|M.gilvum_PYR-GCK GANARARESESDQQTADEVVTALRAPT------PSGVIVTRWAQDPFARG
Mvan_4388|M.vanbaalenii_PYR-1 GANARAREADSDQQTVGEVLAALRAPD------PVGVFVTRWAADPYARG
MMAR_1387|M.marinum_M GRRGRHVESYSPSELMSGALPVARQLFGNDIA-PAEVRSSGWSTDPLALG
MUL_2489|M.ulcerans_Agy99 GHRGRHVESCSPSELMSGALPVARQLFGKDIA-PAEVRSSGWSTDPLALG
Mb3195|M.bovis_AF2122/97 ---ARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPG
Rv3170|M.tuberculosis_H37Rv ---ARGFDSLPIEERRRDALRCFASLFGDEALDPLDYVDYRWGTEEFAPG
MAV_4062|M.avium_104 ---ARAFDSLPADQRRRDALRCFATLFGDDALKPLDYVDHRWGAEEFAPG
MSMEG_2035|M.smegmatis_MC2_155 ---ARTFDALPPEQRRQRALGGFATFFGDAARDPIDYLDHCWGTEAFAPG
MAB_2659|M.abscessus_ATCC_1997 ---ARVYDGFGPEVRRKLVLKQLVDLYGEQANTPIDYIDHCWGTEPFAAG
TH_2921|M.thermoresistible__bu GSQARELGRADTRTRREAVIGCFARMFGPRAARPVDYVEKVWAADQWTRG
MLBr_00092|M.leprae_Br4923 REYSRFAG-YDDEPYYPINTEADRAMLAAYRAKAKSETASSKVLFGGRLG
.* . *
Mflv_2278|M.gilvum_PYR-GCK SYSFLAVGSSPDDQDALAAPVADRVAFAGEATHRDFFATVHGAYLSGLRE
Mvan_4388|M.vanbaalenii_PYR-1 SYSFLAVGSSPADQQALAEPVADRVAFAGEATHPEFFATVHGAYLSGLRE
MMAR_1387|M.marinum_M SYSFHAPGSGLDDRRQLQEPISDRLYLAGEAVGVDNPATVHGALISGRSA
MUL_2489|M.ulcerans_Agy99 SYSFHAPGSGLDDRRQLQEPISDRLYLAGEAVGVDNPATVHGALISGRSA
Mb3195|M.bovis_AF2122/97 GPTAAVPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRA
Rv3170|M.tuberculosis_H37Rv GPTAAVPPGSWTKYGHWLREPVGPIHWASTETADEWTGYFDGAVRSGQRA
MAV_4062|M.avium_104 GPTAAVPPGSWTRFGRWLREPVGPIHWAGTETADEWTGFLDGAIRSGRRA
MSMEG_2035|M.smegmatis_MC2_155 GPTAAVPPEAWTAYGPWLRKPIDGIHWAGTETADVWTGFLDGAVRSGQRA
MAB_2659|M.abscessus_ATCC_1997 GPHPAAPPFASVNYGEALREPHGRIHWAGTETAGEWVGTMNGAILMGLHT
TH_2921|M.thermoresistible__bu CYGAFLPPNTWTQVGPALRRAVGPIHWAGAETAVRSMGYMDGAVASGERA
MLBr_00092|M.leprae_Br4923 TYQYLDMHMAIAAALNMYDNILAPHLRDGSPLMEEP------AVAAAQHA
. * .
Mflv_2278|M.gilvum_PYR-GCK ADRILESGV-------
Mvan_4388|M.vanbaalenii_PYR-1 ADRILR----------
MMAR_1387|M.marinum_M AAELMRQLQ-------
MUL_2489|M.ulcerans_Agy99 AAELMRQLQ-------
Mb3195|M.bovis_AF2122/97 AAEVAALL--------
Rv3170|M.tuberculosis_H37Rv AAEVAALL--------
MAV_4062|M.avium_104 AAEVTALL--------
MSMEG_2035|M.smegmatis_MC2_155 ATEVAEALKSSAAAG-
MAB_2659|M.abscessus_ATCC_1997 ADQIAQQLGVTGEVSK
TH_2921|M.thermoresistible__bu AAEVLTALGSGA----
MLBr_00092|M.leprae_Br4923 APAIGREGGA------
* :