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RAPFDRVIASPVDLTGPGQRRLSLLLVEDDRADAILVEELIADAPDIDFVWAKSMSDAERTLADHRPDCV LLDLNLPDAAGIDALHHLGKLDARIPIIVLTGLNDEHFGVSAVASGAQDYLVKGRVEPEMLRRAVLYAIE RKRAELTSVDLHASQLRAQENARLERGLLPSPLLMEGSGVDIVVEARPSRQHALIGGDFYDVVQTPDRTV HVMIGDVAGHGPDEAALGVALRIGWRALTFAGLRGNERMRQLDRILTTERPGKGIFATLCSVALEPDSGR FTVVRAGHPGLLVHGNGTVDWLEPRPGAALGLGAREWPVNHYELPEGHGLLLLTDGLFEGHAGRGDERLG ESGLLAVARALAATPGRDFVTSLINEAESRAQTHGGLSDDIAVIRVERSRR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6131 | - | - | 100% (402) | magnesium or manganese-dependent protein phosphatase |
| M. smegmatis MC2 155 | MSMEG_5396 | - | 9e-12 | 35.29% (153) | KDP operon transcriptional regulatory protein KdpE |
| M. smegmatis MC2 155 | MSMEG_5662 | prrA | 2e-09 | 30.30% (132) | DNA-binding response regulator PrrA |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1399c | - | 3e-16 | 27.92% (265) | hypothetical protein Mb1399c |
| M. gilvum PYR-GCK | Mflv_3268 | - | 1e-158 | 72.70% (381) | response regulator receiver protein |
| M. tuberculosis H37Rv | Rv1364c | - | 1e-16 | 28.30% (265) | hypothetical protein Rv1364c |
| M. leprae Br4923 | MLBr_02123 | - | 9e-10 | 30.65% (124) | two-component response regulator |
| M. abscessus ATCC 19977 | MAB_0956c | - | 3e-10 | 31.45% (124) | transcriptional regulatory protein PrrA |
| M. marinum M | MMAR_1263 | - | 1e-143 | 66.50% (403) | hypothetical protein MMAR_1263 |
| M. avium 104 | MAV_4242 | - | 1e-145 | 65.83% (398) | response regulator receiver modulated serine phosphatase |
| M. thermoresistible (build 8) | TH_2176 | - | 1e-160 | 70.83% (408) | magnesium or manganese-dependent protein phosphatase |
| M. ulcerans Agy99 | MUL_2625 | - | 1e-143 | 66.50% (403) | hypothetical protein MUL_2625 |
| M. vanbaalenii PYR-1 | Mvan_2987 | - | 1e-156 | 71.92% (381) | response regulator receiver protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3268|M.gilvum_PYR-GCK --MLAPTDG----------------EMLSLLLVEDDRADAILVEELIADA
Mvan_2987|M.vanbaalenii_PYR-1 --MLAPNDG----------------DSLSLLLVEDDRGDAILVEELIADA
MMAR_1263|M.marinum_M --MRVPHEHDLTAGLGPSTGQRAQWQTLSLLLVEDDRADAMLVEELIADA
MUL_2625|M.ulcerans_Agy99 --MRVPHEHDLTAGLGPSTGQRAQWQTLSLLLVEDARADAMLVEELIADA
MAV_4242|M.avium_104 ---MIPAQAAVTP-----AAQRQSLKPLSVLLVEDDRGDAVLVEELVTDA
TH_2176|M.thermoresistible__bu MPMRAPHESEPLPMAGLGAVPTGQTQPISLLLVEDDRADALLVEELIADT
MSMEG_6131|M.smegmatis_MC2_155 --MRAPFDRVIAS---PVDLTGPGQRRLSLLLVEDDRADAILVEELIADA
MLBr_02123|M.leprae_Br4923 --------------------MDTGVSSPRVLVVDDDSDVLASLERGLRLS
MAB_0956c|M.abscessus_ATCC_199 --------------------MVDGQGSPRVLVVDDDADVLASLERGLRLS
Mb1399c|M.bovis_AF2122/97 ----MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYR
Rv1364c|M.tuberculosis_H37Rv ----MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYR
::* :
Mflv_3268|M.gilvum_PYR-GCK GVDIDVVWAESMAKAEQEIAIARPDCVLLDLHLHDTTGIDGLNRISKQDA
Mvan_2987|M.vanbaalenii_PYR-1 GGDIQVVWAESMARAEQEIAIARPDCILLDLHLHDTDGIDGVNRIAKYDA
MMAR_1263|M.marinum_M AVDIQVVWARSMAHAERELSAARPDCVLLDLNLPDASGIDALDRIANRDA
MUL_2625|M.ulcerans_Agy99 AVDIQVVWARSMAHAERELSAARPDCVLLDLNLPDASGIDALDRIANRDA
MAV_4242|M.avium_104 VTDIRVVWAQSMAHAERELESTRPDCVLLDLHLPDASGIDALNRIAKLDA
TH_2176|M.thermoresistible__bu NADIRVTWAASVADAQHRLAADRPDCVLLDLNLPDADGIDALDRICGYDA
MSMEG_6131|M.smegmatis_MC2_155 P-DIDFVWAKSMSDAERTLADHRPDCVLLDLNLPDAAGIDALHHLGKLDA
MLBr_02123|M.leprae_Br4923 GFEVSTAIDG--AEALRNATETRPDAIVLDINMPVLDGVSVVTALRAMDN
MAB_0956c|M.abscessus_ATCC_199 GFEVNTASDG--AEALRCATEHRPDAIVLDINMPVLDGVSVVTALRAMDN
Mb1399c|M.bovis_AF2122/97 GFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDY
Rv1364c|M.tuberculosis_H37Rv GFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDY
. : : :** . *
Mflv_3268|M.gilvum_PYR-GCK TIPVVVLTGLNDEHFGVSAVSAGAQDYLIKGRVDSEVLRRAVLYAIERKR
Mvan_2987|M.vanbaalenii_PYR-1 TLPIVVLTGLNDEHVGVSAVSAGAQDYLIKDRVDPEVLRRAVLYAIERKR
MMAR_1263|M.marinum_M TVPVVVLTGLNDEYFGATAVAAGAQDYLVKGRVDPEMLRRAMLYAIERKR
MUL_2625|M.ulcerans_Agy99 TVPVVVLTGLNDEYFGATAVAAGAQDYLVKGRVDPEMLRRAMLYAIERKR
MAV_4242|M.avium_104 TVPIVVLTGLNDEYFGASAVAAGAQDYLVKGRVEPEMLRRALLYAIERKR
TH_2176|M.thermoresistible__bu TMPIVVLTGLIDEHFGVLAVASGAQDYLIKGRVEPESLRRSVLYAIERKR
MSMEG_6131|M.smegmatis_MC2_155 RIPIIVLTGLNDEHFGVSAVASGAQDYLVKGRVEPEMLRRAVLYAIERKR
MLBr_02123|M.leprae_Br4923 DVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVAR--VKALLRRR
MAB_0956c|M.abscessus_ATCC_199 DVPVCVLSARTSVDDRVAGLEAGADDYLTKPFVLAELVAR--VKALLRRR
Mb1399c|M.bovis_AF2122/97 DG-----SGVEERYFDFVVTPRRRADGSIEG--VQLIVDDVTSRVRARQA
Rv1364c|M.tuberculosis_H37Rv DG-----SGVEERYFDFVVTPRRRADGSIEG--VQLIVDDVTSRVRARQA
:. . * : : . *:
Mflv_3268|M.gilvum_PYR-GCK AELTTVDLHASQLRARENARLERGLLPSPLLLDDPGVEIVTQYRPSRENA
Mvan_2987|M.vanbaalenii_PYR-1 AELTAVDLHASQLRARENARLERGLLPSPLLLDDPGVEIVAQYQPSRENA
MMAR_1263|M.marinum_M AELIAADLHATQLRARENALLERGLLPSPLLLDSPGVDIVARYRPSREDA
MUL_2625|M.ulcerans_Agy99 AELIAADLHATQLRARENALLERGLLPSPLLLDSPGVDIVARYRPSREDA
MAV_4242|M.avium_104 AELIAADLHATQLRARENALLERGLLPSPLLLDDPGVDIVARYRPSREDA
TH_2176|M.thermoresistible__bu HELTAVDLQASRLQAQENARLERGLLPSPLLLDEPGFDIVAQYRPSHQHA
MSMEG_6131|M.smegmatis_MC2_155 AELTSVDLHASQLRAQENARLERGLLPSPLLMEGSGVDIVVEARPSRQHA
MLBr_02123|M.leprae_Br4923 GATATSSSET--------------IAVGPLEVDIP---------------
MAB_0956c|M.abscessus_ATCC_199 GAVATSSTET--------------ITVGPLEVEIP---------------
Mb1399c|M.bovis_AF2122/97 AEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDT
Rv1364c|M.tuberculosis_H37Rv AEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDT
. .. .
