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MRRSIRKRAGLACGAVFASAAMAVSTATGASAVTTAVAIGGLGTPDMHEIVINPLLGGKLARENDILDGV EWPAEAKRPGTGQTLGQSITVGITNLGTHFDAAFARLEAGEQFTVVGFSAGSLVVNDFMRELANDPDAPT KDQVKFILVADSSRQKLLNETSKYNPQYDYTYRPAPQTMYDIDVVTGEYDGAADLPDRWWNFLALANAIA GGLFVHVPMMFSDYEAVTPEENITRVTNTLGGTTTTYLVPTKTLPLVQLLPFLKSQEASLKAKIDAGYSR NDDRLAAAAAATSTARSLAAPTVTNEATDEVADDEAVATVQKISTDSDAEQADVPAERTSSKPAVDDAAD DDEAAANEDAEADAADAKVDAKEDAEAAVKDDADASAGTNDDGEEGADSGSNDSAAAAGDTDSSDGSSSE GPGSSDSGSSE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3371 | - | - | 100% (431) | hypothetical protein Mflv_3371 |
| M. gilvum PYR-GCK | Mflv_4518 | - | 3e-93 | 45.85% (434) | hypothetical protein Mflv_4518 |
| M. gilvum PYR-GCK | Mflv_3864 | - | 1e-85 | 43.25% (437) | hypothetical protein Mflv_3864 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3569 | PPE63 | 2e-25 | 33.45% (278) | PPE family protein |
| M. tuberculosis H37Rv | Rv3539 | PPE63 | 2e-25 | 33.45% (278) | PPE family protein |
| M. leprae Br4923 | MLBr_01232 | - | 1e-25 | 35.94% (217) | hypothetical protein MLBr_01232 |
| M. abscessus ATCC 19977 | MAB_0936c | - | 4e-27 | 35.12% (242) | hypothetical protein MAB_0936c |
| M. marinum M | MMAR_0370 | - | 9e-18 | 31.56% (282) | PE family protein |
| M. avium 104 | MAV_1760 | - | 4e-25 | 33.48% (221) | hypothetical protein MAV_1760 |
| M. smegmatis MC2 155 | MSMEG_6144 | - | 1e-32 | 28.57% (427) | PE family protein |
| M. thermoresistible (build 8) | TH_3724 | - | 3e-13 | 24.22% (417) | PUTATIVE putative PE-PPE, C-terminal domain protein |
| M. ulcerans Agy99 | MUL_1034 | - | 3e-14 | 27.72% (303) | PE family protein |
| M. vanbaalenii PYR-1 | Mvan_3103 | - | 1e-100 | 48.64% (440) | hypothetical protein Mvan_3103 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3569|M.bovis_AF2122/97 MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFESVC
Rv3539|M.tuberculosis_H37Rv MADFLTLSPEVNSARMYAGGGPGSLSAAAAAWDELAAELWLAAASFESVC
MAB_0936c|M.abscessus_ATCC_199 MRNLLAGTAVLVVACVTGCFGIPSAVADDPQV------------------
MAV_1760|M.avium_104 MKQLLAGVTALLSVSTAGYFGIGTAAADGGPI------------------
MLBr_01232|M.leprae_Br4923 MKRLLATTLAALTVGTVSGFGSTVASSEPGEP------------------
Mflv_3371|M.gilvum_PYR-GCK MRRSIRKRAGLACGAVFASAAMAVSTATGASA------------------
Mvan_3103|M.vanbaalenii_PYR-1 MRKGLRK-AGVACGTAFASVAIALSTATPGLA------------------
MMAR_0370|M.marinum_M MSYLLAEPELLASVATEIDGIGSAISTAGTAAAGPT--------------
MUL_1034|M.ulcerans_Agy99 MSYVLTAPDLLASAATDVDGIAATLQVANSAAAALT--------------
TH_3724|M.thermoresistible__bu ----VVAVGALTWGGXGVASPAGQPERAAALR------------------
MSMEG_6144|M.smegmatis_MC2_155 MIAAVAAVVTAALVTTVPALGATAFTISG---------------------
:
Mb3569|M.bovis_AF2122/97 SGLADRWWQGPSSRMMAAQAARHTGWLAAAATQAEGAASQAQTMALAYEA
