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QAAVVTAFGEPLVVEERDLPAPGPGEALVKLVTSGVCHTDLHAAHGDWPVKPSPPFIPGHEGYGTVVAVG DGVDDLSVGDMVGNAWLWSSCGRCEYCRTGWETLCEQQRNGGYSVDGSFGTYMLVDAAYAARIPDGVDPV EVAPILCAGVTVYKGLKVTDTRPGQWVAISGIGGLGHVAVQYARAMGLRVVAIDVDDSKLDLATGLGAEV VVNARTADVVAEVHRATGGVHGVLVTAVHRDAFGQAIGLARRGGTIVFVGLPPGDFPAPIFDIVLKGLTI RGSIVGTRQDMVEAIDFFARGLVHPTVHTTRLDDINDVFDRMERGQIDGRVVIDYR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4951 | - | - | 100% (337) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0236 | - | 4e-48 | 34.53% (333) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_3343 | - | 3e-47 | 35.19% (324) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3071 | adhC | 4e-42 | 32.34% (334) | NADP-dependent alcohol dehydrogenase ADHC |
| M. tuberculosis H37Rv | Rv3045 | adhC | 5e-42 | 32.34% (334) | NADP-dependent alcohol dehydrogenase ADHC |
| M. leprae Br4923 | MLBr_01730 | adhA | 7e-45 | 30.61% (343) | alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3400 | - | 5e-42 | 29.15% (343) | NADP-dependent alcohol dehydrogenase C |
| M. marinum M | MMAR_4911 | adhX | 1e-169 | 85.07% (335) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. avium 104 | MAV_2812 | - | 2e-45 | 34.29% (312) | aldehyde dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_6833 | - | 2e-53 | 35.20% (321) | alcohol dehydrogenase |
| M. thermoresistible (build 8) | TH_2673 | - | 5e-48 | 35.80% (324) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_0495 | adhX | 1e-169 | 84.27% (337) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. vanbaalenii PYR-1 | Mvan_0669 | - | 3e-49 | 34.83% (333) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4911|M.marinum_M -----MTQTLANPGATQATETLCAAVVTGFG----EPLQIKELALPTPGY
MUL_0495|M.ulcerans_Agy99 -----MTQTLANPGATQATETLRAAVVTGFG----EPLQIKELALPTPGY
Mflv_4951|M.gilvum_PYR-GCK ---------------------MQAAVVTAFG----EPLVVEERDLPAPGP
TH_2673|M.thermoresistible__bu ---LWTTGAVARDDDRMSASMMSAWRVREPGPMRTRPLEWVRTPVPEPGP
MAV_2812|M.avium_104 -------------------------------------MELVDTETRPPGR
Mvan_0669|M.vanbaalenii_PYR-1 ---------------------MPTHKAVQVPSAN-EALTHVEVDTLPPPA
