For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MLAPNDGDSLSLLLVEDDRGDAILVEELIADAGGDIQVVWAESMARAEQEIAIARPDCILLDLHLHDTDG IDGVNRIAKYDATLPIVVLTGLNDEHVGVSAVSAGAQDYLIKDRVDPEVLRRAVLYAIERKRAELTAVDL HASQLRARENARLERGLLPSPLLLDDPGVEIVAQYQPSRENALLGGDFYDFVQTPDRTVHVMIGDVAGHG PDEAALGVALRIAWRALTFAGLRGSDRMRQLERILRAERGGRGIFATVLSLAIPPEGPMITAVRAGHPGM LLHGGGTVDWVEPAGGPALGLHGSDWTPQQVELPEGKGLVLLTDGLFEGHIGSGNERLGEEGLLELARSL AALPGRAFVHALINAVEERAAAHGGISDDIAVVRVERTPRA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2987 | - | - | 100% (391) | response regulator receiver protein |
| M. vanbaalenii PYR-1 | Mvan_5805 | - | 4e-14 | 29.17% (264) | putative GAF sensor protein |
| M. vanbaalenii PYR-1 | Mvan_3797 | - | 3e-13 | 28.77% (219) | putative GAF sensor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 4e-14 | 26.32% (266) | hypothetical protein Mb1399c |
| M. gilvum PYR-GCK | Mflv_3268 | - | 0.0 | 88.97% (390) | response regulator receiver protein |
| M. tuberculosis H37Rv | Rv1364c | - | 1e-14 | 26.69% (266) | hypothetical protein Rv1364c |
| M. leprae Br4923 | MLBr_00773 | mtrA | 8e-09 | 34.82% (112) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_3891c | - | 3e-08 | 29.75% (158) | LuxR family transcriptional regulator |
| M. marinum M | MMAR_1263 | - | 1e-154 | 70.18% (399) | hypothetical protein MMAR_1263 |
| M. avium 104 | MAV_4242 | - | 1e-156 | 72.03% (379) | response regulator receiver modulated serine phosphatase |
| M. smegmatis MC2 155 | MSMEG_6131 | - | 1e-156 | 71.92% (381) | magnesium or manganese-dependent protein phosphatase |
| M. thermoresistible (build 8) | TH_2176 | - | 1e-161 | 74.67% (379) | magnesium or manganese-dependent protein phosphatase |
| M. ulcerans Agy99 | MUL_2625 | - | 1e-154 | 69.92% (399) | hypothetical protein MUL_2625 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2987|M.vanbaalenii_PYR-1 --MLAPNDG----------------DSLSLLLVEDDRGDAILVEELIADA
Mflv_3268|M.gilvum_PYR-GCK --MLAPTDG----------------EMLSLLLVEDDRADAILVEELIADA
MSMEG_6131|M.smegmatis_MC2_155 --MRAPFDR--VIASPVDLTGPGQRR-LSLLLVEDDRADAILVEELIADA
TH_2176|M.thermoresistible__bu MPMRAPHESEPLPMAGLGAVPTGQTQPISLLLVEDDRADALLVEELIADT
MMAR_1263|M.marinum_M --MRVPHEHDLTAGLGPSTGQRAQWQTLSLLLVEDDRADAMLVEELIADA
MUL_2625|M.ulcerans_Agy99 --MRVPHEHDLTAGLGPSTGQRAQWQTLSLLLVEDARADAMLVEELIADA
MAV_4242|M.avium_104 ---MIPAQAAVTP-----AAQRQSLKPLSVLLVEDDRGDAVLVEELVTDA
Mb1399c|M.bovis_AF2122/97 ----MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYR
Rv1364c|M.tuberculosis_H37Rv ----MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYR
MLBr_00773|M.leprae_Br4923 ----------------------MDIMRQRILVVDDDASLAEMLTIVLRGE
MAB_3891c|M.abscessus_ATCC_199 --------------------------MITVFLVDDHEVVRRGLADLLEEE
