For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VDLDYCVVGAGFAGLTAALRLKQAGHSVTLLEARDRIGGRTFTVNRDDGTWIDRGGAWIGPGQDRIDALM EEFGIPSYKQYVDGDAMMFIDGKTYRYHGTIPMSMSPFAVANLGVVFLELTRMCKSIPPEAPWTAPKAHK WDQVTWAKWLDGNTLSTPARQLLESAVSGLYTSAASELSLLFCLYQMAAAGGPSFVLGVKDAAEDARPVG GMGAIHRAVAAELGDVVQLSQPVRSIAQDAEGVTVRSEDRVVRARRAIVTVPIAIASHILYEPMLPVDRS FLHQRMPSGAVFKIAMVFDEPFWRADGLSGQSFAPGSAANLTIDSCTDTGSPGILTAITEGLEARELCKL SDADRRKAVLAAVAERFGDKALSPLDYIEHNWTVERYSGGGMIAHTPPGVLTEYGPALRRPCGRIHWAGT ESSALMYGFIDGAVRSGERAAAEVVEHEAMATS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1178 | - | - | 100% (454) | amine oxidase |
| M. vanbaalenii PYR-1 | Mvan_5578 | - | 5e-72 | 36.64% (453) | amine oxidase (flavin-containing) |
| M. vanbaalenii PYR-1 | Mvan_1866 | - | 3e-68 | 34.39% (442) | amine oxidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3195 | aofH | 3e-78 | 38.69% (442) | flavin-containing monoamine oxidase |
| M. gilvum PYR-GCK | Mflv_1230 | - | 7e-70 | 35.10% (453) | amine oxidase (flavin-containing) |
| M. tuberculosis H37Rv | Rv3170 | aofH | 3e-78 | 38.69% (442) | flavin-containing monoamine oxidase |
| M. leprae Br4923 | MLBr_01044 | hemY | 5e-06 | 25.10% (243) | protoporphyrinogen oxidase |
| M. abscessus ATCC 19977 | MAB_2659 | - | 7e-72 | 34.01% (444) | putative flavin-containing monoamine oxidase AofH |
| M. marinum M | MMAR_3362 | aofH_1 | 0.0 | 66.96% (451) | flavin-containing monoamine oxidase AofH_1 |
| M. avium 104 | MAV_4062 | - | 3e-80 | 39.59% (442) | putative flavin-containing monoamine oxidase AofH |
| M. smegmatis MC2 155 | MSMEG_2035 | - | 7e-72 | 36.26% (444) | amine oxidase |
| M. thermoresistible (build 8) | TH_2921 | - | 5e-95 | 41.57% (445) | PUTATIVE putative flavin-containing monoamine oxidase AofH_1 |
| M. ulcerans Agy99 | MUL_1281 | aofH_1 | 1e-180 | 66.96% (451) | flavin-containing monoamine oxidase AofH_1 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3362|M.marinum_M ----------MAEVDVCVVGAGFAGLTAALRLKQAG---HSVALLEARDR
MUL_1281|M.ulcerans_Agy99 ----------MAEVDVCVVGAGFAGLTAALRLKQAG---HSVALLEARDR
