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IAAVAAVVTAALVTTVPALGATAFTISGTRILHDPPYPEQLVPGEFAGYDVEHIKYPASVFGMDRGIWEA AGAVAAGVDRFVGVDDEGNPITEKIIVAGFSQGAIVIAYEKKRLMKLDEDERPTVDQLKFVTIGDPTGPN GILRWIPFRIPIIGLTPVRPPDTPYETTIINGEYDGWADFPDRPWNLIATANALLGIIYVHGRYEDKVDG WDLSTVPEKNIVETVNKAGGKTTTYLIPTEKLPLLQPLRDLGFPESFVAALEAPLRKIIDAAYKRNDPGR VTVTTTEETVVEDESEITQTAVTEIDETPSTDGDIDETAVQSTTQRRTVANTAADRTAETAEVAEVTEDV DELAEQEEPVKEEATKDDEVTKVADEADKATPVKESTSVEKTDQAVKPDDTDKTVTTAEKVEKADEAEKV EKTKPNVRKVKRPQFNVFKPKKTRVTVPKAEPSTKAKPATKPDNDNDDTSDTTDKTAEKDAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6144 | - | - | 100% (483) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_5759 | - | 2e-52 | 41.18% (289) | PE family protein |
| M. smegmatis MC2 155 | MSMEG_5350 | - | 1e-40 | 32.71% (425) | PPE family protein, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1465 | PE16 | 4e-31 | 33.67% (294) | PE family protein |
| M. gilvum PYR-GCK | Mflv_3371 | - | 1e-32 | 28.57% (427) | hypothetical protein Mflv_3371 |
| M. tuberculosis H37Rv | Rv1430 | PE16 | 4e-31 | 33.67% (294) | PE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 6e-27 | 39.18% (194) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_4141 | - | 1e-27 | 28.12% (480) | PE/PPE family protein |
| M. marinum M | MMAR_2235 | - | 1e-29 | 40.43% (188) | PE-PGRS family protein, PE16 |
| M. avium 104 | MAV_1760 | - | 2e-25 | 32.49% (237) | hypothetical protein MAV_1760 |
| M. thermoresistible (build 8) | TH_3724 | - | 2e-39 | 34.31% (376) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 8e-22 | 34.04% (188) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_2535 | - | 1e-38 | 33.17% (404) | hypothetical protein Mvan_2535 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3371|M.gilvum_PYR-GCK --------MRRSIR--KRAGLACGAVFASAAMAVSTATGASAVTT-----
Mvan_2535|M.vanbaalenii_PYR-1 --------MRRTTGKVRRSAVTCAAAAVTAGLAMATATPGWGVST-----
MLBr_01232|M.leprae_Br4923 --------MKRLLATTLAALTVGTVSGFGSTVASSEPGEPWLPPSPVPVR
MAV_1760|M.avium_104 --------MKQLLAGVTALLSVSTAGYFGIGTAAADGGPIGGPPTPGAPG
Mb1465|M.bovis_AF2122/97 --MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVS
Rv1430|M.tuberculosis_H37Rv --MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVS
MMAR_2235|M.marinum_M --MSFVVTAPETVVAAASQLTGIGSAIEAANAAAAALTTRLLPAAADEVS
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
TH_3724|M.thermoresistible__bu -----VVAVGALTWGGXGVASPAGQPERAAALRLTATADAIIMPG-----
MSMEG_6144|M.smegmatis_MC2_155 --------MIAAVAAVVTAALVTTVPALGATAFTISGTRILHDPPYP---
MAB_4141|M.abscessus_ATCC_1997 -------MAGQYSVPGKRHSLRRYVATITAVAATCTVLAPLAMES-----
Mflv_3371|M.gilvum_PYR-GCK -------AVAIGGLGTPDMHEIVINPLLGGKLARENDILDGVEWPAEAK-
