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IPAQAAVTPAAQRQSLKPLSVLLVEDDRGDAVLVEELVTDAVTDIRVVWAQSMAHAERELESTRPDCVLL DLHLPDASGIDALNRIAKLDATVPIVVLTGLNDEYFGASAVAAGAQDYLVKGRVEPEMLRRALLYAIERK RAELIAADLHATQLRARENALLERGLLPSPLLLDDPGVDIVARYRPSREDALLCGDFYDVVQTPDRVVHV LIGDVAGHGPHEAALGAALRIAFRALTLAGVHGVELMRQLERVLHSERTGTGIFATVLSLEISPQRPEVS VIRAGHPGMLLQGGGTVEWVEPPGGPALGLRADDWPRHQLRLPAGHGLLLLTDGLYEGYSGRGTQRLGED GLLALARSQVDRPGPAFVDALIDGAQRLARPRGGLTDDIAVLRVERTIT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4242 | - | - | 100% (400) | response regulator receiver modulated serine phosphatase |
| M. avium 104 | MAV_1619 | - | 1e-18 | 29.48% (268) | anti-anti-sigma factor |
| M. avium 104 | MAV_2108 | - | 2e-15 | 29.29% (239) | stage II sporulation protein E (SpoIIE) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 5e-16 | 28.30% (265) | hypothetical protein Mb1399c |
| M. gilvum PYR-GCK | Mflv_3268 | - | 1e-156 | 72.30% (379) | response regulator receiver protein |
| M. tuberculosis H37Rv | Rv1364c | - | 2e-16 | 28.68% (265) | hypothetical protein Rv1364c |
| M. leprae Br4923 | MLBr_00773 | mtrA | 1e-09 | 36.61% (112) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_2581 | - | 5e-09 | 32.05% (156) | putative two component transcriptional regulatory protein |
| M. marinum M | MMAR_1263 | - | 1e-175 | 79.85% (392) | hypothetical protein MMAR_1263 |
| M. smegmatis MC2 155 | MSMEG_6131 | - | 1e-145 | 65.83% (398) | magnesium or manganese-dependent protein phosphatase |
| M. thermoresistible (build 8) | TH_2176 | - | 1e-147 | 65.82% (395) | magnesium or manganese-dependent protein phosphatase |
| M. ulcerans Agy99 | MUL_2625 | - | 1e-175 | 79.85% (392) | hypothetical protein MUL_2625 |
| M. vanbaalenii PYR-1 | Mvan_2987 | - | 1e-156 | 72.03% (379) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1263|M.marinum_M --MRVPHEHDLTAGLGPSTGQRAQWQTLSLLLVEDDRADAMLVEELIADA
MUL_2625|M.ulcerans_Agy99 --MRVPHEHDLTAGLGPSTGQRAQWQTLSLLLVEDARADAMLVEELIADA
MAV_4242|M.avium_104 ---MIPAQAAVTP-----AAQRQSLKPLSVLLVEDDRGDAVLVEELVTDA
Mflv_3268|M.gilvum_PYR-GCK --MLAPTDG----------------EMLSLLLVEDDRADAILVEELIADA
Mvan_2987|M.vanbaalenii_PYR-1 --MLAPNDG----------------DSLSLLLVEDDRGDAILVEELIADA
TH_2176|M.thermoresistible__bu MPMRAPHESEPLPMAGLGAVPTGQTQPISLLLVEDDRADALLVEELIADT
MSMEG_6131|M.smegmatis_MC2_155 --MRAPFDRVIAS---PVDLTGPGQRRLSLLLVEDDRADAILVEELIADA
MLBr_00773|M.leprae_Br4923 -----------------MDIMR-----QRILVVDDDASLAEMLTIVLRGE
MAB_2581|M.abscessus_ATCC_1997 ----MSDAASVSSEKARSSLRRPDGSPVRVLVVDDERSLAELISMALRYE
Mb1399c|M.bovis_AF2122/97 ----MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYR
Rv1364c|M.tuberculosis_H37Rv ----MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYR
::* ::
MMAR_1263|M.marinum_M AVDIQVVWARSMAHAERELSAARPDCVLLDLNLPDASGIDALDRIANRDA
MUL_2625|M.ulcerans_Agy99 AVDIQVVWARSMAHAERELSAARPDCVLLDLNLPDASGIDALDRIANRDA
MAV_4242|M.avium_104 VTDIRVVWAQSMAHAERELESTRPDCVLLDLHLPDASGIDALNRIAKLDA
Mflv_3268|M.gilvum_PYR-GCK GVDIDVVWAESMAKAEQEIAIARPDCVLLDLHLHDTTGIDGLNRISKQDA
Mvan_2987|M.vanbaalenii_PYR-1 GGDIQVVWAESMARAEQEIAIARPDCILLDLHLHDTDGIDGVNRIAKYDA
TH_2176|M.thermoresistible__bu NADIRVTWAASVADAQHRLAADRPDCVLLDLNLPDADGIDALDRICGYDA
MSMEG_6131|M.smegmatis_MC2_155 P-DIDFVWAKSMSDAERTLADHRPDCVLLDLNLPDAAGIDALHHLGKLDA
MLBr_00773|M.leprae_Br4923 GFDTAVIGDG--TQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLR-ADS
MAB_2581|M.abscessus_ATCC_1997 GWEIHVAGDG--MSAVKLARQVHPDIVVLDVMLPDVSGLEVLRQLRDLYP
Mb1399c|M.bovis_AF2122/97 GFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDY
Rv1364c|M.tuberculosis_H37Rv GFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDY
. . : :** .
