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VWRGCEEATMGAGPPLDVDSGNDAAWAAVPHPVLVVDRDGIVRTSSGSARSLLPGLSPGVALKDLAPSWL SGAHQHLTAASGSVHGRDFDAHPTPLPGGEVAWWLVEDSDRSARDARRALTVERERAAFLDEASAVLMAS LNIDRCMEATVQMAARHLADAAVLVTPVAGGRIPVVCSGTDGTAEHRRVDADPSDVAGLSEALRGFPPVP SRWIDPASVPGWLVPESFPGPVGSVVITPLPGHGVAAGALVLLRRTSQTAFSEGEEVFARLFAARAGAAL SAARLYAEQSAITRTLLRDLLPPQLHRLDGIELAGGYRASEDHEAVGGDFYDVHPAATPDDETLVVLGDV CGKGLEAAVLTGKIRNTLMALSPLAQDHAGVLRLLNAALLCVDDSRFATLVLASVSRRDGQVLLRLTSAG HLAPLIVRNDGRVEEAETAGTLVGVMPQIRARTVETSLAPGETCLLYTDGVTEARGGPLGTDMFGEQRLS AALAECAGLPAEAVVERIMMLTTGWLNERAHDDIAVVAITAPRRTHLSAVDGRTAGRYTA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5805 | - | - | 100% (550) | putative GAF sensor protein |
| M. vanbaalenii PYR-1 | Mvan_2987 | - | 6e-14 | 29.17% (264) | response regulator receiver protein |
| M. vanbaalenii PYR-1 | Mvan_3797 | - | 7e-13 | 27.27% (231) | putative GAF sensor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 8e-13 | 24.73% (279) | hypothetical protein Mb1399c |
| M. gilvum PYR-GCK | Mflv_1031 | - | 0.0 | 76.89% (541) | putative GAF sensor protein |
| M. tuberculosis H37Rv | Rv1364c | - | 8e-13 | 24.73% (279) | hypothetical protein Rv1364c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3991 | rsbU | 3e-17 | 29.00% (269) | regulator of sigma subunit, anti-anti-sigma factor RsbU |
| M. avium 104 | MAV_0430 | - | 4e-16 | 24.36% (427) | stage II sporulation protein E (SpoIIE) |
| M. smegmatis MC2 155 | MSMEG_6131 | - | 1e-13 | 30.42% (263) | magnesium or manganese-dependent protein phosphatase |
| M. thermoresistible (build 8) | TH_3243 | - | 2e-50 | 35.61% (410) | PUTATIVE putative putative GAF sensor protein |
| M. ulcerans Agy99 | MUL_3853 | rsbU | 2e-17 | 29.00% (269) | regulator of sigma subunit, anti-anti-sigma factor RsbU |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1399c|M.bovis_AF2122/97 -------------------------------------------------M
Rv1364c|M.tuberculosis_H37Rv -------------------------------------------------M
MMAR_3991|M.marinum_M -------------------------------------------------M
MUL_3853|M.ulcerans_Agy99 -------------------------MLLLDLLRQRTYSFVRSVHRRDGYM
Mvan_5805|M.vanbaalenii_PYR-1 --------------------------------------------MWRGCE
Mflv_1031|M.gilvum_PYR-GCK --------------------------------------------------
TH_3243|M.thermoresistible__bu --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0430|M.avium_104 MSDDNDFHDQYARALRAYLASRDEASLAVGHELGRRALQEQISLLEIIEQ
Mb1399c|M.bovis_AF2122/97 AAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPL
Rv1364c|M.tuberculosis_H37Rv AAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPL
MMAR_3991|M.marinum_M AAEMDWDKSVGTANTVRRIFENVPTMLVGLEGPEHRFVAANAAYRRFSPT
MUL_3853|M.ulcerans_Agy99 AAEMDWDKNVGTANTVRRIFENVPTMLVGLEGPEHRFVAANAAYRRFSPT
Mvan_5805|M.vanbaalenii_PYR-1 EATMGAGPPLDVDSGNDAAWAAVPHPVLVVDR-DGIVRTSSGSARSLLPG
Mflv_1031|M.gilvum_PYR-GCK ---MGEITPLDVVSGIDSVWDSVPHPVLVVDR-GGMVRTLSASARSVLPD