Mvan_2535|M.vanbaalenii_PYR-1 -------ALVIGGIGTPTLHDVVMSELLGGALR-DYDQRRAVSWPAQARP
MLBr_01232|M.leprae_Br4923 ENSPAKIVYALGGARPPTFDWDYYTIRAGDEFFPDVNR-KLIDYPARAPF
MAV_1760|M.avium_104 D----QTAYALGGAHVLGIPYDQYIRMEGADWFPGQQR-QIVRYPAGQVQ
Mb1465|M.bovis_AF2122/97 AAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALV
Rv1430|M.tuberculosis_H37Rv AAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALV
MMAR_2235|M.marinum_M AGIAALMSTHAQEYQLLGGQLATYHDQLVQALDRTAGWYADAETGNAALL
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKAL
TH_3724|M.thermoresistible__bu ---------TKIGYIPSQDEFTAYATAVIGATAGAPGAVDYLGVPGEFWP
MSMEG_6144|M.smegmatis_MC2_155 ------EQLVPGEFAGYDVEHIKYPASVFGMDRGIWEAAGAVAAGVDRFV
MAB_4141|M.abscessus_ATCC_1997 -------RTIASTLASYVIGIGGNNDGASANIPRKLGGAYSVDYHPVSYP
Mflv_3371|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2535|M.vanbaalenii_PYR-1 Y-------------------------------------------------
MLBr_01232|M.leprae_Br4923 R-------------------------------------------------
MAV_1760|M.avium_104 G-------------------------------------------------
Mb1465|M.bovis_AF2122/97 D---------------------TAATGAS--------ELGSGG-----RT
Rv1430|M.tuberculosis_H37Rv D---------------------TAATGAS--------ELGSGG-----RT
MMAR_2235|M.marinum_M RNVQQELLTGLTAPGRAWSGAGAASAGASGVDALMSSALLSGG-----RS
MUL_0967|M.ulcerans_Agy99 AGLTEPVAN---LFAPVLSGPESVAASAT--------ALLSGAPLKPVEA
TH_3724|M.thermoresistible__bu A-------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 G-------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 G-------------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK ----------------------------RPGTGQTLGQS--------ITV
Mvan_2535|M.vanbaalenii_PYR-1 ----------------------------TGAADMTLGDS--------IEI
MLBr_01232|M.leprae_Br4923 ----------------------------YVPTFLVPGP-----------R
MAV_1760|M.avium_104 ----------------------------HVLERLFPGIGKLDESFPGLGM
Mb1465|M.bovis_AF2122/97 ALILGSTGTPRPPFDYMQQVYDRYIAPHY-LGYAFSGLYTPAQFQPWTGI
Rv1430|M.tuberculosis_H37Rv ALILGSTGTPRPPFDYMQQVYDRYIAPHY-LGYAFSGLYTPAQFQPWTGI
MMAR_2235|M.marinum_M VLVVGSTGTPRPSYRFMREVYDLFVAPHY-FGDSLFGVQTPAQFQPFTGI
MUL_0967|M.ulcerans_Agy99 ALILSESGVPTPSASYISDVYTKYVEPNFPSATAPQGVSTPNGLYPFTGI
TH_3724|M.thermoresistible__bu -----------------------------------------------TGL
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
MAB_4141|M.abscessus_ATCC_1997 ------------------------------------------AIWPVSGL
Mflv_3371|M.gilvum_PYR-GCK GITNLGTHFDAAFARLE-----------AGEQFTVVGFSAGSLVVNDFMR
Mvan_2535|M.vanbaalenii_PYR-1 GTANLNADIDAALGRLERDADG---NLLEGERVTVVGLSAGSLVVTEVLR
MLBr_01232|M.leprae_Br4923 DEVTIGEAIAVATKNLNQAIHR------GTEPAAVVGLSQGSLALDTEQE
MAV_1760|M.avium_104 DGPSVGESVAEGIDNLDAAIRT------TGRPGTAIGLSEGAFVVDGEQA
