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MKIGVRKAGLACGAAFASAVLAASTATSAWGSSSALVIGGIATSSMHDVVMGQVLGGALKNQQRVSVNWP AEAAPWTGKDDLTLGASIDIGITNLNAQIDAALGRLGKDANGNYVDGEKVTVVGLSAGSLVVNEVLRQLA ADADAPDKDQITFIVVADSSRQKLINRTRYNSKFDYTYQPAPETEYDIVVVTGEYDGLADFPDRWWNALA VANAIAGSIYVHVPVMFADLSKVPAENITVDVNSKGGTTTSYLVPTAKLPLVQLFPSLAAKEAELKAKID KAYSRNDAPPAGALSTLVAAAPAVVADQAAVVEESPAEAVAEPVEQAVTEPVEQAVTEPVEQAVTEPVEQ ADTDGATPVLEEVVEEVVEEAPDDDTDVTDADGEQTPAPEGADVPVVADDAVESAGADLTESTETESPSD YLSIDAESAGTPESE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1838 | - | - | 100% (435) | hypothetical protein Mvan_1838 |
| M. vanbaalenii PYR-1 | Mvan_3103 | - | e-108 | 52.27% (440) | hypothetical protein Mvan_3103 |
| M. vanbaalenii PYR-1 | Mvan_2535 | - | e-105 | 50.81% (433) | hypothetical protein Mvan_2535 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1216c | - | 1e-27 | 31.06% (293) | hypothetical protein Mb1216c |
| M. gilvum PYR-GCK | Mflv_4518 | - | 1e-113 | 54.19% (430) | hypothetical protein Mflv_4518 |
| M. tuberculosis H37Rv | Rv3822 | - | 6e-29 | 29.91% (331) | hypothetical protein Rv3822 |
| M. leprae Br4923 | MLBr_01232 | - | 6e-28 | 35.68% (227) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 5e-30 | 33.93% (280) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_1027 | - | 3e-18 | 24.59% (427) | PPE family protein |
| M. avium 104 | MAV_1760 | - | 1e-24 | 32.48% (234) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 2e-38 | 33.57% (426) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 2e-15 | 26.20% (374) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 1e-12 | 27.81% (320) | PE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1216c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Rv3822|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_1838|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4518|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1027|M.marinum_M MLMLASFSVLPPEINSARLFGGAGSAPTLAAATAWDGLSAELSGAAGSFG
MUL_1034|M.ulcerans_Agy99 ----MSYVLTAPDLLAS-------------AATDVDGIAATLQVANSAAA
TH_3724|M.thermoresistible__bu --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
Mb1216c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Rv3822|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_1838|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4518|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1027|M.marinum_M SVTSELAAGVWQGPASAAMTVAAGRYVGWLRTSALHAAGAAAAARAAAAE
MUL_1034|M.ulcerans_Agy99 ALTSGLLAAAQDEVSAAIAKVFS----------------------AYGQE
