For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VSYVVAAPDFLSTAAEDLAAMGSAVSTATAAAARSTTLLLAAGADEVSTHIAALFSTHGLQYQLASAQAA EFHERFVLTLAADANTYLTTEIANAQRCLAGAINAPATALLGHPLLGADPTASASTAATPAGGASMAPAA AGTRITVPGAGPLYYPRFLTELPYLGQALLLGIPGPSSASILQGYDLINHAIGENWFPDTIASVINYPAS IGILSGSLAAPDTNTAVAIGARMLHEQIMSAVTNGSGLPVHVATLSQGTIVANRELAYLATDPNAPPAHA LEFALFGSPELGLAHIYLPDGLTVPLINYTVHGLSNTQYDVSVVNGQYDFWGNPPDRPWNLPAWVNSLFG AAYYHNTSSFASLSDAVEVSSVTTSLGGTITTYLIPSPTLPMLLPLEQIGVPAPIVAGLNSVLAPIVNDG YSSLTPNAGPYFSQGALVGLPSAADVLGSWPWPALGSVTAHIC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4939 | - | - | 100% (463) | PE-PGRS family protein |
| M. marinum M | MMAR_2235 | - | 4e-38 | 31.34% (485) | PE-PGRS family protein, PE16 |
| M. marinum M | MMAR_0371 | - | 1e-36 | 31.11% (434) | PE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3569 | PPE63 | 7e-89 | 44.72% (436) | PPE family protein |
| M. gilvum PYR-GCK | Mflv_0401 | - | 2e-28 | 30.90% (343) | hypothetical protein Mflv_0401 |
| M. tuberculosis H37Rv | Rv3539 | PPE63 | 7e-89 | 44.72% (436) | PPE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 3e-26 | 32.28% (254) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 2e-26 | 33.22% (286) | hypothetical protein MAB_0936c |
| M. avium 104 | MAV_1760 | - | 4e-27 | 30.81% (344) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_5350 | - | 3e-28 | 35.58% (208) | PPE family protein, putative |
| M. thermoresistible (build 8) | TH_3724 | - | 4e-14 | 26.56% (320) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 7e-34 | 29.57% (443) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_0761 | - | 5e-30 | 38.55% (166) | hypothetical protein Mvan_0761 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3569|M.bovis_AF2122/97 ---MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFE
Rv3539|M.tuberculosis_H37Rv ---MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFE
MMAR_4939|M.marinum_M ----MSYVVAAPDFLSTAAEDLAAMGSAVSTATAAAARSTTLLLAAGADE
MAB_0936c|M.abscessus_ATCC_199 ---MRNLLAGTAVLVVACVTGCFGIPSAVADDPQVPGPP-IPGIAPDGTV
MAV_1760|M.avium_104 ---MKQLLAGVTALLSVSTAGYFGIGTAAADGGPIGGPP-TPG-APG---
Mflv_0401|M.gilvum_PYR-GCK ---MRRHLAFATAITTLGATGILGLGIAAAQPAPAPPPPPAPGAAAG---
MLBr_01232|M.leprae_Br4923 ---MKRLLATTLAALTVGTVSGFGSTVASSEPGEPWLPP-SPVPVRE---
MSMEG_5350|M.smegmatis_MC2_155 MISWRKQLVPLIAAASLVLASGTVVDVASRAEEAILIPGATVLKPIN---
Mvan_0761|M.vanbaalenii_PYR-1 MVVVRRWLVPLIALVSVLLGIGTAANPVSAAEEAVLIPGASPFKPIN---
TH_3724|M.thermoresistible__bu -------------VVAVGALTWGGXGVASPAGQPERAAALRLTATAD---
MUL_1034|M.ulcerans_Agy99 ----MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALTSGLLAAAQDE
Mb3569|M.bovis_AF2122/97 SVCSGLADRWWQGPSSRMMAAQAAR-HTGWLAAAATQAEGAASQAQTMAL
Rv3539|M.tuberculosis_H37Rv SVCSGLADRWWQGPSSRMMAAQAAR-HTGWLAAAATQAEGAASQAQTMAL
MMAR_4939|M.marinum_M VSTHIAALFSTHGLQYQLASAQAAEFHERFVLTLAADAN-----------
MAB_0936c|M.abscessus_ATCC_199 ----KAAPSAPDRTAYALGGAHVLG------------------------I
