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MRRTTGKVRRSAVTCAAAAVTAGLAMATATPGWGVSTALVIGGIGTPTLHDVVMSELLGGALRDYDQRRA VSWPAQARPYTGAADMTLGDSIEIGTANLNADIDAALGRLERDADGNLLEGERVTVVGLSAGSLVVTEVL REWQSDGEENPEADEINFVVVADSSRQQIIDDTERYNPVYDYTYRRAPQTPYDTVEVTGEYDGLADFPDR WWNLTAVANALAGAAVRHILAMFADLSQVPDENVTVTQNLLGGTTTRYLVPAQRLPLVLLNPSLAPREAE LKATVDRGYSRNDPVRTALRTLTNEVPDDVEDTVTPQDTQDEVEASEGDGAAPTGTSADHAEVSEATAED RDVTADDAEAPGDETRSTEDVDREATEPDSESDDTVTQNDAEPRESAADTAAEDSGPSD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2535 | - | - | 100% (409) | hypothetical protein Mvan_2535 |
| M. vanbaalenii PYR-1 | Mvan_1838 | - | e-105 | 50.12% (429) | hypothetical protein Mvan_1838 |
| M. vanbaalenii PYR-1 | Mvan_3103 | - | 2e-92 | 45.82% (419) | hypothetical protein Mvan_3103 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1216c | - | 6e-23 | 30.61% (294) | hypothetical protein Mb1216c |
| M. gilvum PYR-GCK | Mflv_3864 | - | 1e-134 | 58.25% (424) | hypothetical protein Mflv_3864 |
| M. tuberculosis H37Rv | Rv1184c | - | 6e-23 | 30.61% (294) | hypothetical protein Rv1184c |
| M. leprae Br4923 | MLBr_01232 | - | 2e-22 | 29.96% (277) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 2e-23 | 32.34% (235) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_2235 | - | 2e-18 | 29.93% (294) | PE-PGRS family protein, PE16 |
| M. avium 104 | MAV_1760 | - | 3e-20 | 28.57% (371) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 9e-39 | 33.17% (404) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 1e-15 | 26.49% (370) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 7e-14 | 27.34% (289) | PE family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2535|M.vanbaalenii_PYR-1 ---MRRTTGKVRRSAVTCAAAAVTAGLAMATATP-GWGV-----------
Mflv_3864|M.gilvum_PYR-GCK ---MRITKRGARSAGMACGTVAASAALAVSTATS-GWGV-----------
Mb1216c|M.bovis_AF2122/97 ---MKRVIAGAFAVWLVGWAGGFGTAIAASEPAY-PWAPG---PPPSPSP
Rv1184c|M.tuberculosis_H37Rv ---MKRVIAGAFAVWLVGWAGGFGTAIAASEPAY-PWAPG---PPPSPSP
MLBr_01232|M.leprae_Br4923 ---MKRLLATTLAALTVGTVSGFGSTVASSEPGE-PWLP------PSPVP
MAB_0936c|M.abscessus_ATCC_199 ---MRNLLAGTAVLVVACVTGCFGIPSAVADDPQ-VPGP----PIPGIAP
MAV_1760|M.avium_104 ---MKQLLAGVTALLSVSTAGYFGIGTAAADGGP-IGGP----PTPG-AP
MMAR_2235|M.marinum_M --MSFVVTAPETVVAAASQLTGIGSAIEAANAAA-AALTTRLLPAAADEV
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAV-AGPTTGLAAAAAAEV
TH_3724|M.thermoresistible__bu -----------VVAVGALTWGGXGVASPAGQPER-AAALR----------
MSMEG_6144|M.smegmatis_MC2_155 --------------MIAAVAAVVTAALVTTVPALG---------------
.
