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MRKGLRKAGVACGTAFASVAIALSTATPGLATPSGLVVGGLATPTMHDLVMAQILKDELHGMERVSIYWP AEAKPYSGDTYTLGESIAIGITNLNTEIDTAIGKLAPGEQVKIVGLSAGSLVVTEVLRLLAADPDAPAAD QLTFIVVADSSRQKLIDKARYNSRYDYTYQPPPETKYDVKEVTGEYDGMADFPDRWWNFVAVANAMAGGI FVHIPMMFADLKDEYITEIDVNELGGTTTKYLIPTAKLPLVQLLPFLAPMEAELKEMVDRGYSRNDIVET SALRTLTAAVEETDDAAEVTAPAEESVEVDDADLKTEAKGDDGEDLGAVGEDADTGSSTGDDEAEVIDEA DEVDEPDAIDEAVEDADEADSVDAGQGDEDAAESEDSTDTDDSDSSGDAASDGTGSSESGSSE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_3103 | - | - | 100% (413) | hypothetical protein Mvan_3103 |
| M. vanbaalenii PYR-1 | Mvan_1838 | - | e-108 | 52.27% (440) | hypothetical protein Mvan_1838 |
| M. vanbaalenii PYR-1 | Mvan_2535 | - | 2e-92 | 45.82% (419) | hypothetical protein Mvan_2535 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3569 | PPE63 | 1e-24 | 35.14% (222) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_3371 | - | 1e-100 | 48.64% (440) | hypothetical protein Mflv_3371 |
| M. tuberculosis H37Rv | Rv3539 | PPE63 | 1e-24 | 35.14% (222) | PPE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 1e-25 | 35.24% (227) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 3e-24 | 34.15% (246) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_4939 | - | 7e-20 | 32.43% (222) | PE-PGRS family protein |
| M. avium 104 | MAV_1760 | - | 7e-23 | 32.02% (253) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 1e-34 | 28.30% (424) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 2e-17 | 32.02% (228) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 3e-14 | 27.59% (290) | PE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_3103|M.vanbaalenii_PYR-1 MRKGLRK-AGVACGTAFASVAIALSTATPGLATP----------------
Mflv_3371|M.gilvum_PYR-GCK MRRSIRKRAGLACGAVFASAAMAVSTATGASAVT----------------
Mb3569|M.bovis_AF2122/97 MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFESVC
Rv3539|M.tuberculosis_H37Rv MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFESVC
MMAR_4939|M.marinum_M -MSYVVAAPDFLSTAAEDLAAMGSAVSTATAAAARSTTLLLAAGADEVST
MAB_0936c|M.abscessus_ATCC_199 MRNLLAGTAVLVVACVTGCFGIPSAVADDPQVPGPPIPGIAPDGTVKAAP
MAV_1760|M.avium_104 MKQLLAGVTALLSVSTAGYFGIGTAAADGGPIGGPPTPG-APG-------
MLBr_01232|M.leprae_Br4923 MKRLLATTLAALTVGTVSGFGSTVASSEPGEPWLPPSPVPVRE-------
MSMEG_6144|M.smegmatis_MC2_155 ---MIAAVAAVVTAALVTTVPALGAT------------------------
TH_3724|M.thermoresistible__bu --------VVAVGALTWGGXGVASPAGQPERAAALR--------------
MUL_1034|M.ulcerans_Agy99 -MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALTSGLLAAAQDEVSA
Mvan_3103|M.vanbaalenii_PYR-1 ----------SGLVVGGLATPT-------------------------MHD
Mflv_3371|M.gilvum_PYR-GCK ----------TAVAIGGLGTPD-------------------------MHE
Mb3569|M.bovis_AF2122/97 SGLADRWWQGPSSRMMAAQAAR-HTGWLAAAATQAEGAASQAQTMALAYE