MSMEG_6833|M.smegmatis_MC2_155 MGRLMVITPIPHPWLIWCRDLMSSYRAYQVTGR--RKFELVQREIRDPAE
Mb3071|M.bovis_AF2122/97 ---------------------MSTVAAYAAMSAT-EPLTKTTITRRDPGP
Rv3045|M.tuberculosis_H37Rv ---------------------MSTVAAYAAMSAT-EPLTKTTITRRDPGP
MLBr_01730|M.leprae_Br4923 -----MKSHVSKHRRKRRLGAMTTVSAYAATSAT-EPLTKVTINRRAPGP
MAB_3400|M.abscessus_ATCC_1997 ---------------------MVTVSAYAATSGK-DPLVPTTIERREVGP
:
MMAR_4911|M.marinum_M GEALVKLETSGVCHTDLHAAHGDWPVKPAPPFVPGHEGCGTVVALGDGVT
MUL_0495|M.ulcerans_Agy99 GEALVKLETSGVCHTDLHAAHGDWPVKPAPPFVPGHEGCGTVVALGDGVT
Mflv_4951|M.gilvum_PYR-GCK GEALVKLVTSGVCHTDLHAAHGDWPVKPSPPFIPGHEGYGTVVAVGDGVD
TH_2673|M.thermoresistible__bu GELLVAVRACGVCRTDLHVAEGDLPVHR-PGVTPGHEVVGEVVATADG-T
MAV_2812|M.avium_104 DEVRLTVGACGICGTDAHFVNGAFPGLS-WPLTPGHEIAGRIAELGEGVE
Mvan_0669|M.vanbaalenii_PYR-1 GHVRIDVAACGVCGTDREFRAGHFPGLQ-WPITLGHEIAGTVAELGDGVE
MSMEG_6833|M.smegmatis_MC2_155 EQVRIRTLACGVCHSDALAVEGQRPNPE-EPVVPGHEVVGVVDAVGSGIQ
Mb3071|M.bovis_AF2122/97 HDVAIDIKFAGICHSDIHTVKAEWGQPN-YPVVPGHEIAGVVTAVGSEVT
Rv3045|M.tuberculosis_H37Rv HDVAIDIKFAGICHSDIHTVKAEWGQPN-YPVVPGHEIAGVVTAVGSEVT
MLBr_01730|M.leprae_Br4923 HDVAIQIKFAGICHSDIHTVKAEWGQPN-YPVVPGHEIAGVVTAVGTEVT
MAB_3400|M.abscessus_ATCC_1997 HDVFIDIKFAGICHSDIHTVRDEWGRAN-YPIVPGHEIAGVITEVGSEVT
. : .*:* :* . *** * : .
MMAR_4911|M.marinum_M D-LKVGDKVGNAWLWSACGSCEQCRTGWETLCEN--------QRNGGYTV
MUL_0495|M.ulcerans_Agy99 D-LKVGDKVGNAWLWSACGSCEQCRTGWETLCEN--------QRNGGYTV
Mflv_4951|M.gilvum_PYR-GCK D-LSVGDMVGNAWLWSSCGRCEYCRTGWETLCEQ--------QRNGGYSV
TH_2673|M.thermoresistible__bu D-FRVGDRVGIAWLRHTCGQCRYCRRGQENLCPE--------SRYTGWDA
MAV_2812|M.avium_104 G-FAVGQRVAVGWFGGCCYRCDPCRAGLFIHCVN--------GKVPSWHY
Mvan_0669|M.vanbaalenii_PYR-1 E-FAVGDRVAVGWFGGNCNRCVPCRRGFFMQCER--------MQVPSWQY
MSMEG_6833|M.smegmatis_MC2_155 ERWRIGERVGVGFLGGQCGHCDYCRRGDFVNCLD--------QPLTGTTV
Mb3071|M.bovis_AF2122/97 K-YRQGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPT
Rv3045|M.tuberculosis_H37Rv K-YRQGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPT
MLBr_01730|M.leprae_Br4923 K-HKVGDRVGVGCMVGSCGECSSCLAGIEQYCKRGATFTYNSIGTDGQST
MAB_3400|M.abscessus_ATCC_1997 K-FKPGDHAGVGCFVNSCRECPSCLAGLEQFCERGMVGTYGAKDRDGTQT
*: .. . : * * * * * .
