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RNLLAGTAVLVVACVTGCFGIPSAVADDPQVPGPPIPGIAPDGTVKAAPSAPDRTAYALGGAHVLGIPYD EYIRMTGKDWFPNMKRENVWYPAGQVQGHTLERFFPGIGPIGEKILPGLGLDGPSIGESIDIGEPNLENA IRSGGPGTAMGLSEGALVLNAVKNALATDPTAPEPESLTFATFGDPIAKSPFSESFLTQNFAPGSVVPFM DYPVPARVDSQYHTDQFISAYDSIADWPDRPDNLFALANAIAGLATGHTAVAFTNPKMVPARNIVTETNS RGGTTTTYFIPEQHLPLVMGFKYLGVPEETLNRLDAILQPRVDAGYSRNDDPATAPIAVDPRRGFDPAEV TAPASQATFGGGSDPISQITSGALAVLGNGTRPTPPN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0936c | - | - | 100% (388) | hypothetical protein MAB_0936c |
| M. abscessus ATCC 19977 | MAB_4141 | - | 5e-09 | 27.63% (228) | PE/PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1216c | - | 3e-79 | 43.21% (361) | hypothetical protein Mb1216c |
| M. gilvum PYR-GCK | Mflv_0401 | - | 1e-141 | 65.35% (381) | hypothetical protein Mflv_0401 |
| M. tuberculosis H37Rv | Rv1184c | - | 3e-79 | 43.21% (361) | hypothetical protein Rv1184c |
| M. leprae Br4923 | MLBr_01232 | - | 4e-70 | 41.48% (352) | hypothetical protein MLBr_01232 |
| M. marinum M | MMAR_4939 | - | 2e-26 | 33.22% (286) | PE-PGRS family protein |
| M. avium 104 | MAV_1760 | - | 1e-137 | 63.61% (382) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_0412 | - | 1e-139 | 64.43% (388) | hypothetical protein MSMEG_0412 |
| M. thermoresistible (build 8) | TH_3724 | - | 2e-18 | 31.27% (259) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_0967 | - | 2e-09 | 26.03% (242) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_0276 | - | 1e-138 | 64.04% (381) | hypothetical protein Mvan_0276 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1216c|M.bovis_AF2122/97 -------------------------------------MKRVIAGAFAVWL
Rv1184c|M.tuberculosis_H37Rv -------------------------------------MKRVIAGAFAVWL
MLBr_01232|M.leprae_Br4923 -------------------------------------MKRLLATTLAALT
Mflv_0401|M.gilvum_PYR-GCK -------------------------------------MRRHLAFATAITT
MSMEG_0412|M.smegmatis_MC2_155 ------------------------------------MRRRLLAFGTAFTT
Mvan_0276|M.vanbaalenii_PYR-1 -------------------------MQPSRSGWCVKAMKRLLAFGTALTT
MAV_1760|M.avium_104 -------------------------------------MKQLLAGVTALLS
MAB_0936c|M.abscessus_ATCC_199 -------------------------------------MRNLLAGTAVLVV
MMAR_4939|M.marinum_M --MSYVVAAPDFLSTAAEDLAAMGSAVSTATAAAARSTTLLLAAGADEVS
TH_3724|M.thermoresistible__bu -----------------------------------------------VVA
MUL_0967|M.ulcerans_Agy99 MAVIDLLASPQAMTATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVS
Mb1216c|M.bovis_AF2122/97 VGWAGGFGTA--------------------IAASEPAY----PWAPGPPP
Rv1184c|M.tuberculosis_H37Rv VGWAGGFGTA--------------------IAASEPAY----PWAPGPPP
MLBr_01232|M.leprae_Br4923 VGTVSGFGST--------------------VASSEPGE----PWLP---P
Mflv_0401|M.gilvum_PYR-GCK LGATGILGLG--------------------IAAAQPAPAPPPPPAPGAAA
MSMEG_0412|M.smegmatis_MC2_155 IGTAGFLGFG--------------------VAAADDT--KPVDPAPGGAH
Mvan_0276|M.vanbaalenii_PYR-1 IGAAGCLGFG--------------------IAAADEAPAVPPSPTP---A
MAV_1760|M.avium_104 VSTAGYFGIG--------------------TAAADGGP-----------I
MAB_0936c|M.abscessus_ATCC_199 ACVTGCFGIP--------------------SAVADDPQVPGPPIPGIAPD
MMAR_4939|M.marinum_M THIAALFSTHGLQYQLASAQAAEFHERFVLTLAADANTYLTTEIANAQRC
TH_3724|M.thermoresistible__bu VGALTWGGXG----------------------------------------
MUL_0967|M.ulcerans_Agy99 EAIATLFDNYAQG----------YQAVSRQTAAFHDAFAQTLFAASDSYV
.