Mflv_3268|M.gilvum_PYR-GCK LLGGDFYDFVQTPDRTVHVMIGDVAGHGADEAALGVALRIAWRALTFAGL
Mvan_2987|M.vanbaalenii_PYR-1 LLGGDFYDFVQTPDRTVHVMIGDVAGHGPDEAALGVALRIAWRALTFAGL
MMAR_1263|M.marinum_M LLCGDFYDVVQTADRVVHVLIGDVAGHGPNEAALGAALRIAFRALTLAGV
MUL_2625|M.ulcerans_Agy99 LLCGDFYDVVQTVDRVVHVLIGDVAGHGPNEAALGAALRIAFRALTLAGV
MAV_4242|M.avium_104 LLCGDFYDVVQTPDRVVHVLIGDVAGHGPHEAALGAALRIAFRALTLAGV
TH_2176|M.thermoresistible__bu LLGGDFYDFVQTPDQTLHVMVGDVSGHGPDEAAVGVALRIGWRALTFAGL
MSMEG_6131|M.smegmatis_MC2_155 LIGGDFYDVVQTPDRTVHVMIGDVAGHGPDEAALGVALRIGWRALTFAGL
MLBr_02123|M.leprae_Br4923 ---------------------------GRRARVNGVDVDLTKREFDLLAV
MAB_0956c|M.abscessus_ATCC_199 ---------------------------GRRARINGVEVDLTKREFDLLAV
Mb1399c|M.bovis_AF2122/97 AAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVMSQLRTALRMQISTGY
Rv1364c|M.tuberculosis_H37Rv AAGGDWFDALALGDR-LVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGY
* : * .
Mflv_3268|M.gilvum_PYR-GCK HGSDRMRQLERILRAERAGRGIFATVLSLRIPPTGS------TVTAVRAG
Mvan_2987|M.vanbaalenii_PYR-1 RGSDRMRQLERILRAERGGRGIFATVLSLAIPPEGP------MITAVRAG
MMAR_1263|M.marinum_M HGGQLMRQLDRVLRAERTGEGIFATVLSLAIPPQPAGSADGAHIQVIRAG
MUL_2625|M.ulcerans_Agy99 HGGELMRQLDRVLRAERTGEGIFATVLSLAIPPQPAGSADGAHIQVIRAG
MAV_4242|M.avium_104 HGVELMRQLERVLHSERTGTGIFATVLSLEISPQRP------EVSVIRAG
TH_2176|M.thermoresistible__bu RGNERMWQLERILRAERPGRGIFATVLSIALSPKDL------TFTAVRAG
MSMEG_6131|M.smegmatis_MC2_155 RGNERMRQLDRILTTERPGKGIFATLCSVALEPDSG------RFTVVRAG
MLBr_02123|M.leprae_Br4923 LAEHKTTVLSRAQ--------LLELVWGYDFAADTN-------VVDVFIG
MAB_0956c|M.abscessus_ATCC_199 LAEHKTAVLSRAQ--------LLELVWGYDFAADTN-------VVDVFIG
Mb1399c|M.bovis_AF2122/97 TVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEF--------QYCTAG
Rv1364c|M.tuberculosis_H37Rv TVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEF--------QYCTAG
. :.* : . : . *
Mflv_3268|M.gilvum_PYR-GCK HPGMLLHGRGTVEWVEPPGGPALGLHGSDWAPQHLELPEGMGLVLLTDGL
Mvan_2987|M.vanbaalenii_PYR-1 HPGMLLHGGGTVDWVEPAGGPALGLHGSDWTPQQVELPEGKGLVLLTDGL
MMAR_1263|M.marinum_M HPGMLLHGGGTVHWLEPPAGPALGLNLGNWCQHEVELPVDHGLLLLTDGL
MUL_2625|M.ulcerans_Agy99 HPGMLLHGGGTVHWLEPPAGPALGLNLGNWCQHEVELPVDHGLLLLTDGL
MAV_4242|M.avium_104 HPGMLLQGGGTVEWVEPPGGPALGLRADDWPRHQLRLPAGHGLLLLTDGL
TH_2176|M.thermoresistible__bu HPGLLVHGPDTVDWLEPPAGPALGLKGTDWPTNEYELPAGHGLLLLTDGL
MSMEG_6131|M.smegmatis_MC2_155 HPGLLVHGNGTVDWLEPRPGAALGLGAREWPVNHYELPEGHGLLLLTDGL
MLBr_02123|M.leprae_Br4923 YLRRKLEANSGPRLLHTVRGVGFVLRMQ----------------------
MAB_0956c|M.abscessus_ATCC_199 YLRRKLEAGGAPRLLHTVRGVGFVLRSQ----------------------
Mb1399c|M.bovis_AF2122/97 HPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGL
Rv1364c|M.tuberculosis_H37Rv HPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGL
: : . * .