Rv3539|M.tuberculosis_H37Rv SGLADRWWQGPSSRMMAAQAAR-HTGWLAAAATQAEGAASQAQTMALAYE
MMAR_4939|M.marinum_M HIAALFSTHGLQYQLASAQAAEFHERFVLTLAADAN-----------TYL
MAB_0936c|M.abscessus_ATCC_199 -----SAPDRTAYALGGAHVLG------------------------IPYD
MAV_1760|M.avium_104 --------DQTAYALGGAHVLG------------------------IPYD
MLBr_01232|M.leprae_Br4923 -----NSPAKIVYALGGARPPT------------------------FDWD
MSMEG_6144|M.smegmatis_MC2_155 -----------AFTISGTRILH--------------------------DP
TH_3724|M.thermoresistible__bu ----------LTATADAIIMPG---------------------------T
MUL_1034|M.ulcerans_Agy99 AIAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAG----AAYAQAEAANA
Mvan_3103|M.vanbaalenii_PYR-1 LVMAQILKDELHGMERVS--------------------------------
Mflv_3371|M.gilvum_PYR-GCK IVINPLLGGKLARENDILDG------------------------------
Mb3569|M.bovis_AF2122/97 AAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWAQDV
Rv3539|M.tuberculosis_H37Rv AAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWAQDV
MMAR_4939|M.marinum_M TTEIANAQRCLAGAINAPATALLGHPLLGADPTASASTAATPAGGASMAP
MAB_0936c|M.abscessus_ATCC_199 EYIRMTGKDWFPNMKRENVWYPAG--------------------------
MAV_1760|M.avium_104 QYIRMEGADWFPGQQRQIVRYPAG--------------------------
MLBr_01232|M.leprae_Br4923 YYTIRAGDEFFPDVNRKLIDYPAR--------------------------
MSMEG_6144|M.smegmatis_MC2_155 PYPEQLVPGEFAGYDVEHIKYPAS--------------------------
TH_3724|M.thermoresistible__bu KIGYIPSQDEFTAYATAVIGATAGAPG-----------------------
MUL_1034|M.ulcerans_Agy99 SLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTAVSSTLMADPV
:
Mvan_3103|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK --------------------------------------------------
Mb3569|M.bovis_AF2122/97 VAMLNYHAVASAVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPSSTT
Rv3539|M.tuberculosis_H37Rv VAMLNYHAVASAVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPSSTT
MMAR_4939|M.marinum_M AAAGTRITVP---GAGPLYYPRFLTELP-YLG----------------QA
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
MUL_1034|M.ulcerans_Agy99 VALIMGGTSVPLPGPG----------------------------------
Mvan_3103|M.vanbaalenii_PYR-1 ------------------------------IYWPAEAKPYSGDT------
Mflv_3371|M.gilvum_PYR-GCK ------------------------------VEWPAEAK-RPGTG------
Mb3569|M.bovis_AF2122/97 TRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEVVSY
Rv3539|M.tuberculosis_H37Rv TRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEVVSY
MMAR_4939|M.marinum_M LLLGIPGPS---SASIL--------QGYDLINHAIGENWFPDTIASVINY
MAB_0936c|M.abscessus_ATCC_199 -----------------------------QVQGHTLERFFPGIGPIGEKI
MAV_1760|M.avium_104 -----------------------------QVQGHVLERLFPGIGKLDES-
MLBr_01232|M.leprae_Br4923 -----------------------------APFRYVPTFLVPGP-------