Mvan_1178|M.vanbaalenii_PYR-1 ----------MVDLDYCVVGAGFAGLTAALRLKQAG---HSVTLLEARDR
Mb3195|M.bovis_AF2122/97 MT------NPPWTVDVVVVGAGFAGLAAARELTRQG---HEVLVFEGRDR
Rv3170|M.tuberculosis_H37Rv MT------NPPWTVDVVVVGAGFAGLAAARELTRQG---HEVLVFEGRDR
MAV_4062|M.avium_104 MS------GPPRIVDVVVVGAGFAGLAAARELNRQG---HDVVVFEGRDR
MSMEG_2035|M.smegmatis_MC2_155 MS------IPT-SADVVVVGAGFAGLTAARRLVQLG---YDVVVLEGRDR
MAB_2659|M.abscessus_ATCC_1997 MSRSVDNAVEAASVDVVIVGAGFAGLSAADRLVNMG---VSVLVIDARER
Mflv_1230|M.gilvum_PYR-GCK --------MARDEADVLIVGAGISGLIAARTVLAAG---LTPLVVEADTR
TH_2921|M.thermoresistible__bu ---------------VVVVGAGLAGLTAARTLRRAG---VDVVVLEARDR
MLBr_01044|M.leprae_Br4923 ----------MTSRSYCVVGGGISGLTAAYRLRVATGDDVAITLFDPGDR
:**.*::** ** : :.: *
MMAR_3362|M.marinum_M VGGRTFTVVREDGS------WIDKGGAWIGPTQHRIYALMKEFGVAAFKQ
MUL_1281|M.ulcerans_Agy99 VGGRTFTVVREDGS------WIDKGGAWIGPTQHRIYALMKEFGVAAFKQ
Mvan_1178|M.vanbaalenii_PYR-1 IGGRTFTVNRDDGT------WIDRGGAWIGPGQDRIDALMEEFGIPSYKQ
Mb3195|M.bovis_AF2122/97 VGGRSLTGRVAGVP-------ADMGGSFIGPTQDAVLALATELGIPTTPT
Rv3170|M.tuberculosis_H37Rv VGGRSLTGRVAGVP-------ADMGGSFIGPTQDAVLALATELGIPTTPT
MAV_4062|M.avium_104 VGGRSFTGSVAGLP-------ADLGGTFVGPTQDAVLALAAELEVPTTPT
MSMEG_2035|M.smegmatis_MC2_155 VGGRSSTATIAGVP-------VDLGGTFVGPTQDAVLGLAAELGCATVPT
MAB_2659|M.abscessus_ATCC_1997 VGGRSFTGEVAGVK-------VDLGATWVAKRHTAIRDLMDRLGCSLTPQ
Mflv_1230|M.gilvum_PYR-GCK VGGRVLTEELAGLP-------MELGAQWIGDTHHRMFALAAELGVETYPQ
TH_2921|M.thermoresistible__bu VGGRTLNHFLEHGPDPENDAVVELGGQWIGPGHQRIRALIDELGLSTFDT
MLBr_01044|M.leprae_Br4923 LGGVLRTECVGGQP-------MDLGAEAFLLRRPEVPALLAELGLSERQR
:** . : *. . : : * .:
MMAR_3362|M.marinum_M YTDGEAMMVVDGKQYRYQGTIPRTLSPLASMNLGTAMFEISQMCKTIPLE
MUL_1281|M.ulcerans_Agy99 YTDGEAMMVVDGKQYRYQGTIPRTLSPLASMNLGTAMFEISQMCKTIPLE
Mvan_1178|M.vanbaalenii_PYR-1 YVDGDAMMFIDGKTYRYHGTIPMSMSPFAVANLGVVFLELTRMCKSIPPE
Mb3195|M.bovis_AF2122/97 HRDGRNVIQWRGSARSYRGTIP-KLSLTGLIDIGRLRWQFERIARGVPVA
Rv3170|M.tuberculosis_H37Rv HRDGRNVIQWRGSARSYRGTIP-KLSLTGLIDIGRLRWQFERIARGVPVA
