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VTRAAVWEGSAIAVREVRLPEPGPGETLIRISAATVCGSDLHTVSGRRPAPCPSILGHEAVGVVVATGAD SPVSVGDRVVWSVTVSCGECPRCRAGLSAKCCSVRKVGHESFAGDWPLSGGYAEHILLPAGTAFARVPES MPDVVAAPAACATATVMATLEAAGPVTGRRVLILGAGMLGVTAVAACSVADADVRVVDLDEQRADSATGF GARPDDGGPADVVIDFTGSTPAIAAALGRLDVGATMVLAGSVLPAPPLAVDPETVVRRWLTLTGVHNYEP RHLTRAVEFLETTQADFDWAELVGSPVPLERISSVMSPPGSGRLRSAVAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2907 | - | - | 100% (330) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2879 | - | 2e-37 | 32.30% (356) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3073 | - | 8e-26 | 31.14% (334) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0167c | adhE1 | 2e-27 | 30.55% (347) | putative zinc-type alcohol dehydrogenase (e subunit) adhE |
| M. gilvum PYR-GCK | Mflv_4951 | - | 4e-29 | 32.67% (303) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | 2e-27 | 30.55% (347) | zinc-type alcohol dehydrogenase E subunit |
| M. leprae Br4923 | MLBr_01730 | adhA | 1e-22 | 27.24% (323) | alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_2041c | - | 3e-24 | 30.48% (315) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_0405 | adhE | 1e-26 | 30.00% (340) | zinc-type alcohol dehydrogenase (E subunit) AdhE |
| M. avium 104 | MAV_2812 | - | 1e-23 | 30.86% (269) | aldehyde dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_4400 | - | 1e-94 | 52.19% (343) | alcohol dehydrogenase, zinc-containing |
| M. thermoresistible (build 8) | TH_3514 | - | 2e-35 | 61.95% (113) | PUTATIVE putative hypothetical protein Mflv_4945 |
| M. ulcerans Agy99 | MUL_0495 | adhX | 3e-25 | 29.70% (303) | Zn-dependent alcohol dehydrogenase, AdhX |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01730|M.leprae_Br4923 --------------------------------------------------
MAV_2812|M.avium_104 --------------------------------------------------
Mflv_4951|M.gilvum_PYR-GCK --------------------------------------------------
MUL_0495|M.ulcerans_Agy99 --------------------------------------------------
Mb0167c|M.bovis_AF2122/97 --------------------------------------------------
Rv0162c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0405|M.marinum_M --------------------------------------------------
Mvan_2907|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4400|M.smegmatis_MC2_155 --------------------------------------------------
TH_3514|M.thermoresistible__bu VTGGLDVAARLADGLPAVRAAQEYLSACESLGYRQPDLSGRPGQVFDWYR
MAB_2041c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01730|M.leprae_Br4923 -----------------------------MKSHVSKHRRKRRLGAMTTVS
MAV_2812|M.avium_104 --------------------------------------------------
Mflv_4951|M.gilvum_PYR-GCK ------------------------------------------------MQ
MUL_0495|M.ulcerans_Agy99 --------------------------------MTQTLANPGATQATETLR
Mb0167c|M.bovis_AF2122/97 --------------------------MPAVQPWLYSNMPAIRGAVLDQIG
Rv0162c|M.tuberculosis_H37Rv --------------------------MPAVQPWLYSNMPAIRGAVLDQIG
MMAR_0405|M.marinum_M -------------------------MELGLQPWLYSNMIHIRGAVLERIG
Mvan_2907|M.vanbaalenii_PYR-1 ------------------------------------------------MT
MSMEG_4400|M.smegmatis_MC2_155 ------------------------------------MEENATTFTELSHT
TH_3514|M.thermoresistible__bu SEDGLDLGALADDSAALDRAAARAAEVLELQDRQSAALGAGWRGVGGTAA
MAB_2041c|M.abscessus_ATCC_199 -----------------------------------------------MIA
MLBr_01730|M.leprae_Br4923 AYAATSATEPLTKVTINRRAPGPHDVAIQIKFAGICHSDIHTVKAEWGQ-
MAV_2812|M.avium_104 ----------MELVDTETRPPGRDEVRLTVGACGICGTDAHFVNGAFPG-
Mflv_4951|M.gilvum_PYR-GCK AAVVTAFGEPLVVEERDLPAPGPGEALVKLVTSGVCHTDLHAAHGDWPVK
MUL_0495|M.ulcerans_Agy99 AAVVTGFGEPLQIKELALPTPGYGEALVKLETSGVCHTDLHAAHGDWPVK
Mb0167c|M.bovis_AF2122/97 VPRPYWRSKPISVVELHLDPPDRGEVLVRIEAAGVCHSDLSVVDGTRVR-
Rv0162c|M.tuberculosis_H37Rv VPRPYWRSKPISVVELHLDPPDRGEVLVRIEAAGVCHSDLSVVDGTRVR-
MMAR_0405|M.marinum_M SPRPYAQSRPISVVDLDLDPPGDDEVLVRIEAAGVCHSDLSVVDGNRVR-
Mvan_2907|M.vanbaalenii_PYR-1 RAAVWEG-SAIAVREVRLPEPGPGETLIRISAATVCGSDLHTVSGRRPA-
MSMEG_4400|M.smegmatis_MC2_155 RAAIWRGGGDVVIESVPLPVLQTGEVLVRVRLATVCGSDRHTVTGRRPQ-
TH_3514|M.thermoresistible__bu AELLRRHGAASAAATAALRTAADALTTLRTELWQLVDRKVTATQGIDGGG
MAB_2041c|M.abscessus_ATCC_199 EAMVLTGPRSLQRRQMIIPDVGDRGAILRVEACGLCGTDHEQFTGHLPAG
. : : . .
