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RVPHEHDLTAGLGPSTGQRAQWQTLSLLLVEDARADAMLVEELIADAAVDIQVVWARSMAHAERELSAAR PDCVLLDLNLPDASGIDALDRIANRDATVPVVVLTGLNDEYFGATAVAAGAQDYLVKGRVDPEMLRRAML YAIERKRAELIAADLHATQLRARENALLERGLLPSPLLLDSPGVDIVARYRPSREDALLCGDFYDVVQTV DRVVHVLIGDVAGHGPNEAALGAALRIAFRALTLAGVHGGELMRQLDRVLRAERTGEGIFATVLSLAIPP QPAGSADGAHIQVIRAGHPGMLLHGGGTVHWLEPPAGPALGLNLGNWCQHEVELPVDHGLLLLTDGLFEG YSGHRRERLGEHGLLSLARSHAGLSGPAFVDALIDGAQQRAQSLGGLTDDIAVLRVERTPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2625 | - | - | 100% (412) | hypothetical protein MUL_2625 |
| M. ulcerans Agy99 | MUL_3853 | rsbU | 9e-14 | 27.07% (314) | regulator of sigma subunit, anti-anti-sigma factor RsbU |
| M. ulcerans Agy99 | MUL_4624 | trcR | 2e-09 | 31.19% (109) | two component transcriptional regulator TrcR |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 6e-15 | 27.78% (270) | hypothetical protein Mb1399c |
| M. gilvum PYR-GCK | Mflv_3268 | - | 1e-155 | 70.18% (399) | response regulator receiver protein |
| M. tuberculosis H37Rv | Rv1364c | - | 2e-15 | 28.15% (270) | hypothetical protein Rv1364c |
| M. leprae Br4923 | MLBr_00773 | mtrA | 4e-09 | 33.33% (129) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_3891c | - | 1e-08 | 25.49% (153) | LuxR family transcriptional regulator |
| M. marinum M | MMAR_1263 | - | 0.0 | 99.27% (412) | hypothetical protein MMAR_1263 |
| M. avium 104 | MAV_4242 | - | 1e-175 | 79.85% (392) | response regulator receiver modulated serine phosphatase |
| M. smegmatis MC2 155 | MSMEG_6131 | - | 1e-143 | 66.50% (403) | magnesium or manganese-dependent protein phosphatase |
| M. thermoresistible (build 8) | TH_2176 | - | 1e-149 | 65.85% (410) | magnesium or manganese-dependent protein phosphatase |
| M. vanbaalenii PYR-1 | Mvan_2987 | - | 1e-153 | 69.92% (399) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2625|M.ulcerans_Agy99 --MRVPHEHDLTAGLGPSTGQRAQWQTLSLLLVEDARADAMLVEELIADA
MMAR_1263|M.marinum_M --MRVPHEHDLTAGLGPSTGQRAQWQTLSLLLVEDDRADAMLVEELIADA
MAV_4242|M.avium_104 ---MIPAQAAVTP-----AAQRQSLKPLSVLLVEDDRGDAVLVEELVTDA
MSMEG_6131|M.smegmatis_MC2_155 --MRAPFDR--VIASPVDLTGPGQRR-LSLLLVEDDRADAILVEELIADA
TH_2176|M.thermoresistible__bu MPMRAPHESEPLPMAGLGAVPTGQTQPISLLLVEDDRADALLVEELIADT
Mflv_3268|M.gilvum_PYR-GCK --MLAPTDG----------------EMLSLLLVEDDRADAILVEELIADA
Mvan_2987|M.vanbaalenii_PYR-1 --MLAPNDG----------------DSLSLLLVEDDRGDAILVEELIADA
Mb1399c|M.bovis_AF2122/97 ----MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYR
Rv1364c|M.tuberculosis_H37Rv ----MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYR
MLBr_00773|M.leprae_Br4923 ----------------------MDIMRQRILVVDDDASLAEMLTIVLRGE
