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ELGLQPWLYSNMIHIRGAVLERIGSPRPYAQSRPISVVDLDLDPPGDDEVLVRIEAAGVCHSDLSVVDGN RVRPVPMLLGHEAAGIVERVGDRVDDLAVGQRVVLVFLPRCGHCPSCATEGITPCAPGSATNAAGTLLGG GIRISRSGQPIYHHLGVSGFATHAVVNRASAVAVPDEVPPQVAALLGCAVLTGGGAVLNVGKPVAGQSVA VVGLGGVGMAAVLTALTQDGVAVFGVDQLPQKLSAAEALGASATYTPQQAAAAGVKADVVIEAAGHPAAL ETAIGLTAPGGRTITVGLPPPDARISVAPLGFVAEGRSLIGSYLGSAVPSRDIPRFVSLWQSGRLPVESL VSATIRLDDLNEAMDHLADGTAVRQIIVF*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0405 | adhE | - | 100% (380) | zinc-type alcohol dehydrogenase (E subunit) AdhE |
| M. marinum M | MMAR_4935 | adhB | 6e-53 | 32.87% (359) | zinc-containing alcohol dehydrogenase NAD- dependent AdhB |
| M. marinum M | MMAR_3350 | adhE2 | 1e-50 | 33.71% (356) | zinc-dependent alcohol dehydrogenase AdhE2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0167c | adhE1 | 1e-175 | 81.65% (376) | putative zinc-type alcohol dehydrogenase (e subunit) adhE |
| M. gilvum PYR-GCK | Mflv_0725 | - | 8e-56 | 38.44% (359) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | 1e-175 | 81.65% (376) | zinc-type alcohol dehydrogenase E subunit |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 6e-49 | 33.43% (356) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0983c | - | 1e-101 | 51.91% (366) | zinc-containing alcohol dehydrogenase |
| M. avium 104 | MAV_5022 | - | 1e-171 | 82.27% (361) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_0127 | - | 1e-155 | 74.25% (365) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3466 | - | 1e-116 | 73.82% (275) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_0470 | adhB | 2e-52 | 32.59% (359) | zinc-containing alcohol dehydrogenase NAD- dependent AdhB |
| M. vanbaalenii PYR-1 | Mvan_3767 | - | 1e-51 | 34.55% (356) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01784|M.leprae_Br4923 -------------------MSQTVRGVISRKKDEPVELVDIVIPDPGPGE
Mvan_3767|M.vanbaalenii_PYR-1 -------------------MTQTVRGVISRTKGQPVEVVEIVIPDPGPGE
Mb0167c|M.bovis_AF2122/97 -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
Rv0162c|M.tuberculosis_H37Rv -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
MMAR_0405|M.marinum_M MELGLQPWLYSNMIHIRGAVLERIGSPRPYAQSRPISVVDLDLDPPGDDE
MAV_5022|M.avium_104 -------------------MLQRIGAPRPYARSRPISITDVELAPPGRDE
MSMEG_0127|M.smegmatis_MC2_155 -------------MKIRGAVLERIGAPRPYAESRPLTISELDLADPGPDE
TH_3466|M.thermoresistible__bu --------------------------------------------------
MAB_0983c|M.abscessus_ATCC_199 -------------MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGE
Mflv_0725|M.gilvum_PYR-GCK --------------------MPETTAVLSYAPEDPFSVAEVRVDDPRADE
MUL_0470|M.ulcerans_Agy99 ---------------------MKTKGALIWEFNQPWSVEDIEIGDPVKDE
MLBr_01784|M.leprae_Br4923 AVVDVTACGVCHTDLT-YREGGINDRYPFLLGHEAAGTVEVVGPGVTAVE
Mvan_3767|M.vanbaalenii_PYR-1 VVVDIQACGVCHTDLH-YREGGINDEFPFLLGHEAAGTVESVGAGVTNVA
Mb0167c|M.bovis_AF2122/97 VLVRIEAAGVCHSDLS-VVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVA
Rv0162c|M.tuberculosis_H37Rv VLVRIEAAGVCHSDLS-VVDGTRVRPVPILLGHEAAGIVEQVGDGVDGVA
