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MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFESVCSGLADRWWQGPSSRMMAAQA ARHTGWLAAAATQAEGAASQAQTMALAYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAI YEQMWAQDVVAMLNYHAVASAVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPSSTTTRITVPGASPV HAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEVVSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEI LAATASGQPVTVAGLSMGSMVIDRELAYLAIDPNAPPSSALTFVELAGPERGLAQTYLPVGTTIPIAGYT VGNAPESQYNTSVVYSQYDIWADPPDRPWNLLAGANALMGAAYFHDLTAYAAPQQGIEIAAVTSSLGGTT TTYMIPSPTLPLLLPLKQIGVPDWIVGGLNNVLKPLVDAGYSQYAPTAGPYFSHGNLVW
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3539 | PPE63 | - | 100% (479) | PPE FAMILY PROTEIN |
| M. tuberculosis H37Rv | Rv1800 | PPE28 | 4e-71 | 36.70% (485) | PPE family protein |
| M. tuberculosis H37Rv | Rv0878c | PPE13 | 3e-52 | 60.11% (178) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3569 | PPE63 | 0.0 | 100.00% (479) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0401 | - | 9e-37 | 37.46% (307) | hypothetical protein Mflv_0401 |
| M. leprae Br4923 | MLBr_01182 | - | 2e-30 | 46.06% (165) | PPE-family protein |
| M. abscessus ATCC 19977 | MAB_0936c | - | 6e-35 | 38.15% (270) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_4939 | - | 1e-88 | 44.72% (436) | PE-PGRS family protein |
| M. avium 104 | MAV_4704 | - | 5e-49 | 59.54% (173) | PPE family protein |
| M. smegmatis MC2 155 | MSMEG_0412 | - | 1e-34 | 36.80% (269) | hypothetical protein MSMEG_0412 |
| M. thermoresistible (build 8) | TH_3569 | - | 8e-24 | 39.10% (156) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2440 | - | 2e-52 | 35.27% (465) | PPE family protein |
| M. vanbaalenii PYR-1 | Mvan_0761 | - | 1e-39 | 36.11% (288) | hypothetical protein Mvan_0761 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3539|M.tuberculosis_H37Rv ---MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAAS-F
Mb3569|M.bovis_AF2122/97 ---MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAAS-F
MAV_4704|M.avium_104 -MTNPHFAWLPPEVNSALIYSGPGPGPLLAAAAAWDGLAEELASSAQS-F
MUL_2440|M.ulcerans_Agy99 ---------------------------MLAAAAAWDGTGQELAAAASA-F
MLBr_01182|M.leprae_Br4923 ---MFDFAALSPETNSTRMYLGPGSSPILTAAAAWVVLAKELTAAAQG-L
TH_3569|M.thermoresistible__bu MMTAPIWMALPPEVHSALLSSGPGPGSLLAAASAWHALSAEYASAAAE-L
Mflv_0401|M.gilvum_PYR-GCK ---MRRHLAFATAITTLGATGILGLGIAAAQPAPAPPPPPAPGAAAG---
MSMEG_0412|M.smegmatis_MC2_155 --MRRRLLAFGTAFTTIGTAGFLGFGVAAADDT--KPVDPAPGGAHA---
MAB_0936c|M.abscessus_ATCC_199 ---MRNLLAGTAVLVVACVTGCFGIPSAVADDP-QVPGPPIPGIAPDGTV
MMAR_4939|M.marinum_M ----MSYVVAAPDFLSTAAEDLAAMGSAVSTATAAAARSTTLLLAAG---
Mvan_0761|M.vanbaalenii_PYR-1 ------MVVVRRWLVPLIALVSVLLGIGTAANPVSAAEEAVLIPGASPFK
: . .