MAV_1760|M.avium_104 -----------DQTAYALGGAHVLG------------------------I
Mflv_0401|M.gilvum_PYR-GCK ----APTPLGTPGRGYALGGAHVLG------------------------I
MLBr_01232|M.leprae_Br4923 --------NSPAKIVYALGGARPPT------------------------F
MSMEG_5350|M.smegmatis_MC2_155 -------------PFYPLIALNYPK-------------------------
Mvan_0761|M.vanbaalenii_PYR-1 -------------PFYPIIAATYRY-------------------------
TH_3724|M.thermoresistible__bu --------------AIIMPGTKIGY-------------------------
MUL_1034|M.ulcerans_Agy99 VSAAIAKVFSAYGQEYQAAIAQASAFHTEFTRALAAAG-----------A
Mb3569|M.bovis_AF2122/97 AYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWA
Rv3539|M.tuberculosis_H37Rv AYEAAFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWA
MMAR_4939|M.marinum_M TYLTTEIANAQRCLAGAINAPATALLGHPLLGADPTASASTAATPAGGAS
MAB_0936c|M.abscessus_ATCC_199 PYDEYIRMTGKDWFPNMKRENVWYPAG-----------------------
MAV_1760|M.avium_104 PYDQYIRMEGADWFPGQQRQIVRYPAG-----------------------
Mflv_0401|M.gilvum_PYR-GCK PYDEYIMRTGADWFPGLDREIVDYPAG-----------------------
MLBr_01232|M.leprae_Br4923 DWDYYTIRAGDEFFPDVNRKLIDYPAR-----------------------
MSMEG_5350|M.smegmatis_MC2_155 --------IGIHFHEDGQPLLIDYSQD-----------------------
Mvan_0761|M.vanbaalenii_PYR-1 --------IGINLHDDADAQLVDYSQN-----------------------
TH_3724|M.thermoresistible__bu -------IPSQDEFTAYATAVIGATAG-----------------------
MUL_1034|M.ulcerans_Agy99 AYAQAEAANASLITAGVSDALTAITTPIQSLLGPAAIGTGGAGSAGALTA
Mb3569|M.bovis_AF2122/97 QDVVAMLNYHAVASAVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPS
Rv3539|M.tuberculosis_H37Rv QDVVAMLNYHAVASAVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPS
MMAR_4939|M.marinum_M MAPAAAGTRITVP---GAGPLYYPRFLTELP-YLG---------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mflv_0401|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MSMEG_5350|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_0761|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
MUL_1034|M.ulcerans_Agy99 VSSTLMADPVVALIMGGTSVPLPGP-------------------------
Mb3569|M.bovis_AF2122/97 STTTRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEV
Rv3539|M.tuberculosis_H37Rv STTTRITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEV
MMAR_4939|M.marinum_M -QALLLGIPGPS---SASIL--------QGYDLINHAIGENWFPDTIASV
MAB_0936c|M.abscessus_ATCC_199 --------------------------------QVQGHTLERFFPGIGPIG
MAV_1760|M.avium_104 --------------------------------QVQGHVLERLFPGIGKLD
Mflv_0401|M.gilvum_PYR-GCK --------------------------------QVQGHTLERLFPGIGAFG
MLBr_01232|M.leprae_Br4923 --------------------------------APFRYVPTFLVPGP----
MSMEG_5350|M.smegmatis_MC2_155 ----------------------------------ALNSDKALLDGV----
Mvan_0761|M.vanbaalenii_PYR-1 ----------------------------------PFSTDRALLDGV----
TH_3724|M.thermoresistible__bu ---------------------------------APGAVDYLGVPGEFWPA
MUL_1034|M.ulcerans_Agy99 ----------------------------GYVSDINNNYIQPLFSGAIPQA
. .