MMAR_0405|M.marinum_M VLVRIEAAGVCHSDLS-VVDGNRVRPVPMLLGHEAAGIVERVGDRVDDLA
MAV_5022|M.avium_104 VLVRIEAAGICHSDLS-VVDGNRVRPVPMLLGHEAAGIVERVGPGVADLA
MSMEG_0127|M.smegmatis_MC2_155 LLVRIESAGLCHSDLS-VVDGNRVRPVPMLLGHEAAGVVETPG---ADLE
TH_3466|M.thermoresistible__bu --------------------------------------------------
MAB_0983c|M.abscessus_ATCC_199 VLVRIEAAGLCHSDLS-VVDGNRIRPVPMALGHEAAGVIAAVGPGVRDVS
Mflv_0725|M.gilvum_PYR-GCK ILVRIEAAGVCHTDLVNRVAGKPDR--PVLLGHEGAGIVERVGDGLQSVK
MUL_0470|M.ulcerans_Agy99 VKIQMEAAGMCRSDNHLVTGGIPMAGFPVLGGHEGAGVVTEVGPGVDDIA
MLBr_01784|M.leprae_Br4923 PGDFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDGTELTP---
Mvan_3767|M.vanbaalenii_PYR-1 PGDFVVLNWRAVCGQCRACKRGRPHLCFDTFNAEQKMTLTDGTELTP---
Mb0167c|M.bovis_AF2122/97 VGQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLS-RG
Rv0162c|M.tuberculosis_H37Rv VGQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLS-RG
MMAR_0405|M.marinum_M VGQRVVLVFLPRCGHCPSCATEGITPCAPGSATNAAGTLLGGGIRIS-RS
MAV_5022|M.avium_104 VGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLS-RA
MSMEG_0127|M.smegmatis_MC2_155 TGQRVVMTFLPRCGSCPACGTDGLTPCGPGSVANGAGTLMNGDIRLR-RD
TH_3466|M.thermoresistible__bu ----VVMTFLPRCGHCPACATDGLTPCEPGSAANTAGTLLSGAIRLT-RD
MAB_0983c|M.abscessus_ATCC_199 PGDHVVLVYVPSCGACRYCSSGRPALCPDAAAANGRGDLIRGGTRLHDLD
Mflv_0725|M.gilvum_PYR-GCK PGDRVVLSFR-SCGACTNCRARRPAYCRKAVRLNQFGQRADGTPRVT-VD
MUL_0470|M.ulcerans_Agy99 PGDHVVLSFIPSCGRCPTCQAGLRNLCDLGAGLLAGAAVSDGTFRIQ-AR
*:: : ** * * * *
MLBr_01784|M.leprae_Br4923 -------ALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGA
Mvan_3767|M.vanbaalenii_PYR-1 -------ALGIGAFADKTLVHEGQCTKVDPAADPAAAGLLGCGVMAGLGA
Mb0167c|M.bovis_AF2122/97 GRPVYH-HLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGA
Rv0162c|M.tuberculosis_H37Rv GRPVYH-HLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGA
MMAR_0405|M.marinum_M GQPIYH-HLGVSGFATHAVVNRASAVAVPDEVPPQVAALLGCAVLTGGGA
MAV_5022|M.avium_104 GRPVYH-HLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGGGA
MSMEG_0127|M.smegmatis_MC2_155 GEPVFH-HLGVSGFATHAVVDRRSIVPVPDDVPATVAALLGCAVLTGGGA
TH_3466|M.thermoresistible__bu GQPVHH-HLGISGFASHAVVDRRSVVPVDSDVPPSVAALLGCAVLTGGGA
MAB_0983c|M.abscessus_ATCC_199 GTEVRH-HLGVSGFADHAVVDRNSVVVIDENVPLDTAALFGCAMLTGFGA
Mflv_0725|M.gilvum_PYR-GCK GRSVLDGFFGQSSLAGYALTTQDNTVVVGPDVDPVLAAPLGCGFQTGAGA
MUL_0470|M.ulcerans_Agy99 GQNVYP-MTLLGTFSPYMVVHRSSVVKIDPAIPFEVAALVGCGVTTGYGS
. :: :. . . : *. .**.. :* *:
MLBr_01784|M.leprae_Br4923 AINTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWA
Mvan_3767|M.vanbaalenii_PYR-1 AINTGAVNRDDTVAVIGCGGVGDAAIAGARLVGAKRIIAVDMDNRKLDWA
Mb0167c|M.bovis_AF2122/97 VLNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAA
Rv0162c|M.tuberculosis_H37Rv VLNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAA
MMAR_0405|M.marinum_M VLNVGKPVAGQSVAVVGLGGVGMAAVLTALTQDGVAVFGVDQLPQKLSAA
MAV_5022|M.avium_104 VLNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAA
MSMEG_0127|M.smegmatis_MC2_155 VLNVGRPKPGQTVVVVGLGGVGMAAALTALAHDDVRVVGVDQLSDKLARA
TH_3466|M.thermoresistible__bu VLNVGRPRPGQRVIVVGLGGVGLAAVLTALAHPDVRVVGVDQRTDKLHTA