Rv3539|M.tuberculosis_H37Rv SGLADRWWQGPSSRMMAAQAARHTGWLAAAATQAEGAASQAQTMALAYEA
MAB_0936c|M.abscessus_ATCC_199 --------PGPPIPGIAPDGTVKA--APSAPDRTAYALGGAHVLGIPYDE
MAV_1760|M.avium_104 --------GGPPTPG-APG------------DQTAYALGGAHVLGIPYDQ
MLBr_01232|M.leprae_Br4923 --------WLPPSPVPVRE---------NSPAKIVYALGGARPPTFDWDY
Mflv_3371|M.gilvum_PYR-GCK ------------------------------------VTTAVAIGGLGTPD
Mvan_3103|M.vanbaalenii_PYR-1 ------------------------------------TPSGLVVGGLATPT
MMAR_0370|M.marinum_M --------SSLLAAAGDEVSGAIANLFSVYGRECQAVLAQVEAFRSEFAQ
MUL_1034|M.ulcerans_Agy99 --------SGLLAAAQDEVSAAIAKVFSAYGQEYQAAIAQASAFHTEFTR
TH_3724|M.thermoresistible__bu ------------------------------------LTATADAIIMPGTK
MSMEG_6144|M.smegmatis_MC2_155 ------------------------------------------TRILHDPP
Mb3569|M.bovis_AF2122/97 AFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWAQDVV
Rv3539|M.tuberculosis_H37Rv AFAATVHPALVAANRALVAWLAGSNVFGQNTPAIAAAEAIYEQMWAQDVV
MAB_0936c|M.abscessus_ATCC_199 YIRMTGKDWFPNMKRENVWYPAG---------------------------
MAV_1760|M.avium_104 YIRMEGADWFPGQQRQIVRYPAG---------------------------
MLBr_01232|M.leprae_Br4923 YTIRAGDEFFPDVNRKLIDYPAR---------------------------
Mflv_3371|M.gilvum_PYR-GCK MHEIVINPLLGGKLARENDILDG---------------------------
Mvan_3103|M.vanbaalenii_PYR-1 MHDLVMAQILKDELHGMERVS-----------------------------
MMAR_0370|M.marinum_M TLAAAGVAYAQTEAASLAALRG--------------------ALGIPSAA
MUL_1034|M.ulcerans_Agy99 ALAAAGAAYAQAEAANASLITAGVSDALTAITTPIQSLLGPAAIGTGGAG
TH_3724|M.thermoresistible__bu IGYIPSQDEFTAYATAVIGATAG---------------------------
MSMEG_6144|M.smegmatis_MC2_155 YPEQLVPGEFAGYDVEHIKYPAS---------------------------
Mb3569|M.bovis_AF2122/97 AMLNYHAVASAVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPSSTTT
Rv3539|M.tuberculosis_H37Rv AMLNYHAVASAVGARLRPWQQLLHELPRRLGGEHSDSTNTELANPSSTTT
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3103|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0370|M.marinum_M PAVSSASTIPPFTAN-LTSLFLG---------------------------
MUL_1034|M.ulcerans_Agy99 SAGALTAVSSTLMADPVVALIMG---------------------------
TH_3724|M.thermoresistible__bu --------------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 --------------------------------------------------
Mb3569|M.bovis_AF2122/97 RITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEVVSYP
Rv3539|M.tuberculosis_H37Rv RITVPGASPVHAATLLPFIGRLLAARYAELNTAIGTNWFPGTTPEVVSYP
MAB_0936c|M.abscessus_ATCC_199 ----------------------------QVQGHTLERFFPGIGPIGEKIL
MAV_1760|M.avium_104 ----------------------------QVQGHVLERLFPGIGKLDES-F
MLBr_01232|M.leprae_Br4923 ----------------------------APFRYVPTFLVPGP--------
Mflv_3371|M.gilvum_PYR-GCK -----------------------------VEWPAEAK-RPGTG-------
Mvan_3103|M.vanbaalenii_PYR-1 -----------------------------IYWPAEAKPYSGDT-------