MAB_3891c|M.abscessus_ATCC_199 --------------------------MITVFLVDDHEVVRRGLADLLEEE
::* :
MUL_2625|M.ulcerans_Agy99 AVDIQVVWARSMAHAERELSAARPDCVLLDLNLPDASGIDALDRIANRDA
MMAR_1263|M.marinum_M AVDIQVVWARSMAHAERELSAARPDCVLLDLNLPDASGIDALDRIANRDA
MAV_4242|M.avium_104 VTDIRVVWAQSMAHAERELESTRPDCVLLDLHLPDASGIDALNRIAKLDA
MSMEG_6131|M.smegmatis_MC2_155 -PDIDFVWAKSMSDAERTLADHRPDCVLLDLNLPDAAGIDALHHLGKLDA
TH_2176|M.thermoresistible__bu NADIRVTWAASVADAQHRLAADRPDCVLLDLNLPDADGIDALDRICGYDA
Mflv_3268|M.gilvum_PYR-GCK GVDIDVVWAESMAKAEQEIAIARPDCVLLDLHLHDTTGIDGLNRISKQDA
Mvan_2987|M.vanbaalenii_PYR-1 GGDIQVVWAESMARAEQEIAIARPDCILLDLHLHDTDGIDGVNRIAKYDA
Mb1399c|M.bovis_AF2122/97 GFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDY
Rv1364c|M.tuberculosis_H37Rv GFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDY
MLBr_00773|M.leprae_Br4923 GFDTAVIGDG--TQALTAVRELRPDLVLLDLMLPGMNGID-VCRVLRADS
MAB_3891c|M.abscessus_ATCC_199 ADFSVIGQASSVAEAMARIPALQPDIAVLDIRLPDGNGVELCRELRSKLP
. : : :** .
MUL_2625|M.ulcerans_Agy99 TVPVVVLTGLNDEYFGATAVAAGAQDYLVKGRVDPEMLRRAMLYAIERKR
MMAR_1263|M.marinum_M TVPVVVLTGLNDEYFGATAVAAGAQDYLVKGRVDPEMLRRAMLYAIERKR
MAV_4242|M.avium_104 TVPIVVLTGLNDEYFGASAVAAGAQDYLVKGRVEPEMLRRALLYAIERKR
MSMEG_6131|M.smegmatis_MC2_155 RIPIIVLTGLNDEHFGVSAVASGAQDYLVKGRVEPEMLRRAVLYAIERKR
TH_2176|M.thermoresistible__bu TMPIVVLTGLIDEHFGVLAVASGAQDYLIKGRVEPESLRRSVLYAIERKR
Mflv_3268|M.gilvum_PYR-GCK TIPVVVLTGLNDEHFGVSAVSAGAQDYLIKGRVDSEVLRRAVLYAIERKR
Mvan_2987|M.vanbaalenii_PYR-1 TLPIVVLTGLNDEHVGVSAVSAGAQDYLIKDRVDPEVLRRAVLYAIERKR
Mb1399c|M.bovis_AF2122/97 DG-----SGVEERYFDFVVTPRRRADGSIEG--VQLIVDDVTSRVRARQA
Rv1364c|M.tuberculosis_H37Rv DG-----SGVEERYFDFVVTPRRRADGSIEG--VQLIVDDVTSRVRARQA
MLBr_00773|M.leprae_Br4923 GVPIVMLTAKTDTVDVVLGLESGADDYIMKP-------------------
MAB_3891c|M.abscessus_ATCC_199 NLNCLMLTSFTDEHAMLDAIMAGAGGYVIKDIKGMELIS-----------
:. : . ::
MUL_2625|M.ulcerans_Agy99 AELIAADLHATQLRARENALLERGLLPSPLLLDSPGVDIVARYRPSREDA
MMAR_1263|M.marinum_M AELIAADLHATQLRARENALLERGLLPSPLLLDSPGVDIVARYRPSREDA
MAV_4242|M.avium_104 AELIAADLHATQLRARENALLERGLLPSPLLLDDPGVDIVARYRPSREDA
MSMEG_6131|M.smegmatis_MC2_155 AELTSVDLHASQLRAQENARLERGLLPSPLLMEGSGVDIVVEARPSRQHA
TH_2176|M.thermoresistible__bu HELTAVDLQASRLQAQENARLERGLLPSPLLLDEPGFDIVAQYRPSHQHA
Mflv_3268|M.gilvum_PYR-GCK AELTTVDLHASQLRARENARLERGLLPSPLLLDDPGVEIVTQYRPSRENA
Mvan_2987|M.vanbaalenii_PYR-1 AELTAVDLHASQLRARENARLERGLLPSPLLLDDPGVEIVAQYQPSRENA
Mb1399c|M.bovis_AF2122/97 AEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDT
Rv1364c|M.tuberculosis_H37Rv AEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDT
MLBr_00773|M.leprae_Br4923 -------FKPKELVARVRARLRRNDDEPAEMLSIADVDIDVPAHKVTRN-
MAB_3891c|M.abscessus_ATCC_199 -AVRTVGAGRSLLDNRAAAALMNRLRAAADNPS-PLAGLTAQERT-----
: * : . .. . : .