TH_3724|M.thermoresistible__bu --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
Mb1216c|M.bovis_AF2122/97 ---------------------------------------------MKRVI
MLBr_01232|M.leprae_Br4923 ---------------------------------------------MKRLL
MAB_0936c|M.abscessus_ATCC_199 ---------------------------------------------MRNLL
MAV_1760|M.avium_104 ---------------------------------------------MKQLL
Rv3822|M.tuberculosis_H37Rv ----------------------------------------MKCPGVSDCV
Mvan_1838|M.vanbaalenii_PYR-1 ------------------------------------------------MK
Mflv_4518|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_1027|M.marinum_M FEAALAATVHPVAVAANRAQLASLVMTNLFGQNAPAIAAAESSYEQMWAQ
MUL_1034|M.ulcerans_Agy99 YQAAIAQ--------------ASAFHT----EFTRALAAAGAAYAQAEAA
TH_3724|M.thermoresistible__bu --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
Mb1216c|M.bovis_AF2122/97 AGAFAVWLVGWAGGFGTAIAASEPAYPWAPGPPPSPSPVGD-------AS
MLBr_01232|M.leprae_Br4923 ATTLAALTVGTVSGFGSTVASSEPGEPWLP---PSPVPVRE-------NS
MAB_0936c|M.abscessus_ATCC_199 AGTAVLVVACVTGCFGIPSAVADDPQVPGP---PIPGIAPDGTVKAAPSA
MAV_1760|M.avium_104 AGVTALLSVSTAGYFGIGTAAADGGPIGGP---PTPG-APG---------
Rv3822|M.tuberculosis_H37Rv ATVRHDNVFAIAAGLRWSAAVPPLHKGDAVTKLLVGAIAGG-MLACAAIL
Mvan_1838|M.vanbaalenii_PYR-1 IGVRKAGLACGAAFASAVLAASTATSAWGS--------------------
Mflv_4518|M.gilvum_PYR-GCK --MRKTGVVCGTVFASAALALSSSSLGQAA--------------------
MMAR_1027|M.marinum_M DVSAMAGYYGGAAAVAAQLAPWSQQLGTIVG-AVGGSAGAGLSRASGLSA
MUL_1034|M.ulcerans_Agy99 NASLIT------AGVSDALTAITTPIQSLLGPAAIGTGGAG---------
TH_3724|M.thermoresistible__bu --------------------------VVAVGALTWGGXGVAS--------
MSMEG_6144|M.smegmatis_MC2_155 ----------MIAAVAAVVTAALVTTVPALG-------------------
Mb1216c|M.bovis_AF2122/97 TAKVVYALGGARMPGIPWYEYTNQAGSQYFPNAKHDLIDYPAGAAFSWWP
MLBr_01232|M.leprae_Br4923 PAKIVYALGGARPPTFDWDYYTIRAGDEFFPDVNRKLIDYPARAPFRYVP
MAB_0936c|M.abscessus_ATCC_199 PDRTAYALGGAHVLGIPYDEYIRMTGKDWFPNMKRENVWYPAGQVQGHTL
MAV_1760|M.avium_104 -DQTAYALGGAHVLGIPYDQYIRMEGADWFPGQQRQIVRYPAGQVQGHVL
Rv3822|M.tuberculosis_H37Rv GDGIASADTALIVPGTAPSPYGPLRSLYHFNPAMQPQIGANYYNPTATRH
Mvan_1838|M.vanbaalenii_PYR-1 --SSALVIGGIATSSMHDVVMGQVLGGALKNQQRVSVNWPAEAAPWTGKD
Mflv_4518|M.gilvum_PYR-GCK --NTALVIGGISTPSMADALMSPLLGGKFKDQQRVSVKWPAQAGPMTGKG
MMAR_1027|M.marinum_M TAANTSSIGTNVAAAQTIAEVMGGSGIP-MPSRRYVQLANSLYIGRSVGG
MUL_1034|M.ulcerans_Agy99 SAGALTAVSSTLMADPVVALIMGGTSVP-LPGPGYVSDINNNYIQPLFSG
TH_3724|M.thermoresistible__bu PAGQPERAAALRLTATADAIIMPGTKIGYIPSQDEFTAYATAVIGATAGA