MMAR_0370|M.marinum_M ---------------PTGVPIPDESYVQAANNLFVR---SSDILRPLYTP
MUL_1034|M.ulcerans_Agy99 ---------------GTSVPLPGPGYVSDINNNYIQPLFSGAIPQALFTP
TH_3724|M.thermoresistible__bu -----------------------------APGAVDYLGVPGEFWP-----
MSMEG_6144|M.smegmatis_MC2_155 --------------------------VFGMDRGIWEAAG-----------
Mb3569|M.bovis_AF2122/97 ATIGVLSGSLGAVDANQSIAIGQQMLHNEILAAT---ASGQPVTVAGLSM
Rv3539|M.tuberculosis_H37Rv ATIGVLSGSLGAVDANQSIAIGQQMLHNEILAAT---ASGQPVTVAGLSM
MAB_0936c|M.abscessus_ATCC_199 PGLGLDGPSIG-----ESIDIGEPNLENAIR------SGG-PGTAMGLSE
MAV_1760|M.avium_104 PGLGMDGPSVG-----ESVAEGIDNLDAAIR------TTGRPGTAIGLSE
MLBr_01232|M.leprae_Br4923 ----RDEVTIG-----EAIAVATKNLNQAIH------RGTEPAAVVGLSQ
Mflv_3371|M.gilvum_PYR-GCK -------QTLG-----QSITVGITNLGTHFDAAFARLEAGEQFTVVGFSA
Mvan_3103|M.vanbaalenii_PYR-1 -------YTLG-----ESIAIGITNLNTEIDTAIGKLAPGEQVKIVGLSA
MMAR_0370|M.marinum_M EELYPLT-GVKSLTLNASVEEGLTILDNAIMAQ--LSIPGNSVTVFGYSQ
MUL_1034|M.ulcerans_Agy99 EQFWPVTPGLGNLTFNQSVAQGVTLLNDAINTQ--LAL-GNKVVAFGYSQ
TH_3724|M.thermoresistible__bu ------ATGLDSLTFDASVAXGQAMLTPMVDG---AIESDTPIVVFGHSQ
MSMEG_6144|M.smegmatis_MC2_155 -----------------AVAAGVDRFVGVDDEGN---PITEKIIVAGFSQ
:: . : * *
Mb3569|M.bovis_AF2122/97 GSMVIDRELAYLAID--PNAPPSSALTFVELAGP------ERGLAQTYLP
Rv3539|M.tuberculosis_H37Rv GSMVIDRELAYLAID--PNAPPSSALTFVELAGP------ERGLAQTYLP
MAB_0936c|M.abscessus_ATCC_199 GALVLNAVKNALATD--PTAPEPESLTFATFGDPIAKSPFSESFLTQNFA
MAV_1760|M.avium_104 GAFVVDGEQARLAND--PTAPPPNTLNFATFGDPIGRHAFGQSFLTAMFG
MLBr_01232|M.leprae_Br4923 GSLALDTEQEQLATD--PTAPPPDQLTFNTFGDPSGYHGFGKSVLASIFR
Mflv_3371|M.gilvum_PYR-GCK GSLVVNDFMRELAND--PDAPTKDQVKFILVADS--------SRQKLLNE
Mvan_3103|M.vanbaalenii_PYR-1 GSLVVTEVLRLLAAD--PDAPAADQLTFIVVADS--------SRQKLIDK
MMAR_0370|M.marinum_M SAIIASLEMQKLAALG-PSAPTASQLNFVLVGNEMNP---NGGMLARFPD
MUL_1034|M.ulcerans_Agy99 SATIVNNEILALMAMG-TGAPDPGDLSFIMVGAPNNP---DGGLLARFPG
TH_3724|M.thermoresistible__bu SAVIATKEKQRLLAEY-PDPDTAPDVTFVMVANPNRP---NGGLLARFPG
MSMEG_6144|M.smegmatis_MC2_155 GAIVIAYEKKRLMKLDEDERPTVDQLKFVTIGDP-------TGPNGILRW
.: * :.* .. .
Mb3569|M.bovis_AF2122/97 VGTTIPIAGYTVGNAP--ESQYNTSVVYSQYDIWADPPDRPWNLLAGANA
Rv3539|M.tuberculosis_H37Rv VGTTIPIAGYTVGNAP--ESQYNTSVVYSQYDIWADPPDRPWNLLAGANA
MAB_0936c|M.abscessus_ATCC_199 PGSVVPFMDYPVPARV--DSQYHTDQFISAYDSIADWPDRPDNLFALANA
MAV_1760|M.avium_104 VGSVVPALDYTMPPPY--ESQYDTNRFVAAYDSIADFPDRPDNMFALANT
MLBr_01232|M.leprae_Br4923 PGDYIPLIDYTMPQRM--DSQYDSNRVVAAYDGLSEFPDRADNLLAQLNC
Mflv_3371|M.gilvum_PYR-GCK TSKYNPQYDYTYRPAP--QTMYDIDVVTGEYDGAADLPDRWWNFLALANA
Mvan_3103|M.vanbaalenii_PYR-1 -ARYNSRYDYTYQPPP--ETKYDVKEVTGEYDGMADFPDRWWNFVAVANA
MMAR_0370|M.marinum_M LSLPSLGLTFYGATPS--DTIYPTAIYTLEYDGFADFPRYPLNFIADLNA
MUL_1034|M.ulcerans_Agy99 FYIPFLDVSFNGATPA--ANPYPTSIFTAQYDGIAHAPQYRLNILSDINA