TH_3243|M.thermoresistible__bu --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0430|M.avium_104 HVRLVFEISQDVRIDAPIALEFLLQLLVPLDVATRGFIDGNRRYAEQRAR
Mb1399c|M.bovis_AF2122/97 LD--------TVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQ
Rv1364c|M.tuberculosis_H37Rv LD--------TVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQ
MMAR_3991|M.marinum_M FT--------AVGQPAREVYPELESQQIYHMLDRVYETGEPQSGAEWRLQ
MUL_3853|M.ulcerans_Agy99 FT--------AVGQPAREVYPELESQQIYHMLDRVYETGEPQSGAEWRLQ
Mvan_5805|M.vanbaalenii_PYR-1 LS--------PGVALKDLAPSWLSGAHQHLTAASGSVHGRDFDAHPTPLP
Mflv_1031|M.gilvum_PYR-GCK IG--------PGSAVEDFVPSWLSGDD-------------DREARTTELP
TH_3243|M.thermoresistible__bu VS--------AHTDIGDTAP------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0430|M.avium_104 AEGLADRDKFRNALVNSLQEGFFVADHEGSVIEVNNAFIEILGFPAEGLP
Mb1399c|M.bovis_AF2122/97 TDYDGSGVEERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEAR
Rv1364c|M.tuberculosis_H37Rv TDYDGSGVEERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEAR
MMAR_3991|M.marinum_M ADFDGSGIDERYFDFLVTPRRREDGSIEGVQILFDDVTTRVRARLAAEAR
MUL_3853|M.ulcerans_Agy99 ADFDGSGIDERYFDFLVTPRRREDGSIEGVQILFDDVTTRVRARLAAEAR
Mvan_5805|M.vanbaalenii_PYR-1 GGEVAWWLVEDSDRSARDARRALTVERERAAFLDEASAVLMASLNIDRCM
Mflv_1031|M.gilvum_PYR-GCK DGEMAWWLLEDS---ARSTRLALTLERERSEFLDEASAVLMASLNIDRCM
TH_3243|M.thermoresistible__bu -------------------------ASMGESVIADVAETLGGSLNLRRTA
MSMEG_6131|M.smegmatis_MC2_155 -----------------------------MRAPFDRVIASPVDLTGPGQR
MAV_0430|M.avium_104 YRWPHPWLVDPKTASEQIGVVLRTGSAEYETPIRHADGHLAWVKVSINAV
.
Mb1399c|M.bovis_AF2122/97 VEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAGG
Rv1364c|M.tuberculosis_H37Rv VEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAGG
MMAR_3991|M.marinum_M VEELSERYRHLRDSAIVMQQALLAPSVPVVSGADIAAQYLVAAQDTAAGG
MUL_3853|M.ulcerans_Agy99 VEELSERYRHLRDSAIVMQQALLAPSVPVVSGPDIAAQYLVAAQDTAAGG
Mvan_5805|M.vanbaalenii_PYR-1 EATVQMAARHLADAAVLVTP-VAGGRIPVVCSGTDGTAEHRRVDADPS--
Mflv_1031|M.gilvum_PYR-GCK EATVQMAARHLADAAVLVAP-ASGGVVPLVFGLPDGTTEHRRIDADPA--
TH_3243|M.thermoresistible__bu LRLISLIQPRLADWAMVVLPDPRAGVLVAVGDAAPAGVPLRRADLDDL--
MSMEG_6131|M.smegmatis_MC2_155 RLSLLLVEDDRADAILVEELIADAPDIDFVWAKSMSDAERTLADHRPD--
MAV_0430|M.avium_104 KDSGSDRDAYVGTIRDVTAERAFAARESAVLRLATAVAVAKSVDELLSIT
: . * . :
Mb1399c|M.bovis_AF2122/97 DWFDALALGDRLVLVVGDVVGHGVEAAAVMSQLRTALR-----------M
Rv1364c|M.tuberculosis_H37Rv DWFDALALGDRLVLVVGDVVGHGVEAAAVMSQLRTALR-----------M
MMAR_3991|M.marinum_M DWFDAVALGDRLVLIVGDVVGHGVEAAAVMSQLRTALR-----------L
MUL_3853|M.ulcerans_Agy99 DWFDAVALGDRLVLIVGDVVGHGVEAAAVMSQLRTALR-----------L
Mvan_5805|M.vanbaalenii_PYR-1 ----DVAGLSEALRGFPPVPSRWIDPASVPGWLVPES------------F
Mflv_1031|M.gilvum_PYR-GCK ----EVAGLSEALRGFPPVPSRWIDPGSLPEWLVPPG------------F
TH_3243|M.thermoresistible__bu ----PLGRVLRSGS-VEQIHDTDLAGLIPVEPFQQSA------------V
MSMEG_6131|M.smegmatis_MC2_155 ----------CVLLDLNLPDAAGIDALHHLGKLDARIP-----------I
MAV_0430|M.avium_104 LDECSTAIDVQRVVAVSWPSGDGDPAVQVAGRPAASSWRELDPWLRDTFA
.