Mb1216c|M.bovis_AF2122/97 SPSPVGDASTAKVVYALGGARMPGIPWYEYTNQAGSQYFPNAKHDLIDYP
Rv1184c|M.tuberculosis_H37Rv SPSPVGDASTAKVVYALGGARMPGIPWYEYTNQAGSQYFPNAKHDLIDYP
MLBr_01232|M.leprae_Br4923 SPVPVRENSPAKIVYALGGARPPTFDWDYYTIRAGDEFFPDVNRKLIDYP
Mflv_0401|M.gilvum_PYR-GCK GAPTPLGTPG--RGYALGGAHVLGIPYDEYIMRTGADWFPGLDREIVDYP
MSMEG_0412|M.smegmatis_MC2_155 AEAPSMGTPG--RGYALGGAHVLGIPYDEYIMRTGADWFPGLDRQIVDYP
Mvan_0276|M.vanbaalenii_PYR-1 DAPPPLGTPG--RAYALGGAHVLGIPYDEYIMRTGADWFPGLDRQIVDYP
MAV_1760|M.avium_104 GGPPTPGAPGDQTAYALGGAHVLGIPYDQYIRMEGADWFPGQQRQIVRYP
MAB_0936c|M.abscessus_ATCC_199 GTVKAAPSAPDRTAYALGGAHVLGIPYDEYIRMTGKDWFPNMKRENVWYP
MMAR_4939|M.marinum_M LAGAINAPATALLGHPLLGADPTASASTAATPAGGASMAPAAAGTRITVP
TH_3724|M.thermoresistible__bu VASPAGQPERAAALRLTATADAIIMPGTKIGYIPSQDEFTAYATAVIGAT
MUL_0967|M.ulcerans_Agy99 RAEAAAVKALAGLTEPVANLFAPVLSGPESVAASATALLSGAPLKPVEAA
. . : .
Mb1216c|M.bovis_AF2122/97 AG---------------------AAFSWWPTMLLPPGSHQDNMT------
Rv1184c|M.tuberculosis_H37Rv AG---------------------AAFSWWPTMLLPPGSHQDNMT------
MLBr_01232|M.leprae_Br4923 AR---------------------APFRYVPTFLVP--GPRDEVT------
Mflv_0401|M.gilvum_PYR-GCK AG---------------------QVQGHTLERLFPGIGAFGDRIAP----
MSMEG_0412|M.smegmatis_MC2_155 AG---------------------QVQGHTLERLFPGIGALGERFMP----
Mvan_0276|M.vanbaalenii_PYR-1 AG---------------------QVQGHTLERLFPGIGRLDDSF-P----
MAV_1760|M.avium_104 AG---------------------QVQGHVLERLFPGIGKLDESF-P----
MAB_0936c|M.abscessus_ATCC_199 AG---------------------QVQGHTLERFFPGIGPIGEKILP----
MMAR_4939|M.marinum_M GAGPLYYPRFLTELPYLGQALLLGIPGPSSASILQGYDLINHAIGENWFP
TH_3724|M.thermoresistible__bu AG----------------------APGAVDYLGVPGEFWPATGLDS----
MUL_0967|M.ulcerans_Agy99 LILSE------SGVPTPSASYISDVYTKYVEPNFPSATAPQGVSTPNG--
.
