For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VTASAPDGRPGQPEATNRRSQLKSDRRFQLLAAAERLFAERGFLAVRLEDIGAAAGVSGPAIYRHFPNKE SLLVELLVGVSARLLAGARDVTTRSANLAAALDGLIEFHLDFALGEADLIRIQDRDLAHLPAVAERQVRK AQRQYVEVWVGVLRELNPGLAEADARLMAHAVFGLLNSTPHSMKAADSKPARTVRARAVLRAMTVAALSA ADRCL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2506 | - | - | 100% (215) | PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY TETR-FAMILY) |
| M. tuberculosis H37Rv | Rv1963c | mce3R | 3e-14 | 26.38% (163) | transcriptional repressor (probably TETR-family) MCE3R |
| M. tuberculosis H37Rv | Rv3557c | - | 8e-12 | 34.46% (148) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2534 | - | 1e-116 | 100.00% (215) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2551 | - | 1e-72 | 69.00% (200) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_00815 | - | 8e-09 | 28.83% (163) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_4541 | - | 4e-59 | 60.91% (197) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3853 | - | 1e-90 | 81.34% (209) | putative regulatory protein |
| M. avium 104 | MAV_1669 | - | 7e-87 | 83.67% (196) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_4718 | - | 1e-71 | 70.05% (197) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_2795 | - | 1e-13 | 29.48% (173) | PUTATIVE transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_3785 | - | 2e-90 | 80.86% (209) | putative regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_4092 | - | 1e-71 | 69.15% (201) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Rv2506|M.tuberculosis_H37Rv --------------------------------------------------
Mb2534|M.bovis_AF2122/97 --------------------------------------------------
MAV_1669|M.avium_104 --------------------------------------------------
MMAR_3853|M.marinum_M --------------------------------------------------
MUL_3785|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2551|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4092|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4718|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2795|M.thermoresistible__bu MSAAGSDAHRNGRHRPKNRKALIARASADAFGAQGYHAVSMEEIAARVGI
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
Rv2506|M.tuberculosis_H37Rv --------------------------------------------------
Mb2534|M.bovis_AF2122/97 --------------------------------------------------
MAV_1669|M.avium_104 --------------------------------------------------
MMAR_3853|M.marinum_M --------------------------------------------------
MUL_3785|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2551|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4092|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4718|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2795|M.thermoresistible__bu SPAALYRHSQGKYDLFRDSVLGLGQLLVDATDFGDDVDPAEDPHGLLAAL
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
Rv2506|M.tuberculosis_H37Rv --------------------------------------------------
Mb2534|M.bovis_AF2122/97 --------------------------------------------------
MAV_1669|M.avium_104 --------------------------------------------------
MMAR_3853|M.marinum_M --------------------------------------------------