MSMEG_6144|M.smegmatis_MC2_155 ----ATAFTISGTRILHDPPYPEQLVPGEFAGYDVEHIKYPASVFGMDRG
Mb1216c|M.bovis_AF2122/97 TMLLPPGSHQDNM----------TVGVAVKDGTNSLDNAIH---HGTDPA
MLBr_01232|M.leprae_Br4923 TFLVP--GPRDEV----------TIGEAIAVATKNLNQAIH---RGTEPA
MAB_0936c|M.abscessus_ATCC_199 ERFFPGIGPIGEKILPGLGLDGPSIGESIDIGEPNLENAIR---SGG-PG
MAV_1760|M.avium_104 ERLFPGIGKLDES-FPGLGMDGPSVGESVAEGIDNLDAAIR---TTGRPG
Rv3822|M.tuberculosis_H37Rv VVSYPGSFWPVTG------LNSPTVGSSVSAGTNNLDAAIR---STDGPI
Mvan_1838|M.vanbaalenii_PYR-1 DLTLGASIDIGIT----------NLNAQIDAALGRLGKDANGNYVDGEKV
Mflv_4518|M.gilvum_PYR-GCK DLTLGASIAQGAT----------NLNAQIDAALAQLK--------SGEKV
MMAR_1027|M.marinum_M -AVAQALFTPEGLYPVT-GVKNLTFDTSVARGVVILESAIREQITAGNNV
MUL_1034|M.ulcerans_Agy99 -AIPQALFTPEQFWPVTPGLGNLTFNQSVAQGVTLLNDAINTQLALGNKV
TH_3724|M.thermoresistible__bu PGAVDYLGVPGEFWPAT-GLDSLTFDASVAXGQAMLTPMVDGAIESDTPI
MSMEG_6144|M.smegmatis_MC2_155 IWEAAG---------------------AVAAGVDRFVGVDDEGNPITEKI
: . :
Mb1216c|M.bovis_AF2122/97 AAVGLSQGSLVLD-QEQARLANDPTA-PAPDKLQFTTFGDPTGRHAFGAS
MLBr_01232|M.leprae_Br4923 AVVGLSQGSLALD-TEQEQLATDPTA-PPPDQLTFNTFGDPSGYHGFGKS
MAB_0936c|M.abscessus_ATCC_199 TAMGLSEGALVLN-AVKNALATDPTA-PEPESLTFATFGDPIAKSPFSES
MAV_1760|M.avium_104 TAIGLSEGAFVVD-GEQARLANDPTA-PPPNTLNFATFGDPIGRHAFGQS
Rv3822|M.tuberculosis_H37Rv FVAGLSQGTLVLD-REQARLANDPTA-PPPGQLTFIKAGDP-------NN
Mvan_1838|M.vanbaalenii_PYR-1 TVVGLSAGSLVVN-EVLRQLAADADA-PDKDQITFIVVADSSRQKLINRT
Mflv_4518|M.gilvum_PYR-GCK TVVGLSAGSLVVN-EILRELDESADA-PGKDKITFVVVADSSRQKVISRT
MMAR_1027|M.marinum_M TVFGYSQSATISS-LTMTKLAASINP-PTPDQLSFTLVGDPNNPNGGVAT
MUL_1034|M.ulcerans_Agy99 VAFGYSQSATIVNNEILALMAMGTGA-PDPGDLSFIMVGAPNNPDGGLLA
TH_3724|M.thermoresistible__bu VVFGHSQSAVIATKEKQRLLAEYPDP-DTAPDVTFVMVANPNRPNGGLLA
MSMEG_6144|M.smegmatis_MC2_155 IVAGFSQGAIVIAYEKKRLMKLDEDERPTVDQLKFVTIGDPTGPNGILRW
. * * .: : : * . .
Mb1216c|M.bovis_AF2122/97 FLARIFPPGSHIPIPFIEYTMPQQVDSQYDTNHVVTAYDGFSDFPDRPDN
MLBr_01232|M.leprae_Br4923 VLASIFRPGDYIPL--IDYTMPQRMDSQYDSNRVVAAYDGLSEFPDRADN
MAB_0936c|M.abscessus_ATCC_199 FLTQNFAPGSVVPF--MDYPVPARVDSQYHTDQFISAYDSIADWPDRPDN
MAV_1760|M.avium_104 FLTAMFGVGSVVPA--LDYTMPPPYESQYDTNRFVAAYDSIADFPDRPDN
Rv3822|M.tuberculosis_H37Rv LLWRAFRPGTHVPI--IDYTVPAPAESQYDTINIVGQYDIFSDPPNRPGN
Mvan_1838|M.vanbaalenii_PYR-1 RYNSKF-----------DYTYQPAPETEYDIVVVTGEYDGLADFPDRWWN
Mflv_4518|M.gilvum_PYR-GCK RYNANL-----------DYTYQTAPETKYDIIVVTGEYDGMADFPDR-LN
MMAR_1027|M.marinum_M RFPGLSLPSLGITAS---GATP---DNLYPTRIYTLEYDGVADFPRYPLN
MUL_1034|M.ulcerans_Agy99 RFPGFYIPFLDVSFN---GATPA--ANPYPTSIFTAQYDGIAHAPQYRLN