MLBr_01730|M.leprae_Br4923 ------PNYPVVPGHEIAGVVTAVGTEVTKHKVG-------DRVGVGCMV
MAV_2812|M.avium_104 ------LSWPLTPGHEIAGRIAELGEGVEGFAVG-------QRVAVGWFG
Mflv_4951|M.gilvum_PYR-GCK ------PSPPFIPGHEGYGTVVAVGDGVDDLSVG-------DMVGNAWLW
MUL_0495|M.ulcerans_Agy99 ------PAPPFVPGHEGCGTVVALGDGVTDLKVG-------DKVGNAWLW
Mb0167c|M.bovis_AF2122/97 -------PVPILLGHEAAGIVEQVGDGVDGVAVG-------QRVVLVFLP
Rv0162c|M.tuberculosis_H37Rv -------PVPILLGHEAAGIVEQVGDGVDGVAVG-------QRVVLVFLP
MMAR_0405|M.marinum_M -------PVPMLLGHEAAGIVERVGDRVDDLAVG-------QRVVLVFLP
Mvan_2907|M.vanbaalenii_PYR-1 -------PCPSILGHEAVGVVVATGADSPVSV---------GDRVVWSVT
MSMEG_4400|M.smegmatis_MC2_155 -------PCPSVLGHETVGEIVALGDGEPLAVDGNPL--GKGRRVVWSVT
TH_3514|M.thermoresistible__bu RTDWQAAAHTVLTGAGDRSVASELVDAEVKPFVDEAIGCEWLTVMNQTLT
MAB_2041c|M.abscessus_ATCC_199 --------FSFVPGHEIVGIVEHVGAAAGQRWGVQAG-----QRVAVEVF
. * . .
MLBr_01730|M.leprae_Br4923 GSCGECSSCLAGIEQYCKRGATFTYNSIGTDG-------------QSTQG
MAV_2812|M.avium_104 GCCYRCDPCRAGLFIHCVNGKVPSWHYP---------------------G
Mflv_4951|M.gilvum_PYR-GCK SSCGRCEYCRTGWETLCEQQRNGGYSVD---------------------G
MUL_0495|M.ulcerans_Agy99 SACGSCEQCRTGWETLCENQRNGGYTVN---------------------G
Mb0167c|M.bovis_AF2122/97 -RCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLSRGGRPVYHHLGVS
Rv0162c|M.tuberculosis_H37Rv -RCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLSRGGRPVYHHLGVS
MMAR_0405|M.marinum_M -RCGHCPSCATEGITPCAPGSATNAAGTLLGGGIRISRSGQPIYHHLGVS
Mvan_2907|M.vanbaalenii_PYR-1 VSCGECPRCRAGLSAKCCSVRKVGHESFAGDWP--------------LSG
MSMEG_4400|M.smegmatis_MC2_155 LPCGTCDRCVAGVTAKCRTLRKAGHESLYSAWP--------------LSG
TH_3514|M.thermoresistible__bu SIEEKFDAAIAELTGSAAVPDFGAGEGEAPPWAANWGPPWAANWGQPGAA
MAB_2041c|M.abscessus_ATCC_199 RSCRDCPECRRGEYRRCAVNGIATMFGFVDVEIG-----------AGLWG
. . .