TH_3724|M.thermoresistible__bu LYIPILGVTFNGATPAPADGPFDSYDVAREFDGWADFPRYPLNLVATANA
MSMEG_6144|M.smegmatis_MC2_155 IPFRIPIIGLTPVRPP--DTPYETTIINGEYDGWADFPDRPWNLIATANA
: :* :. * *:.: *
Mb3569|M.bovis_AF2122/97 LMGAAYFHDLTAYAAPQ--QGIEIAAVT----SSLGGTTTTYMIPSPTLP
Rv3539|M.tuberculosis_H37Rv LMGAAYFHDLTAYAAPQ--QGIEIAAVT----SSLGGTTTTYMIPSPTLP
MAB_0936c|M.abscessus_ATCC_199 IAGLATGHTAVAFTNPKMVPARNIVTET----NSRGGTTTTYFIPEQHLP
MAV_1760|M.avium_104 LMGLATGHTAVAFTNPSMVPPQNIRTTI----NSRGAKDTTIMIPEKHLP
MLBr_01232|M.leprae_Br4923 FAGGAISHTPSGFFNPEDVPPQNIRTTV----NSRGAKTTTYLIPVNHLP
Mflv_3371|M.gilvum_PYR-GCK IAGGLFVHVPMMFSDYEAVTPEENITRV-T--NTLGGTTTTYLVPTKTLP
Mvan_3103|M.vanbaalenii_PYR-1 MAGGIFVHIPMMFADLK----DEYITEIDV--NELGGTTTKYLIPTAKLP
MMAR_0370|M.marinum_M VMGIPFVHVKYLDLTAAQVDSAIELPTS----PGYSGVTSYYVIPTENLP
MUL_1034|M.ulcerans_Agy99 IMGYFYVHGNYPDLMSG---QAIQLPTS----PGYTGNTDYYMYLTQDLP
TH_3724|M.thermoresistible__bu ILGIYYLHGGYYELLTENPDILDDPERTIV--QQYG-DTTYYLIRTEQLP
MSMEG_6144|M.smegmatis_MC2_155 LLGIIYVHGRYEDKVDGWDLSTVPEKNIVETVNKAGGKTTTYLIPTEKLP
. * * . **
Mb3569|M.bovis_AF2122/97 LLLPLKQIG-----------------------------------------
Rv3539|M.tuberculosis_H37Rv LLLPLKQIG-----------------------------------------
MAB_0936c|M.abscessus_ATCC_199 LVMGFKYLG-----------------------------------------
MAV_1760|M.avium_104 LVMPLKYIG-----------------------------------------
MLBr_01232|M.leprae_Br4923 LTLPLRYLG-----------------------------------------
Mflv_3371|M.gilvum_PYR-GCK LVQLLPFLKSQEASLKAKIDAGYSRNDDRLAAAAAATSTARSLAAPTVTN
Mvan_3103|M.vanbaalenii_PYR-1 LVQLLPFLAPMEAELKEMVDRGYSRND------IVETSALRTLTA---AV
MMAR_0370|M.marinum_M LLEPLRAIP-----------------------------------------
MUL_1034|M.ulcerans_Agy99 LVQPIRDIP-----------------------------------------
TH_3724|M.thermoresistible__bu LLRPLRDLG-----------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 LLQPLRDLG-----------------------------------------
* : :
Mb3569|M.bovis_AF2122/97 ------------VPDWIVGGLNNVLKPLVDAGYSQ-YAPTAGPYFSHGNL
Rv3539|M.tuberculosis_H37Rv ------------VPDWIVGGLNNVLKPLVDAGYSQ-YAPTAGPYFSHGNL
MAB_0936c|M.abscessus_ATCC_199 ------------VPEETLNRLDAILQPRVDAGYSR-NDDPATAPIAVDPR
MAV_1760|M.avium_104 ------------IDENTLNKLDAILTPRVNAGYSR-NDDPATAPVQVDPV
MLBr_01232|M.leprae_Br4923 ------------WSDALVDQIDAVLQPKIDAAYAY-NDNPLNKPISVDPV
Mflv_3371|M.gilvum_PYR-GCK EATDEVADDEAVATVQKISTDSDAEQADVPAERTS-SKPAVDDAADDDEA
Mvan_3103|M.vanbaalenii_PYR-1 EETDDAAEVTAPAEES-VEVDDADLKTEAKGDDGE-DLGAVGEDADTGSS
MMAR_0370|M.marinum_M -----------VIGNPLANLIQPDLKVIVNLGYGDPNYGYSTSYADVRTP
MUL_1034|M.ulcerans_Agy99 -----------YAGPPLADLIQPQLRVLVDLGYSD--YGPGLSYADVPTP
TH_3724|M.thermoresistible__bu ------------VPEEFVDALEPYVRRIVDLGYDR--NTPYGEPAPVRVL
MSMEG_6144|M.smegmatis_MC2_155 ------------FPESFVAALEAPLRKIIDAAYKRNDPGRVTVTTTEETV
.