Mb3569|M.bovis_AF2122/97 VSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQ--PVTVAG
Rv3539|M.tuberculosis_H37Rv VSYPATIGVLSGSLGAVDANQSIAIGQQMLHNEILAATASGQ--PVTVAG
MMAR_4939|M.marinum_M INYPASIGILSGSLAAPDTNTAVAIGARMLHEQIMSAVTNGSGLPVHVAT
MAB_0936c|M.abscessus_ATCC_199 EKILPGLGLDGPSIG-----ESIDIGEPNLENAIR-----SGG-PGTAMG
MAV_1760|M.avium_104 ES-FPGLGMDGPSVG-----ESVAEGIDNLDAAIR-----TTGRPGTAIG
Mflv_0401|M.gilvum_PYR-GCK DRIAPGLGLDGPSYG-----ESIDVGAPNLIGAIR-----RGG-PGTAIG
MLBr_01232|M.leprae_Br4923 --------RDEVTIG-----EAIAVATKNLNQAIH-----RGTEPAAVVG
MSMEG_5350|M.smegmatis_MC2_155 --------------------QQTMIAVQQTDGKIV------------IIG
Mvan_0761|M.vanbaalenii_PYR-1 --------------------ERADVAVREIDGQVV------------VIG
TH_3724|M.thermoresistible__bu TG-LDSLTFDASVAX------GQAMLTPMVDGAIES------DTPIVVFG
MUL_1034|M.ulcerans_Agy99 LFTPEQFWPVTPGLGNLTFNQSVAQGVTLLNDAIN--TQLALGNKVVAFG
:
Mb3569|M.bovis_AF2122/97 LSMGSMVIDRE-LAYLAIDPNAPPSSALTFVELAGP------ERGLAQTY
Rv3539|M.tuberculosis_H37Rv LSMGSMVIDRE-LAYLAIDPNAPPSSALTFVELAGP------ERGLAQTY
MMAR_4939|M.marinum_M LSQGTIVANRE-LAYLATDPNAPPAHALEFALFGSP------ELGLAHIY
MAB_0936c|M.abscessus_ATCC_199 LSEGALVLNAV-KNALATDPTAPEPESLTFATFGDPIAKSPFSESFLTQN
MAV_1760|M.avium_104 LSEGAFVVDGE-QARLANDPTAPPPNTLNFATFGDPIGRHAFGQSFLTAM
Mflv_0401|M.gilvum_PYR-GCK LSEGASVLDEV-QARLAYDPAAPPPDQLSFATYGNPVGKHAFGESFLTQN
MLBr_01232|M.leprae_Br4923 LSQGSLALDTE-QEQLATDPTAPPPDQLTFNTFGDPSGYHGFGKSVLASI
MSMEG_5350|M.smegmatis_MC2_155 ESMGSMVAARV-AKELAASPNP-RLDDVRVVLIAPP-------EVGVAEY
Mvan_0761|M.vanbaalenii_PYR-1 ESMGSMVASRL-AADLAHSPDPPSPDDIRFVLIASP-------EEGVAQY
TH_3724|M.thermoresistible__bu HSQSAVIATKEKQRLLAEYPDPDTAPDVTFVMVANPNR----PNGGLLAR
MUL_1034|M.ulcerans_Agy99 YSQSATIVNNEILALMAMGTGAPDPGDLSFIMVGAPNN----PDGGLLAR
* .: :* . . : . . *
Mb3569|M.bovis_AF2122/97 LPVGTTIPIAGYTVG----NAPESQYNTSVVYSQYDIWADPPDRPWNLLA
Rv3539|M.tuberculosis_H37Rv LPVGTTIPIAGYTVG----NAPESQYNTSVVYSQYDIWADPPDRPWNLLA
MMAR_4939|M.marinum_M LPDGLTVPLINYTVH----GLSNTQYDVSVVNGQYDFWGNPPDRPWNLPA
MAB_0936c|M.abscessus_ATCC_199 FAPGSVVPFMDYPVP----ARVDSQYHTDQFISAYDSIADWPDRPDNLFA
MAV_1760|M.avium_104 FGVGSVVPALDYTMP----PPYESQYDTNRFVAAYDSIADFPDRPDNMFA
Mflv_0401|M.gilvum_PYR-GCK FPVGSVVPSLDYRIP----APVESQYDTYKFVSAYDSIADWPDRPDNWLS
MLBr_01232|M.leprae_Br4923 FRPGDYIPLIDYTMP----QRMDSQYDSNRVVAAYDGLSEFPDRADNLLA
MSMEG_5350|M.smegmatis_MC2_155 FKEGTFIPILNYRVK----RVALSPYPTTIVIGEYDGWADPPDRPWNLLA