::* :
Mvan_2987|M.vanbaalenii_PYR-1 GGDIQVVWAESMARAEQEIAIARPDCILLDLHLHDTDGIDGVNRIAKYDA
Mflv_3268|M.gilvum_PYR-GCK GVDIDVVWAESMAKAEQEIAIARPDCVLLDLHLHDTTGIDGLNRISKQDA
MSMEG_6131|M.smegmatis_MC2_155 -PDIDFVWAKSMSDAERTLADHRPDCVLLDLNLPDAAGIDALHHLGKLDA
TH_2176|M.thermoresistible__bu NADIRVTWAASVADAQHRLAADRPDCVLLDLNLPDADGIDALDRICGYDA
MMAR_1263|M.marinum_M AVDIQVVWARSMAHAERELSAARPDCVLLDLNLPDASGIDALDRIANRDA
MUL_2625|M.ulcerans_Agy99 AVDIQVVWARSMAHAERELSAARPDCVLLDLNLPDASGIDALDRIANRDA
MAV_4242|M.avium_104 VTDIRVVWAQSMAHAERELESTRPDCVLLDLHLPDASGIDALNRIAKLDA
Mb1399c|M.bovis_AF2122/97 GFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDY
Rv1364c|M.tuberculosis_H37Rv GFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDY
MLBr_00773|M.leprae_Br4923 GFDTAVIGDG--TQALTAVRELRPDLVLLDLMLPGMNGID-VCRVLRADS
MAB_3891c|M.abscessus_ATCC_199 ADFSVIGQASSVAEAMARIPALQPDIAVLDIRLPDGNGVELCRELRSKLP
. : : :** .
Mvan_2987|M.vanbaalenii_PYR-1 TLPIVVLTGLNDEHVGVSAVSAGAQDYLIKDRVDPEVLRRAVLYAIERKR
Mflv_3268|M.gilvum_PYR-GCK TIPVVVLTGLNDEHFGVSAVSAGAQDYLIKGRVDSEVLRRAVLYAIERKR
MSMEG_6131|M.smegmatis_MC2_155 RIPIIVLTGLNDEHFGVSAVASGAQDYLVKGRVEPEMLRRAVLYAIERKR
TH_2176|M.thermoresistible__bu TMPIVVLTGLIDEHFGVLAVASGAQDYLIKGRVEPESLRRSVLYAIERKR
MMAR_1263|M.marinum_M TVPVVVLTGLNDEYFGATAVAAGAQDYLVKGRVDPEMLRRAMLYAIERKR
MUL_2625|M.ulcerans_Agy99 TVPVVVLTGLNDEYFGATAVAAGAQDYLVKGRVDPEMLRRAMLYAIERKR
MAV_4242|M.avium_104 TVPIVVLTGLNDEYFGASAVAAGAQDYLVKGRVEPEMLRRALLYAIERKR
Mb1399c|M.bovis_AF2122/97 DG-----SGVEERYFDFVVTPRRRADGSIEG--VQLIVDDVTSRVRARQA
Rv1364c|M.tuberculosis_H37Rv DG-----SGVEERYFDFVVTPRRRADGSIEG--VQLIVDDVTSRVRARQA
MLBr_00773|M.leprae_Br4923 GVPIVMLTAKTDTVDVVLGLESGADDYIMKP-------------------
MAB_3891c|M.abscessus_ATCC_199 NLNCLMLTSFTDEHAMLDAIMAGAGGYVIKDIKGMELIS-----------
:. : . ::
Mvan_2987|M.vanbaalenii_PYR-1 AELTAVDLHASQLRARENARLERGLLPSPLLLDDPGVEIVAQYQPSRENA
Mflv_3268|M.gilvum_PYR-GCK AELTTVDLHASQLRARENARLERGLLPSPLLLDDPGVEIVTQYRPSRENA
MSMEG_6131|M.smegmatis_MC2_155 AELTSVDLHASQLRAQENARLERGLLPSPLLMEGSGVDIVVEARPSRQHA
TH_2176|M.thermoresistible__bu HELTAVDLQASRLQAQENARLERGLLPSPLLLDEPGFDIVAQYRPSHQHA
MMAR_1263|M.marinum_M AELIAADLHATQLRARENALLERGLLPSPLLLDSPGVDIVARYRPSREDA
MUL_2625|M.ulcerans_Agy99 AELIAADLHATQLRARENALLERGLLPSPLLLDSPGVDIVARYRPSREDA
MAV_4242|M.avium_104 AELIAADLHATQLRARENALLERGLLPSPLLLDDPGVDIVARYRPSREDA
Mb1399c|M.bovis_AF2122/97 AEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDT
Rv1364c|M.tuberculosis_H37Rv AEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDT
MLBr_00773|M.leprae_Br4923 -------FKPKELVARVRARLRRNDDEPAEMLSIADVDIDVPAHKVTRN-
MAB_3891c|M.abscessus_ATCC_199 -AVRTVGAGRSLLDNRAAAALMNRLRAAADNPS-PLAGLTAQERT-----
: * : . .. . : .