Mflv_3268|M.gilvum_PYR-GCK FEGHIGRGNERLGEEGLLEMARSLAH-----LPGREFVDALINGVEARAA
Mvan_2987|M.vanbaalenii_PYR-1 FEGHIGSGNERLGEEGLLELARSLAA-----LPGRAFVHALINAVEERAA
MMAR_1263|M.marinum_M FEGYSGHRRERLGEHGLLSLARSHAG-----LSGPAFVDALIDGAQQRAQ
MUL_2625|M.ulcerans_Agy99 FEGYSGHRRERLGEHGLLSLARSHAG-----LSGPAFVDALIDGAQQRAQ
MAV_4242|M.avium_104 YEGYSGRGTQRLGEDGLLALARSQVD-----RPGPAFVDALIDGAQRLAR
TH_2176|M.thermoresistible__bu FEGHSGRGYERLGEEGLLDLARSHAA-----LPGAEFVHALIDDAEHRAQ
MSMEG_6131|M.smegmatis_MC2_155 FEGHAGRGDERLGESGLLAVARALAA-----TPGRDFVTSLINEAESRAQ
MLBr_02123|M.leprae_Br4923 --------------------------------------------------
MAB_0956c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 IERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLL
Rv1364c|M.tuberculosis_H37Rv IERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLL
Mflv_3268|M.gilvum_PYR-GCK SHGGISDDIAVVRVERTPRR------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 AHGGISDDIAVVRVERTPRA------------------------------
MMAR_1263|M.marinum_M SLGGLTDDIAVLRVERTPA-------------------------------
MUL_2625|M.ulcerans_Agy99 SLGGLTDDIAVLRVERTPA-------------------------------
MAV_4242|M.avium_104 PRGGLTDDIAVLRVERTIT-------------------------------
TH_2176|M.thermoresistible__bu AVGGISDDIAVVRVERTR--------------------------------
MSMEG_6131|M.smegmatis_MC2_155 THGGLSDDIAVIRVERSRR-------------------------------
MLBr_02123|M.leprae_Br4923 --------------------------------------------------
MAB_0956c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 RSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGA
Rv1364c|M.tuberculosis_H37Rv RSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGA
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02123|M.leprae_Br4923 --------------------------------------------------
MAB_0956c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 DHSDIADIVHAISEFVENAVEHGYATDVSKGIVVEAALAGDGNVRASVID
Rv1364c|M.tuberculosis_H37Rv DHSDIADIVHAISEFVENAVEHGYATDVSKGIVVAAALAGDGNVRASVID
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02123|M.leprae_Br4923 --------------------------------------------------
MAB_0956c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 RGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPAR
Rv1364c|M.tuberculosis_H37Rv RGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPAR
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02123|M.leprae_Br4923 --------------------------------------------------
MAB_0956c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 FVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQIAVE
Rv1364c|M.tuberculosis_H37Rv FVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQIAVE
Mflv_3268|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2987|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_1263|M.marinum_M --------------------------------------------------
MUL_2625|M.ulcerans_Agy99 --------------------------------------------------
MAV_4242|M.avium_104 --------------------------------------------------
TH_2176|M.thermoresistible__bu --------------------------------------------------
MSMEG_6131|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_02123|M.leprae_Br4923 --------------------------------------------------
MAB_0956c|M.abscessus_ATCC_199 --------------------------------------------------
Mb1399c|M.bovis_AF2122/97 SRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPA
Rv1364c|M.tuberculosis_H37Rv SRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPA
Mflv_3268|M.gilvum_PYR-GCK -----------------------
Mvan_2987|M.vanbaalenii_PYR-1 -----------------------
MMAR_1263|M.marinum_M -----------------------
MUL_2625|M.ulcerans_Agy99 -----------------------
MAV_4242|M.avium_104 -----------------------
TH_2176|M.thermoresistible__bu -----------------------
MSMEG_6131|M.smegmatis_MC2_155 -----------------------
MLBr_02123|M.leprae_Br4923 -----------------------
MAB_0956c|M.abscessus_ATCC_199 -----------------------
Mb1399c|M.bovis_AF2122/97 HHVLSLVQLPVVGADTEDIFAQE
Rv1364c|M.tuberculosis_H37Rv HHVLSLVQLPVVGADTEDIFAQE