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PAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGEVLVRIEAAGVCHSDLSVVDGTR VRPVPILLGHEAAGIVEQVGDGVDGVAVGQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGG IRLSRGGRPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAVLNVGDPQPGQSVAV VGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAKALGAHEIYTPQQATAGGVKAAVVVEAVGHPAALH TAIGLTAPGGRTITVGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFVSLWQSGRLPVESLV TSTIRLDDINEAMDHLADGIAVRQLISFTGDL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | - | 100% (383) | PROBABLE ZINC-TYPE ALCOHOL DEHYDROGENASE (E SUBUNIT) ADHE |
| M. tuberculosis H37Rv | Rv0761c | adhB | 2e-54 | 33.98% (362) | zinc-containing alcohol dehydrogenase NAD dependent ADHB |
| M. tuberculosis H37Rv | Rv2259 | adhE2 | 2e-53 | 34.77% (371) | zinc-dependent alcohol dehydrogenase AdhE2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0167c | adhE1 | 0.0 | 100.00% (383) | putative zinc-type alcohol dehydrogenase (e subunit) adhE |
| M. gilvum PYR-GCK | Mflv_4588 | - | 2e-55 | 37.39% (353) | alcohol dehydrogenase |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 4e-52 | 34.65% (355) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_0983c | - | 1e-100 | 53.02% (364) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_0405 | adhE | 1e-174 | 81.65% (376) | zinc-type alcohol dehydrogenase (E subunit) AdhE |
| M. avium 104 | MAV_5022 | - | 1e-167 | 81.44% (361) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_0127 | - | 1e-147 | 71.51% (365) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3466 | - | 1e-117 | 73.84% (279) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. ulcerans Agy99 | MUL_0470 | adhB | 1e-54 | 33.89% (360) | zinc-containing alcohol dehydrogenase NAD- dependent AdhB |
| M. vanbaalenii PYR-1 | Mvan_3767 | - | 2e-54 | 36.62% (355) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0162c|M.tuberculosis_H37Rv -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
Mb0167c|M.bovis_AF2122/97 -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
MMAR_0405|M.marinum_M MELGLQPWLYSNMIHIRGAVLERIGSPRPYAQSRPISVVDLDLDPPGDDE
MAV_5022|M.avium_104 -------------------MLQRIGAPRPYARSRPISITDVELAPPGRDE
MSMEG_0127|M.smegmatis_MC2_155 -------------MKIRGAVLERIGAPRPYAESRPLTISELDLADPGPDE
TH_3466|M.thermoresistible__bu --------------------------------------------------
MAB_0983c|M.abscessus_ATCC_199 -------------MRIRSAVLHAAPIERPYRDTHPLKVIELELDPPGPGE
MLBr_01784|M.leprae_Br4923 -------------------MSQTVRGVISRKKDEPVELVDIVIPDPGPGE
Mvan_3767|M.vanbaalenii_PYR-1 -------------------MTQTVRGVISRTKGQPVEVVEIVIPDPGPGE
Mflv_4588|M.gilvum_PYR-GCK ---------------------MKTRAAVLWGLGEKWEVDEIELDPPGVDE
MUL_0470|M.ulcerans_Agy99 ---------------------MKTKGALIWEFNQPWSVEDIEIGDPVKDE