Mb1399c|M.bovis_AF2122/97 QISTGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGE---------
Rv1364c|M.tuberculosis_H37Rv QISAGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGE---------
MMAR_3991|M.marinum_M QIAAGRSIGEALEALDAFHEHVPGSNSATLCVGSLDFTTGE---------
MUL_3853|M.ulcerans_Agy99 QIAAGRSIGEALEALDAFHEHVPGSNSATLCVGSLDFTTGE---------
Mvan_5805|M.vanbaalenii_PYR-1 PGPVGSVVITPLPGHG----VAAGALVLLRRTSQTAFSEGE---------
Mflv_1031|M.gilvum_PYR-GCK SDGTGGVVITPLPGHG----VPAGALVLLRRSSESTFSDGE---------
TH_3243|M.thermoresistible__bu ALAPAEVVAVGLTARG----STFGALVVLRR-GDTGFRADE---------
MSMEG_6131|M.smegmatis_MC2_155 IVLTG--LNDEHFGVSAVASGAQDYLVKGRVEPEMLRRAVL---------
MAV_0430|M.avium_104 EARHQLPLTAKTVDHPDNPGKSRGLVAVLSGAGDLALWLELRTPRWVSGE
: . .
Mb1399c|M.bovis_AF2122/97 -FQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIGDA
Rv1364c|M.tuberculosis_H37Rv -FQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIGDA
MMAR_3991|M.marinum_M -FQYCTAGHPPPLVVTAEAKSRYLEPSGAGPLGSDTGFPVRTELIGVGDV
MUL_3853|M.ulcerans_Agy99 -FQYCTAGHPPPLVVTAEAKARYLEPSGAGPLGSDTGFPVRTELIGVGDV
Mvan_5805|M.vanbaalenii_PYR-1 -EVFARLFAARAGAALSAARLYAEQSAITRTLLRDLLPPQLHRLDGIELA
Mflv_1031|M.gilvum_PYR-GCK -EVFARLFAARAGAALSAARLYAEQSTITRTLMRELLPPQLQRLDGIELA
TH_3243|M.thermoresistible__bu -LDVVARVADRAAVAFDSARLYEEQARVASVLQQSLHPPSLPDIPGVRLA
MSMEG_6131|M.smegmatis_MC2_155 -YAIERKRAELTSVDLHASQLRAQEN--ARLERGLLPSPLLMEGSGVDIV
MAV_0430|M.avium_104 DRLLVTVLIGHLSLALQHVRQFENARETSLTLQRAMLPPVQPPP---GFA
: * .