TH_3724|M.thermoresistible__bu RFPGLYIPILGVTFN---GATPAPADGPFDSYDVAREFDGWADFPRYPLN
MSMEG_6144|M.smegmatis_MC2_155 IPFRIPIIG---------LTPVRPPDTPYETTIINGEYDGWADFPDRPWN
. : :* :. * *
Mb1216c|M.bovis_AF2122/97 LLAVANAAIG-AAIAH---TPIGFTGPGDVPPQNIRTTVNSRGATTTTYL
MLBr_01232|M.leprae_Br4923 LLAQLNCFAG-GAISH---TPSGFFNPEDVPPQNIRTTVNSRGAKTTTYL
MAB_0936c|M.abscessus_ATCC_199 LFALANAIAG-LATGH---TAVAFTNPKMVPARNIVTETNSRGGTTTTYF
MAV_1760|M.avium_104 MFALANTLMG-LATGH---TAVAFTNPSMVPPQNIRTTINSRGAKDTTIM
Rv3822|M.tuberculosis_H37Rv LLADLNAIAAGGYYGH---SATAFSDPARVAPRDITTTTNSLGATTTTYF
Mvan_1838|M.vanbaalenii_PYR-1 ALAVANAIAG-SIYVH---VPVMFADLSKVPAENITVDVNSKGGTTTSYL
Mflv_4518|M.gilvum_PYR-GCK LLAIVNAVAG-GIFVH---IPVMYADLSKVPARNISVEMNSEGGTTTHYL
MMAR_1027|M.marinum_M LVSTLNALAGAYYVHT---DYLFLTPAQIDAAVHLTNTVGPT--MTDYYV
MUL_1034|M.ulcerans_Agy99 ILSDINAIMGYFYVHG---NYPDLMSG---QAIQLPTSPGYTG-NTDYYM
TH_3724|M.thermoresistible__bu LVATANAILGIYYLHG---GYYELLTENPDILDDPERTIVQQYGDTTYYL
MSMEG_6144|M.smegmatis_MC2_155 LIATANALLGIIYVHGRYEDKVDGWDLSTVPEKNIVETVNKAGGKTTTYL
.: * . . .
Mb1216c|M.bovis_AF2122/97 VPVNHLPLTLPLRYLG-MSDAEVDQIDSVLQPQIDAAYAR-NDNWFTRP-
MLBr_01232|M.leprae_Br4923 IPVNHLPLTLPLRYLG-WSDALVDQIDAVLQPKIDAAYAY-NDNPLNKP-
MAB_0936c|M.abscessus_ATCC_199 IPEQHLPLVMGFKYLG-VPEETLNRLDAILQPRVDAGYSR-NDDPATAP-
MAV_1760|M.avium_104 IPEKHLPLVMPLKYIG-IDENTLNKLDAILTPRVNAGYSR-NDDPATAP-
Rv3822|M.tuberculosis_H37Rv IRTDQLPLVRALVDMAGLPPQAAGTVDAALRPIIDRAYQP-GPAPAVNPR
Mvan_1838|M.vanbaalenii_PYR-1 VPTAKLPLVQLFPSLA--------AKEAELKAKIDKAYSR-NDAPPAGAL
Mflv_4518|M.gilvum_PYR-GCK VPAEKLPLVRLFPSLA--------NREAELKAKIDAAYSR-NDVVAVSAP
MMAR_1027|M.marinum_M IRTEDLPLLEPLRALPVLGDPLADLVQPNLKVIVNLGYGDPAYGYSTSPP
MUL_1034|M.ulcerans_Agy99 YLTQDLPLVQPIRDIPYAGPPLADLIQPQLRVLVDLGYSD--YGPGLSYA
TH_3724|M.thermoresistible__bu IRTEQLPLLRPLRDLGVP-EEFVDALEPYVRRIVDLGYDR--NTPYGEPA
MSMEG_6144|M.smegmatis_MC2_155 IPTEKLPLLQPLRDLG-FPESFVAALEAPLRKIIDAAYKRNDPGRVTVTT
.*** : : :. : :: .*
Mb1216c|M.bovis_AF2122/97 ---VSVDPVRGLDPLTAPGSIVEG-------------------------A
MLBr_01232|M.leprae_Br4923 ---ISVDPVNGMDPIAGIDAELRDSI-----------------LNVFAQL
MAB_0936c|M.abscessus_ATCC_199 ---IAVDPRRGFDPAEVTAPASQATFGGGSDPI----------SQITSGA
MAV_1760|M.avium_104 ---VQVDPVHGFDPAEVTAPANQATFGGGADPL----------SQIMAGA
Rv3822|M.tuberculosis_H37Rv DLVQGIRGIPAIAPAIAIPIGSTTGASAATSTA----------AATAAAT
Mvan_1838|M.vanbaalenii_PYR-1 STLVAAAPAVVADQAAVVEESPAEAVAEPVEQA----------VTEPVEQ
Mflv_4518|M.gilvum_PYR-GCK KAAVFAAAPAPAAPTAVVQTPSAAQVPGSVAAS----------LRTAKAD
MMAR_1027|M.marinum_M NVATPFGLWPEVSPLTIADALAAGTQQGIHDFGYHISHLDL-PQITNGSS
