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SYAHGCTAVRLDRMTNEEERGTPPLPRALEVLWHDRAGGGRARRLSRQRIVEAAIELADRDGLGALSMAR LAERLGCGTMSLYRHVANKDELVTFMVSAAPGHPPGTTDRADWRDALTDWAVGLWDVYHRHPWILHATVI GPPADPGQLAWLDAGLAALSGTGLSERDKLAAVMALLHFVRGASALDIEAADHHDTAPDYPALLRRLVTG ERFPALAAALQAEAFDADGDRLADFRSGLDQFLDGIDSRVRRSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1315 | - | - | 100% (255) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4078 | - | 1e-21 | 32.20% (236) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1989 | - | 9e-11 | 27.75% (209) | TetR family transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1388c | - | 5e-08 | 25.86% (232) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_2560 | - | 8e-22 | 30.04% (263) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv1353c | - | 5e-08 | 25.86% (232) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2957c | - | 2e-15 | 38.89% (126) | TetR family transcriptional regulator |
| M. marinum M | MMAR_3679 | - | 2e-16 | 29.26% (229) | putative regulatory protein |
| M. avium 104 | MAV_5055 | - | 3e-09 | 31.13% (106) | transcriptional regulator, TetR family protein |
| M. smegmatis MC2 155 | MSMEG_2583 | - | 4e-19 | 34.13% (208) | putative transcriptional regulator |
| M. thermoresistible (build 8) | TH_3256 | - | 2e-46 | 60.26% (156) | PUTATIVE putative transcriptional regulator, TetR family |
| M. ulcerans Agy99 | MUL_3622 | - | 1e-15 | 27.75% (227) | putative regulatory protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3679|M.marinum_M ------------------------------MFTLRTMYLSTVWEGDVRAR
MUL_3622|M.ulcerans_Agy99 ----------------------MISIRTSYVFTLRTMYLSTVWEGDVRAR
MSMEG_2583|M.smegmatis_MC2_155 --------------------------------------------MPRQRS
Mb1388c|M.bovis_AF2122/97 -----------------------------------MQTTPGKRQRRQRGS
Rv1353c|M.tuberculosis_H37Rv -----------------------------------MQTTPGKRQRRQRGS
Mvan_1315|M.vanbaalenii_PYR-1 -----MSYAHGCTAVRLDRMTNEEERGTPPLPRALEVLWHDRAGGGRARR
TH_3256|M.thermoresistible__bu --------------------------------------------------
MAB_2957c|M.abscessus_ATCC_199 ---------------------------------------------MTDPR
Mflv_2560|M.gilvum_PYR-GCK MTSLPPATIGRMDNPGSGSARSSAGDPVRTLELLWRVPAEARSGRGPKQR
MAV_5055|M.avium_104 ---------------------------------------------MRRAG
MMAR_3679|M.marinum_M FTVSDIASAALAIVDQDGLSGLSMRSLAAALGTGPMTLYNYVRDRRELEA
MUL_3622|M.ulcerans_Agy99 FTVSDIASAALAIVDQDGLSGLSMRSLAAALGTGPMTLYNYVRDRRELEA
MSMEG_2583|M.smegmatis_MC2_155 LTRPQIAAAALEVVDTDGLGSLSMRTVARRLGMGTMSLYRYVADRDELEA
Mb1388c|M.bovis_AF2122/97 INPEDIISGAFELAQQVSIDNLSMPLLGKHLGVGVTSIYWYFRKKDDLLN
Rv1353c|M.tuberculosis_H37Rv INPEDIISGAFELAQQVSIDNLSMPLLGKHLGVGVTSIYWYFRKKDDLLN
Mvan_1315|M.vanbaalenii_PYR-1 LSRQRIVEAAIELADRDGLGALSMARLAERLGCGTMSLYRHVANKDELVT
TH_3256|M.thermoresistible__bu --------------------------------------------------
MAB_2957c|M.abscessus_ATCC_199 LTLESIVGKAIEIADSDGLSGVSMRKIADALGVGAMSLYRHVADKDALLV
Mflv_2560|M.gilvum_PYR-GCK TSVDAVVAAAVGIADTQGLSAVTIRAVAGVLGLAPMAIYTYVPGKAELLD
MAV_5055|M.avium_104 LKREAVVRAAVKIADAEGIEAISMRRVSQALGVTPMALYRYLPDKDALID
MMAR_3679|M.marinum_M LVADAVVADVKVPAP---TDDWRADVHAIATAMWETMRQHPNAIPLVLTR
MUL_3622|M.ulcerans_Agy99 LVADAVVADVKVPAP---IDDWRADVHAIATAMWETMRQHPNAIPLVLTR
MSMEG_2583|M.smegmatis_MC2_155 MVVELVLESVDLRPP---AGSARHRILVLAERVRDATARHPAVVPLLLAH