Mvan_2535|M.vanbaalenii_PYR-1 ------------STALVIGGIGTPTLHDVVMSELLGGALRDYDQRRAVSW
Mflv_3864|M.gilvum_PYR-GCK ------------STAIVIGGIGTPSMHEVVTNQLLGGALQDYDQRISVNW
Mb1216c|M.bovis_AF2122/97 VGD-----ASTAKVVYALGGARMPGIPWYEYTNQAGSQYFPNAKHDLIDY
Rv1184c|M.tuberculosis_H37Rv VGD-----ASTAKVVYALGGARMPGIPWYEYTNQAGSQYFPNAKHDLIDY
MLBr_01232|M.leprae_Br4923 VRE-----NSPAKIVYALGGARPPTFDWDYYTIRAGDEFFPDVNRKLIDY
MAB_0936c|M.abscessus_ATCC_199 DGTVKAAPSAPDRTAYALGGAHVLGIPYDEYIRMTGKDWFPNMKRENVWY
MAV_1760|M.avium_104 G----------DQTAYALGGAHVLGIPYDQYIRMEGADWFPGQQRQIVRY
MMAR_2235|M.marinum_M SAGIAALMSTHAQEYQLLGGQLATYHDQLVQALDRTAGWYADAETGNAAL
MUL_0967|M.ulcerans_Agy99 SEAIATLFDNYAQGYQAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKA
TH_3724|M.thermoresistible__bu --------LTATADAIIMPGTKIGYIPSQDEFTAYATAVIG----ATAGA
MSMEG_6144|M.smegmatis_MC2_155 ------------ATAFTISGTRILHDPPYPEQLVPG--EFAGYDVEHIKY
:
Mvan_2535|M.vanbaalenii_PYR-1 PAQARPYTGAADMTLGDSIEIGT---------------------------
Mflv_3864|M.gilvum_PYR-GCK PAEARPYTGEDDMTLGQSIEIGR---------------------------
Mb1216c|M.bovis_AF2122/97 PAGAAFSWWPTMLLPPGSHQDNM---------------------------
Rv1184c|M.tuberculosis_H37Rv PAGAAFSWWPTMLLPPGSHQDNM---------------------------
MLBr_01232|M.leprae_Br4923 PARAPFRYVPTFLVP--GPRDEV---------------------------
MAB_0936c|M.abscessus_ATCC_199 PAGQVQGHTLERFFPGIGPIGEKILPGLGL--------------------
MAV_1760|M.avium_104 PAGQVQGHVLERLFPGIGKLDES-FPGLGM--------------------
MMAR_2235|M.marinum_M LRNVQQELLTGLTAPGRAWSGAGAASAGASGVDALMSSALLSGGRSVLVV
MUL_0967|M.ulcerans_Agy99 LAGLTEPVAN-LFAP--VLSGPESVAASAT---ALLSGAPLKPVEAALIL
TH_3724|M.thermoresistible__bu PGAVDYLGVPGEFWPATGLDSLT---------------------------
MSMEG_6144|M.smegmatis_MC2_155 PASVFGMDRGIWEAAGAVAAG-----------------------------
Mvan_2535|M.vanbaalenii_PYR-1 ------------------------------------------------AN
Mflv_3864|M.gilvum_PYR-GCK ------------------------------------------------AN
Mb1216c|M.bovis_AF2122/97 -------------------------------------------------T
Rv1184c|M.tuberculosis_H37Rv -------------------------------------------------T
MLBr_01232|M.leprae_Br4923 -------------------------------------------------T
MAB_0936c|M.abscessus_ATCC_199 ----------------------------------------------DGPS
MAV_1760|M.avium_104 ----------------------------------------------DGPS
MMAR_2235|M.marinum_M GSTGTPRPSYRFMREVYDLFVAPHY-FGDSLFGVQTPAQFQPFTGIPNLT
MUL_0967|M.ulcerans_Agy99 SESGVPTPSASYISDVYTKYVEPNFPSATAPQGVSTPNGLYPFTGIKDLS
TH_3724|M.thermoresistible__bu --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2535|M.vanbaalenii_PYR-1 LNADIDAALGRLERDADG---NLLEGERVTVVGLSAGSLVVTEVLREWQS