Mb3569|M.bovis_AF2122/97 VW------------------------------------------------
Rv3539|M.tuberculosis_H37Rv VW------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 RGFDPAEVTAPASQATFGGGSDPISQITSGALAVLGNGTRPTPPN-----
MAV_1760|M.avium_104 HGFDPAEVTAPANQATFGGGADPLSQIMAGAMSVLSHGAGEADH------
MLBr_01232|M.leprae_Br4923 NGMDPIAGIDAELR-------DSILNVFAQLRSILPPPPG----------
Mflv_3371|M.gilvum_PYR-GCK AANEDAEADAADAKVDAKEDAEAAVKDDADASAGTNDDGEEGADSGSNDS
Mvan_3103|M.vanbaalenii_PYR-1 TGDDEAEVIDEADEVDEPDAIDEAVEDADEADSVDAGQGDE--DAAESED
MMAR_0370|M.marinum_M FGLFPDVSPGTIVDALAAGTQEGIQDFTADLQAMFGQPIPTPDIVPPTPA
MUL_1034|M.ulcerans_Agy99 AGLLSVPNPFAVSYYLLKG----------SLQAPYGAAVEIG-----VEA
TH_3724|M.thermoresistible__bu PPLTPAPGPATQHNAGQGITVASATSTPDKRTPVVEAPVEEPPVQTGRST
MSMEG_6144|M.smegmatis_MC2_155 VEDESEITQTAVTEIDETPSTDGDIDETAVQSTTQRRTVANTAADRTAET
Mb3569|M.bovis_AF2122/97 --------------------------------------------------
Rv3539|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK AAAAGDTDSSDGSSSEGPGSSDSGSSE-----------------------
Mvan_3103|M.vanbaalenii_PYR-1 STDTDDSDSSGDAASDGTGSSESGSSE-----------------------
MMAR_0370|M.marinum_M DILGKLSELPSPAQVVNTLTAVVANDYAVLLPTADIGLAVVTTLPLYSTQ
MUL_1034|M.ulcerans_Agy99 GLLGPE-SFPDTYPWVPSLNPGLN---------FYLGQPSVTLLSLLS--
TH_3724|M.thermoresistible__bu LKREKPVSARHLVRNSLRAVPGLRRGEPAATPTPDVTPDVTPDAPAGQPE
MSMEG_6144|M.smegmatis_MC2_155 AEVAEVTEDVDELAEQEEPVKEEATKDDEVTKVADEADKATPVKESTSVE
Mb3569|M.bovis_AF2122/97 --------------------------------------------------
Rv3539|M.tuberculosis_H37Rv --------------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_1760|M.avium_104 --------------------------------------------------
MLBr_01232|M.leprae_Br4923 --------------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3103|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0370|M.marinum_M LFFDQLLQGNLIDAFGYPIAATVGLLTIGGAVEFLTIAAAAQTTVQDIGS
MUL_1034|M.ulcerans_Agy99 --------GGLGDIF-HLIPPPVFP-------------------------
TH_3724|M.thermoresistible__bu PAEPNESAAPPAAAEADDASE-----------------------------
MSMEG_6144|M.smegmatis_MC2_155 KTDQAVKPDDTDKTVTTAEKVEKADEAEKVEKTKPNVRKVKRPQFNVFKP
Mb3569|M.bovis_AF2122/97 ------------------------------------------
Rv3539|M.tuberculosis_H37Rv ------------------------------------------
MAB_0936c|M.abscessus_ATCC_199 ------------------------------------------
MAV_1760|M.avium_104 ------------------------------------------
MLBr_01232|M.leprae_Br4923 ------------------------------------------
Mflv_3371|M.gilvum_PYR-GCK ------------------------------------------
Mvan_3103|M.vanbaalenii_PYR-1 ------------------------------------------
MMAR_0370|M.marinum_M LIP---------------------------------------
MUL_1034|M.ulcerans_Agy99 ------------------------------------------
TH_3724|M.thermoresistible__bu ------------------------------------------
MSMEG_6144|M.smegmatis_MC2_155 KKTRVTVPKAEPSTKAKPATKPDNDNDDTSDTTDKTAEKDAA