MAV_4062|M.avium_104 HHEGKNLIHWRGWTHAYHGTIP-KLSLTGLLDIGRLRWQFDRIARSIPLA
MSMEG_2035|M.smegmatis_MC2_155 YNRGKNLIRWHGRVRSYRSTIP-RLSIIELLDVSRIQWRFERLFRHVDVA
MAB_2659|M.abscessus_ATCC_1997 YDEGVNLLWMAGKRKTWTGTLP-TVDPVDLEDLGRITIEMGKLLETINVD
Mflv_1230|M.gilvum_PYR-GCK YDDGETSYELAGTGVLRGNDFH-ERFAGELAELEKVLRRLDELAAEVCAA
TH_2921|M.thermoresistible__bu YDRGAKLWEHNGRVRRYTGEIP-RANPLHLADLQIALTRLERMARRIDPA
MLBr_01044|M.leprae_Br4923 ATTDARPLIYS--QQRLHSLPPDTVAGIPSSATSVAGLVDDATVARIGAE
. . :
MMAR_3362|M.marinum_M APWEAKRAAKWDRMTLAQWLRNNVKSKAAHDLLETAIAGCYTSDASEVSM
MUL_1281|M.ulcerans_Agy99 APWEAKRAAKWDRMTLAQWLRNNVKSKAAHDLLETAIAGCYTSDASEVSM
Mvan_1178|M.vanbaalenii_PYR-1 APWTAPKAHKWDQVTWAKWLDGNTLSTPARQLLESAVSGLYTSAASELSL
Mb3195|M.bovis_AF2122/97 APWDARRARELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVSM
Rv3170|M.tuberculosis_H37Rv APWDARRARELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVSM
MAV_4062|M.avium_104 APWEARRAAELDGLSLGGWLRSVRATASSHALLAMVARVTWGCEPDEVSM
MSMEG_2035|M.smegmatis_MC2_155 EPWNGSLAHKLDQYSMERWLRYVHANASTRNLMAIMSRVTWGAEPDQVSM
MAB_2659|M.abscessus_ATCC_1997 AAWKSPNADQLDSISFGEWLSQQQAVTSTNALMYIVTRVQWGCSPLDVSL
Mflv_1230|M.gilvum_PYR-GCK TPWTAPHAAEWDAITAGAWYDAQGLSPVARTLLEICTVGILAVPTVEVSF
TH_2921|M.thermoresistible__bu APWAAPRAAQWDRQTVAGWIDRHVRTAVGRAFIELVCEAVWAADAADLSL
MLBr_01044|M.leprae_Br4923 AVRPLSWEPGSDPAMAELVADRFGEQAVAR-LVDPLLGGVYAGSAATIGL
* . :: . :.:
MMAR_3362|M.marinum_M LFVLYQMASGG--GPGFVLG-SKGAAQDARPIGGMGAVYGPMAAELGDAI
MUL_1281|M.ulcerans_Agy99 LFVLYQMASGG--GPGFVLG-SKGAAQDARPIGGMGAVYGPMAAELGDAI
Mvan_1178|M.vanbaalenii_PYR-1 LFCLYQMAAAG--GPSFVLG-VKDAAEDARPVGGMGAIHRAVAAELGDVV
Mb3195|M.bovis_AF2122/97 LHAARYVRAAG--GLDRLLD-VKNGAQQDRVPGGTQQIAQAAAAQLGARV
Rv3170|M.tuberculosis_H37Rv LHAARYVRAAG--GLDRLLD-VKNGAQQDRVPGGTQQIAQAAAAQLGARV
MAV_4062|M.avium_104 LHAARYAHAAG--GLDRLLD-VEDGAQQDRFPGGTQQIAAAAAAELGARV
MSMEG_2035|M.smegmatis_MC2_155 LHAVRYVKAAG--GLTRLLD-VEGGAQQDRLVEGTQQIALRMADELGQRI
MAB_2659|M.abscessus_ATCC_1997 LHVLRYVQAVG--GLDHMLA-VEHGQQEYRVTETTQEIAKRLAAQIGDQI