Mflv_3864|M.gilvum_PYR-GCK LNAQIDTALAQLERDADG---NLLDSEQVTVVGLSAGSLVVTETLRGWQS
Mb1216c|M.bovis_AF2122/97 VGVAVKDGTNSLDNAIH------HGTDPAAAVGLSQGSLVLDQEQARLAN
Rv1184c|M.tuberculosis_H37Rv VGVAVKDGTNSLDNAIH------HGTDPAAAVGLSQGSLVLDQEQARLAN
MLBr_01232|M.leprae_Br4923 IGEAIAVATKNLNQAIH------RGTEPAAVVGLSQGSLALDTEQEQLAT
MAB_0936c|M.abscessus_ATCC_199 IGESIDIGEPNLENAIR------SGG-PGTAMGLSEGALVLNAVKNALAT
MAV_1760|M.avium_104 VGESVAEGIDNLDAAIR------TTGRPGTAIGLSEGAFVVDGEQARLAN
MMAR_2235|M.marinum_M FDESAATGASYLHAAITQQLAD---GNRVVVAGFSQGASVATLEMRHLQS
MUL_0967|M.ulcerans_Agy99 LDISLARGATILNDAILQQLAALPAGSSVAVLGYSQSAVLSSRVMPKLLA
TH_3724|M.thermoresistible__bu FDASVAXGQAMLTPMVDG---AIESDTPIVVFGHSQSAVIATKEKQRLLA
MSMEG_6144|M.smegmatis_MC2_155 --VDRFVGVDDEGNPIT---------EKIIVAGFSQGAIVIAYEKKRLMK
. . * * .:
Mvan_2535|M.vanbaalenii_PYR-1 DGEENPEA-DEINFVVVADSSRQQIIDD---TERYNP-------VYDYTY
Mflv_3864|M.gilvum_PYR-GCK DDKEDPDA-EEINFVVVADSSRQEIIDD---TEQYNP-------TYDYTY
Mb1216c|M.bovis_AF2122/97 DP-TAPAP-DKLQFTTFGDPTGRHAFGASFLARIFPPGSHIPIPFIEYTM
Rv1184c|M.tuberculosis_H37Rv DP-TAPAP-DKLQFTTFGDPTGRHAFGASFLARIFPPGSHIPIPFIEYTM
MLBr_01232|M.leprae_Br4923 DP-TAPPP-DQLTFNTFGDPSGYHGFGKSVLASIFRPGDYIPL--IDYTM
MAB_0936c|M.abscessus_ATCC_199 DP-TAPEP-ESLTFATFGDPIAKSPFSESFLTQNFAPGSVVPF--MDYPV
MAV_1760|M.avium_104 DP-TAPPP-NTLNFATFGDPIGRHAFGQSFLTAMFGVGSVVPA--LDYTM
MMAR_2235|M.marinum_M LPIDSRPSPEDLSFVLLGNPNNPNGGILARFPGLYIQS-------VGLTF
MUL_0967|M.ulcerans_Agy99 EGVTS----SQVNFVLLGNPMNPNGGVLARFPDLTLPS-------LGFTF
TH_3724|M.thermoresistible__bu EY-PDPDTAPDVTFVMVANPNRPNGGLLARFPGLYIP-------ILGVTF
MSMEG_6144|M.smegmatis_MC2_155 LDEDERPTVDQLKFVTIGDPTGPNGILRWIPFRIPIIG-------LTPVR
: * ..:.
Mvan_2535|M.vanbaalenii_PYR-1 R----RAPQTPYDTVEVTGEYDGLADFPDRWWNLTAVANALAGAAVRHI-
Mflv_3864|M.gilvum_PYR-GCK R----KAPETVYDTVEVTGEYDGMADFPDR-FNLTAISNAMAGSVLRHV-
Mb1216c|M.bovis_AF2122/97 P----QQVDSQYDTNHVVTAYDGFSDFPDRPDNLLAVANAAIGAAIAHT-
Rv1184c|M.tuberculosis_H37Rv P----QQVDSQYDTNHVVTAYDGFSDFPDRPDNLLAVANAAIGAAIAHT-
MLBr_01232|M.leprae_Br4923 P----QRMDSQYDSNRVVAAYDGLSEFPDRADNLLAQLNCFAGGAISHT-
MAB_0936c|M.abscessus_ATCC_199 P----ARVDSQYHTDQFISAYDSIADWPDRPDNLFALANAIAGLATGHT-
MAV_1760|M.avium_104 P----PPYESQYDTNRFVAAYDSIADFPDRPDNMFALANTLMGLATGHT-
MMAR_2235|M.marinum_M NG---ATPVTEYPTTVYTTQYDGFADFPQYPLNVVADVNALLGISYSHS-
MUL_0967|M.ulcerans_Agy99 YG---ATPDNAFPTVSYTLEYDGFADFPRYPINLLADINAVMGIPFVHA-
TH_3724|M.thermoresistible__bu NGATPAPADGPFDSYDVAREFDGWADFPRYPLNLVATANAILGIYYLHGG
MSMEG_6144|M.smegmatis_MC2_155 P------PDTPYETTIINGEYDGWADFPDRPWNLIATANALLGIIYVHGR
: : :*. :::* *: * * * *