MSMEG_6144|M.smegmatis_MC2_155 -------------------------------VFGMDRGIWEAAG------
TH_3724|M.thermoresistible__bu ----------------------------AVDYLGVPGEFWPATG------
MUL_1034|M.ulcerans_Agy99 --------------------------YVSDINNNYIQPLFSGAIPQALFT
Mvan_3103|M.vanbaalenii_PYR-1 -------------YTLGESIAIGITNLNTEIDTAIGKLAPGEQVKIVGLS
Mflv_3371|M.gilvum_PYR-GCK -------------QTLGQSITVGITNLGTHFDAAFARLEAGEQFTVVGFS
Mb3569|M.bovis_AF2122/97 PATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQ---PVTVAGLS
Rv3539|M.tuberculosis_H37Rv PATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQ---PVTVAGLS
MMAR_4939|M.marinum_M PASIGILSGSLAAPDTNTAVAIGARMLHEQIMSAVTNGSG-LPVHVATLS
MAB_0936c|M.abscessus_ATCC_199 LPGL-----GLDGPSIGESIDIGEPNLENAIR---SGG----PGTAMGLS
MAV_1760|M.avium_104 FPGL-----GMDGPSVGESVAEGIDNLDAAIR---TTGR---PGTAIGLS
MLBr_01232|M.leprae_Br4923 ----------RDEVTIGEAIAVATKNLNQAIH---RGTE---PAAVVGLS
MSMEG_6144|M.smegmatis_MC2_155 ------------AVAAGVDRFVGVDDEGNPIT---------EKIIVAGFS
TH_3724|M.thermoresistible__bu ----------LDSLTFDASVAXGQAMLTPMVDGAIESDT---PIVVFGHS
MUL_1034|M.ulcerans_Agy99 PEQFWPVTPGLGNLTFNQSVAQGVTLLNDAINTQLALGN---KVVAFGYS
. . . *
Mvan_3103|M.vanbaalenii_PYR-1 AGSLVVTEVLRLLAA--DPDAPAADQLTFIVVADS--------SRQKLID
Mflv_3371|M.gilvum_PYR-GCK AGSLVVNDFMRELAN--DPDAPTKDQVKFILVADS--------SRQKLLN
Mb3569|M.bovis_AF2122/97 MGSMVIDRELAYLAI--DPNAPPSSALTFVELAGP------ERGLAQTYL
Rv3539|M.tuberculosis_H37Rv MGSMVIDRELAYLAI--DPNAPPSSALTFVELAGP------ERGLAQTYL
MMAR_4939|M.marinum_M QGTIVANRELAYLAT--DPNAPPAHALEFALFGSP------ELGLAHIYL
MAB_0936c|M.abscessus_ATCC_199 EGALVLNAVKNALAT--DPTAPEPESLTFATFGDPIAKSPFSESFLTQNF
MAV_1760|M.avium_104 EGAFVVDGEQARLAN--DPTAPPPNTLNFATFGDPIGRHAFGQSFLTAMF
MLBr_01232|M.leprae_Br4923 QGSLALDTEQEQLAT--DPTAPPPDQLTFNTFGDPSGYHGFGKSVLASIF
MSMEG_6144|M.smegmatis_MC2_155 QGAIVIAYEKKRLMKLDEDERPTVDQLKFVTIGDP-------TGPNGILR
TH_3724|M.thermoresistible__bu QSAVIATKEKQRLLA-EYPDPDTAPDVTFVMVANPN-----RPNGGLLAR
MUL_1034|M.ulcerans_Agy99 QSATIVNNEILALMA-MGTGAPDPGDLSFIMVGAPN-----NPDGGLLAR
.: * : * .. . .
Mvan_3103|M.vanbaalenii_PYR-1 K-ARYNSRYDYTYQ----PPPETKYDVKEVTGEYDGMADFPDRWWNFVAV
Mflv_3371|M.gilvum_PYR-GCK ETSKYNPQYDYTYR----PAPQTMYDIDVVTGEYDGAADLPDRWWNFLAL
Mb3569|M.bovis_AF2122/97 PVGTTIPIAGYTVG----NAPESQYNTSVVYSQYDIWADPPDRPWNLLAG
Rv3539|M.tuberculosis_H37Rv PVGTTIPIAGYTVG----NAPESQYNTSVVYSQYDIWADPPDRPWNLLAG
MMAR_4939|M.marinum_M PDGLTVPLINYTVH----GLSNTQYDVSVVNGQYDFWGNPPDRPWNLPAW
MAB_0936c|M.abscessus_ATCC_199 APGSVVPFMDYPVP----ARVDSQYHTDQFISAYDSIADWPDRPDNLFAL
MAV_1760|M.avium_104 GVGSVVPALDYTMP----PPYESQYDTNRFVAAYDSIADFPDRPDNMFAL
MLBr_01232|M.leprae_Br4923 RPGDYIPLIDYTMP----QRMDSQYDSNRVVAAYDGLSEFPDRADNLLAQ
MSMEG_6144|M.smegmatis_MC2_155 WIPFRIPIIGLTPV----RPPDTPYETTIINGEYDGWADFPDRPWNLIAT