Rv3539|M.tuberculosis_H37Rv ESVCSGLADRWWQGPSSRMMAAQAARHTGWLAAAATQAEGAASQAQTMAL
Mb3569|M.bovis_AF2122/97 ESVCSGLADRWWQGPSSRMMAAQAARHTGWLAAAATQAEGAASQAQTMAL
MAV_4704|M.avium_104 SSVTSDLASGSWQGASSAAMMTVANQYVSWLSAAAAQAEEVSHQASAIAT
MUL_2440|M.ulcerans_Agy99 SSLTSDLAGAAWQGPSAAAMASVATSYVRWLGSAASGAVQTARQVATSAA
MLBr_01182|M.leprae_Br4923 QSAVEALLT-TFEGESAAALAERVTPYEKWLTQNAASAELTATQLTVAAN
TH_3569|M.thermoresistible__bu SSVLANVQAGSWEGPSAERYVAAHAPYLAWLTQQSANSAATAGRHETAAA
Mflv_0401|M.gilvum_PYR-GCK APTPLGTPGRGYALGGAHVLGIPYDEYIMRTGADWFPGLDREIVDYPAGQ
MSMEG_0412|M.smegmatis_MC2_155 EAPSMGTPGRGYALGGAHVLGIPYDEYIMRTGADWFPGLDRQIVDYPAGQ
MAB_0936c|M.abscessus_ATCC_199 KAAPSAPDRTAYALGGAHVLGIPYDEYIRMTGKDWFPNMKRENVWYPAGQ
MMAR_4939|M.marinum_M --------ADEVSTHIAALFSTHGLQYQLASAQAAEFHERFVLTLAADAN
Mvan_0761|M.vanbaalenii_PYR-1 PINPFYPIIAATYRYIGINLHDDADAQLVDYSQNPFSTDRALLDGVERAD
. .
Rv3539|M.tuberculosis_H37Rv AYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWA
Mb3569|M.bovis_AF2122/97 AYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWA
MAV_4704|M.avium_104 AFEVALAATVQPAVVAANRALVQALAATNWLGQNTPAIADIEAAYEQMWA
MUL_2440|M.ulcerans_Agy99 VFEAARTATVPLELVAANRSALMSMVAANVFGLNAPAIAAIEAQYEQMWA
MLBr_01182|M.leprae_Br4923 AYETAFTMTVPPLMVFVNRAQACLLIMSNIFGQNSTAIAEKEAEYTEMWI
TH_3569|M.thermoresistible__bu AYSTALATMPTMAELTLNKTTHAVLVATNFLGINTIPIALNEADYVRMWI
Mflv_0401|M.gilvum_PYR-GCK VQGHTLERLFPGIGAFGDRIAPGLGLDGPSYGESIDVGAPNLIGAIRRGG
MSMEG_0412|M.smegmatis_MC2_155 VQGHTLERLFPGIGALGERFMPGLGLDGPSYGESIDVGAPNLINAIRQGG
MAB_0936c|M.abscessus_ATCC_199 VQGHTLERFFPGIGPIGEKILPGLGLDGPSIGESIDIGEPNLENAIRSGG
MMAR_4939|M.marinum_M TYLTTEIANAQRCLAGAINAPATALLGHPLLGADPTASASTAATPAG---
Mvan_0761|M.vanbaalenii_PYR-1 VAVREIDGQVVVIGESMGSMVASRLAADLAHSPDPPSPDDIRFVLIASPE
. . .
Rv3539|M.tuberculosis_H37Rv QDVVAMLNYHAVASAVGARLRPWQQLLHELPRRLG---------------
Mb3569|M.bovis_AF2122/97 QDVVAMLNYHAVASAVGARLRPWQQLLHELPRRLG---------------
MAV_4704|M.avium_104 SDVAAMFGYHADASAAVAKLPPWNEVLQNLG-------------------
MUL_2440|M.ulcerans_Agy99 QNVGAMFGYHVGVSEALSGLAPWQEVLSGVSGRVASALEGTSAAAAAALG
MLBr_01182|M.leprae_Br4923 QDAAAMTSYQASVLEAVGATKAFTAPPLGVNEVGL---------------
TH_3569|M.thermoresistible__bu QAATSMSTYQAVAGTAVMSAPASSPAPLLLAPG-----------------
Mflv_0401|M.gilvum_PYR-GCK PGTAIGLSEGASVLDEVQARLAYDPAAPPPDQLS----------------
MSMEG_0412|M.smegmatis_MC2_155 PGTVIGLSEGASVLDEVQARLAYDPAAPPPDSLS----------------
MAB_0936c|M.abscessus_ATCC_199 PGTAMGLSEGALVLNAVKNALATDPTAPEPESLT----------------
MMAR_4939|M.marinum_M GASMAPAAAGTRITVPGAGPLYYPRFLTELPYLG----------------
Mvan_0761|M.vanbaalenii_PYR-1 EGVAQYFKEGTRIPLLNYTVSRVAQSPYPTTVVFG---------------
.