Mb1388c|M.bovis_AF2122/97 AMTDRALSKYVFATPYIEAGDWRETLRNHARSMRKTFADNPVLCDLILIR
Rv1353c|M.tuberculosis_H37Rv AMTDRALSKYVFATPYIEAGDWRETLRNHARSMRKTFADNPVLCDLILIR
Mvan_1315|M.vanbaalenii_PYR-1 FMVSAAPG---HPPGTTDRADWRDALTDWAVGLWDVYHRHPWILHATVIG
TH_3256|M.thermoresistible__bu -MVAAAVG---PPP-QLDPTDWVAALRHWSTALWEVYHRHPWILQAAAAG
MAB_2957c|M.abscessus_ATCC_199 EMTAEVTRRFAYPDEMMGVPDWRARVRVAVEHDFDLYSTHPWVLLAYAVP
Mflv_2560|M.gilvum_PYR-GCK LMLDSVYG--QMSRGDLSGLPWRHRVTAIADENRALLDEHPWVTQLATTR
MAV_5055|M.avium_104 VVVDESLAVVPVPDP---SGSVTAELLRCFGGLYDLLLDHPGLARAAGER
: : :*
MMAR_3679|M.marinum_M RTVSASSYMVA----DRLIAALGRSGVGDADLLASFRGVLGLVMGSA---
MUL_3622|M.ulcerans_Agy99 RTVWASSYMVA----DRLIAALGRSGVGDADLLASFRGVLGLVMGSA---
MSMEG_2583|M.smegmatis_MC2_155 RHRLPASLRWG----EAVLGVLAEAGYAGKRRVYAFRALLACTFGAL---
Mb1388c|M.bovis_AF2122/97 AALSPKTARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSV---
Rv1353c|M.tuberculosis_H37Rv AALSPKTARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSV---
Mvan_1315|M.vanbaalenii_PYR-1 PPADPGQLAWL----DAGLAALSGTGLSERDKLAAVMALLHFVRGAS---
TH_3256|M.thermoresistible__bu PPADPQQLAWL----DTALAALQGTGLAERDKLAAVTALMHLVRGAA---
MAB_2957c|M.abscessus_ATCC_199 RNGMQPETLVC---FDWLLEAFSHLGVAAPEAAELTFQVWSYSQGVG---
Mflv_2560|M.gilvum_PYR-GCK PPLGPGTAAKY----DHELRAFDGLGLSDLDMDSALTYVLGFVTSVARIA
MAV_5055|M.avium_104 PLEGPFATRLG----NNVLTLLQHNKIDEADAANLLVSAFSLTLGCA---
: : : .
MMAR_3679|M.marinum_M ----QAELAGPLAGTGREKEQVAVAARIGG-LAGAEHPHIAALAQASQRS
MUL_3622|M.ulcerans_Agy99 ----QAELAGPLAGTGREKEQVAVAARIGG-LAGAEHPHIAALAQASQRS
MSMEG_2583|M.smegmatis_MC2_155 ----EIQHHSALSGPG--------TRALAE-LPADEFPRLSETAAAARGI
Mb1388c|M.bovis_AF2122/97 ----VLDRLSRKSQSAGSGP--SAIEHPVA-IDPATTPLLAHATGRGHRI
Rv1353c|M.tuberculosis_H37Rv ----VLDRLSRKSQSAGSGP--SAIEHPVA-IDPATTPLLAHATGRGHRI
Mvan_1315|M.vanbaalenii_PYR-1 ----ALDIEAADHHDTAPDYP-ALLRRLVT-GERFPALAAALQAEAFD-A
TH_3256|M.thermoresistible__bu ----ALHIDAG--RLDWPEYP-VLLRRLID-ADRFPALTAALDAGAFDPV
MAB_2957c|M.abscessus_ATCC_199 ----LGAVGGQLVSPGARTDFSGLSELIAGNAEVPESPRLAALLGLGDLP
Mflv_2560|M.gilvum_PYR-GCK DDAREARRDSGVSDQAWWDRAGPLLAEVFDDEKFPLAARIGAAAGQAFGS
MAV_5055|M.avium_104 -----LYRTSRSGRTASSR-----LSQVGD-----EAPAVRRLRGRLTVA
.
MMAR_3679|M.marinum_M TPAAD---FERALDILLAGIESFERRRDRR--------------------
MUL_3622|M.ulcerans_Agy99 TPAAD---FERALDILLAGIESFERRRDRR--------------------
MSMEG_2583|M.smegmatis_MC2_155 GAGDE---FRHGLEILLRGLQI----------------------------
Mb1388c|M.bovis_AF2122/97 GAPDET-NFEYGLECILDHAGRLIEQSSKAAGEVAVRRPTATADAPTPGA
Rv1353c|M.tuberculosis_H37Rv GAPDET-NFEYGLECILDHAGRLIEQSSKAAGEVAVRRPTATADAPTPGA
Mvan_1315|M.vanbaalenii_PYR-1 DGDRLA-DFRSGLDQFLDGIDSRVRRSR----------------------
TH_3256|M.thermoresistible__bu DADPLT-DLHSAVDYLLDGIAAKL--------------------------
MAB_2957c|M.abscessus_ATCC_199 EVTNPREVIAKGVEILCDGIARRYHKL-----------------------
Mflv_2560|M.gilvum_PYR-GCK AYDADH-AYRFGLARVLDGLEPVINRTAR---------------------
MAV_5055|M.avium_104 SADDTV--FRDALTRLIAGYVTTAAKTGGRRR------------------
.: .
MMAR_3679|M.marinum_M -------
MUL_3622|M.ulcerans_Agy99 -------
MSMEG_2583|M.smegmatis_MC2_155 -------
Mb1388c|M.bovis_AF2122/97 RAKAVAR
Rv1353c|M.tuberculosis_H37Rv RAKAVAR
Mvan_1315|M.vanbaalenii_PYR-1 -------
TH_3256|M.thermoresistible__bu -------
MAB_2957c|M.abscessus_ATCC_199 -------
Mflv_2560|M.gilvum_PYR-GCK -------
MAV_5055|M.avium_104 -------