Mb1216c|M.bovis_AF2122/97 ------------------------VGVAVKDGTNSLDNAIH------HGT
Rv1184c|M.tuberculosis_H37Rv ------------------------VGVAVKDGTNSLDNAIH------HGT
MLBr_01232|M.leprae_Br4923 ------------------------IGEAIAVATKNLNQAIH------RGT
Mflv_0401|M.gilvum_PYR-GCK ----------------GLGLDGPSYGESIDVGAPNLIGAIR------RGG
MSMEG_0412|M.smegmatis_MC2_155 ----------------GLGLDGPSYGESIDVGAPNLINAIR------QGG
Mvan_0276|M.vanbaalenii_PYR-1 ----------------GIGIDGPSVGESVDVGTPNVITAIR------EGG
MAV_1760|M.avium_104 ----------------GLGMDGPSVGESVAEGIDNLDAAIR------TTG
MAB_0936c|M.abscessus_ATCC_199 ----------------GLGLDGPSIGESIDIGEPNLENAIR------SGG
MMAR_4939|M.marinum_M DTIASVINYPASIGILSGSLAAPDTNTAVAIGARMLHEQIMSAV-TNGSG
TH_3724|M.thermoresistible__bu ----------------------LTFDASVAXGQAMLTPMVDG---AIESD
MUL_0967|M.ulcerans_Agy99 -------------LYPFTGIKDLSLDISLARGATILNDAILQQLAALPAG
. :: . : :
Mb1216c|M.bovis_AF2122/97 DPAAAVGLSQGSLVLDQEQARLANDPTAP-APDKLQFTTFGDPTGRHAFG
Rv1184c|M.tuberculosis_H37Rv DPAAAVGLSQGSLVLDQEQARLANDPTAP-APDKLQFTTFGDPTGRHAFG
MLBr_01232|M.leprae_Br4923 EPAAVVGLSQGSLALDTEQEQLATDPTAP-PPDQLTFNTFGDPSGYHGFG
Mflv_0401|M.gilvum_PYR-GCK -PGTAIGLSEGASVLDEVQARLAYDPAAP-PPDQLSFATYGNPVGKHAFG
MSMEG_0412|M.smegmatis_MC2_155 -PGTVIGLSEGASVLDEVQARLAYDPAAP-PPDSLSFATYGNPVGKHAFG
Mvan_0276|M.vanbaalenii_PYR-1 -RGTAIGLSEGAMVLNDVQAKLAYDPAAP-PPDQLSFAMYGDPVARHAFG
MAV_1760|M.avium_104 RPGTAIGLSEGAFVVDGEQARLANDPTAP-PPNTLNFATFGDPIGRHAFG
MAB_0936c|M.abscessus_ATCC_199 -PGTAMGLSEGALVLNAVKNALATDPTAP-EPESLTFATFGDPIAKSPFS
MMAR_4939|M.marinum_M LPVHVATLSQGTIVANRELAYLATDPNAP-PAHALEFALFGSP------E
TH_3724|M.thermoresistible__bu TPIVVFGHSQSAVIATKEKQRLLAEYPDPDTAPDVTFVMVANPNRPNGGL
MUL_0967|M.ulcerans_Agy99 SSVAVLGYSQSAVLSSRVMPKLLAEGVTS---SQVNFVLLGNPMNPNGGV
. *:.: * : . : * ..*
Mb1216c|M.bovis_AF2122/97 ASFLARIFPPGSHIPIPFIEYTMPQQVDSQYDTNHVVTAYDGFSDFPDRP
Rv1184c|M.tuberculosis_H37Rv ASFLARIFPPGSHIPIPFIEYTMPQQVDSQYDTNHVVTAYDGFSDFPDRP
MLBr_01232|M.leprae_Br4923 KSVLASIFRPGDYIPL--IDYTMPQRMDSQYDSNRVVAAYDGLSEFPDRA
Mflv_0401|M.gilvum_PYR-GCK ESFLTQNFPVGSVVPS--LDYRIPAPVESQYDTYKFVSAYDSIADWPDRP
MSMEG_0412|M.smegmatis_MC2_155 ESFLTQMFPVGSVVPS--LDYRIPAPVESQYDTYQFVSAYDSIADWPDRP
Mvan_0276|M.vanbaalenii_PYR-1 ESFLTQNFPVGSVVPS--LDYRIPPPVESQYDTYQFVSAYDSIADWPDRP
MAV_1760|M.avium_104 QSFLTAMFGVGSVVPA--LDYTMPPPYESQYDTNRFVAAYDSIADFPDRP
MAB_0936c|M.abscessus_ATCC_199 ESFLTQNFAPGSVVPF--MDYPVPARVDSQYHTDQFISAYDSIADWPDRP
MMAR_4939|M.marinum_M LGLAHIYLPDGLTVPL--INYTVHGLSNTQYDVSVVNGQYDFWGNPPDRP
TH_3724|M.thermoresistible__bu LARFPGLYIPILGVTF---NGATPAPADGPFDSYDVAREFDGWADFPRYP
MUL_0967|M.ulcerans_Agy99 LARFPDLTLPSLGFTF------YGATPDNAFPTVSYTLEYDGFADFPRYP
. .. : : :* .: * .