Mvan_0761|M.vanbaalenii_PYR-1 FKEGTRIPLLNYTVS----RVAQSPYPTTVVFGEYDGWADPPDRPWNLVA
TH_3724|M.thermoresistible__bu FP-GLYIPILGVTFNGATPAPADGPFDSYDVAREFDGWADFPRYPLNLVA
MUL_1034|M.ulcerans_Agy99 FP-GFYIPFLDVSFNG--ATPAANPYPTSIFTAQYDGIAHAPQYRLNILS
: * :* . . : . :* .. * * :
Mb3569|M.bovis_AF2122/97 GANALMGAAYFHD-LTAY-AAPQ--QGIEIAAVTSSLG-GTTTTYMIPSP
Rv3539|M.tuberculosis_H37Rv GANALMGAAYFHD-LTAY-AAPQ--QGIEIAAVTSSLG-GTTTTYMIPSP
MMAR_4939|M.marinum_M WVNSLFGAAYYHN-TSSF-ASLS--DAVEVSSVTTSLG-GTITTYLIPSP
MAB_0936c|M.abscessus_ATCC_199 LANAIAGLATGHT-AVAF-TNPKMVPARNIVTETNSRG-GTTTTYFIPEQ
MAV_1760|M.avium_104 LANTLMGLATGHT-AVAF-TNPSMVPPQNIRTTINSRG-AKDTTIMIPEK
Mflv_0401|M.gilvum_PYR-GCK VANAIVGLATGHT-AVAF-TDPSMVPERNIRTTVNSRG-ATTTTYMIPEE
MLBr_01232|M.leprae_Br4923 QLNCFAGGAISHT-PSGF-FNPEDVPPQNIRTTVNSRG-AKTTTYLIPVN
MSMEG_5350|M.smegmatis_MC2_155 TANALLGIVYVHG-VPSFTTDPNDVPPENVKTIPGNADHGPITTMLVPTK
Mvan_0761|M.vanbaalenii_PYR-1 VANAAMGLIYVHG-PAMWDVDLSDVPPENITVD------GTVTRYFVPTE
TH_3724|M.thermoresistible__bu TANAILGIYYLHGGYYELLTENPDILDDPERTIVQQYG--DTTYYLIRTE
MUL_1034|M.ulcerans_Agy99 DINAIMGYFYVHG------NYPDLMSGQAIQLPTSPGYTGNTDYYMYLTQ
* * * :
Mb3569|M.bovis_AF2122/97 TLPLLLPLKQIGVP-DWIVGGLNNVLKPLVDAGYSQYAPT--AGPYFSHG
Rv3539|M.tuberculosis_H37Rv TLPLLLPLKQIGVP-DWIVGGLNNVLKPLVDAGYSQYAPT--AGPYFSHG
MMAR_4939|M.marinum_M TLPMLLPLEQIGVP-APIVAGLNSVLAPIVNDGYSSLTPN--AGPYFSQG
MAB_0936c|M.abscessus_ATCC_199 HLPLVMGFKYLGVP-EETLNRLDAILQPRVDAGYSRNDDP--ATAPIAVD
MAV_1760|M.avium_104 HLPLVMPLKYIGID-ENTLNKLDAILTPRVNAGYSRNDDP--ATAPVQVD
Mflv_0401|M.gilvum_PYR-GCK HLPLVLPFKYLGVP-KDTLMELDKVLLPYVDAGYSRNDDP--ATAPITVD
MLBr_01232|M.leprae_Br4923 HLPLTLPLRYLGWS-DALVDQIDAVLQPKIDAAYAYNDNP--LNKPISVD
MSMEG_5350|M.smegmatis_MC2_155 NLPLTQFLRDIGVP-DQWVDAIDNILRPIIDSAYVRNDKPGDSRPYLYNG
Mvan_0761|M.vanbaalenii_PYR-1 HLPLTRPFRDLGVP-DCLVDAADHILRPIIDAGYRRHDQPGDSRPYLYDG
TH_3724|M.thermoresistible__bu QLPLLRPLRDLGVP-EEFVDALEPYVRRIVDLGYDRNTPYGEPAPVRVLP
MUL_1034|M.ulcerans_Agy99 DLPLVQPIRDIPYAGPPLADLIQPQLRVLVDLGYSDYGPG---LSYADVP
**: :. : : : :: .*
Mb3569|M.bovis_AF2122/97 NLVW----------------------------------------------
Rv3539|M.tuberculosis_H37Rv NLVW----------------------------------------------
MMAR_4939|M.marinum_M ALVGLPSAADVLGSWPWPALGSVTAHIC----------------------
MAB_0936c|M.abscessus_ATCC_199 PRRGFDPAEVTAPASQATFGGGSDPISQITSGALAVLGNGTRPTPPN---