Mb1465|M.bovis_AF2122/97 PSLTYDQSVAEGAGYLHTAIMQQVAA---GNDVVVLGFSQGASVATLEMR
Rv1430|M.tuberculosis_H37Rv PSLTYDQSVAEGAGYLHTAIMQQVAA---GNDVVVLGFSQGASVATLEMR
MMAR_2235|M.marinum_M PNLTFDESAATGASYLHAAITQQLAD---GNRVVVAGFSQGASVATLEMR
MUL_0967|M.ulcerans_Agy99 KDLSLDISLARGATILNDAILQQLAALPAGSSVAVLGYSQSAVLSSRVMP
TH_3724|M.thermoresistible__bu DSLTFDASVAXGQAMLTPMVDGAIES---DTPIVVFGHSQSAVIATKEKQ
MSMEG_6144|M.smegmatis_MC2_155 --------VDDEGNPIT-------------EKIIVAGFSQGAIVIAYEKK
MAB_4141|M.abscessus_ATCC_1997 TAPTFKTSVAQGRTNLNDEIVTAG-----NQPITIVGYSLGAVVVSKSHS
: * * .:
Mflv_3371|M.gilvum_PYR-GCK ELAND--PDAPTKDQVKFILVADS--------SRQKLLNETSKYNPQYDY
Mvan_2535|M.vanbaalenii_PYR-1 EWQSDG-EENPEADEINFVVVADS--------SRQQIIDDTERYNPVYDY
MLBr_01232|M.leprae_Br4923 QLATD--PTAPPPDQLTFNTFGDPSGYHGFGKSVLASIFRPGDYIPLIDY
MAV_1760|M.avium_104 RLAND--PTAPPPNTLNFATFGDPIGRHAFGQSFLTAMFGVGSVVPALDY
Mb1465|M.bovis_AF2122/97 HLASLPAGVAPSPDQLSFVLLGNPN-----NPNGGILARFPGLYLQSLGL
Rv1430|M.tuberculosis_H37Rv HLASLPAGVAPSPDQLSFVLLGNPN-----NPNGGILARFPGLYLQSLGL
MMAR_2235|M.marinum_M HLQSLPIDSRPSPEDLSFVLLGNPN-----NPNGGILARFPGLYIQSVGL
MUL_0967|M.ulcerans_Agy99 KLLAEGVTSS----QVNFVLLGNPM-----NPNGGVLARFPDLTLPSLGF
TH_3724|M.thermoresistible__bu RLLAEY-PDPDTAPDVTFVMVANPN-----RPNGGLLARFPGLYIPILGV
MSMEG_6144|M.smegmatis_MC2_155 RLMKLDEDERPTVDQLKFVTIGDPT-------GPNGILRWIPFRIPIIGL
MAB_4141|M.abscessus_ATCC_1997 DLLQRYPGGNP---NIQFVLMGSAN-----TPNGGIFARFPWLKIPLADI
: * .... . .
Mflv_3371|M.gilvum_PYR-GCK TYR-PAPQT---MYDIDVVTGEYDGAADLPDRWWNFLALANAIAGGLFVH
Mvan_2535|M.vanbaalenii_PYR-1 TYR-RAPQT---PYDTVEVTGEYDGLADFPDRWWNLTAVANALAGAAVRH
MLBr_01232|M.leprae_Br4923 TMP-QRMDS---QYDSNRVVAAYDGLSEFPDRADNLLAQLNCFAGGAISH
MAV_1760|M.avium_104 TMP-PPYES---QYDTNRFVAAYDSIADFPDRPDNMFALANTLMGLATGH
Mb1465|M.bovis_AF2122/97 TFNGATPDT---DYATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSH
Rv1430|M.tuberculosis_H37Rv TFNGATPDT---DYATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSH
MMAR_2235|M.marinum_M TFNGATPVT---EYPTTVYTTQYDGFADFPQYPLNVVADVNALLGISYSH
MUL_0967|M.ulcerans_Agy99 TFYGATPDN---AFPTVSYTLEYDGFADFPRYPINLLADINAVMGIPFVH
TH_3724|M.thermoresistible__bu TFNGATPAPADGPFDSYDVAREFDGWADFPRYPLNLVATANAILGIYYLH
MSMEG_6144|M.smegmatis_MC2_155 TPVRPPDTP----YETTIINGEYDGWADFPDRPWNLIATANALLGIIYVH
MAB_4141|M.abscessus_ATCC_1997 ESNGAWEPD---QFKTKVINTEYDTYGDFPAY-FNPLALANSIAAIQYAH
: :* .::* * * * . . *
Mflv_3371|M.gilvum_PYR-GCK VPMMFSDY---EAVTPEENITRVTNTLGGTTTTYLVPTKTLPLVQLLPFL
Mvan_2535|M.vanbaalenii_PYR-1 ILAMFADL---SQV-PDENVTVTQNLLGGTTTRYLVPAQRLPLVLLNPSL
MLBr_01232|M.leprae_Br4923 TPSGFFNP---EDV-PPQNIRTTVNSRGAKTTTYLIPVNHLPLTLPLRYL
MAV_1760|M.avium_104 TAVAFTNP---SMV-PPQNIRTTINSRGAKDTTIMIPEKHLPLVMPLKYI
Mb1465|M.bovis_AF2122/97 SLYYGLTP---EQV--ASGIVLPVSSPDTNTTYILLPNEDLPLLQPLRGI