Mvan_2535|M.vanbaalenii_PYR-1 LAMFAD---LSQVPDENVTVTQNLLGGTTTRYLVPAQRLPLVLLNPSLAP
Mflv_3864|M.gilvum_PYR-GCK QTMFSD---LSDVPKQNTTVTENALGGTTVRYLVPAETLPLVQSNPSLAP
Mb1216c|M.bovis_AF2122/97 PIGFTG---PGDVPPQNIRTTVNSRGATTTTYLVPVNHLPLTLPLRYLG-
Rv1184c|M.tuberculosis_H37Rv PIGFTG---PGDVPPQNIRTTVNSRGATTTTYLVPVNHLPLTLPLRYLG-
MLBr_01232|M.leprae_Br4923 PSGFFN---PEDVPPQNIRTTVNSRGAKTTTYLIPVNHLPLTLPLRYLG-
MAB_0936c|M.abscessus_ATCC_199 AVAFTN---PKMVPARNIVTETNSRGGTTTTYFIPEQHLPLVMGFKYLG-
MAV_1760|M.avium_104 AVAFTN---PSMVPPQNIRTTINSRGAKDTTIMIPEKHLPLVMPLKYIG-
MMAR_2235|M.marinum_M LYYGLT---PDQVAAG-VVLPVSSPDVNTTYILIPNEHLPLLQPLRGI--
MUL_0967|M.ulcerans_Agy99 DYQDLT---QAQLDSA-VQLPTEGP-TQSTYYMIPTEHLPLLAPLRFIP-
TH_3724|M.thermoresistible__bu YYELLT---ENPDILDDPERTIVQQYGDTTYYLIRTEQLPLLRPLRDLG-
MSMEG_6144|M.smegmatis_MC2_155 YEDKVDGWDLSTVPEKNIVETVNKAGGKTTTYLIPTEKLPLLQPLRDLG-
. :: : *** :
Mvan_2535|M.vanbaalenii_PYR-1 REAELKATVDRGYSRNDPVRTALRTLTNEVPDDVEDTVTP----QDTQD-
Mflv_3864|M.gilvum_PYR-GCK REAELRAQVDRGYSRNDPANVAARLAGPDVPERIRDIVTPEAAAQDTEDV
Mb1216c|M.bovis_AF2122/97 -------------------------MSDAEVDQIDSVLQP----------
Rv1184c|M.tuberculosis_H37Rv -------------------------MSDAEVDQIDSVLQP----------
MLBr_01232|M.leprae_Br4923 -------------------------WSDALVDQIDAVLQP----------
MAB_0936c|M.abscessus_ATCC_199 -------------------------VPEETLNRLDAILQP----------
MAV_1760|M.avium_104 -------------------------IDENTLNKLDAILTP----------
MMAR_2235|M.marinum_M -------------------------VPDSVLDGIEPGLRDVVELGYDR--
MUL_0967|M.ulcerans_Agy99 ------------------------YVGDPLAELLEPNLRVLVNFGYGDPA
TH_3724|M.thermoresistible__bu -------------------------VPEEFVDALEPYVRRIVDLGYDRN-
MSMEG_6144|M.smegmatis_MC2_155 -------------------------FPESFVAALEAPLRKIIDAAYKRND
: :
Mvan_2535|M.vanbaalenii_PYR-1 ------EVEASE--GDGAAPTGTSADHAEVSEATAEDRDVTADDAEAPGD
Mflv_3864|M.gilvum_PYR-GCK DLGIAAAVQQDEESGAGAIPEIDGQRSLGEQLEAAQNAEDGADTSPAPTS
Mb1216c|M.bovis_AF2122/97 ------------------------------QIDAAYARNDNWFTRPVSVD
Rv1184c|M.tuberculosis_H37Rv ------------------------------QIDAAYARNDNWFTRPVSVD
MLBr_01232|M.leprae_Br4923 ------------------------------KIDAAYAYNDNPLNKPISVD
MAB_0936c|M.abscessus_ATCC_199 ------------------------------RVDAGYSRNDDPATAPIAVD
MAV_1760|M.avium_104 ------------------------------RVNAGYSRNDDPATAPVQVD
MMAR_2235|M.marinum_M ----TGYADVPTPASLFPANVNPNVVAGAFVEGAVRGIDNGLAGMGLPPL
MUL_0967|M.ulcerans_Agy99 YGYDTGPANVPTPFGLFPP-VSPLTVAEHLAAGTQQGIVNSGAALQAQGP
TH_3724|M.thermoresistible__bu -------------TPYGEPAPVRVLPPLTPAPGPATQHNAGQGITVASAT
MSMEG_6144|M.smegmatis_MC2_155 PGRVTVTTTEETVVEDESEITQTAVTEIDETPSTDGDIDETAVQSTTQRR
.