MAV_1760|M.avium_104 PVHGFDPAEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAGEADH----
Mflv_0401|M.gilvum_PYR-GCK PVNGYDPAEVTAPATQAAFGGGADPVSQLLSGLQYILNNPP---------
MLBr_01232|M.leprae_Br4923 PVNGMDPIAGIDAELR-------DSILNVFAQLRSILPPPPG--------
MSMEG_5350|M.smegmatis_MC2_155 EIRRNVETPQEVETPEADVAGGVETTDVDTTSTETKDVGTHNAVDGDSKL
Mvan_0761|M.vanbaalenii_PYR-1 RIRRDVPPVVPLQQGGDDGGGGADE--------ENENAAQHPQADGDGRL
TH_3724|M.thermoresistible__bu PLTPAPGPATQHNAGQGITVASATSTPDKRTPVVEAPVEEPPVQTGRSTL
MUL_1034|M.ulcerans_Agy99 TPAGLLSVPNPFAVSYYLLKGSLQAPYGAAVEIGVEAGLLGPESFPDTYP
Mb3569|M.bovis_AF2122/97 --------------------------------------------------
Rv3539|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mflv_0401|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MSMEG_5350|M.smegmatis_MC2_155 GIKESDTKGVTTNDTKNDAKVVIKDVSKDVDTEVVTKDDETTATDTDTDT
Mvan_0761|M.vanbaalenii_PYR-1 DRDDLDVS----------------ESAEDPDVSEAAQDPDVSESAADRDG
TH_3724|M.thermoresistible__bu KREKPVSARHLVRNSLRAVPGLRRGEPAATPTPDVTPDVTPDAPAGQPEP
MUL_1034|M.ulcerans_Agy99 WVPSLNPGLNFYLGQPSVTLLSLLSGGLGDIFHLIPPPVFP---------
Mb3569|M.bovis_AF2122/97 --------------------------------------------------
Rv3539|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4939|M.marinum_M --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
Mflv_0401|M.gilvum_PYR-GCK --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MSMEG_5350|M.smegmatis_MC2_155 DTEARAGDDIEKKKSPRETRRERRHEHRDAIRDGLDNVKSQVESGLKDLA
Mvan_0761|M.vanbaalenii_PYR-1 RAVTHDPDVPESGEDP---------DARESTNDSADDSAQRQEAGG----
TH_3724|M.thermoresistible__bu AEPNESAAPPAAAEADDASE------------------------------
MUL_1034|M.ulcerans_Agy99 --------------------------------------------------
Mb3569|M.bovis_AF2122/97 ------------------------------
Rv3539|M.tuberculosis_H37Rv ------------------------------
MMAR_4939|M.marinum_M ------------------------------
MAB_0936c|M.abscessus_ATCC_199 ------------------------------
MAV_1760|M.avium_104 ------------------------------
Mflv_0401|M.gilvum_PYR-GCK ------------------------------
MLBr_01232|M.leprae_Br4923 ------------------------------
MSMEG_5350|M.smegmatis_MC2_155 KGLKGPRAKQKKVKNENETQSESASESDSE
Mvan_0761|M.vanbaalenii_PYR-1 ------------------------------
TH_3724|M.thermoresistible__bu ------------------------------
MUL_1034|M.ulcerans_Agy99 ------------------------------