MUL_3785|M.ulcerans_Agy99 --------------------------------------------------
Mflv_2551|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4092|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4718|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4541|M.abscessus_ATCC_1997 --------------------------------------------------
TH_2795|M.thermoresistible__bu VDALINVTIANRTAGGLYRWEGRYLREPDRDILERQIQLVNRRLQRPLRV
MLBr_00815|M.leprae_Br4923 --------------------------------------------------
Rv2506|M.tuberculosis_H37Rv ------------------------------------------------MT
Mb2534|M.bovis_AF2122/97 ------------------------------------------------MT
MAV_1669|M.avium_104 --------------------------------------------------
MMAR_3853|M.marinum_M ------------------------------------------------MA
MUL_3785|M.ulcerans_Agy99 ------------------------------------------------MA
Mflv_2551|M.gilvum_PYR-GCK ------------------------------------------------MA
Mvan_4092|M.vanbaalenii_PYR-1 ------------------------------------------------MT
MSMEG_4718|M.smegmatis_MC2_155 ------------------------------------------------MS
MAB_4541|M.abscessus_ATCC_1997 ------------------------------------------------MT
TH_2795|M.thermoresistible__bu MRPELGSRQRWTLTASALSAIGSIADHSAPLSVPGIRSFLASVVEDLLAA
MLBr_00815|M.leprae_Br4923 ------------------------------------MNNLAKAAQRRTVR
Rv2506|M.tuberculosis_H37Rv ASAPDGRPGQPEATNRRSQ--LKSDRRFQLLAAAERLFAERGFLAVRLED
Mb2534|M.bovis_AF2122/97 ASAPDGRPGQPEATNRRSQ--LKSDRRFQLLAAAERLFAERGFLAVRLED
MAV_1669|M.avium_104 ---------------------MKSDRRLQLLSAAERLFAERGFLAVRLED
MMAR_3853|M.marinum_M ASAPDEQTATP---NRRSQ--QKSDRRLQLLSAAERLFAERGFLAVRLED
MUL_3785|M.ulcerans_Agy99 ASAPDEQTATP---NRRSQ--QKSDRRLQLLSAAERLFAERGFLAVRLED
Mflv_2551|M.gilvum_PYR-GCK PTEI---------SSPRSR--AKSDRRDQLVAAAERLFAEHGYLAVRLED
Mvan_4092|M.vanbaalenii_PYR-1 TTDA---------TSPRSR--AKSDRRGQLIGAAERLIAEHGYLAVRLED
MSMEG_4718|M.smegmatis_MC2_155 S------------VTRRSQ--AKSDRRSQLIAAAERLVAERGYLAVRLED
MAB_4541|M.abscessus_ATCC_1997 NLIPESE-----TPNKRER--AKADRRDQLLRAAARLLAMRGYARVRLED
TH_2795|M.thermoresistible__bu DLPTPRRRRAPDPPPPRVT--LAAGIYECVLHESIQMFHERGFRDTGMDD
MLBr_00815|M.leprae_Br4923 PIDRGRLSDDIATPNQRSNRLSRDKRRGQLLIVASDVFVDHGYHAAGMDE
:: : :. :*: . :::
Rv2506|M.tuberculosis_H37Rv IGAAAGVSGPAIYRHFPNKESLLVELLVGVSARLLAGARDVTT-RSANLA
Mb2534|M.bovis_AF2122/97 IGAAAGVSGPAIYRHFPNKESLLVELLVGVSARLLAGARDVTT-RSANLA
MAV_1669|M.avium_104 IGASAGVSGPAIYRHFPNKESLLVELLVGISTRLLAGARQVRA-RSADAA
MMAR_3853|M.marinum_M IGAAAGISGPAIYRHFPNKESLLVELLVGISSRLLAGARQVTT-NSNDAA
MUL_3785|M.ulcerans_Agy99 IGAAAGISGPAIYRHFPNKESLLVELLVGISSRLLAGARQVTT-NSNDAA
Mflv_2551|M.gilvum_PYR-GCK IGSAAGISGPAVYRHFPNKEALLVELLVGISTRLLAGATDVVG-ADDDAA
Mvan_4092|M.vanbaalenii_PYR-1 IGAAAGISGPAIYRHFPNKEALLVELLVGISTRLLAGAVEVVDRAGDDAD
MSMEG_4718|M.smegmatis_MC2_155 IGAAVGVSGPAIYRHFPNKEAMLVELLVGISTRLLDGAREVVE-THDDPA
MAB_4541|M.abscessus_ATCC_1997 LGSAVGISGPAIYRHFPNKEALLVDLLTDVSRRLLEGGMTVAA-AASSPA
TH_2795|M.thermoresistible__bu IAAAVGVPTTGIYRYFPGKADILAASLRRAVDRTSQDLARITA-ATADPH
MLBr_00815|M.leprae_Br4923 IADRAGVSKPVLYQHFSSKLELYLAVLERHMNNLVSSVQQALR-TTTNNR
:. .*:. . :*::*..* : * . . .