MAB_0983c|M.abscessus_ATCC_199 VTHTASVRPGDSVAVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELA
Mflv_0725|M.gilvum_PYR-GCK VLNLMQPAAGSSVAVFGAGAVGLAGVLAALAVDVETVIVVEPSPQRRALA
MUL_0470|M.ulcerans_Agy99 AVRTADVRPGDDVAIVGLGGVGMAALQGAVTAGARYIFAVEPVEWKRDQA
. . .. * :.* *.** * * :. :: : *
MLBr_01784|M.leprae_Br4923 RTFGATHTVNALELEVVKTIQDLTSGFGVDVVIDTVGRPE--TWKQAFYA
Mvan_3767|M.vanbaalenii_PYR-1 REFGATHTINAGELDAVKTIQDLTDGFGADVVIDAVGRPE--TWKQAFYA
Mb0167c|M.bovis_AF2122/97 KALGAHEIYTPQQATAGGV--------KAAVVVEAVGHPA--ALHTAIGL
Rv0162c|M.tuberculosis_H37Rv KALGAHEIYTPQQATAGGV--------KAAVVVEAVGHPA--ALHTAIGL
MMAR_0405|M.marinum_M EALGASATYTPQQAAAAGV--------KADVVIEAAGHPA--ALETAIGL
MAV_5022|M.avium_104 RRLGAHQAYTPQQAVEARV--------KAAVVIEAVGHPA--ALQTAIDL
MSMEG_0127|M.smegmatis_MC2_155 AELGVHETFTPEQAAD--L--------RAEVVIEAAGHPA--ALETAIGL
TH_3466|M.thermoresistible__bu RTLGAHEAYTPDQAVDANL--------KAQVVIEAAGHPD--ALATAIQL
MAB_0983c|M.abscessus_ATCC_199 LELGATSACAPDEAPGG-----------HDWVFEVVGSAA--VLEQAYAL
Mflv_0725|M.gilvum_PYR-GCK ESLGVRAALSPDDHTVRAIREITGG--GVDYALDTTGRPE--VLASAVAA
MUL_0470|M.ulcerans_Agy99 LKFGATHVYPDMEAALMGIAEVTYG-LMAKKVMITVGELQGSDIDTYLAI
:*. : .. ..*
MLBr_01784|M.leprae_Br4923 RDLAGTVVLVGVP-TPDMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPT
Mvan_3767|M.vanbaalenii_PYR-1 RDLAGTVVLVGVP-TPDMTLEMPLIDFFSRGGSLKSSWYGDCLPERDFPT
Mb0167c|M.bovis_AF2122/97 TAPGGRTITVGLP-PPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPR
Rv0162c|M.tuberculosis_H37Rv TAPGGRTITVGLP-PPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPR
MMAR_0405|M.marinum_M TAPGGRTITVGLP-PPDARISVAPLGFVAEGRSLIGSYLGSAVPSRDIPR
MAV_5022|M.avium_104 TAPGGRTITVGLP-PPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPR
MSMEG_0127|M.smegmatis_MC2_155 TGPGGRTITVGLP-RPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPR
TH_3466|M.thermoresistible__bu TAPGGRTITVGLP-PPDARLTVSPLGLVAEGRSLIGSYLGSAVPARDIPR
MAB_0983c|M.abscessus_ATCC_199 TGRGGGTVSVGLP-HPDARISLPALNIVAEGRSILGSYMGSAQPQQDIPA
Mflv_0725|M.gilvum_PYR-GCK LAVGGTAVAVGLG-TGVPAIDLADL--VLRGKTVHGCLEGDSIPSVFIPE
MUL_0470|M.ulcerans_Agy99 TSKGGTCVVTAIGSLLDTQVNLNLAMLTLMQKNLQGTIFGGGNPQYDIPH
.* : ..: : : .: . *. * :*
MLBr_01784|M.leprae_Br4923 LVDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML-----
Mvan_3767|M.vanbaalenii_PYR-1 LISLYLQGRFPLDKFVSERIGLDQIEDAFDKMHAGEVLRSVVVL-----
Mb0167c|M.bovis_AF2122/97 FVSLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL-
Rv0162c|M.tuberculosis_H37Rv FVSLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL-
MMAR_0405|M.marinum_M FVSLWQSGRLPVESLVSATIRLDDLNEAMDHLADGTAVRQIIVF-----
MAV_5022|M.avium_104 FVELWRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIRFDA---
MSMEG_0127|M.smegmatis_MC2_155 FVELWRAGRLPVESLVSSTIALDDINAGMDELAEGRAVRQVIDFA----
TH_3466|M.thermoresistible__bu FVDLWRSGRLPVEQLVSSTITLDELNEGLDRLADGAAVRQLITLPG---
MAB_0983c|M.abscessus_ATCC_199 MLALWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVRQILRPGVSA-
Mflv_0725|M.gilvum_PYR-GCK LLALHARGRFPIERLVT-EFSHRDVTEALAAQHAGDVVKPVLTWP----
MUL_0470|M.ulcerans_Agy99 LLSMYKARNLNIDDMITRQYRLEQINEGYQDMIDGKNIRGVIRFTDADR
:: : .: : : : :: . * :: ::