Mflv_1230|M.gilvum_PYR-GCK LHLLFTIQTCG--VTAELFAESEGGAQTTRFVGGTAEIPKRLAALISEHI
TH_2921|M.thermoresistible__bu LHLLTYTSSNQ--GLSQLIT-TRGGAQQSRIIGGAQQISTAMADELGDAV
MLBr_01044|M.leprae_Br4923 RAGAPSVAAALDCGATSLMEAVRQGLPPVAAGPVFGALDGGYQVLIDELV
: :: . . : :. :
MMAR_3362|M.marinum_M HLS------QPVRSITQDSGG-VTVQAEGLTVRANRTIVAVPLAIASQIV
MUL_1281|M.ulcerans_Agy99 HLS------QPVRSITQDSGG-VTVQAEGLTVRANRTIVAVPLAIASQIV
Mvan_1178|M.vanbaalenii_PYR-1 QLS------QPVRSIAQDAEG-VTVRSEDRVVRARRAIVTVPIAIASHIL
Mb3195|M.bovis_AF2122/97 LLN------AAVRRIDRHGAG-VTVTSDQGQAEAGFVIVAIPPAHRVAIE
Rv3170|M.tuberculosis_H37Rv LLN------AAVRRIDRHGAG-VTVTSDQGQAEAGFVIVAIPPAHRVAIE
MAV_4062|M.avium_104 VLG------APVRRIERHGAG-VTVRTDLGDTEAGFVIVAIPPAHRAAIE
MSMEG_2035|M.smegmatis_MC2_155 ALD------APVQRIERHSGGDIGVTFTTGHVRARAVVIAIAPQHRGDIE
MAB_2659|M.abscessus_ATCC_1997 VLN------TRVRQISQDDNG-VTVSTDSGVINAKYAIVTAAPEHRAYIE
Mflv_1230|M.gilvum_PYR-GCK VLD------SPVQLIEHRADSVTLHCRGGRTAQGRRVIVAVSPTLAGRIM
TH_2921|M.thermoresistible__bu RLG------APVREIRTRDG--VQVVADTATVRAERVVVAMSPTLAGRLH
MLBr_01044|M.leprae_Br4923 RRSRLQWVAATVVGLDRGTCGWTLVDDTGACWSADGVILAVPAPRLVRLL
. * : . .::: . :
MMAR_3362|M.marinum_M YEPMLPTDRSFLHQRMPSGAVVKISAVYDEPFWRADG---LCGQSAAPTS
MUL_1281|M.ulcerans_Agy99 YEPMLPTDRSFLHQRMPSGAVVKISAVYDEPFWRADG---LCGQSAAPTS
Mvan_1178|M.vanbaalenii_PYR-1 YEPMLPVDRSFLHQRMPSGAVFKIAMVFDEPFWRADG---LSGQSFAPGS
Mb3195|M.bovis_AF2122/97 FDPPLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASG---YSGQALSDEA
Rv3170|M.tuberculosis_H37Rv FDPPLPPEYQQLAHHWPQGRLSKAYAAYSTPFWRASG---YSGQALSDEA
MAV_4062|M.avium_104 FAPPLPAEYEQLARHWPQGRLSKAYAAYSTPFWRADG---FSGQALSDEG
MSMEG_2035|M.smegmatis_MC2_155 FDPPLPPEYTELAARWPQGRLSKAYAAYDRPFWRANG---CSGEALSDEG
MAB_2659|M.abscessus_ATCC_1997 YQPALPAKIEGLTTSFPMGALSKAFVAYDKPFWRAEG---LSGEALTDTA
Mflv_1230|M.gilvum_PYR-GCK YDPPLSGYRDQLTQRMPNSAAMKAFFVYDEPFWRADG---LNGQLISDIG
TH_2921|M.thermoresistible__bu YDEPLPADRDQLTQRMPNGSVVKCMAIYDEPFWRADG---LSGQGVGFTG
MLBr_01044|M.leprae_Br4923 QQIAPRTVAAASRIVSASSAVVALSVPRDTTFPQNSGVLVASGERLRAKA
. . . .* : .* *: .