Mvan_2535|M.vanbaalenii_PYR-1 ETR--STEDVDREATEPDSESDDTVTQNDAEPRE----------------
Mflv_3864|M.gilvum_PYR-GCK RTIGAAVEAISERSTAADDDTGATPLTPDAGDTE----------------
Mb1216c|M.bovis_AF2122/97 PVRGLDP--LTAPG--SIVEG--------ARGLL----------------
Rv1184c|M.tuberculosis_H37Rv PVRGLDP--LTAPG--SIVEG--------ARGLL----------------
MLBr_01232|M.leprae_Br4923 PVNGMDP--IAGID--AELRDSILNVFAQLRSIL----------------
MAB_0936c|M.abscessus_ATCC_199 PRRGFDPAEVTAPASQATFGGGSDPISQITSGAL----------------
MAV_1760|M.avium_104 PVHGFDPAEVTAPANQATFGGGADPLSQIMAGAM----------------
MMAR_2235|M.marinum_M PDLPAAPLLPEIWSNAPPIPGWPASVPSAIAVPPQLGGAIAGPLDHLYRT
MUL_0967|M.ulcerans_Agy99 PSIPLSDIAHTLTAN-PPWAGTPALPPSTSPAS----------------S
TH_3724|M.thermoresistible__bu STPDKRTPVVEAPVEEPPVQTGRSTLKREKPVSAR---------------
MSMEG_6144|M.smegmatis_MC2_155 TVANTAADRTAETAEVAEVTEDVDELAEQEEPVKEEATK-----------
.
Mvan_2535|M.vanbaalenii_PYR-1 ------------------------SAADTAAEDSGPSD------------
Mflv_3864|M.gilvum_PYR-GCK ------------------------SSTSDGASESAGSDVGDSTTRTSTKP
Mb1216c|M.bovis_AF2122/97 ------------------------GSPAFGG-------------------
Rv1184c|M.tuberculosis_H37Rv ------------------------GSPAFGG-------------------
MLBr_01232|M.leprae_Br4923 ------------------------PPPPG---------------------
MAB_0936c|M.abscessus_ATCC_199 ------------------------AVLGNGTRPTPPN-------------
MAV_1760|M.avium_104 ------------------------SVLSHGAGEADH--------------
MMAR_2235|M.marinum_M LDSVINGQINPAITSGIYQYGADLSAEAARHGASSELLNAIYVGRQVLPI
MUL_0967|M.ulcerans_Agy99 IEDFI------------------LAVQAANSSISRGFVKTLSTAYATLLP
TH_3724|M.thermoresistible__bu --------------------HLVRNSLRAVPGLRRGEPAATPTPDVTPDV
MSMEG_6144|M.smegmatis_MC2_155 --------------------DDEVTKVADEADKATPVKESTSVEKTDQAV
Mvan_2535|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3864|M.gilvum_PYR-GCK SSDGAARSSSSAE-------------------------------------
Mb1216c|M.bovis_AF2122/97 --------------------------------------------------
Rv1184c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MMAR_2235|M.marinum_M LIEGPGVILTADTYYSINAIKDLAAGNLSGFNQNLQLIPATNAMLLTFGA
MUL_0967|M.ulcerans_Agy99 TTDIASELVFTLPSYNLNLFLDGVIQAINGQ-------------------
TH_3724|M.thermoresistible__bu TPDAPAGQPEPAEPNESAAPPAAAEADDASE-------------------
MSMEG_6144|M.smegmatis_MC2_155 KPDDTDKTVTTAEKVEKADEAEKVEKTKPNVRKVKRPQFNVFKPKKTRVT
Mvan_2535|M.vanbaalenii_PYR-1 ------------------------------------
Mflv_3864|M.gilvum_PYR-GCK ------------------------------------
Mb1216c|M.bovis_AF2122/97 ------------------------------------
Rv1184c|M.tuberculosis_H37Rv ------------------------------------
MLBr_01232|M.leprae_Br4923 ------------------------------------
MAB_0936c|M.abscessus_ATCC_199 ------------------------------------
MAV_1760|M.avium_104 ------------------------------------
MMAR_2235|M.marinum_M TIPIAAGVSAYIGRDFP-------------------
MUL_0967|M.ulcerans_Agy99 --PIGD------------------------------
TH_3724|M.thermoresistible__bu ------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 VPKAEPSTKAKPATKPDNDNDDTSDTTDKTAEKDAA