Mb1399c|M.bovis_AF2122/97 ILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLC
Rv1364c|M.tuberculosis_H37Rv ILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLC
MMAR_3991|M.marinum_M VLLYTDGLIERPGRPLGASTAEFADLAANITSG-GGFVIDAQSRPIDRLC
MUL_3853|M.ulcerans_Agy99 VLLYTDGLIERPGRPLGASTAEFADLAANITSG-GGFVIDAQSRPIDRLC
Mvan_5805|M.vanbaalenii_PYR-1 GGYRASEDHEAVG-------GDFYDVHPAATPDDETLVVLG------DVC
Mflv_1031|M.gilvum_PYR-GCK GGYRASADHETIG-------GDFYDVHPAAGPDDETLVILG------DVC
TH_3243|M.thermoresistible__bu ACYRPAAEHLDIG-------GDFYDVT---GSDHDWLIAIG------DVC
MSMEG_6131|M.smegmatis_MC2_155 VEARPSRQHALIG-------GDFYDVVQ--TPDRTVHVMIG------DVA
MAV_0430|M.avium_104 VRYEPAVPPLEIG-------GDWYDVLP--IGDHRIGIVVG------DCV
. * .:: *: . : .
Mb1399c|M.bovis_AF2122/97 SDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLR
Rv1364c|M.tuberculosis_H37Rv SDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLR
MMAR_3991|M.marinum_M SETLELLLRSTGYNDDITLLAVQRRAPTPPLNITEDATIHAARAIRSRLR
MUL_3853|M.ulcerans_Agy99 SETLELLLRSTGYNDDITLLAVQRRAPTPPLNITEDATIHAARAIRSRLR
Mvan_5805|M.vanbaalenii_PYR-1 GKGLEAAVLTG------------------------------------KIR
Mflv_1031|M.gilvum_PYR-GCK GKGLDAAVLTG------------------------------------KIR
TH_3243|M.thermoresistible__bu GKGVEAAALTG------------------------------------QTR
MSMEG_6131|M.smegmatis_MC2_155 GHGPDEAALGV------------------------------------ALR
MAV_0430|M.avium_104 GRGLPAAAIMGQLRSSARALLINGAEPAVLLDQLDSAASLIPNAYCTTVF
.
Mb1399c|M.bovis_AF2122/97 EWLAEIGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVEAALAGDG
Rv1364c|M.tuberculosis_H37Rv EWLAEIGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDG
MMAR_3991|M.marinum_M QWLSEIGADSSDISDIVHAISEFVENAVEHGYSTDVSDGLAVAAALGGDG
MUL_3853|M.ulcerans_Agy99 QWLSEIGADSGDISDIVHAISEFVENAVEHGYSTDVSDGLAVAAALGGDG
Mvan_5805|M.vanbaalenii_PYR-1 NTLMALSPLAQDHAGVLRLLNAALLCVDDSRFATLVLASVSRR-----DG
Mflv_1031|M.gilvum_PYR-GCK NTLQALAPLAADHTGVLKLLNSALLSIDDTRFATLVLASVVRR-----DG
TH_3243|M.thermoresistible__bu QSLRTAAHFDRSPDVVLGAVNSVLCDLRVKQFVTVLCARIRARP----GG
MSMEG_6131|M.smegmatis_MC2_155 IGWRALTFAGLRGNERMRQLDRILTTERPGKGIFATLCSVALEP-----D
MAV_0430|M.avium_104 LAILDTETGVLQYSNAGHMPAVLAGPEPGTTTLLTDAASVPLAVRREDPR
:
Mb1399c|M.bovis_AF2122/97 NVRASVIDRG-----QWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGT
Rv1364c|M.tuberculosis_H37Rv NVRASVIDRG-----QWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGT
MMAR_3991|M.marinum_M KLRVAVIDHG-----TWKHHREGERGRGRGLAMAEALVSETHVSHDGAGT
MUL_3853|M.ulcerans_Agy99 KLRVAVIDHG-----TWKHHREGERGRGRGLAMAEALVSETHVSHDGAGT
Mvan_5805|M.vanbaalenii_PYR-1 QVLLRLTSAG-----HLAPLIVRNDGR----------VEEAETAGTLVGV
Mflv_1031|M.gilvum_PYR-GCK FVRLRLTSAG-----HLAPLIVRNDGS----------VEEADTGGTLVGV