TH_3724|M.thermoresistible__bu FPGLYIPILGVTFNGATPAPADGPFDSYDVAREFDGWADFPRYPLNLVAT
MUL_1034|M.ulcerans_Agy99 FPGFYIPFLDVSFNG--ATPAANPYPTSIFTAQYDGIAHAPQYRLNILSD
. . . : . :* .. * *: :
Mvan_3103|M.vanbaalenii_PYR-1 ANAMAGGIFVH----IPMMFADLK----DEYITEIDVNELGGTTTKYLIP
Mflv_3371|M.gilvum_PYR-GCK ANAIAGGLFVH----VPMMFSDYEAVTPEENITRV-TNTLGGTTTTYLVP
Mb3569|M.bovis_AF2122/97 ANALMGAAYFH----DLTAYAAPQ--QGIEIAAVT--SSLGGTTTTYMIP
Rv3539|M.tuberculosis_H37Rv ANALMGAAYFH----DLTAYAAPQ--QGIEIAAVT--SSLGGTTTTYMIP
MMAR_4939|M.marinum_M VNSLFGAAYYH----NTSSFASLS--DAVEVSSVT--TSLGGTITTYLIP
MAB_0936c|M.abscessus_ATCC_199 ANAIAGLATGH----TAVAFTNPKMVPARNIVTET--NSRGGTTTTYFIP
MAV_1760|M.avium_104 ANTLMGLATGH----TAVAFTNPSMVPPQNIRTTI--NSRGAKDTTIMIP
MLBr_01232|M.leprae_Br4923 LNCFAGGAISH----TPSGFFNPEDVPPQNIRTTV--NSRGAKTTTYLIP
MSMEG_6144|M.smegmatis_MC2_155 ANALLGIIYVHGRYEDKVDGWDLSTVPEKNIVETV--NKAGGKTTTYLIP
TH_3724|M.thermoresistible__bu ANAILGIYYLHG-----GYYELLTENPDILDDPERTIVQQYGDTTYYLIR
MUL_1034|M.ulcerans_Agy99 INAIMGYFYVHG------NYPDLMSGQAIQLPTSP---GYTGNTDYYMYL
* : * * . :
Mvan_3103|M.vanbaalenii_PYR-1 TAKLPLVQLLPFLAPMEAELKEMVDRGYSRND------IVETSALRTLTA
Mflv_3371|M.gilvum_PYR-GCK TKTLPLVQLLPFLKSQEASLKAKIDAGYSRNDDRLAAAAAATSTARSLAA
Mb3569|M.bovis_AF2122/97 SPTLPLLLPLKQIG------------------------------------
Rv3539|M.tuberculosis_H37Rv SPTLPLLLPLKQIG------------------------------------
MMAR_4939|M.marinum_M SPTLPMLLPLEQIG------------------------------------
MAB_0936c|M.abscessus_ATCC_199 EQHLPLVMGFKYLG------------------------------------
MAV_1760|M.avium_104 EKHLPLVMPLKYIG------------------------------------
MLBr_01232|M.leprae_Br4923 VNHLPLTLPLRYLG------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 TEKLPLLQPLRDLG------------------------------------
TH_3724|M.thermoresistible__bu TEQLPLLRPLRDLG------------------------------------
MUL_1034|M.ulcerans_Agy99 TQDLPLVQPIRDIP------------------------------------
**: : :
Mvan_3103|M.vanbaalenii_PYR-1 ---AVEETDDAAEVTAPAEES-VEVDDADLKTEAKGDDGEDLG------A
Mflv_3371|M.gilvum_PYR-GCK PTVTNEATDEVADDEAVATVQKISTDSDAEQADVPAERTSSKP------A
Mb3569|M.bovis_AF2122/97 -----------------VPDWIVGGLNNVLKPLVDAGYSQYAP------T
Rv3539|M.tuberculosis_H37Rv -----------------VPDWIVGGLNNVLKPLVDAGYSQYAP------T
MMAR_4939|M.marinum_M -----------------VPAPIVAGLNSVLAPIVNDGYSSLTP------N
MAB_0936c|M.abscessus_ATCC_199 -----------------VPEETLNRLDAILQPRVDAGYSRNDD------P
MAV_1760|M.avium_104 -----------------IDENTLNKLDAILTPRVNAGYSRNDD------P
MLBr_01232|M.leprae_Br4923 -----------------WSDALVDQIDAVLQPKIDAAYAYNDN------P
MSMEG_6144|M.smegmatis_MC2_155 -----------------FPESFVAALEAPLRKIIDAAYKRNDPGRVTVTT
TH_3724|M.thermoresistible__bu -----------------VPEEFVDALEPYVRRIVDLGYDRNTP-------
MUL_1034|M.ulcerans_Agy99 ----------------YAGPPLADLIQPQLRVLVDLGYSDYGPG---LSY
.
Mvan_3103|M.vanbaalenii_PYR-1 VGEDADTGSSTGDDEAEVIDEADEVDEPDAIDEAVEDADEADSVDAGQGD
Mflv_3371|M.gilvum_PYR-GCK VDDAADDDEAAANEDAEADAADAKVDAKEDAEAAVKDDADASAGTNDDGE
Mb3569|M.bovis_AF2122/97 AGPYFSHGNLVW--------------------------------------
Rv3539|M.tuberculosis_H37Rv AGPYFSHGNLVW--------------------------------------
MMAR_4939|M.marinum_M AGPYFSQGALVGLPSAADVLGSWPWPALGSVTAHIC--------------
MAB_0936c|M.abscessus_ATCC_199 ATAPIAVDPRRGFDPAEVTAPASQATFGGGSDPISQITSGALAVLGNGTR
MAV_1760|M.avium_104 ATAPVQVDPVHGFDPAEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAG
MLBr_01232|M.leprae_Br4923 LNKPISVDPVNGMDPIAGIDAELR-------DSILNVFAQLRSILPPPPG
MSMEG_6144|M.smegmatis_MC2_155 TEETVVEDESEITQTAVTEIDETPSTDGDIDETAVQSTTQRRTVANTAAD
TH_3724|M.thermoresistible__bu YGEPAPVRVLPPLTPAPGPATQHNAGQGITVASATSTPDKRTPVVEAPVE
MUL_1034|M.ulcerans_Agy99 ADVPTPAGLLSVPNPFAVSYYLLKGSLQAPYGAAVEIGVEAGLLGPESFP
Mvan_3103|M.vanbaalenii_PYR-1 E--DAAESEDSTDTDDSDSSGDAASDGTGSSESGSSE-------------
Mflv_3371|M.gilvum_PYR-GCK EGADSGSNDSAAAAGDTDSSDGSSSEGPGSSDSGSSE-------------
Mb3569|M.bovis_AF2122/97 --------------------------------------------------
Rv3539|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 PTPPN---------------------------------------------
MAV_1760|M.avium_104 EADH----------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 RTAETAEVAEVTEDVDELAEQEEPVKEEATKDDEVTKVADEADKATPVKE
TH_3724|M.thermoresistible__bu EPPVQTGRSTLKREKPVSARHLVRNSLRAVPGLRRGEPAATPTPDVTPDV
MUL_1034|M.ulcerans_Agy99 DTYPWVPSLNPGLNFYLGQPSVTLLSLLSGGLGDIFHLIPPPVFP-----
Mvan_3103|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK --------------------------------------------------
Mb3569|M.bovis_AF2122/97 --------------------------------------------------
Rv3539|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 STSVEKTDQAVKPDDTDKTVTTAEKVEKADEAEKVEKTKPNVRKVKRPQF
TH_3724|M.thermoresistible__bu TPDAPAGQPEPAEPNESAAPPAAAEADDASE-------------------
MUL_1034|M.ulcerans_Agy99 --------------------------------------------------
Mvan_3103|M.vanbaalenii_PYR-1 -----------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK -----------------------------------------------
Mb3569|M.bovis_AF2122/97 -----------------------------------------------
Rv3539|M.tuberculosis_H37Rv -----------------------------------------------
MMAR_4939|M.marinum_M -----------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 -----------------------------------------------
MAV_1760|M.avium_104 -----------------------------------------------
MLBr_01232|M.leprae_Br4923 -----------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 NVFKPKKTRVTVPKAEPSTKAKPATKPDNDNDDTSDTTDKTAEKDAA
TH_3724|M.thermoresistible__bu -----------------------------------------------
MUL_1034|M.ulcerans_Agy99 -----------------------------------------------