Rv1430|M.tuberculosis_H37Rv SLYYGLTP---EQV--ASGIVLPVSSPDTNTTYILLPNEDLPLLQPLRGI
MMAR_2235|M.marinum_M SLYYGLTP---DQV--AAGVVLPVSSPDVNTTYILIPNEHLPLLQPLRGI
MUL_0967|M.ulcerans_Agy99 ADYQDLTQ---AQL--DSAVQLPTEGP-TQSTYYMIPTEHLPLLAPLRFI
TH_3724|M.thermoresistible__bu GGYYELLT---ENPDILDDPERTIVQQYGDTTYYLIRTEQLPLLRPLRDL
MSMEG_6144|M.smegmatis_MC2_155 GRYEDKVDGWDLSTVPEKNIVETVNKAGGKTTTYLIPTEKLPLLQPLRDL
MAB_4141|M.abscessus_ATCC_1997 PDAYYDRID--PAALDDPDNPNVVKTVQGNTTYYLVRAEHLPLLQPLRDL
* :: : *** :
Mflv_3371|M.gilvum_PYR-GCK KS--QEASLKAKIDAGYSRNDDRLAAAA----AATSTARSLAAPTVTNEA
Mvan_2535|M.vanbaalenii_PYR-1 AP--REAELKATVDRGYSRND-----------PVRTALR-----TLTNEV
MLBr_01232|M.leprae_Br4923 G--------------------------------------------WSDAL
MAV_1760|M.avium_104 G--------------------------------------------IDENT
Mb1465|M.bovis_AF2122/97 ----VPEPLLDLIEPDLRAIIELGYDR------TGYADVPTPAALFPVHI
Rv1430|M.tuberculosis_H37Rv ----VPEPLLDLIEPDLRAIIELGYDR------TGYADVPTPAALFPVHI
MMAR_2235|M.marinum_M ----VPDSVLDGIEPGLRDVVELGYDR------TGYADVPTPASLFPANV
MUL_0967|M.ulcerans_Agy99 PY--VGDPLAELLEPNLRVLVNFGYGDPAYGYDTGPANVPTPFGLFPP-V
TH_3724|M.thermoresistible__bu G---VPEEFVDALEPYVRRIVDLGYDRN-----TPYGEPAP---------
MSMEG_6144|M.smegmatis_MC2_155 G---FPESFVAALEAPLRKIIDAAYKRNDPGRVTVTTTEETVVEDESEIT
MAB_4141|M.abscessus_ATCC_1997 TNPIGASFVLDAIEPTLRVFIDMAYDRDTGPGTTTQFSFFTPSKNIVDAF
Mflv_3371|M.gilvum_PYR-GCK TD------------------------------------------------
Mvan_2535|M.vanbaalenii_PYR-1 PD------------------------------------------------
MLBr_01232|M.leprae_Br4923 VD------------------------------------------------
MAV_1760|M.avium_104 LN------------------------------------------------
Mb1465|M.bovis_AF2122/97 DP------------------------------------------------
Rv1430|M.tuberculosis_H37Rv DP------------------------------------------------
MMAR_2235|M.marinum_M NPNVVAGAFVEGAVRGIDNGLAGMGLPPLPDLPAAPLLPEIWSNAPPIPG
MUL_0967|M.ulcerans_Agy99 SP------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 QTAVTEIDETPSTDG-----------------------------------
MAB_4141|M.abscessus_ATCC_1997 NKLPTAIAEGAHNVENGLAG------------------------------
Mflv_3371|M.gilvum_PYR-GCK ---------EVADDEAVATVQKISTDSDAEQADVPAERTSSKPAVDDAAD
Mvan_2535|M.vanbaalenii_PYR-1 ---------DVEDTVTPQDTQDEVEASEGDGA-APTGTSADHAEVSEATA
MLBr_01232|M.leprae_Br4923 ---------QIDAVLQPKIDAAYAYNDN------PLNKPISVDPVNGMDP
MAV_1760|M.avium_104 ---------KLDAILTPRVNAGYSRNDD------PATAPVQVDPVHGFDP
Mb1465|M.bovis_AF2122/97 --------IAVPPQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQAG
Rv1430|M.tuberculosis_H37Rv --------IAVPPQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQAG
MMAR_2235|M.marinum_M WPASVPSAIAVPPQLGGAIAGPLDHLYRTLDSVINGQINPAITSGIYQYG