MLBr_01730|M.leprae_Br4923 GYSQAIVVDE-NFVVHIPDALPLDAAAPLLCAGIT-LYSPLRHWNAKPGT
MAV_2812|M.avium_104 GYAESVTVPT-SALARIPEELTDAEAAPMGCAGVT-TYNALRHTKALPGD
Mflv_4951|M.gilvum_PYR-GCK SFGTYMLVDA-AYAARIPDGVDPVEVAPILCAGVT-VYKGLKVTDTRPGQ
MUL_0495|M.ulcerans_Agy99 SFGTYMLVNA-DYAARIPDGADPLEVAPILCAGVT-VYKGLKVTDTRPGQ
Mb0167c|M.bovis_AF2122/97 GFATHVVVNR-ASVVPVPHEVPPTVAALLGCAVLTGGGAVLNVGDPQPGQ
Rv0162c|M.tuberculosis_H37Rv GFATHVVVNR-ASVVPVPHEVPPTVAALLGCAVLTGGGAVLNVGDPQPGQ
MMAR_0405|M.marinum_M GFATHAVVNR-ASAVAVPDEVPPQVAALLGCAVLTGGGAVLNVGKPVAGQ
Mvan_2907|M.vanbaalenii_PYR-1 GYAEHILLPAGTAFARVPESMPDVVAAPAACATAT-VMATLEAAGPVTGR
MSMEG_4400|M.smegmatis_MC2_155 GYAEHVVLPRGMPVAVVADDIADALAAPAACATAT-VMAVIERALPVGGR
TH_3514|M.thermoresistible__bu SWGSPPVADG--AASAIGADPAPAEAAAPGVPPPAVPPTGPGGGLPDPGA
MAB_2041c|M.abscessus_ATCC_199 GYATHVELPWDAMLLPIAEDMDPVLATLFNPLGAG-IQWGATLPDTKAGD
.:. : .: . *
MLBr_01730|M.leprae_Br4923 RLAIIG-------LGGLGHMGVKLGRKMG-CEVTVLSQ---SLKKMEDGL
MAV_2812|M.avium_104 RVAILG-------VGGLGHLGVQFAAAMG-FETIAINR---GTGKADDAR
Mflv_4951|M.gilvum_PYR-GCK WVAISG-------IGGLGHVAVQYARAMG-LRVVAIDV---DDSKLDLAT
MUL_0495|M.ulcerans_Agy99 WVAISG-------IGGLGHVAVQYARAMG-LRVVAIDI---DDDKLALAA
Mb0167c|M.bovis_AF2122/97 SVAVVG-------LGGVGMAAVLTALTYTDVRVVAVDQ---LPEKLSAAK
Rv0162c|M.tuberculosis_H37Rv SVAVVG-------LGGVGMAAVLTALTYTDVRVVAVDQ---LPEKLSAAK
MMAR_0405|M.marinum_M SVAVVG-------LGGVGMAAVLTALTQDGVAVFGVDQ---LPQKLSAAE
Mvan_2907|M.vanbaalenii_PYR-1 RVLILG-------AGMLGVTAVAACS-VADADVRVVDL---DEQRADSAT
MSMEG_4400|M.smegmatis_MC2_155 RVVVIG-------AGMLGLTALAAAADLGASTVTAVDP---SAERREIAA
TH_3514|M.thermoresistible__bu GLSTVGRQLVDLLGGLLGPVGEALGNGVGAAGVDPMGG---EDAGGEDAG
MAB_2041c|M.abscessus_ATCC_199 VVAILG-------PGIRGICAAVAAKEAGAAFVAMTGVGPRDEQRLAIAR
: * * * . . . .
MLBr_01730|M.leprae_Br4923 QLGASNYYATADPDTFRKLR------------------------------
MAV_2812|M.avium_104 KLGAHHYIDSTAEDPAEALRAL----------------------------
Mflv_4951|M.gilvum_PYR-GCK GLGAEVVVNARTADVVAEVHRAT---------------------------
MUL_0495|M.ulcerans_Agy99 RLGAELVVNARTSDVVAQVQEAT---------------------------
Mb0167c|M.bovis_AF2122/97 ALGAHEIYTPQQATAGGVKA------------------------------
Rv0162c|M.tuberculosis_H37Rv ALGAHEIYTPQQATAGGVKA------------------------------
MMAR_0405|M.marinum_M ALGASATYTPQQAAAAGVKA------------------------------
Mvan_2907|M.vanbaalenii_PYR-1 GFGARPDDGGP---------------------------------------
MSMEG_4400|M.smegmatis_MC2_155 HFGAEVTAESVNEIEE----------------------------------
TH_3514|M.thermoresistible__bu TEERDGASDADTDAEDDDRGDDTPEDDTPDDGDPDAGGSPGEDPQEAPDP
MAB_2041c|M.abscessus_ATCC_199 SFGVDLPIDVSQDDAATALQRETG--------------------------
MLBr_01730|M.leprae_Br4923 ------------------GSFDLILNTVSANL-DLGKYLNLLDVNGTLVE
MAV_2812|M.avium_104 ------------------GGAAVVLATAGNSQ-AMAATVGGLAPQGELVT
Mflv_4951|M.gilvum_PYR-GCK ------------------GGVHGVLVTAVHRD-AFGQAIGLARRGGTIVF