Mb1216c|M.bovis_AF2122/97 DNLLAVANAAIGAAIAHT--PIGFTGPGDVPPQNIRTTVNSRGATTTTYL
Rv1184c|M.tuberculosis_H37Rv DNLLAVANAAIGAAIAHT--PIGFTGPGDVPPQNIRTTVNSRGATTTTYL
MLBr_01232|M.leprae_Br4923 DNLLAQLNCFAGGAISHT--PSGFFNPEDVPPQNIRTTVNSRGAKTTTYL
Mflv_0401|M.gilvum_PYR-GCK DNWLSVANAIVGLATGHT--AVAFTDPSMVPERNIRTTVNSRGATTTTYM
MSMEG_0412|M.smegmatis_MC2_155 DNWISVANAIVGLATGHT--AVAFTNPSMVPPQNIRTTVNSRGAKDTTIM
Mvan_0276|M.vanbaalenii_PYR-1 DNWISVANAIVGLATGHT--AVAFTEPSMVPPQNIRTTVNSRGAKTTTYM
MAV_1760|M.avium_104 DNMFALANTLMGLATGHT--AVAFTNPSMVPPQNIRTTINSRGAKDTTIM
MAB_0936c|M.abscessus_ATCC_199 DNLFALANAIAGLATGHT--AVAFTNPKMVPARNIVTETNSRGGTTTTYF
MMAR_4939|M.marinum_M WNLPAWVNSLFGAAYYHN--TSSFASLS--DAVEVSSVTTSLGGTITTYL
TH_3724|M.thermoresistible__bu LNLVATANAILGIYYLHGGYYELLTENPDILDDPERTIVQQYG-DTTYYL
MUL_0967|M.ulcerans_Agy99 INLLADINAVMGIPFVHA----DYQDLTQAQLDSAVQLPTEGPTQSTYYM
* : * * * . * :
Mb1216c|M.bovis_AF2122/97 VPVNHLPLTLPLRYLG-MSDAEVDQIDSVLQPQIDAAY-----ARNDNWF
Rv1184c|M.tuberculosis_H37Rv VPVNHLPLTLPLRYLG-MSDAEVDQIDSVLQPQIDAAY-----ARNDNWF
MLBr_01232|M.leprae_Br4923 IPVNHLPLTLPLRYLG-WSDALVDQIDAVLQPKIDAAY-----AYNDNPL
Mflv_0401|M.gilvum_PYR-GCK IPEEHLPLVLPFKYLG-VPKDTLMELDKVLLPYVDAGY-----SRNDDPA
MSMEG_0412|M.smegmatis_MC2_155 IPEEHLPLVLPFKYLG-VDKDTLNKLDGVLKPYVDAGY-----SRNDDPL
Mvan_0276|M.vanbaalenii_PYR-1 IPEEHLPLVLPFKYLG-VPTETLIELDAVLKPFVDAGY-----SRNDDPL
MAV_1760|M.avium_104 IPEKHLPLVMPLKYIG-IDENTLNKLDAILTPRVNAGY-----SRNDDPA
MAB_0936c|M.abscessus_ATCC_199 IPEQHLPLVMGFKYLG-VPEETLNRLDAILQPRVDAGY-----SRNDDPA
MMAR_4939|M.marinum_M IPSPTLPMLLPLEQIG-VPAPIVAGLNSVLAPIVNDGY-----SSLTPNA
TH_3724|M.thermoresistible__bu IRTEQLPLLRPLRDLG-VPEEFVDALEPYVRRIVDLGY-----DRN-TPY
MUL_0967|M.ulcerans_Agy99 IPTEHLPLLAPLRFIPYVGDPLAELLEPNLRVLVNFGYGDPAYGYDTGPA
: **: :. : :: : :: .*
Mb1216c|M.bovis_AF2122/97 TRPVSVDPVRGLDPLTAPGSIVEG-------------------------A
Rv1184c|M.tuberculosis_H37Rv TRPVSVDPVRGLDPLTAPGSIVEG-------------------------A
MLBr_01232|M.leprae_Br4923 NKPISVDPVNGMDPIAGIDAELRDSI-----------------LNVFAQL
Mflv_0401|M.gilvum_PYR-GCK TAPITVDPVNGYDPAEVTAPATQAAFGGGA----------DPVSQLLSGL
MSMEG_0412|M.smegmatis_MC2_155 TAPITVDPVNGYDPAAVTAPATQAAFGGGT----------DPVSQLLAGL