Rv3539|M.tuberculosis_H37Rv ---GEHSDSTNTELANPSSTTTR---------------------------
Mb3569|M.bovis_AF2122/97 ---GEHSDSTNTELANPSSTTTR---------------------------
MAV_4704|M.avium_104 ----------FSNASTAVTRP-----------------------------
MUL_2440|M.ulcerans_Agy99 PTALTAAGSALPAAATDVTLVIGGSGFPIPSQSYVDNVVNNFVTPNFPSF
MLBr_01182|M.leprae_Br4923 --AQEVVEEVVEEVVEEVVEA-----------------------------
TH_3569|M.thermoresistible__bu ----------VSEAADAMATT-----------------------------
Mflv_0401|M.gilvum_PYR-GCK ----------FATYGNPVGKHAFG--------------------------
MSMEG_0412|M.smegmatis_MC2_155 ----------FATYGNPVGKHAFG--------------------------
MAB_0936c|M.abscessus_ATCC_199 ----------FATFGDPIAKSPFS--------------------------
MMAR_4939|M.marinum_M -----------QALLLGIPGP-----------------------------
Mvan_0761|M.vanbaalenii_PYR-1 ---------EYDGWADPPDRP-----------------------------
Rv3539|M.tuberculosis_H37Rv -------------------------------------------ITVPGAS
Mb3569|M.bovis_AF2122/97 -------------------------------------------ITVPGAS
MAV_4704|M.avium_104 ---------------------------------------------AGSGA
MUL_2440|M.ulcerans_Agy99 TVSNAISLFTPAESYWITGIKTMTEDASWAEGLTILDTAIKAQLAAGNNV
MLBr_01182|M.leprae_Br4923 -------------------------------------------EQAISQA
TH_3569|M.thermoresistible__bu -------------------------------------------QQIGSQA
Mflv_0401|M.gilvum_PYR-GCK -------------------------------------------ESFLTQN
MSMEG_0412|M.smegmatis_MC2_155 -------------------------------------------ESFLTQM
MAB_0936c|M.abscessus_ATCC_199 -------------------------------------------ESFLTQN
MMAR_4939|M.marinum_M ----------------------------------------------SSAS
Mvan_0761|M.vanbaalenii_PYR-1 ---------------------------------------------WNLVA
Rv3539|M.tuberculosis_H37Rv PVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEVVSYPATIGVLSG
Mb3569|M.bovis_AF2122/97 PVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEVVSYPATIGVLSG
MAV_4704|M.avium_104 VARGYTS---------------------------------------RIAG
MUL_2440|M.ulcerans_Agy99 VVQGYSQGAGIASLEMSNLKAAGVPTGSVSFSLIGNAMNPNGGLYERFAG
MLBr_01182|M.leprae_Br4923 ALDQAVNEGMEATVVPQVDQQVNVDVATPQTAVPDSSSAAAPQLWGGFAQ
TH_3569|M.thermoresistible__bu TAADSG---------------TALNLSDLIANLLQYYQDYLDQLFGPIVD
Mflv_0401|M.gilvum_PYR-GCK FPVGSVVPSLDYRIPAPVESQYDTYKFVSAYDSIADWPDRPDNWLSVANA
MSMEG_0412|M.smegmatis_MC2_155 FPVGSVVPSLDYRIPAPVESQYDTYQFVSAYDSIADWPDRPDNWISVANA
MAB_0936c|M.abscessus_ATCC_199 FAPGSVVPFMDYPVPARVDSQYHTDQFISAYDSIADWPDRPDNLFALANA
MMAR_4939|M.marinum_M ILQGYDLINHAIGENWFPDTIASVINYPASIGILSGSLAAPDTNTAVAIG
Mvan_0761|M.vanbaalenii_PYR-1 VANAAMGLIYVHGPAMWDVDLSDVPPENITVDGTVTRYFVPTEHLPLTRP