MUL_0967|M.ulcerans_Agy99 --------LTVAEHLAAGTQQGIVNSG----AALQAQGPPSIP--LSDIA
TH_3724|M.thermoresistible__bu --------VRVLPPLTPAPGPATQHNAGQGITVASATSTPDKRTPVVEAP
MSMEG_6144|M.smegmatis_MC2_155 ---------DIDETAVQSTTQRRTVANTAADRTAETAEVAEVTEDVDELA
MAB_4141|M.abscessus_ATCC_1997 --ATPKQSASPEKPASPPVPQPGPTNPGSATTQIPAPEAPTPSVVSLSTA
Mflv_3371|M.gilvum_PYR-GCK DDEAAANEDAEADAADAKVDAKEDAEAAVKDDADASAGTNDDGEEGADSG
Mvan_2535|M.vanbaalenii_PYR-1 EDRDVTADDAEAPGDETRSTEDVDREATEPDSESDDTVTQNDAE------
MLBr_01232|M.leprae_Br4923 ----IAGIDAELR---DSILNVFAQLRSILPPPPG---------------
MAV_1760|M.avium_104 AEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAGEADH-----------
Mb1465|M.bovis_AF2122/97 AELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDAIQ
Rv1430|M.tuberculosis_H37Rv AELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDAIQ
MMAR_2235|M.marinum_M ADLSAEAARHGASSELLNAIYVGRQVLPILIEGPGVILTADTYYSINAIK
MUL_0967|M.ulcerans_Agy99 HTLTANPPWAGTPA-LPPSTSPASSIEDFIL----AVQAANSSISRGFVK
TH_3724|M.thermoresistible__bu VEEPPVQTGRSTLKREKPVSARHLVRNSLRAVPGLRRGEPAATPTPDVTP
MSMEG_6144|M.smegmatis_MC2_155 EQEEPVKEEATKDDEVTKVADEADKATPVKESTSVEKTDQAVKPDDTDKT
MAB_4141|M.abscessus_ATCC_1997 EPPAPPASAKAADPTAISVSTAGASTARDQDFQPDTKPDPKSTPPPTKDS
Mflv_3371|M.gilvum_PYR-GCK SNDSAAAAGDTDSSDGSSSEGPGSSDSGSSE-------------------
Mvan_2535|M.vanbaalenii_PYR-1 PRESAADTAAEDS---------GPSD------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mb1465|M.bovis_AF2122/97 DLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV---
Rv1430|M.tuberculosis_H37Rv DLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV---
MMAR_2235|M.marinum_M DLAAGNLSGFNQNLQLIPATNAMLLTFGATIPIAAGVSAYIGRDFP----
MUL_0967|M.ulcerans_Agy99 TLSTAYAT-LLPTTDIASELVFTLPSYNLNLFLDGVIQAINGQPIGD---
TH_3724|M.thermoresistible__bu DVTPDAPAGQPEPAEPNESAAPPAAAEADDASE-----------------
MSMEG_6144|M.smegmatis_MC2_155 VTTAEKVEKADEAEKVEKTKPNVRKVKRPQFNVFKPKKTRVTVPKAEPST
MAB_4141|M.abscessus_ATCC_1997 VGEADKSKNTLKPTLRLPKLPVAQPGTAPKSPKFPSLKNHLKSVPGLSEK
Mflv_3371|M.gilvum_PYR-GCK -------------------------------------
Mvan_2535|M.vanbaalenii_PYR-1 -------------------------------------
MLBr_01232|M.leprae_Br4923 -------------------------------------
MAV_1760|M.avium_104 -------------------------------------
Mb1465|M.bovis_AF2122/97 -------------------------------------
Rv1430|M.tuberculosis_H37Rv -------------------------------------
MMAR_2235|M.marinum_M -------------------------------------
MUL_0967|M.ulcerans_Agy99 -------------------------------------
TH_3724|M.thermoresistible__bu -------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 KAKPATKPDNDNDDTSDTTDKTAEKDAA---------
MAB_4141|M.abscessus_ATCC_1997 KNPAADASSKHSQPANAPAHTSDKTSDHASETGRGAA