Rv0162c|M.tuberculosis_H37Rv VLVRIEAAGVCHSDLSVVDGTRVRP-VPILLGHEAAGIVEQVGDGVDGVA
Mb0167c|M.bovis_AF2122/97 VLVRIEAAGVCHSDLSVVDGTRVRP-VPILLGHEAAGIVEQVGDGVDGVA
MMAR_0405|M.marinum_M VLVRIEAAGVCHSDLSVVDGNRVRP-VPMLLGHEAAGIVERVGDRVDDLA
MAV_5022|M.avium_104 VLVRIEAAGICHSDLSVVDGNRVRP-VPMLLGHEAAGIVERVGPGVADLA
MSMEG_0127|M.smegmatis_MC2_155 LLVRIESAGLCHSDLSVVDGNRVRP-VPMLLGHEAAGVVETPG---ADLE
TH_3466|M.thermoresistible__bu --------------------------------------------------
MAB_0983c|M.abscessus_ATCC_199 VLVRIEAAGLCHSDLSVVDGNRIRP-VPMALGHEAAGVIAAVGPGVRDVS
MLBr_01784|M.leprae_Br4923 AVVDVTACGVCHTDLTYREGGINDR-YPFLLGHEAAGTVEVVGPGVTAVE
Mvan_3767|M.vanbaalenii_PYR-1 VVVDIQACGVCHTDLHYREGGINDE-FPFLLGHEAAGTVESVGAGVTNVA
Mflv_4588|M.gilvum_PYR-GCK VLVQLTASGLCHSDEHLVTGDLPFP-LPVVGGHEGAGTVVEVGAGVEDLA
MUL_0470|M.ulcerans_Agy99 VKIQMEAAGMCRSDNHLVTGGIPMAGFPVLGGHEGAGVVTEVGPGVDDIA
Rv0162c|M.tuberculosis_H37Rv VGQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLS-RG
Mb0167c|M.bovis_AF2122/97 VGQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLLGGGIRLS-RG
MMAR_0405|M.marinum_M VGQRVVLVFLPRCGHCPSCATEGITPCAPGSATNAAGTLLGGGIRIS-RS
MAV_5022|M.avium_104 VGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLLGGDIRLS-RA
MSMEG_0127|M.smegmatis_MC2_155 TGQRVVMTFLPRCGSCPACGTDGLTPCGPGSVANGAGTLMNGDIRLR-RD
TH_3466|M.thermoresistible__bu ----VVMTFLPRCGHCPACATDGLTPCEPGSAANTAGTLLSGAIRLT-RD
MAB_0983c|M.abscessus_ATCC_199 PGDHVVLVYVPSCGACRYCSSGRPALCPDAAAANGRGDLIRGGTRLHDLD
MLBr_01784|M.leprae_Br4923 PGDFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLIDG--------
Mvan_3767|M.vanbaalenii_PYR-1 PGDFVVLNWRAVCGQCRACKRGRPHLCFDTFNAEQKMTLTDG--------
Mflv_4588|M.gilvum_PYR-GCK VGDSVILTFLPSCGHCSYCARGMGNLCDMGAAIMMGPQI-DGTYRFH-AR
MUL_0470|M.ulcerans_Agy99 PGDHVVLSFIPSCGRCPTCQAGLRNLCDLGAGLLAGAAVSDGTFRIQ-AR
*:: : . ** * * * : *
Rv0162c|M.tuberculosis_H37Rv GRPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAV
Mb0167c|M.bovis_AF2122/97 GRPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGCAVLTGGGAV
MMAR_0405|M.marinum_M GQPIYHHLGVSGFATHAVVNRASAVAVPDEVPPQVAALLGCAVLTGGGAV
MAV_5022|M.avium_104 GRPVYHHLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGCAVLTGGGAV
MSMEG_0127|M.smegmatis_MC2_155 GEPVFHHLGVSGFATHAVVDRRSIVPVPDDVPATVAALLGCAVLTGGGAV
TH_3466|M.thermoresistible__bu GQPVHHHLGISGFASHAVVDRRSVVPVDSDVPPSVAALLGCAVLTGGGAV
MAB_0983c|M.abscessus_ATCC_199 GTEVRHHLGVSGFADHAVVDRNSVVVIDENVPLDTAALFGCAMLTGFGAV
MLBr_01784|M.leprae_Br4923 -TELTPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGCGVMAGLGAA
Mvan_3767|M.vanbaalenii_PYR-1 -TELTPALGIGAFADKTLVHEGQCTKVDPAADPAAAGLLGCGVMAGLGAA
Mflv_4588|M.gilvum_PYR-GCK GEDVGQMCLLGTFSEYTVVPKASLVKVDHGTPLDKAALIGCGVTTGYGSA
MUL_0470|M.ulcerans_Agy99 GQNVYPMTLLGTFSPYMVVHRSSVVKIDPAIPFEVAALVGCGVTTGYGSA
: :. *: :* . . : *.*.**.: :* *:.