Mvan_2987|M.vanbaalenii_PYR-1 LLGGDFYDFVQTPDRTVHVMIGDVAGHGPDEAALGVALRIAWRALTFAGL
Mflv_3268|M.gilvum_PYR-GCK LLGGDFYDFVQTPDRTVHVMIGDVAGHGADEAALGVALRIAWRALTFAGL
MSMEG_6131|M.smegmatis_MC2_155 LIGGDFYDVVQTPDRTVHVMIGDVAGHGPDEAALGVALRIGWRALTFAGL
TH_2176|M.thermoresistible__bu LLGGDFYDFVQTPDQTLHVMVGDVSGHGPDEAAVGVALRIGWRALTFAGL
MMAR_1263|M.marinum_M LLCGDFYDVVQTADRVVHVLIGDVAGHGPNEAALGAALRIAFRALTLAGV
MUL_2625|M.ulcerans_Agy99 LLCGDFYDVVQTVDRVVHVLIGDVAGHGPNEAALGAALRIAFRALTLAGV
MAV_4242|M.avium_104 LLCGDFYDVVQTPDRVVHVLIGDVAGHGPHEAALGAALRIAFRALTLAGV
Mb1399c|M.bovis_AF2122/97 AAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVMSQLRTALRMQISTGY
Rv1364c|M.tuberculosis_H37Rv AAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGY
MLBr_00773|M.leprae_Br4923 ---------------------GEHISLTPLEFDLLVALARKPRQVFTRDV
MAB_3891c|M.abscessus_ATCC_199 --------------------LLELIGEGLTNRQIAERMFLAEKTVK----
: . : : :
Mvan_2987|M.vanbaalenii_PYR-1 RGSDRMRQLERILRAERGGRGIFATVLSLAIPPEGP------MITAVRAG
Mflv_3268|M.gilvum_PYR-GCK HGSDRMRQLERILRAERAGRGIFATVLSLRIPPTGS------TVTAVRAG
MSMEG_6131|M.smegmatis_MC2_155 RGNERMRQLDRILTTERPGKGIFATLCSVALEPDSG------RFTVVRAG
TH_2176|M.thermoresistible__bu RGNERMWQLERILRAERPGRGIFATVLSIALSPKDL------TFTAVRAG
MMAR_1263|M.marinum_M HGGQLMRQLDRVLRAERTGEGIFATVLSLAIPPQPAGSADGAHIQVIRAG
MUL_2625|M.ulcerans_Agy99 HGGELMRQLDRVLRAERTGEGIFATVLSLAIPPQPAGSADGAHIQVIRAG
MAV_4242|M.avium_104 HGVELMRQLERVLHSERTGTGIFATVLSLEISPQRP------EVSVIRAG
Mb1399c|M.bovis_AF2122/97 TVVEALEAVDRFHKQVPGSK--SATMCVGSLDFTSG------EFQYCTAG
Rv1364c|M.tuberculosis_H37Rv TVVEALEAVDRFHKQVPGSK--SATMCVGSLDFTSG------EFQYCTAG
MLBr_00773|M.leprae_Br4923 -------LLEQVWGYRHPADTRLVNVHVQRLRAKVE-----------KDP
MAB_3891c|M.abscessus_ATCC_199 ------NYVSRLLTKLDLERRTQVAVLATKLARENQ--------------
:.:. . : :
Mvan_2987|M.vanbaalenii_PYR-1 HPG-MLLHGGGTVDWVEPAGGPALGLHGSDWTPQQVELPEGKGLVLLTDG
Mflv_3268|M.gilvum_PYR-GCK HPG-MLLHGRGTVEWVEPPGGPALGLHGSDWAPQHLELPEGMGLVLLTDG
MSMEG_6131|M.smegmatis_MC2_155 HPG-LLVHGNGTVDWLEPRPGAALGLGAREWPVNHYELPEGHGLLLLTDG
TH_2176|M.thermoresistible__bu HPG-LLVHGPDTVDWLEPPAGPALGLKGTDWPTNEYELPAGHGLLLLTDG
MMAR_1263|M.marinum_M HPG-MLLHGGGTVHWLEPPAGPALGLNLGNWCQHEVELPVDHGLLLLTDG
MUL_2625|M.ulcerans_Agy99 HPG-MLLHGGGTVHWLEPPAGPALGLNLGNWCQHEVELPVDHGLLLLTDG
MAV_4242|M.avium_104 HPG-MLLQGGGTVEWVEPPGGPALGLRADDWPRHQLRLPAGHGLLLLTDG
Mb1399c|M.bovis_AF2122/97 HPPPLLVTADASARYVEPTGAGPLGS-GTGFPVRSEVLNIGDAILFYTDG
Rv1364c|M.tuberculosis_H37Rv HPPPLLVTADASARYVEPTGAGPLGS-GTGFPVRSEVLNIGDAILFYTDG
MLBr_00773|M.leprae_Br4923 ENPTVVLTVRGVGYKAGPP-------------------------------
MAB_3891c|M.abscessus_ATCC_199 -----GLHG-----------------------------------------
:
Mvan_2987|M.vanbaalenii_PYR-1 LFEGHIGSGNERLGEEGLLELARSLAALPG-------RAFVHALINAVEE