MUL_1034|M.ulcerans_Agy99 DVPTPAGLLSVPNPFAVSYYLLKGSLQAPYG-----------AAVEIGVE
TH_3724|M.thermoresistible__bu PVRVLPPLTPAPGPATQHNAGQGITVASATSTP---------DKRTPVVE
MSMEG_6144|M.smegmatis_MC2_155 TEETVVEDESEITQTAVTEIDETPSTDGDIDETAVQSTTQRRTVANTAAD
Mb1216c|M.bovis_AF2122/97 RGLLGSPAFGG---------------------------------------
MLBr_01232|M.leprae_Br4923 RSILPPPPG-----------------------------------------
MAB_0936c|M.abscessus_ATCC_199 LAVLGNGTRPTPPN------------------------------------
MAV_1760|M.avium_104 MSVLSHGAGEADH-------------------------------------
Rv3822|M.tuberculosis_H37Rv NALRGANVGPGANKALSMVRGLLPKGKKH---------------------
Mvan_1838|M.vanbaalenii_PYR-1 AVTEPVEQAVTEPVEQADTDGATPVLEEVVEEV-----------------
Mflv_4518|M.gilvum_PYR-GCK AAVEDAVVSEDAAVEDAVVSEEAAVSEEVDVKG-----------------
MMAR_1027|M.marinum_M SPVGNPQAAPTTGPAAPMVSINTIIDDLQAANSQVANTITEVGAASYAAL
MUL_1034|M.ulcerans_Agy99 AGLLGPESFPDTYPWVPSLNP-----------------------------
TH_3724|M.thermoresistible__bu APVEEPPVQTGRSTLKREKPVS----------------------------
MSMEG_6144|M.smegmatis_MC2_155 RTAETAEVAEVTEDVDELAEQEEPVKEEATKDDEVTKVADEADKATPVKE
Mb1216c|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Rv3822|M.tuberculosis_H37Rv --------------------------------------------------
Mvan_1838|M.vanbaalenii_PYR-1 ---------------VEEAPDDDTDVTDADGEQTPAPEGADVPVVADDAV
Mflv_4518|M.gilvum_PYR-GCK ---------------ADSADADIEETDTADQADIDSGAEKEAAQEDSDAG
MMAR_1027|M.marinum_M LPTADIANAAITSVPSYNINLFLDGIQQVANGDPMGFVNAVGYPLAADVA
MUL_1034|M.ulcerans_Agy99 -----------------GLNFYLG---------------------QPSVT
TH_3724|M.thermoresistible__bu -----------------ARHLVRNSLRAVPGLRRGEPAATPTPDVTPDVT
MSMEG_6144|M.smegmatis_MC2_155 STSVEKTDQAVKPDDTDKTVTTAEKVEKADEAEKVEKTKPNVRKVKRPQF
Mb1216c|M.bovis_AF2122/97 -----------------------------------------------
MLBr_01232|M.leprae_Br4923 -----------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 -----------------------------------------------
MAV_1760|M.avium_104 -----------------------------------------------
Rv3822|M.tuberculosis_H37Rv -----------------------------------------------
Mvan_1838|M.vanbaalenii_PYR-1 ESAGADLTESTETESPSDYLSIDAESAGTPESE--------------
Mflv_4518|M.gilvum_PYR-GCK AQSGDDADKDGSVSSDSGASTDRSPSKPSATSDS-------------
MMAR_1027|M.marinum_M LITVAGLLQAFVLVNAGQAIAHAITTPIG------------------
MUL_1034|M.ulcerans_Agy99 LLS--------LLSGGLGDIFHLIPPPVFP-----------------
TH_3724|M.thermoresistible__bu PDAPAGQPEPAEPNESAAPPAAAEADDASE-----------------
MSMEG_6144|M.smegmatis_MC2_155 NVFKPKKTRVTVPKAEPSTKAKPATKPDNDNDDTSDTTDKTAEKDAA