MUL_0495|M.ulcerans_Agy99 ------------------GGVHGVLVTAVHPQ-AFGQAIGLARRGGTIVF
Mb0167c|M.bovis_AF2122/97 ---------------------AVVVEAVGHPA-ALHTAIGLTAPGGRTIT
Rv0162c|M.tuberculosis_H37Rv ---------------------AVVVEAVGHPA-ALHTAIGLTAPGGRTIT
MMAR_0405|M.marinum_M ---------------------DVVIEAAGHPA-ALETAIGLTAPGGRTIT
Mvan_2907|M.vanbaalenii_PYR-1 --------------------ADVVIDFTGSTP-AIAAALGRLDVGATMVL
MSMEG_4400|M.smegmatis_MC2_155 --------------------CDVLLEFSGKSA-ALQAGLRTLDVSGVAVF
TH_3514|M.thermoresistible__bu EHDPDPAPGEPETHXXXAGPGDVAIDFSGSTE-ALGEALDRLDVGGVLVL
MAB_2041c|M.abscessus_ATCC_199 -----------------GRLADVVVDVTAKAPSAFADAVGLARPGGTIVV
: : : . :
MLBr_01730|M.leprae_Br4923 LGIPEH--PMLVPAFALALMRRSLAGSNIGGITETQEMMNFSAEH-----
MAV_2812|M.avium_104 IGVTPE--PLPISPLQLITPGLSIVGHPSGTAKDVEDTMQFAVLS-----
Mflv_4951|M.gilvum_PYR-GCK VGLPPG--DFPAPIFDIVLKGLTIRGSIVGTRQDMVEAIDFFARG-----
MUL_0495|M.ulcerans_Agy99 NGLPPG--DFPAPIFVIVLKGLTIRGSIVGTRQDMAEALDFYARG-----
Mb0167c|M.bovis_AF2122/97 VGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFVSLWQSGRL
Rv0162c|M.tuberculosis_H37Rv VGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFVSLWQSGRL
MMAR_0405|M.marinum_M VGLPPPDARISVAPLGFVAEGRSLIGSYLGSAVPSRDIPRFVSLWQSGRL
Mvan_2907|M.vanbaalenii_PYR-1 AGSVLPAPPLAVDPETVVRRWLTLTGVHNYEPRHLTRAVEFLETTQAD-F
MSMEG_4400|M.smegmatis_MC2_155 AGSVAPDGDIAVDPEAVVRRHLTLVGVHNYEPRHLLQALNFLQRTKDR-F
TH_3514|M.thermoresistible__bu AGSVSPAPALPVDPELIVRRWLTLTGVHNYEPQHLRDAVAFLRHSRDR-F
MAB_2041c|M.abscessus_ATCC_199 AGTRGGGGAPRFEPDLLVYKELHVVGALGVEYPAYRAALEILAMGR---W
* . : * :
MLBr_01730|M.leprae_Br4923 -SVTPEIELIEPDYINEAYERVLASDVRYRFVINISSL------------
MAV_2812|M.avium_104 -GVRAWIEELPLSRAADGYAALEGGRAHYRTVLTM---------------
Mflv_4951|M.gilvum_PYR-GCK -LVHPTVHTTRLDDINDVFDRMERGQIDGRVVIDYR--------------
MUL_0495|M.ulcerans_Agy99 -LIHPTVEGAALEDINHVFERMERGQIDGRVVIDYR--------------
Mb0167c|M.bovis_AF2122/97 PVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL------------
Rv0162c|M.tuberculosis_H37Rv PVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL------------
MMAR_0405|M.marinum_M PVESLVSATIRLDDLNEAMDHLADGTAVRQIIVF----------------
Mvan_2907|M.vanbaalenii_PYR-1 DWAELVGSPVPLERISSVMSPPGSGRLRSAVAP-----------------
MSMEG_4400|M.smegmatis_MC2_155 PWADLVADPVPLDRIAGLLLDAPGPKPRYAVAP-----------------
TH_3514|M.thermoresistible__bu DWPALVDDPVGLDDIAAALMPAPTGRLRKAVSPGLPPRTAARNSPGSRPP
MAB_2041c|M.abscessus_ATCC_199 PFDRITRESTGFAGLAQLLTSLADESARSSGALHNVFLPTP---------
MLBr_01730|M.leprae_Br4923 --
MAV_2812|M.avium_104 --
Mflv_4951|M.gilvum_PYR-GCK --
MUL_0495|M.ulcerans_Agy99 --
Mb0167c|M.bovis_AF2122/97 --
Rv0162c|M.tuberculosis_H37Rv --
MMAR_0405|M.marinum_M --
Mvan_2907|M.vanbaalenii_PYR-1 --
MSMEG_4400|M.smegmatis_MC2_155 --
TH_3514|M.thermoresistible__bu DS
MAB_2041c|M.abscessus_ATCC_199 --