MMAR_1263|M.marinum_M TVPVVVLTGLNDEYFGATAVAAGAQDYLVKGRVDPEMLRRAMLYAIERKR
MUL_2625|M.ulcerans_Agy99 TVPVVVLTGLNDEYFGATAVAAGAQDYLVKGRVDPEMLRRAMLYAIERKR
MAV_4242|M.avium_104 TVPIVVLTGLNDEYFGASAVAAGAQDYLVKGRVEPEMLRRALLYAIERKR
Mflv_3268|M.gilvum_PYR-GCK TIPVVVLTGLNDEHFGVSAVSAGAQDYLIKGRVDSEVLRRAVLYAIERKR
Mvan_2987|M.vanbaalenii_PYR-1 TLPIVVLTGLNDEHVGVSAVSAGAQDYLIKDRVDPEVLRRAVLYAIERKR
TH_2176|M.thermoresistible__bu TMPIVVLTGLIDEHFGVLAVASGAQDYLIKGRVEPESLRRSVLYAIERKR
MSMEG_6131|M.smegmatis_MC2_155 RIPIIVLTGLNDEHFGVSAVASGAQDYLVKGRVEPEMLRRAVLYAIERKR
MLBr_00773|M.leprae_Br4923 GVPIVMLTAKTDTVDVVLGLESGADDYIMK----PFKPKELVARVRARLR
MAB_2581|M.abscessus_ATCC_1997 GLPLLLLTAKDSLEDRIAGLTAGGDDYVTK----PFSLEEVVLRLRALLR
Mb1399c|M.bovis_AF2122/97 DG-----SGVEERYFDFVVTPRRRADGSIEG--VQLIVDDVTSRVRARQA
Rv1364c|M.tuberculosis_H37Rv DG-----SGVEERYFDFVVTPRRRADGSIEG--VQLIVDDVTSRVRARQA
:. . * :
MMAR_1263|M.marinum_M AELIAADLHATQLRARENALLERGLLPSPLLLDSPGVDIVARYRPSREDA
MUL_2625|M.ulcerans_Agy99 AELIAADLHATQLRARENALLERGLLPSPLLLDSPGVDIVARYRPSREDA
MAV_4242|M.avium_104 AELIAADLHATQLRARENALLERGLLPSPLLLDDPGVDIVARYRPSREDA
Mflv_3268|M.gilvum_PYR-GCK AELTTVDLHASQLRARENARLERGLLPSPLLLDDPGVEIVTQYRPSRENA
Mvan_2987|M.vanbaalenii_PYR-1 AELTAVDLHASQLRARENARLERGLLPSPLLLDDPGVEIVAQYQPSRENA
TH_2176|M.thermoresistible__bu HELTAVDLQASRLQAQENARLERGLLPSPLLLDEPGFDIVAQYRPSHQHA
MSMEG_6131|M.smegmatis_MC2_155 AELTSVDLHASQLRAQENARLERGLLPSPLLMEGSGVDIVVEARPSRQHA
MLBr_00773|M.leprae_Br4923 RN---DDEPAEMLSIAD------------VDIDVPAHKVTRN--------
MAB_2581|M.abscessus_ATCC_1997 RTGIAGDSGDARLIVGD------------LVLDEDSHEVTRD--------
Mb1399c|M.bovis_AF2122/97 AEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDT
Rv1364c|M.tuberculosis_H37Rv AEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDT
: : . .:.