Mvan_0276|M.vanbaalenii_PYR-1 TAPITVDPVNGYDPAEVTAPATQAAFGGAA----------DPVSQLLSGL
MAV_1760|M.avium_104 TAPVQVDPVHGFDPAEVTAPANQATFGGGA----------DPLSQIMAGA
MAB_0936c|M.abscessus_ATCC_199 TAPIAVDPRRGFDPAEVTAPASQATFGGGS----------DPISQITSGA
MMAR_4939|M.marinum_M GPYFSQGALVGLPSAADVLGSWPWP-----------------------AL
TH_3724|M.thermoresistible__bu GEPAPVRVLPPLTPAPGPATQHNAGQGITV----------ASATSTPDKR
MUL_0967|M.ulcerans_Agy99 NVPTPFGLFPPVSPLTVAEHLAAGTQQGIVNSGAALQAQGPPSIPLSDIA
.
Mb1216c|M.bovis_AF2122/97 RGLLGSPAFGG---------------------------------------
Rv1184c|M.tuberculosis_H37Rv RGLLGSPAFGG---------------------------------------
MLBr_01232|M.leprae_Br4923 RSILPPPPG-----------------------------------------
Mflv_0401|M.gilvum_PYR-GCK QYILNNPP------------------------------------------
MSMEG_0412|M.smegmatis_MC2_155 QYVVNNQPAPKP--------------------------------------
Mvan_0276|M.vanbaalenii_PYR-1 QYVLNNPP------------------------------------------
MAV_1760|M.avium_104 MSVLSHGAGEADH-------------------------------------
MAB_0936c|M.abscessus_ATCC_199 LAVLGNGTRPTPPN------------------------------------
MMAR_4939|M.marinum_M GSVTAHIC------------------------------------------
TH_3724|M.thermoresistible__bu TPVVEAPVEEPPVQTGRSTLKREKPVSARHLVRNSLRAVP-GLRRGEPAA
MUL_0967|M.ulcerans_Agy99 HTLTANPPWAGTPALPPSTSPASSIEDFILAVQAANSSISRGFVKTLSTA
:
Mb1216c|M.bovis_AF2122/97 -----------------------------------------
Rv1184c|M.tuberculosis_H37Rv -----------------------------------------
MLBr_01232|M.leprae_Br4923 -----------------------------------------
Mflv_0401|M.gilvum_PYR-GCK -----------------------------------------
MSMEG_0412|M.smegmatis_MC2_155 -----------------------------------------
Mvan_0276|M.vanbaalenii_PYR-1 -----------------------------------------
MAV_1760|M.avium_104 -----------------------------------------
MAB_0936c|M.abscessus_ATCC_199 -----------------------------------------
MMAR_4939|M.marinum_M -----------------------------------------
TH_3724|M.thermoresistible__bu TPTPDVTPDVTPDAPAGQPEPAEPNESAAPPAAAEADDASE
MUL_0967|M.ulcerans_Agy99 YATLLPTTDIASELVFTLPSYNLNLFLDGVIQAINGQPIGD