Rv3539|M.tuberculosis_H37Rv SLGAVDANQSIAIG--------QQMLHNEILAATASGQPVTVAGLSMGSM
Mb3569|M.bovis_AF2122/97 SLGAVDANQSIAIG--------QQMLHNEILAATASGQPVTVAGLSMGSM
MAV_4704|M.avium_104 FLAPRAPQ------------------------------------------
MUL_2440|M.ulcerans_Agy99 LVSPSLGKTFWGATPDNYYTTDVYTLEYDGFADFPRYPPNFVSDLNAIMG
MLBr_01182|M.leprae_Br4923 HLS-PINDTLSMIN---------------------NHAGMANAGLSLVNG
TH_3569|M.thermoresistible__bu FLRDPIGNLFQLID---------------------DFLTNPAG-------
Mflv_0401|M.gilvum_PYR-GCK IVGLATGHTAVAFT-----------------------DPSMVPERNIRTT
MSMEG_0412|M.smegmatis_MC2_155 IVGLATGHTAVAFT-----------------------NPSMVPPQNIRTT
MAB_0936c|M.abscessus_ATCC_199 IAGLATGHTAVAFT-----------------------NPKMVPARNIVTE
MMAR_4939|M.marinum_M ARMLHEQIMSAVTN--------------------GSGLPVHVATLSQGTI
Mvan_0761|M.vanbaalenii_PYR-1 FRDLGVPDCLVDAAD-------------------HILRPIIDAGYRRHDQ
Rv3539|M.tuberculosis_H37Rv VIDRELAYLAIDPNAPPSSALTFVELAGPERGLAQTYLPVGTTIPIAGYT
Mb3569|M.bovis_AF2122/97 VIDRELAYLAIDPNAPPSSALTFVELAGPERGLAQTYLPVGTTIPIAGYT
MAV_4704|M.avium_104 --------------------------------------------------
MUL_2440|M.ulcerans_Agy99 IYYVHTQYPTLTAAQVATAFTLPTEGATMTTYHMIPTENLPLLEPLRGVP
MLBr_01182|M.leprae_Br4923 MGSAMKSLAPTTTKAAESAFKAMGSAVQSTGRGLLGSSSGGHVTAQLGR-
TH_3569|M.thermoresistible__bu ------ALVTWWPLLFAVAYQVFTNLVGWPTWAMILASP-----VLIPL-
Mflv_0401|M.gilvum_PYR-GCK VNSRGATTTTYMIPEEHLPLVLPFKYLGVPKDTLMELDKVLLPYVDAGYS
MSMEG_0412|M.smegmatis_MC2_155 VNSRGAKDTTIMIPEEHLPLVLPFKYLGVDKDTLNKLDGVLKPYVDAGYS
MAB_0936c|M.abscessus_ATCC_199 TNSRGGTTTTYFIPEQHLPLVMGFKYLGVPEETLNRLDAILQPRVDAGYS
MMAR_4939|M.marinum_M VANRELAYLATDPNAPPAHALEFALFGSPELGLAHIYLPDGLTVPLINYT
Mvan_0761|M.vanbaalenii_PYR-1 PGDSRPYLYDGRIRRDVPPVVPLQQGGDDGGGGADEENENAAQHPQADGD
Rv3539|M.tuberculosis_H37Rv VG----------------NAPESQYNTSVVYSQYDIWADPPDRPWNLLAG
Mb3569|M.bovis_AF2122/97 VG----------------NAPESQYNTSVVYSQYDIWADPPDRPWNLLAG
MAV_4704|M.avium_104 --------------------------------------------------
MUL_2440|M.ulcerans_Agy99 FIGNTLADLVQPDLKVLVNLGYGDPNYGYSTGPANVPTPFGLFPDVAPAT
MLBr_01182|M.leprae_Br4923 ---------------------------AASIGSLRVPQTWTTASQPVTAA
TH_3569|M.thermoresistible__bu ---------------------------AITLG----------VAGLVMIA
Mflv_0401|M.gilvum_PYR-GCK RN------------------------------------DDPATAPITVDP
MSMEG_0412|M.smegmatis_MC2_155 RN------------------------------------DDPLTAPITVDP
MAB_0936c|M.abscessus_ATCC_199 RN------------------------------------DDPATAPIAVDP
MMAR_4939|M.marinum_M VHG----------------LSNTQYDVSVVNGQYDFWGNPPDRPWNLPAW
Mvan_0761|M.vanbaalenii_PYR-1 GR-----------------------------------LDRDDLDVSESAE
Rv3539|M.tuberculosis_H37Rv ANALMGAAYFHDLTAYAAPQQGIEIAAVTSSLGGTTTTYMIPSPTLPLLL