MMAR_1263|M.marinum_M LLCGDFYDVVQTADRVVHVLIGDVAGHGPNEAALGAALRIAFRALTLAGV
MUL_2625|M.ulcerans_Agy99 LLCGDFYDVVQTVDRVVHVLIGDVAGHGPNEAALGAALRIAFRALTLAGV
MAV_4242|M.avium_104 LLCGDFYDVVQTPDRVVHVLIGDVAGHGPHEAALGAALRIAFRALTLAGV
Mflv_3268|M.gilvum_PYR-GCK LLGGDFYDFVQTPDRTVHVMIGDVAGHGADEAALGVALRIAWRALTFAGL
Mvan_2987|M.vanbaalenii_PYR-1 LLGGDFYDFVQTPDRTVHVMIGDVAGHGPDEAALGVALRIAWRALTFAGL
TH_2176|M.thermoresistible__bu LLGGDFYDFVQTPDQTLHVMVGDVSGHGPDEAAVGVALRIGWRALTFAGL
MSMEG_6131|M.smegmatis_MC2_155 LIGGDFYDVVQTPDRTVHVMIGDVAGHGPDEAALGVALRIGWRALTFAGL
MLBr_00773|M.leprae_Br4923 ---GEHISLTPLEFDLLVALARKPR-------------------------
MAB_2581|M.abscessus_ATCC_1997 ---GELINLTATEFELLRFMMRNNK-------------------------
Mb1399c|M.bovis_AF2122/97 AAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVMSQLRTALRMQISTGY
Rv1364c|M.tuberculosis_H37Rv AAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGY
*: . : : .
MMAR_1263|M.marinum_M HGGQLMRQLDRVLRAERTGEGIFATVLSLAIPPQPAGSADGAHIQVIRAG
MUL_2625|M.ulcerans_Agy99 HGGELMRQLDRVLRAERTGEGIFATVLSLAIPPQPAGSADGAHIQVIRAG
MAV_4242|M.avium_104 HGVELMRQLERVLHSERTGTGIFATVLSLEISPQRP------EVSVIRAG
Mflv_3268|M.gilvum_PYR-GCK HGSDRMRQLERILRAERAGRGIFATVLSLRIPPTGS------TVTAVRAG
Mvan_2987|M.vanbaalenii_PYR-1 RGSDRMRQLERILRAERGGRGIFATVLSLAIPPEGP------MITAVRAG
TH_2176|M.thermoresistible__bu RGNERMWQLERILRAERPGRGIFATVLSIALSPKDL------TFTAVRAG
MSMEG_6131|M.smegmatis_MC2_155 RGNERMRQLDRILTTERPGKGIFATLCSVALEPDSG------RFTVVRAG
MLBr_00773|M.leprae_Br4923 QVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVE----------KDPE
MAB_2581|M.abscessus_ATCC_1997 RVLSKHQILDRVWSYDFGGRSNVVELYISYLRKKID----------TGRE
Mb1399c|M.bovis_AF2122/97 TVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQ-------YCTAGH
Rv1364c|M.tuberculosis_H37Rv TVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQ-------YCTAGH
:::. . : :
MMAR_1263|M.marinum_M HPGMLLHGGGTVHWLEPPAGPALGLNLGNWCQHEVELPVDHGLLLLTDGL
MUL_2625|M.ulcerans_Agy99 HPGMLLHGGGTVHWLEPPAGPALGLNLGNWCQHEVELPVDHGLLLLTDGL
MAV_4242|M.avium_104 HPGMLLQGGGTVEWVEPPGGPALGLRADDWPRHQLRLPAGHGLLLLTDGL
Mflv_3268|M.gilvum_PYR-GCK HPGMLLHGRGTVEWVEPPGGPALGLHGSDWAPQHLELPEGMGLVLLTDGL
Mvan_2987|M.vanbaalenii_PYR-1 HPGMLLHGGGTVDWVEPAGGPALGLHGSDWTPQQVELPEGKGLVLLTDGL
TH_2176|M.thermoresistible__bu HPGLLVHGPDTVDWLEPPAGPALGLKGTDWPTNEYELPAGHGLLLLTDGL
MSMEG_6131|M.smegmatis_MC2_155 HPGLLVHGNGTVDWLEPRPGAALGLGAREWPVNHYELPEGHGLLLLTDGL
MLBr_00773|M.leprae_Br4923 NPTVVLTVRGVGYKAGPP--------------------------------
MAB_2581|M.abscessus_ATCC_1997 --PMIHTLRGAGYVLKPAH-------------------------------
Mb1399c|M.bovis_AF2122/97 PPPLLVTADASARYVEPTGAGPLGS-GTGFPVRSEVLNIGDAILFYTDGL
Rv1364c|M.tuberculosis_H37Rv PPPLLVTADASARYVEPTGAGPLGS-GTGFPVRSEVLNIGDAILFYTDGL
:: *
MMAR_1263|M.marinum_M FEGYSGHRRERLGEHGLLSLARSHAG-----LSGPAFVDALIDGAQQRAQ
MUL_2625|M.ulcerans_Agy99 FEGYSGHRRERLGEHGLLSLARSHAG-----LSGPAFVDALIDGAQQRAQ
MAV_4242|M.avium_104 YEGYSGRGTQRLGEDGLLALARSQVD-----RPGPAFVDALIDGAQRLAR
Mflv_3268|M.gilvum_PYR-GCK FEGHIGRGNERLGEEGLLEMARSLAH-----LPGREFVDALINGVEARAA