MMAR_3362|M.marinum_M LATLTIDASPNSGTPGVLCVVIEGPVARQYERLDDDGRRQAVLAALVERF
MUL_1281|M.ulcerans_Agy99 LATLTIDASPNSGTPGVLCVVIEGPVARQYERLDDDGRRQAVLAALVERF
Mvan_1178|M.vanbaalenii_PYR-1 AANLTIDSCTDTGSPGILTAITEGLEARELCKLSDADRRKAVLAAVAERF
Mb3195|M.bovis_AF2122/97 PVFITFDVSPHADGPGILMGFVD---ARGFDSLPIEERRRDALRCFASLF
Rv3170|M.tuberculosis_H37Rv PVFITFDVSPHADGPGILMGFVD---ARGFDSLPIEERRRDALRCFASLF
MAV_4062|M.avium_104 PVFITFDVSPHPDGPGILMGFVD---ARAFDSLPADQRRRDALRCFATLF
MSMEG_2035|M.smegmatis_MC2_155 PVFITFDVSPGDEGPGILLGFTD---ARTFDALPPEQRRQRALGGFATFF
MAB_2659|M.abscessus_ATCC_1997 PVFITFDVSPSDDGPGILMVFCT---ARVYDGFGPEVRRKLVLKQLVDLY
Mflv_1230|M.gilvum_PYR-GCK PARMSNDTCIQGDDHGVILLFLEGEQARTHGHWSEEERREALTAELVRHF
TH_2921|M.thermoresistible__bu PVKVFFDNSPPSGRPGVLLGFLEGSQARELGRADTRTRREAVIGCFARMF
MLBr_01044|M.leprae_Br4923 VTLSSRKWGLQGDTQLVRLSFGKFG-DQVASTASDDELLAWAVSDLAAVF
. . : . : .. :
MMAR_3362|M.marinum_M GAKAAKPIDYFEQNWSRERYSGGGMLSHTPPGVLTQFGHALRRPCGRIHW
MUL_1281|M.ulcerans_Agy99 GAKAAKPIDYFEQNWSRERYSGGGMLSHTPPGVLTQFGHALRRPCGRIHW
Mvan_1178|M.vanbaalenii_PYR-1 GDKALSPLDYIEHNWTVERYSGGGMIAHTPPGVLTEYGPALRRPCGRIHW
Mb3195|M.bovis_AF2122/97 GDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHW
Rv3170|M.tuberculosis_H37Rv GDEALDPLDYVDYRWGTEEFAPGGPTAAVPPGSWTKYGHWLREPVGPIHW
MAV_4062|M.avium_104 GDDALKPLDYVDHRWGAEEFAPGGPTAAVPPGSWTRFGRWLREPVGPIHW
MSMEG_2035|M.smegmatis_MC2_155 GDAARDPIDYLDHCWGTEAFAPGGPTAAVPPEAWTAYGPWLRKPIDGIHW
MAB_2659|M.abscessus_ATCC_1997 GEQANTPIDYIDHCWGTEPFAAGGPHPAAPPFASVNYGEALREPHGRIHW
Mflv_1230|M.gilvum_PYR-GCK GDRAARPSHYIDGEWGSRQWTRGCYNANCGPLVWTTYGAALAEPIGVIHW
TH_2921|M.thermoresistible__bu GPRAARPVDYVEKVWAADQWTRGCYGAFLPPNTWTQVGPALRRAVGPIHW
MLBr_01044|M.leprae_Br4923 -DVTVDPVDVCVQRWIDAMPQYGPGHADLVAEVRAGLPPTLVVAGSHMDG
: * . * * . . . * . . :.
MMAR_3362|M.marinum_M AGTETSAKMCGWIDGAIRSGERAASEVMANQTMTMASDS
MUL_1281|M.ulcerans_Agy99 AGTEISAKMCGWIDGAIRSGERAASEVMANQTMTMASDS
Mvan_1178|M.vanbaalenii_PYR-1 AGTESSALMYGFIDGAVRSGERAAAEVVEHEAMATS---
Mb3195|M.bovis_AF2122/97 ASTETADEWTGYFDGAVRSGQRAAAEVAALL--------
Rv3170|M.tuberculosis_H37Rv ASTETADEWTGYFDGAVRSGQRAAAEVAALL--------
MAV_4062|M.avium_104 AGTETADEWTGFLDGAIRSGRRAAAEVTALL--------
MSMEG_2035|M.smegmatis_MC2_155 AGTETADVWTGFLDGAVRSGQRAATEVAEALKSSAAAG-
MAB_2659|M.abscessus_ATCC_1997 AGTETAGEWVGTMNGAILMGLHTADQIAQQLGVTGEVSK
Mflv_1230|M.gilvum_PYR-GCK ASTDTAVEWSAYMEGAVEAGERAAREVIDALVSQRDR--
TH_2921|M.thermoresistible__bu AGAETAVRSMGYMDGAVASGERAAAEVLTALGSGA----
MLBr_01044|M.leprae_Br4923 IG----------VPACISAAGRAIEALQAEVAR------
. . ..: . :: :