Rv2506|M.tuberculosis_H37Rv AALDGLIEFHLDFALGEADLIRIQDRDLAHLPAVAERQVRKAQRQYVEVW
Mb2534|M.bovis_AF2122/97 AALDGLIEFHLDFALGEADLIRIQDRDLAHLPAVAERQVRKAQRQYVEVW
MAV_1669|M.avium_104 AALDGLIDFHLDFALNEPDLIRIQDRDLAYLPKPAERQVRKAQRQYVEVW
MMAR_3853|M.marinum_M AALDGLIDFHLDFALGEPDLIRIQDRDLGHLPAAAERQVRKAQRQYVEIW
MUL_3785|M.ulcerans_Agy99 AALDGLIDFHLDFALGEPDLIRIQDRDLGHLPAAAERQVRKAQRQYVEIW
Mflv_2551|M.gilvum_PYR-GCK STLENLIDFHLDFALDESDLIRIQDRDLGNLPPAAKRQVRRKQRQYVEIW
Mvan_4092|M.vanbaalenii_PYR-1 SALEGLIDFHLDFVFGEPDLIRIQDRDLGNLPPAAKRQVRRKQRQYVEIW
MSMEG_4718|M.smegmatis_MC2_155 KALDALVDFHLDFAFDESDLIRIQDRDLAHLPDTAKRQVRRAQRQYVEIW
MAB_4541|M.abscessus_ATCC_1997 EALDGLIDFHLDFALNESDLIRVQDRDLDSLPENARRQVRQYQRRYVEAW
TH_2795|M.thermoresistible__bu TALTQLVRAYLDQFRERPALAYVQHTERRNLPESEARVVERIEQSLVDSW
MLBr_00815|M.leprae_Br4923 QRLHAAVQAFFDFIEHDGQGYRLIFENDNITEPRVAAQVRVATESCIDAV
* : .:* : : *. . ::
Rv2506|M.tuberculosis_H37Rv VGVLRELNPGLAEADARLMAHAVFGLLNSTP-HSMKAADS---KPARTVR
Mb2534|M.bovis_AF2122/97 VGVLRELNPGLAEADARLMAHAVFGLLNSTP-HSMKAADS---KPARTVR
MAV_1669|M.avium_104 VGVLRELNPELAEADARLTAHAVFGLLNSTP-HSMKSQDSGRGKPARAAR
MMAR_3853|M.marinum_M VGVLRQLDPGLAEADARLMAHAAFGLLNSTP-HSMKSADT---KSACAPH
MUL_3785|M.ulcerans_Agy99 VGVLRQLDPGLAEADARLMAHAAFGLLNSTP-HSMESADT---KSACAPH
Mflv_2551|M.gilvum_PYR-GCK VDVLRRCTPGLSEADARLMAHGTFGLLNSTA-HSMKPGTT--KT--AEAG
Mvan_4092|M.vanbaalenii_PYR-1 VDVLRRRTPGLTETDARLMAHAAFGLLNSTP-HGVKPGLN--KA--AEAS
MSMEG_4718|M.smegmatis_MC2_155 VSVLTRLRRDLPEEEARVMAHATFGLLNSTP-HSVKPAVT--KAQSSTAQ
MAB_4541|M.abscessus_ATCC_1997 VQVLCRSQQGLDESDARIKAHAAFGLMNSTP-YSAGRSAP--------SQ
TH_2795|M.thermoresistible__bu ARLVTEQRPELTVATARYAVYCAFALVTDLG-RLTDSHAS-------PSA
MLBr_00815|M.leprae_Br4923 FALIS-ADSRLDPHRARMVAVGLVGISVDCARYWLDTNRPISKSDAVEGT
:: * ** . ..: .
Rv2506|M.tuberculosis_H37Rv ARAVLRAMTVAALSAADRCL-
Mb2534|M.bovis_AF2122/97 ARAVLRAMTVAALSAADRCL-
MAV_1669|M.avium_104 SRAIMRAMTVAALAAGNQCP-
MMAR_3853|M.marinum_M SRAVMRAMTVAALTVDVGA--
MUL_3785|M.ulcerans_Agy99 SRAVMRAMTVAALTVDVGA--
Mflv_2551|M.gilvum_PYR-GCK SRTVLREMTVAALTSAERRRG
Mvan_4092|M.vanbaalenii_PYR-1 SRTVLRTMTVAALTSAGRRA-
MSMEG_4718|M.smegmatis_MC2_155 SRGVLRRMTVAALTATG----
MAB_4541|M.abscessus_ATCC_1997 TRTVLRQMVVAALRS------
TH_2795|M.thermoresistible__bu QAAVQHLMEVVLLGG------
MLBr_00815|M.leprae_Br4923 VQFAWGGLSHVPLTRL-----
: . *