MUL_2625|M.ulcerans_Agy99 LLCGDFYDVVQTVDRVVHVLIGDVAGHGPNEAALGAALRIAFRALTLAGV
MMAR_1263|M.marinum_M LLCGDFYDVVQTADRVVHVLIGDVAGHGPNEAALGAALRIAFRALTLAGV
MAV_4242|M.avium_104 LLCGDFYDVVQTPDRVVHVLIGDVAGHGPHEAALGAALRIAFRALTLAGV
MSMEG_6131|M.smegmatis_MC2_155 LIGGDFYDVVQTPDRTVHVMIGDVAGHGPDEAALGVALRIGWRALTFAGL
TH_2176|M.thermoresistible__bu LLGGDFYDFVQTPDQTLHVMVGDVSGHGPDEAAVGVALRIGWRALTFAGL
Mflv_3268|M.gilvum_PYR-GCK LLGGDFYDFVQTPDRTVHVMIGDVAGHGADEAALGVALRIAWRALTFAGL
Mvan_2987|M.vanbaalenii_PYR-1 LLGGDFYDFVQTPDRTVHVMIGDVAGHGPDEAALGVALRIAWRALTFAGL
Mb1399c|M.bovis_AF2122/97 AAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVMSQLRTALRMQISTGY
Rv1364c|M.tuberculosis_H37Rv AAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGY
MLBr_00773|M.leprae_Br4923 ---------------------GEHISLTPLEFDLLVALARKPRQVFTRDV
MAB_3891c|M.abscessus_ATCC_199 --------------------LLELIGEGLTNRQIAERMFLAEKTVK----
: . : : :
MUL_2625|M.ulcerans_Agy99 HGGELMRQLDRVLRAERTGEGIFATVLSLAIPPQPAGSADGAHIQVIRAG
MMAR_1263|M.marinum_M HGGQLMRQLDRVLRAERTGEGIFATVLSLAIPPQPAGSADGAHIQVIRAG
MAV_4242|M.avium_104 HGVELMRQLERVLHSERTGTGIFATVLSLEISPQRP------EVSVIRAG
MSMEG_6131|M.smegmatis_MC2_155 RGNERMRQLDRILTTERPGKGIFATLCSVALEPDSG------RFTVVRAG
TH_2176|M.thermoresistible__bu RGNERMWQLERILRAERPGRGIFATVLSIALSPKDL------TFTAVRAG
Mflv_3268|M.gilvum_PYR-GCK HGSDRMRQLERILRAERAGRGIFATVLSLRIPPTGS------TVTAVRAG
Mvan_2987|M.vanbaalenii_PYR-1 RGSDRMRQLERILRAERGGRGIFATVLSLAIPPEGP------MITAVRAG
Mb1399c|M.bovis_AF2122/97 TVVEALEAVDRFHKQVPGSK--SATMCVGSLDFTSG------EFQYCTAG
Rv1364c|M.tuberculosis_H37Rv TVVEALEAVDRFHKQVPGSK--SATMCVGSLDFTSG------EFQYCTAG
MLBr_00773|M.leprae_Br4923 -------LLEQVWGYRHPADTRLVNVHVQRLRAKVE-----------KDP
MAB_3891c|M.abscessus_ATCC_199 ------NYVSRLLTKLDLERRTQVAVLATKLARENQ--------------
:.:. . : :
MUL_2625|M.ulcerans_Agy99 HPG-MLLHGGGTVHWLEPPAGPALGLNLGNWCQHEVELPVDHGLLLLTDG
MMAR_1263|M.marinum_M HPG-MLLHGGGTVHWLEPPAGPALGLNLGNWCQHEVELPVDHGLLLLTDG
MAV_4242|M.avium_104 HPG-MLLQGGGTVEWVEPPGGPALGLRADDWPRHQLRLPAGHGLLLLTDG
MSMEG_6131|M.smegmatis_MC2_155 HPG-LLVHGNGTVDWLEPRPGAALGLGAREWPVNHYELPEGHGLLLLTDG
TH_2176|M.thermoresistible__bu HPG-LLVHGPDTVDWLEPPAGPALGLKGTDWPTNEYELPAGHGLLLLTDG
Mflv_3268|M.gilvum_PYR-GCK HPG-MLLHGRGTVEWVEPPGGPALGLHGSDWAPQHLELPEGMGLVLLTDG
Mvan_2987|M.vanbaalenii_PYR-1 HPG-MLLHGGGTVDWVEPAGGPALGLHGSDWTPQQVELPEGKGLVLLTDG
Mb1399c|M.bovis_AF2122/97 HPPPLLVTADASARYVEPTGAGPLGS-GTGFPVRSEVLNIGDAILFYTDG
Rv1364c|M.tuberculosis_H37Rv HPPPLLVTADASARYVEPTGAGPLGS-GTGFPVRSEVLNIGDAILFYTDG
MLBr_00773|M.leprae_Br4923 ENPTVVLTVRGVGYKAGPP-------------------------------
MAB_3891c|M.abscessus_ATCC_199 -----GLHG-----------------------------------------
:
MUL_2625|M.ulcerans_Agy99 LFEGYSGHRRERLGEHGLLSLARSHAGLSG-------PAFVDALIDGAQQ
MMAR_1263|M.marinum_M LFEGYSGHRRERLGEHGLLSLARSHAGLSG-------PAFVDALIDGAQQ