MMAR_4911|M.marinum_M NGSFGTYMLVNADYAARIPDGADPLEVAPILCAGVTVYKGLKVTDTRPGQ
MUL_0495|M.ulcerans_Agy99 NGSFGTYMLVNADYAARIPDGADPLEVAPILCAGVTVYKGLKVTDTRPGQ
Mflv_4951|M.gilvum_PYR-GCK DGSFGTYMLVDAAYAARIPDGVDPVEVAPILCAGVTVYKGLKVTDTRPGQ
TH_2673|M.thermoresistible__bu DGGYAEFATVPAAYAHRLPAGYSDAELAPLLCAGIIGYRALRRAELPPGG
MAV_2812|M.avium_104 PGGYAESVTVPTSALARIPEELTDAEAAPMGCAGVTTYNALRHTKALPGD
Mvan_0669|M.vanbaalenii_PYR-1 PGGYAESVTAPATALARIPDGLSFVEAAPMGCAGVTTFNGLRRTRAKAGD
MSMEG_6833|M.smegmatis_MC2_155 DGGYSEMLYVRESALVRVPEGFDALTAAPLLCAGVTVFNALRAGDAPPNT
Mb3071|M.bovis_AF2122/97 QGGYSEAIVVDENYVLRIPDVLPLDVAAPLLCAGITLYSPLRHWNAGANT
Rv3045|M.tuberculosis_H37Rv QGGYSEAIVVDENYVLRIPDVLPLDVAAPLLCAGITLYSPLRHWNAGANT
MLBr_01730|M.leprae_Br4923 QGGYSQAIVVDENFVVHIPDALPLDAAAPLLCAGITLYSPLRHWNAKPGT
MAB_3400|M.abscessus_ATCC_1997 QGGYSQAIVVDENYVLRIPDSLPLDAAAPLLCAGITTFSPLRHWNAGPGK
*.:. . ::* **: ***: : *: ..
MMAR_4911|M.marinum_M WVAISGIGGLGHVAVQYARAMGLRVVAIDIDDDKLALAARLGAELVVNAR
MUL_0495|M.ulcerans_Agy99 WVAISGIGGLGHVAVQYARAMGLRVVAIDIDDDKLALAARLGAELVVNAR
Mflv_4951|M.gilvum_PYR-GCK WVAISGIGGLGHVAVQYARAMGLRVVAIDVDDSKLDLATGLGAEVVVNAR
TH_2673|M.thermoresistible__bu RLGIYGFGGSAHLTAQVALAQGAEVHVMTRGAQARELALALGAASAQGAA
MAV_2812|M.avium_104 RVAILGVGGLGHLGVQFAAAMGFETIAINRGTGKADDARKLGAHHYIDST
Mvan_0669|M.vanbaalenii_PYR-1 LVAVLGVGGLGHLGVQWARAMGFETVAIGRGTGKAEEATQFGAHHYIDST
MSMEG_6833|M.smegmatis_MC2_155 LVAVQGLGGLGHLGVQYAKKLGYEVAAIARGTDKADLAATLGADHYIDSA
Mb3071|M.bovis_AF2122/97 RVAIIGLGGLGHMGVKLGAAMGADVTVLSQSLKKMEDGLRLGAKSYYATA
Rv3045|M.tuberculosis_H37Rv RVAIIGLGGLGHMGVKLGAAMGADVTVLSQSLKKMEDGLRLGAKSYYATA
MLBr_01730|M.leprae_Br4923 RLAIIGLGGLGHMGVKLGRKMGCEVTVLSQSLKKMEDGLQLGASNYYATA
MAB_3400|M.abscessus_ATCC_1997 RVAVVGLGGLGHMAVKLGKAMGAEVTVLSQSLKKMEDGLRLGASHYYATA
:.: *.** .*: .: . * . .: . . :** :
MMAR_4911|M.marinum_M TSDVVAQVQEATGGVHGVLVTAVHPQAFGQAIGLARRGGTIVFNGLPPGD
MUL_0495|M.ulcerans_Agy99 TSDVVAQVQEATGGVHGVLVTAVHPQAFGQAIGLARRGGTIVFNGLPPGD
Mflv_4951|M.gilvum_PYR-GCK TADVVAEVHRATGGVHGVLVTAVHRDAFGQAIGLARRGGTIVFVGLPPGD
TH_2673|M.thermoresistible__bu DPPPVP--------LDAAILFAPVGHLVLPALEALDRGGTLSIAGIHLTD