Mvan_2987|M.vanbaalenii_PYR-1 FEGHIGSGNERLGEEGLLELARSLAA-----LPGRAFVHALINAVEERAA
TH_2176|M.thermoresistible__bu FEGHSGRGYERLGEEGLLDLARSHAA-----LPGAEFVHALIDDAEHRAQ
MSMEG_6131|M.smegmatis_MC2_155 FEGHAGRGDERLGESGLLAVARALAA-----TPGRDFVTSLINEAESRAQ
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_2581|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 IERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLL
Rv1364c|M.tuberculosis_H37Rv IERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLL
MMAR_1263|M.marinum_M SLGGLTDDIAVLRVERTPA-------------------------------
MUL_2625|M.ulcerans_Agy99 SLGGLTDDIAVLRVERTPA-------------------------------
MAV_4242|M.avium_104 PRGGLTDDIAVLRVERTIT-------------------------------
Mflv_3268|M.gilvum_PYR-GCK SHGGISDDIAVVRVERTPRR------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 AHGGISDDIAVVRVERTPRA------------------------------
TH_2176|M.thermoresistible__bu AVGGISDDIAVVRVERTR--------------------------------
MSMEG_6131|M.smegmatis_MC2_155 THGGLSDDIAVIRVERSRR-------------------------------
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_2581|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 RSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGA
Rv1364c|M.tuberculosis_H37Rv RSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGA
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_2581|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 DHSDIADIVHAISEFVENAVEHGYATDVSKGIVVEAALAGDGNVRASVID
Rv1364c|M.tuberculosis_H37Rv DHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRASVID
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_2581|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 RGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPAR
Rv1364c|M.tuberculosis_H37Rv RGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPAR
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_2581|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 FVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQIAVE
Rv1364c|M.tuberculosis_H37Rv FVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQIAVE
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_2581|M.abscessus_ATCC_1997 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 SRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPA
Rv1364c|M.tuberculosis_H37Rv SRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPA
MMAR_1263|M.marinum_M -----------------------
MUL_2625|M.ulcerans_Agy99 -----------------------
MAV_4242|M.avium_104 -----------------------
Mflv_3268|M.gilvum_PYR-GCK -----------------------
Mvan_2987|M.vanbaalenii_PYR-1 -----------------------
TH_2176|M.thermoresistible__bu -----------------------
MSMEG_6131|M.smegmatis_MC2_155 -----------------------
MLBr_00773|M.leprae_Br4923 -----------------------
MAB_2581|M.abscessus_ATCC_1997 -----------------------
Mb1399c|M.bovis_AF2122/97 HHVLSLVQLPVVGADTEDIFAQE
Rv1364c|M.tuberculosis_H37Rv HHVLSLVQLPVVGADTEDIFAQE