MAV_4242|M.avium_104 LYEGYSGRGTQRLGEDGLLALARSQVDRPG-------PAFVDALIDGAQR
MSMEG_6131|M.smegmatis_MC2_155 LFEGHAGRGDERLGESGLLAVARALAATPG-------RDFVTSLINEAES
TH_2176|M.thermoresistible__bu LFEGHSGRGYERLGEEGLLDLARSHAALPG-------AEFVHALIDDAEH
Mflv_3268|M.gilvum_PYR-GCK LFEGHIGRGNERLGEEGLLEMARSLAHLPG-------REFVDALINGVEA
Mvan_2987|M.vanbaalenii_PYR-1 LFEGHIGSGNERLGEEGLLELARSLAALPG-------RAFVHALINAVEE
Mb1399c|M.bovis_AF2122/97 LIE-RPGRPLEAS-TAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLE
Rv1364c|M.tuberculosis_H37Rv LIE-RPGRPLEAS-TAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLE
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 RAQSLGGLTDDIAVLRVERTPA----------------------------
MMAR_1263|M.marinum_M RAQSLGGLTDDIAVLRVERTPA----------------------------
MAV_4242|M.avium_104 LARPRGGLTDDIAVLRVERTIT----------------------------
MSMEG_6131|M.smegmatis_MC2_155 RAQTHGGLSDDIAVIRVERSRR----------------------------
TH_2176|M.thermoresistible__bu RAQAVGGISDDIAVVRVERTR-----------------------------
Mflv_3268|M.gilvum_PYR-GCK RAASHGGISDDIAVVRVERTPRR---------------------------
Mvan_2987|M.vanbaalenii_PYR-1 RAAAHGGISDDIAVVRVERTPRA---------------------------
Mb1399c|M.bovis_AF2122/97 LLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAE
Rv1364c|M.tuberculosis_H37Rv LLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAE
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 IGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVEAALAGDGNVRAS
Rv1364c|M.tuberculosis_H37Rv IGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRAS
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 VIDRGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSR
Rv1364c|M.tuberculosis_H37Rv VIDRGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSR
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 PARFVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQI
Rv1364c|M.tuberculosis_H37Rv PARFVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQI
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 AVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPG
Rv1364c|M.tuberculosis_H37Rv AVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPG
MLBr_00773|M.leprae_Br4923 --------------------------------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------
MMAR_1263|M.marinum_M --------------------------
MAV_4242|M.avium_104 --------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------
TH_2176|M.thermoresistible__bu --------------------------
Mflv_3268|M.gilvum_PYR-GCK --------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------
Mb1399c|M.bovis_AF2122/97 SPAHHVLSLVQLPVVGADTEDIFAQE
Rv1364c|M.tuberculosis_H37Rv SPAHHVLSLVQLPVVGADTEDIFAQE
MLBr_00773|M.leprae_Br4923 --------------------------
MAB_3891c|M.abscessus_ATCC_199 --------------------------