MAV_2812|M.avium_104 AEDPAEALRALGG-AAVVLATAGNSQAMAATVGGLAPQGELVTIGVTPEP
Mvan_0669|M.vanbaalenii_PYR-1 GQDVAAELTKLGG-ASVVLATANNAAAMAAAVGGLGPAGELVVVGVTAEN
MSMEG_6833|M.smegmatis_MC2_155 TEDVAAGLTRLGG-AAAVVATASSGQSMAGLVAGLRPRGRLVVVGAAPDP
Mb3071|M.bovis_AF2122/97 DPDTFRKLR---GGFDLILNTVSANLDLGQYLNLLDVDGTLVELGIPEHP
Rv3045|M.tuberculosis_H37Rv DPDTFRKLR---GGFDLILNTVSANLDLGQYLNLLDVDGTLVELGIPEHP
MLBr_01730|M.leprae_Br4923 DPDTFRKLR---GSFDLILNTVSANLDLGKYLNLLDVNGTLVELGIPEHP
MAB_3400|M.abscessus_ATCC_1997 DPDTFKSLR---NSFDLILNTVSSNLDMGKYLGLLGVDGTLVELGLPENP
: . . : * : *
MMAR_4911|M.marinum_M FPAPIFDIVLKG-LTIRGSIVGTRQDMAEALDFYARGLIHPTVEGAALED
MUL_0495|M.ulcerans_Agy99 FPAPIFVIVLKG-LTIRGSIVGTRQDMAEALDFYARGLIHPTVEGAALED
Mflv_4951|M.gilvum_PYR-GCK FPAPIFDIVLKG-LTIRGSIVGTRQDMVEAIDFFARGLVHPTVHTTRLDD
TH_2673|M.thermoresistible__bu IPTLDYQRHLFQERQVRSVTANTRDDARAFLDFAAQHRIEVTTPEYPLDR
MAV_2812|M.avium_104 LPISPLQLITPG-LSIVGHPSGTAKDVEDTMQFAVLSGVRAWIEELPLSR
Mvan_0669|M.vanbaalenii_PYR-1 LPISPLDLINAG-RSVTGHPSGTSRDVEETMHFALLSGVRAKVEEVPLAR
MSMEG_6833|M.smegmatis_MC2_155 IPVQTPDLIFGG-RTIVGSLTGSAIDNEDNLAFSLNHQIAPMIERMPFTE
Mb3071|M.bovis_AF2122/97 MAVPAFALALMR-RSLAGSNIGGIAETQEMLNFCAEHGVTPEIELIEPDY
Rv3045|M.tuberculosis_H37Rv MAVPAFALALMR-RSLAGSNIGGIAETQEMLNFCAEHGVTPEIELIEPDY
MLBr_01730|M.leprae_Br4923 MLVPAFALALMR-RSLAGSNIGGITETQEMMNFSAEHSVTPEIELIEPDY
MAB_3400|M.abscessus_ATCC_1997 IEVPGFPLLTNR-RSISGSLIGGIPETQEMLDFCAKHGIGSEIEVIDASY
: : . . : : * :
MMAR_4911|M.marinum_M INHVFERMERGQIDGRVVIDYR--
MUL_0495|M.ulcerans_Agy99 INHVFERMERGQIDGRVVIDYR--
Mflv_4951|M.gilvum_PYR-GCK INDVFDRMERGQIDGRVVIDYR--
TH_2673|M.thermoresistible__bu ADDALTDLSEGRIAGAAVLRV---
MAV_2812|M.avium_104 AADGYAALEGGRAHYRTVLTM---
Mvan_0669|M.vanbaalenii_PYR-1 AAEAYESMDSGRARYRMVLTM---
MSMEG_6833|M.smegmatis_MC2_155 APQAYERMMSGHARFRVVLDFS--
Mb3071|M.bovis_AF2122/97 INDAYERVLASDVRYRFVIDISAL
Rv3045|M.tuberculosis_H37Rv INDAYERVLASDVRYRFVIDISAL
MLBr_01730|M.leprae_Br4923 INEAYERVLASDVRYRFVINISSL
MAB_3400|M.abscessus_ATCC_1997 INEAYERVVASDVRYRFVIDTQTL
. : . *: