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MLAPTDGEMLSLLLVEDDRADAILVEELIADAGVDIDVVWAESMAKAEQEIAIARPDCVLLDLHLHDTTG IDGLNRISKQDATIPVVVLTGLNDEHFGVSAVSAGAQDYLIKGRVDSEVLRRAVLYAIERKRAELTTVDL HASQLRARENARLERGLLPSPLLLDDPGVEIVTQYRPSRENALLGGDFYDFVQTPDRTVHVMIGDVAGHG ADEAALGVALRIAWRALTFAGLHGSDRMRQLERILRAERAGRGIFATVLSLRIPPTGSTVTAVRAGHPGM LLHGRGTVEWVEPPGGPALGLHGSDWAPQHLELPEGMGLVLLTDGLFEGHIGRGNERLGEEGLLEMARSL AHLPGREFVDALINGVEARAASHGGISDDIAVVRVERTPRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3268 | - | - | 100% (391) | response regulator receiver protein |
| M. gilvum PYR-GCK | Mflv_3857 | - | 4e-18 | 31.88% (276) | putative PAS/PAC sensor protein |
| M. gilvum PYR-GCK | Mflv_4519 | - | 6e-17 | 30.74% (257) | putative GAF sensor protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 4e-14 | 26.32% (266) | hypothetical protein Mb1399c |
| M. tuberculosis H37Rv | Rv1364c | - | 1e-14 | 26.69% (266) | hypothetical protein Rv1364c |
| M. leprae Br4923 | MLBr_00773 | mtrA | 8e-09 | 33.93% (112) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_3591c | - | 3e-08 | 32.43% (111) | DNA-binding response regulator MtrA |
| M. marinum M | MMAR_1263 | - | 1e-155 | 70.43% (399) | hypothetical protein MMAR_1263 |
| M. avium 104 | MAV_4242 | - | 1e-156 | 72.30% (379) | response regulator receiver modulated serine phosphatase |
| M. smegmatis MC2 155 | MSMEG_6131 | - | 1e-158 | 72.70% (381) | magnesium or manganese-dependent protein phosphatase |
| M. thermoresistible (build 8) | TH_2176 | - | 1e-158 | 73.61% (379) | magnesium or manganese-dependent protein phosphatase |
| M. ulcerans Agy99 | MUL_2625 | - | 1e-155 | 70.18% (399) | hypothetical protein MUL_2625 |
| M. vanbaalenii PYR-1 | Mvan_2987 | - | 0.0 | 88.97% (390) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3268|M.gilvum_PYR-GCK --MLAPTDG----------------EMLSLLLVEDDRADAILVEELIADA
Mvan_2987|M.vanbaalenii_PYR-1 --MLAPNDG----------------DSLSLLLVEDDRGDAILVEELIADA
MMAR_1263|M.marinum_M --MRVPHEHDLTAGLGPSTGQRAQWQTLSLLLVEDDRADAMLVEELIADA
MUL_2625|M.ulcerans_Agy99 --MRVPHEHDLTAGLGPSTGQRAQWQTLSLLLVEDARADAMLVEELIADA
MAV_4242|M.avium_104 ---MIPAQAAVTP-----AAQRQSLKPLSVLLVEDDRGDAVLVEELVTDA
MSMEG_6131|M.smegmatis_MC2_155 --MRAPFDR--VIASPVDLTGPGQRR-LSLLLVEDDRADAILVEELIADA
TH_2176|M.thermoresistible__bu MPMRAPHESEPLPMAGLGAVPTGQTQPISLLLVEDDRADALLVEELIADT
MLBr_00773|M.leprae_Br4923 ----------------------MDIMRQRILVVDDDASLAEMLTIVLRGE
MAB_3591c|M.abscessus_ATCC_199 -------------------------MRQRILVVDDDASLAEMLTIVLRGE
Mb1399c|M.bovis_AF2122/97 ----MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYR
Rv1364c|M.tuberculosis_H37Rv ----MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYR
::* ::
Mflv_3268|M.gilvum_PYR-GCK GVDIDVVWAESMAKAEQEIAIARPDCVLLDLHLHDTTGIDGLNRISKQDA
Mvan_2987|M.vanbaalenii_PYR-1 GGDIQVVWAESMARAEQEIAIARPDCILLDLHLHDTDGIDGVNRIAKYDA
MMAR_1263|M.marinum_M AVDIQVVWARSMAHAERELSAARPDCVLLDLNLPDASGIDALDRIANRDA
MUL_2625|M.ulcerans_Agy99 AVDIQVVWARSMAHAERELSAARPDCVLLDLNLPDASGIDALDRIANRDA
MAV_4242|M.avium_104 VTDIRVVWAQSMAHAERELESTRPDCVLLDLHLPDASGIDALNRIAKLDA
MSMEG_6131|M.smegmatis_MC2_155 -PDIDFVWAKSMSDAERTLADHRPDCVLLDLNLPDAAGIDALHHLGKLDA
TH_2176|M.thermoresistible__bu NADIRVTWAASVADAQHRLAADRPDCVLLDLNLPDADGIDALDRICGYDA
MLBr_00773|M.leprae_Br4923 GFDTAVIGDG--TQALTAVRELRPDLVLLDLMLPGMNGID-VCRVLRADS
MAB_3591c|M.abscessus_ATCC_199 GFETAVVSDG--TQALTAVRELRPDLVLLDLMLPGMNGID-VCRVLRSDS
Mb1399c|M.bovis_AF2122/97 GFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDY
Rv1364c|M.tuberculosis_H37Rv GFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDY
. . : : :** . *
Mflv_3268|M.gilvum_PYR-GCK TIPVVVLTGLNDEHFGVSAVSAGAQDYLIKGRVDSEVLRRAVLYAIERKR
Mvan_2987|M.vanbaalenii_PYR-1 TLPIVVLTGLNDEHVGVSAVSAGAQDYLIKDRVDPEVLRRAVLYAIERKR
MMAR_1263|M.marinum_M TVPVVVLTGLNDEYFGATAVAAGAQDYLVKGRVDPEMLRRAMLYAIERKR
MUL_2625|M.ulcerans_Agy99 TVPVVVLTGLNDEYFGATAVAAGAQDYLVKGRVDPEMLRRAMLYAIERKR
MAV_4242|M.avium_104 TVPIVVLTGLNDEYFGASAVAAGAQDYLVKGRVEPEMLRRALLYAIERKR
MSMEG_6131|M.smegmatis_MC2_155 RIPIIVLTGLNDEHFGVSAVASGAQDYLVKGRVEPEMLRRAVLYAIERKR
TH_2176|M.thermoresistible__bu TMPIVVLTGLIDEHFGVLAVASGAQDYLIKGRVEPESLRRSVLYAIERKR
MLBr_00773|M.leprae_Br4923 GVPIVMLTAKTDTVDVVLGLESGADDYIMKP-------------------
MAB_3591c|M.abscessus_ATCC_199 GVPIVMLTAKTDTVDVVLGLESGADDYIMKP-------------------
Mb1399c|M.bovis_AF2122/97 DG-----SGVEERYFDFVVTPRRRADGSIEG--VQLIVDDVTSRVRARQA
Rv1364c|M.tuberculosis_H37Rv DG-----SGVEERYFDFVVTPRRRADGSIEG--VQLIVDDVTSRVRARQA
:. : * ::
Mflv_3268|M.gilvum_PYR-GCK AELTTVDLHASQLRARENARLERGLLPSPLLLDDPGVEIVTQYRPSRENA
Mvan_2987|M.vanbaalenii_PYR-1 AELTAVDLHASQLRARENARLERGLLPSPLLLDDPGVEIVAQYQPSRENA
MMAR_1263|M.marinum_M AELIAADLHATQLRARENALLERGLLPSPLLLDSPGVDIVARYRPSREDA
MUL_2625|M.ulcerans_Agy99 AELIAADLHATQLRARENALLERGLLPSPLLLDSPGVDIVARYRPSREDA
MAV_4242|M.avium_104 AELIAADLHATQLRARENALLERGLLPSPLLLDDPGVDIVARYRPSREDA
MSMEG_6131|M.smegmatis_MC2_155 AELTSVDLHASQLRAQENARLERGLLPSPLLMEGSGVDIVVEARPSRQHA
TH_2176|M.thermoresistible__bu HELTAVDLQASRLQAQENARLERGLLPSPLLLDEPGFDIVAQYRPSHQHA
MLBr_00773|M.leprae_Br4923 -------FKPKELVARVRARLRRNDDEPAEMLSIADVDIDVPAHKVTR--
MAB_3591c|M.abscessus_ATCC_199 -------FKPKELVARIRARLRRNDDEPAELLNIAGIDIDVPAHKVTR--
Mb1399c|M.bovis_AF2122/97 AEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDT
Rv1364c|M.tuberculosis_H37Rv AEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDT
: .: * : : .. : .. :* . .
Mflv_3268|M.gilvum_PYR-GCK LLGGDFYDFVQTPDRTVHVMIGDVAGHGADEAALGVALRIAWRALTFAGL
Mvan_2987|M.vanbaalenii_PYR-1 LLGGDFYDFVQTPDRTVHVMIGDVAGHGPDEAALGVALRIAWRALTFAGL
MMAR_1263|M.marinum_M LLCGDFYDVVQTADRVVHVLIGDVAGHGPNEAALGAALRIAFRALTLAGV
MUL_2625|M.ulcerans_Agy99 LLCGDFYDVVQTVDRVVHVLIGDVAGHGPNEAALGAALRIAFRALTLAGV
MAV_4242|M.avium_104 LLCGDFYDVVQTPDRVVHVLIGDVAGHGPHEAALGAALRIAFRALTLAGV
MSMEG_6131|M.smegmatis_MC2_155 LIGGDFYDVVQTPDRTVHVMIGDVAGHGPDEAALGVALRIGWRALTFAGL
TH_2176|M.thermoresistible__bu LLGGDFYDFVQTPDQTLHVMVGDVSGHGPDEAAVGVALRIGWRALTFAGL
MLBr_00773|M.leprae_Br4923 --------------------NGEHISLTPLEFDLLVALARKPRQVFTRDV
MAB_3591c|M.abscessus_ATCC_199 --------------------EGEQISLTPLEFDLLVALARKPRQVFTRDV
Mb1399c|M.bovis_AF2122/97 AAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVMSQLRTALRMQISTGY
Rv1364c|M.tuberculosis_H37Rv AAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGY
*: . : * * .
Mflv_3268|M.gilvum_PYR-GCK HGSDRMRQLERILRAERAGRGIFATVLSLRIPPTGS------TVTAVRAG
Mvan_2987|M.vanbaalenii_PYR-1 RGSDRMRQLERILRAERGGRGIFATVLSLAIPPEGP------MITAVRAG
MMAR_1263|M.marinum_M HGGQLMRQLDRVLRAERTGEGIFATVLSLAIPPQPAGSADGAHIQVIRAG
MUL_2625|M.ulcerans_Agy99 HGGELMRQLDRVLRAERTGEGIFATVLSLAIPPQPAGSADGAHIQVIRAG
MAV_4242|M.avium_104 HGVELMRQLERVLHSERTGTGIFATVLSLEISPQRP------EVSVIRAG
MSMEG_6131|M.smegmatis_MC2_155 RGNERMRQLDRILTTERPGKGIFATLCSVALEPDSG------RFTVVRAG
TH_2176|M.thermoresistible__bu RGNERMWQLERILRAERPGRGIFATVLSIALSPKDL------TFTAVRAG
MLBr_00773|M.leprae_Br4923 -------LLEQVWGYRHPADTRLVNVHVQRLRAKVE----------KDPE
MAB_3591c|M.abscessus_ATCC_199 -------LLEQVWGYRHPADTRLVNVHVQRLRAKVE----------KDPE
Mb1399c|M.bovis_AF2122/97 TVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQ-------YCTAGH
Rv1364c|M.tuberculosis_H37Rv TVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQ-------YCTAGH
:::. . : : .
Mflv_3268|M.gilvum_PYR-GCK HPGMLLHGRGTVEWVEPPGGPALGLHGSDWAPQHLELPEGMGLVLLTDGL
Mvan_2987|M.vanbaalenii_PYR-1 HPGMLLHGGGTVDWVEPAGGPALGLHGSDWTPQQVELPEGKGLVLLTDGL
MMAR_1263|M.marinum_M HPGMLLHGGGTVHWLEPPAGPALGLNLGNWCQHEVELPVDHGLLLLTDGL
MUL_2625|M.ulcerans_Agy99 HPGMLLHGGGTVHWLEPPAGPALGLNLGNWCQHEVELPVDHGLLLLTDGL
MAV_4242|M.avium_104 HPGMLLQGGGTVEWVEPPGGPALGLRADDWPRHQLRLPAGHGLLLLTDGL
MSMEG_6131|M.smegmatis_MC2_155 HPGLLVHGNGTVDWLEPRPGAALGLGAREWPVNHYELPEGHGLLLLTDGL
TH_2176|M.thermoresistible__bu HPGLLVHGPDTVDWLEPPAGPALGLKGTDWPTNEYELPAGHGLLLLTDGL
MLBr_00773|M.leprae_Br4923 NPTVVLTVRGVGYKAGPP--------------------------------
MAB_3591c|M.abscessus_ATCC_199 NPTVVLTVRGVGYKAGPP--------------------------------
Mb1399c|M.bovis_AF2122/97 PPPLLVTADASARYVEPTGAGPLGS-GTGFPVRSEVLNIGDAILFYTDGL
Rv1364c|M.tuberculosis_H37Rv PPPLLVTADASARYVEPTGAGPLGS-GTGFPVRSEVLNIGDAILFYTDGL
* ::: *
Mflv_3268|M.gilvum_PYR-GCK FEGHIGRGNERLGEEGLLEMARSLAH-----LPGREFVDALINGVEARAA
Mvan_2987|M.vanbaalenii_PYR-1 FEGHIGSGNERLGEEGLLELARSLAA-----LPGRAFVHALINAVEERAA
MMAR_1263|M.marinum_M FEGYSGHRRERLGEHGLLSLARSHAG-----LSGPAFVDALIDGAQQRAQ
MUL_2625|M.ulcerans_Agy99 FEGYSGHRRERLGEHGLLSLARSHAG-----LSGPAFVDALIDGAQQRAQ
MAV_4242|M.avium_104 YEGYSGRGTQRLGEDGLLALARSQVD-----RPGPAFVDALIDGAQRLAR
MSMEG_6131|M.smegmatis_MC2_155 FEGHAGRGDERLGESGLLAVARALAA-----TPGRDFVTSLINEAESRAQ
TH_2176|M.thermoresistible__bu FEGHSGRGYERLGEEGLLDLARSHAA-----LPGAEFVHALIDDAEHRAQ
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3591c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 IERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLL
Rv1364c|M.tuberculosis_H37Rv IERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLL
Mflv_3268|M.gilvum_PYR-GCK SHGGISDDIAVVRVERTPRR------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 AHGGISDDIAVVRVERTPRA------------------------------
MMAR_1263|M.marinum_M SLGGLTDDIAVLRVERTPA-------------------------------
MUL_2625|M.ulcerans_Agy99 SLGGLTDDIAVLRVERTPA-------------------------------
MAV_4242|M.avium_104 PRGGLTDDIAVLRVERTIT-------------------------------
MSMEG_6131|M.smegmatis_MC2_155 THGGLSDDIAVIRVERSRR-------------------------------
TH_2176|M.thermoresistible__bu AVGGISDDIAVVRVERTR--------------------------------
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3591c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 RSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGA
Rv1364c|M.tuberculosis_H37Rv RSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGA
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3591c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 DHSDIADIVHAISEFVENAVEHGYATDVSKGIVVEAALAGDGNVRASVID
Rv1364c|M.tuberculosis_H37Rv DHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRASVID
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3591c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 RGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPAR
Rv1364c|M.tuberculosis_H37Rv RGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPAR
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3591c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 FVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQIAVE
Rv1364c|M.tuberculosis_H37Rv FVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQIAVE
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3591c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 SRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPA
Rv1364c|M.tuberculosis_H37Rv SRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPA
Mflv_3268|M.gilvum_PYR-GCK -----------------------
Mvan_2987|M.vanbaalenii_PYR-1 -----------------------
MMAR_1263|M.marinum_M -----------------------
MUL_2625|M.ulcerans_Agy99 -----------------------
MAV_4242|M.avium_104 -----------------------
MSMEG_6131|M.smegmatis_MC2_155 -----------------------
TH_2176|M.thermoresistible__bu -----------------------
MLBr_00773|M.leprae_Br4923 -----------------------
MAB_3591c|M.abscessus_ATCC_199 -----------------------
Mb1399c|M.bovis_AF2122/97 HHVLSLVQLPVVGADTEDIFAQE
Rv1364c|M.tuberculosis_H37Rv HHVLSLVQLPVVGADTEDIFAQE