Mflv_3268|M.gilvum_PYR-GCK LFEGHIGRGNERLGEEGLLEMARSLAHLPG-------REFVDALINGVEA
MSMEG_6131|M.smegmatis_MC2_155 LFEGHAGRGDERLGESGLLAVARALAATPG-------RDFVTSLINEAES
TH_2176|M.thermoresistible__bu LFEGHSGRGYERLGEEGLLDLARSHAALPG-------AEFVHALIDDAEH
MMAR_1263|M.marinum_M LFEGYSGHRRERLGEHGLLSLARSHAGLSG-------PAFVDALIDGAQQ
MUL_2625|M.ulcerans_Agy99 LFEGYSGHRRERLGEHGLLSLARSHAGLSG-------PAFVDALIDGAQQ
MAV_4242|M.avium_104 LYEGYSGRGTQRLGEDGLLALARSQVDRPG-------PAFVDALIDGAQR
Mb1399c|M.bovis_AF2122/97 LIE-RPGRPLEAS-TAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLE
Rv1364c|M.tuberculosis_H37Rv LIE-RPGRPLEAS-TAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLE
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 RAAAHGGISDDIAVVRVERTPRA---------------------------
Mflv_3268|M.gilvum_PYR-GCK RAASHGGISDDIAVVRVERTPRR---------------------------
MSMEG_6131|M.smegmatis_MC2_155 RAQTHGGLSDDIAVIRVERSRR----------------------------
TH_2176|M.thermoresistible__bu RAQAVGGISDDIAVVRVERTR-----------------------------
MMAR_1263|M.marinum_M RAQSLGGLTDDIAVLRVERTPA----------------------------
MUL_2625|M.ulcerans_Agy99 RAQSLGGLTDDIAVLRVERTPA----------------------------
MAV_4242|M.avium_104 LARPRGGLTDDIAVLRVERTIT----------------------------
Mb1399c|M.bovis_AF2122/97 LLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAE
Rv1364c|M.tuberculosis_H37Rv LLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAE
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 IGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVEAALAGDGNVRAS
Rv1364c|M.tuberculosis_H37Rv IGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRAS
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 VIDRGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSR
Rv1364c|M.tuberculosis_H37Rv VIDRGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSR
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 PARFVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQI
Rv1364c|M.tuberculosis_H37Rv PARFVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQI
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 AVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPG
Rv1364c|M.tuberculosis_H37Rv AVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPG
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------
TH_2176|M.thermoresistible__bu --------------------------
MMAR_1263|M.marinum_M --------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------
MAV_4242|M.avium_104 --------------------------
Mb1399c|M.bovis_AF2122/97 SPAHHVLSLVQLPVVGADTEDIFAQE
Rv1364c|M.tuberculosis_H37Rv SPAHHVLSLVQLPVVGADTEDIFAQE
MLBr_00773|M.leprae_Br4923 --------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------