TH_3243|M.thermoresistible__bu GVGVDLATAG-----HPAPLIVRGDGR----------VEQAEVYGTAAGL
MSMEG_6131|M.smegmatis_MC2_155 SGRFTVVRAG-----HPG-LLVHGNGT----------VDWLEPRPGAALG
MAV_0430|M.avium_104 PQATRLLPPGSTLMLFTDGLVERKHEPIDDGIGRAAEVLAQTMTLPLDTV
: * *
Mb1399c|M.bovis_AF2122/97 TATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVS-LVESGRIVVRGDVD
Rv1364c|M.tuberculosis_H37Rv TATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVS-LVESGRIVVRGDVD
MMAR_3991|M.marinum_M TATVVHRLSRPAQFVTDPVVSRAPNRPTIDSEFASTVTESGHIVVRGDVD
MUL_3853|M.ulcerans_Agy99 TATVVHRLSRPAQFVTDPVVSRAPNRPAIDSEFASTVTESGHIVVRGDVD
Mvan_5805|M.vanbaalenii_PYR-1 MPQIRARTVETSLAPGETCL----------------------LYTDGVTE
Mflv_1031|M.gilvum_PYR-GCK MPTIRARTVDAALAPGETCL----------------------LFTDGVTE
TH_3243|M.thermoresistible__bu VSGMRYGATALELHRGDTMV----------------------MFTDGIDE
MSMEG_6131|M.smegmatis_MC2_155 LGAREWPVNHYELPEGHGLL----------------------LLTDGLFE
MAV_0430|M.avium_104 ADEVLRELAPAAGYDDDVAMVIYRHQQSPLRIETAATADQLVRIRHRLAD
. : :
Mb1399c|M.bovis_AF2122/97 STTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAG--VGALAAACDRA-
Rv1364c|M.tuberculosis_H37Rv STTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAG--VGALAAACDRA-
MMAR_3991|M.marinum_M SNTAPTLDRQIAVESRSGIASLTIDLSAVTHLGSAG--VSALVTARDRA-
MUL_3853|M.ulcerans_Agy99 SNTAPTLDRQIAVESRSGIASLTIDLSAVTHLGSAG--VSALVTARDRA-
Mvan_5805|M.vanbaalenii_PYR-1 ARGGPLGTDMFGEQRLSAALAECAGLPAEAVVERIM--MLTTGWLNERA-
Mflv_1031|M.gilvum_PYR-GCK ARGGPLGADMFGEARLSAALSQCAGLPAEAVVERIM--MLTSEWVHNRA-
TH_3243|M.thermoresistible__bu AWG---AGGQYGMARLHALLPAYAGAAPEVVCEAVE--QDVMEYLDGRP-
MSMEG_6131|M.smegmatis_MC2_155 GHAGR-GDERLGESGLLAVARALAATPGRDFVTSLI--NEAESRAQTHGG
MAV_0430|M.avium_104 WLGAAGITGELAADIVLVVNEACTNCVEHAYRGFVAGTMVLDARLGEGEV
.
Mb1399c|M.bovis_AF2122/97 -RKQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE---------
Rv1364c|M.tuberculosis_H37Rv -RKQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE---------
MMAR_3991|M.marinum_M -RKQGGRCVLMAPPGSPAHHVLSLVQIPVISGETENVFAED---------
MUL_3853|M.ulcerans_Agy99 -RKQGGRCVLMAPPGSPAHHVLSLVQIPVISGETENVFAED---------
Mvan_5805|M.vanbaalenii_PYR-1 -HDDIAVVAITAPRR---------THLSAVDGRTAGRYTA----------
Mflv_1031|M.gilvum_PYR-GCK -HDDIAVVAITAPRR---------THLSAVDGHTAGRFTA----------
TH_3243|M.thermoresistible__bu -HDDMAMVAVTCVR------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 LSDDIAVIRVERSRR-----------------------------------
MAV_0430|M.avium_104 HTRITDYGSWKTPAANPVNSGRGLPLMKALSQAMELRTSATGTVADITFR
Mb1399c|M.bovis_AF2122/97 ----
Rv1364c|M.tuberculosis_H37Rv ----
MMAR_3991|M.marinum_M ----
MUL_3853|M.ulcerans_Agy99 ----
Mvan_5805|M.vanbaalenii_PYR-1 ----
Mflv_1031|M.gilvum_PYR-GCK ----
TH_3243|M.thermoresistible__bu ----
MSMEG_6131|M.smegmatis_MC2_155 ----
MAV_0430|M.avium_104 RPAE