Mb3569|M.bovis_AF2122/97 ANALMGAAYFHDLTAYAAPQQGIEIAAVTSSLGGTTTTYMIPSPTLPLLL
MAV_4704|M.avium_104 --------------------------------------------------
MUL_2440|M.ulcerans_Agy99 VFDALVAGTQQGISDAAADIGAWQLPSLPDISLSGISNALGSDPWSALSN
MLBr_01182|M.leprae_Br4923 TRALSPARVAVATESESAPLLGGGLPMAPMVPGGGSGTGGVNTALRLQPR
TH_3569|M.thermoresistible__bu DQAQPPAEEAAPEEDVAAPVRAEPQNPLPLTXXX----------------
Mflv_0401|M.gilvum_PYR-GCK VNGYDPAEVTAPATQAAFGGGADPVSQLLSGLQYILNNPP----------
MSMEG_0412|M.smegmatis_MC2_155 VNGYDPAAVTAPATQAAFGGGTDPVSQLLAGLQYVVNNQPAPKP------
MAB_0936c|M.abscessus_ATCC_199 RRGFDPAEVTAPASQATFGGGSDPISQITSGALAVLGNGTRPTPPN----
MMAR_4939|M.marinum_M VNSLFGAAYYHNTSSFASLSDAVEVSSVTTSLGGTITTYLIPSPTLPMLL
Mvan_0761|M.vanbaalenii_PYR-1 DPDVSEAAQDPDVSESAADRDGRAVTHDPDVPESGEDPDARESTNDSADD
Rv3539|M.tuberculosis_H37Rv PLKQIGVPDWIVGGLNNVLKPLVDAGYSQYAPTAGPYFSHGNLVW-----
Mb3569|M.bovis_AF2122/97 PLKQIGVPDWIVGGLNNVLKPLVDAGYSQYAPTAGPYFSHGNLVW-----
MAV_4704|M.avium_104 --------------------------------------------------
MUL_2440|M.ulcerans_Agy99 ATLPTLSVSTIENAIKGVQTATTDIANTISFDATTAYATLLPTADVVNAM
MLBr_01182|M.leprae_Br4923 AFVMPRNPAAG---------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0401|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0412|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4939|M.marinum_M PLEQIGVPAPIVAGLNSVLAPIVNDGYSSLTPNAGPYFSQGALVGLPSAA
Mvan_0761|M.vanbaalenii_PYR-1 SAQRQEAGG-----------------------------------------
Rv3539|M.tuberculosis_H37Rv --------------------------------------------------
Mb3569|M.bovis_AF2122/97 --------------------------------------------------
MAV_4704|M.avium_104 --------------------------------------------------
MUL_2440|M.ulcerans_Agy99 VTTLPAYNLKLFLDGILQVLDGDPAGLIYALGAPIAADTALVTLLAGFNL
MLBr_01182|M.leprae_Br4923 --------------------------------------------------
TH_3569|M.thermoresistible__bu --------------------------------------------------
Mflv_0401|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_0412|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MMAR_4939|M.marinum_M DVLGSWPWPALGSVTAHIC-------------------------------
Mvan_0761|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv3539|M.tuberculosis_H37Rv ---------------
Mb3569|M.bovis_AF2122/97 ---------------
MAV_4704|M.avium_104 ---------------
MUL_2440|M.ulcerans_Agy99 YAYLYAFNKILPGVL
MLBr_01182|M.leprae_Br4923 ---------------
TH_3569|M.thermoresistible__bu ---------------
Mflv_0401|M.gilvum_PYR-GCK ---------------
MSMEG_0412|M.smegmatis_MC2_155 ---------------
MAB_0936c|M.abscessus_ATCC_199 ---------------
MMAR_4939|M.marinum_M ---------------
Mvan_0761|M.vanbaalenii_PYR-1 ---------------