Rv0162c|M.tuberculosis_H37Rv LNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAK
Mb0167c|M.bovis_AF2122/97 LNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQLPEKLSAAK
MMAR_0405|M.marinum_M LNVGKPVAGQSVAVVGLGGVGMAAVLTALTQDGVAVFGVDQLPQKLSAAE
MAV_5022|M.avium_104 LNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQLPEKLAAAR
MSMEG_0127|M.smegmatis_MC2_155 LNVGRPKPGQTVVVVGLGGVGMAAALTALAHDDVRVVGVDQLSDKLARAA
TH_3466|M.thermoresistible__bu LNVGRPRPGQRVIVVGLGGVGLAAVLTALAHPDVRVVGVDQRTDKLHTAR
MAB_0983c|M.abscessus_ATCC_199 THTASVRPGDSVAVLGLGGVGLAVVMSAAAAGAGEVLAIDPVPAKRELAL
MLBr_01784|M.leprae_Br4923 INTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDIDDTKLEWAR
Mvan_3767|M.vanbaalenii_PYR-1 INTGAVNRDDTVAVIGCGGVGDAAIAGARLVGAKRIIAVDMDNRKLDWAR
Mflv_4588|M.gilvum_PYR-GCK VRTGEVRAGDTVVVIGAGGIGMNAIQGARIAGALTIVAVDPVEFKREQAG
MUL_0470|M.ulcerans_Agy99 VRTADVRPGDDVAIVGLGGVGMAALQGAVTAGARYIFAVEPVEWKRDQAL
... .: * ::* **:* . * :..:: * *
Rv0162c|M.tuberculosis_H37Rv ALGAHEIYTP--------QQATAGGVKAAVVVEAVGHP-AALHTAIGLTA
Mb0167c|M.bovis_AF2122/97 ALGAHEIYTP--------QQATAGGVKAAVVVEAVGHP-AALHTAIGLTA
MMAR_0405|M.marinum_M ALGASATYTP--------QQAAAAGVKADVVIEAAGHP-AALETAIGLTA
MAV_5022|M.avium_104 RLGAHQAYTP--------QQAVEARVKAAVVIEAVGHP-AALQTAIDLTA
MSMEG_0127|M.smegmatis_MC2_155 ELGVHETFTP--------EQAAD--LRAEVVIEAAGHP-AALETAIGLTG
TH_3466|M.thermoresistible__bu TLGAHEAYTP--------DQAVDANLKAQVVIEAAGHP-DALATAIQLTA
MAB_0983c|M.abscessus_ATCC_199 ELGATSACAP--------DEAPGG---HDWVFEVVGSA-AVLEQAYALTG
MLBr_01784|M.leprae_Br4923 TFGATHTVNALELEVVKTIQDLTSGFGVDVVIDTVGRP-ETWKQAFYARD
Mvan_3767|M.vanbaalenii_PYR-1 EFGATHTINAGELDAVKTIQDLTDGFGADVVIDAVGRP-ETWKQAFYARD
Mflv_4588|M.gilvum_PYR-GCK GFGATHAVATIDEAWSLISDITRGKLADVCVLTTDVAEGAYTAEALSLVG
MUL_0470|M.ulcerans_Agy99 KFGATHVYPDMEAALMGIAEVTYGLMAKKVMITVGELQGSDIDTYLAITS
:*. : :. .
Rv0162c|M.tuberculosis_H37Rv PGGRTITVGLP-PPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFV
Mb0167c|M.bovis_AF2122/97 PGGRTITVGLP-PPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFV
MMAR_0405|M.marinum_M PGGRTITVGLP-PPDARISVAPLGFVAEGRSLIGSYLGSAVPSRDIPRFV
MAV_5022|M.avium_104 PGGRTITVGLP-PPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRFV
MSMEG_0127|M.smegmatis_MC2_155 PGGRTITVGLP-RPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRFV
TH_3466|M.thermoresistible__bu PGGRTITVGLP-PPDARLTVSPLGLVAEGRSLIGSYLGSAVPARDIPRFV
MAB_0983c|M.abscessus_ATCC_199 RGGGTVSVGLP-HPDARISLPALNIVAEGRSILGSYMGSAQPQQDIPAML
MLBr_01784|M.leprae_Br4923 LAGTVVLVGVP-TPDMRLDMPLLDFFSHGGSLKSSWYGDCLPERDFPTLV
Mvan_3767|M.vanbaalenii_PYR-1 LAGTVVLVGVP-TPDMTLEMPLIDFFSRGGSLKSSWYGDCLPERDFPTLI
Mflv_4588|M.gilvum_PYR-GCK KRGRVVITAIGHPEDTSMSGSLLELTLYEKQIRGALYGSSNAAHDIPRLV
MUL_0470|M.ulcerans_Agy99 KGGTCVVTAIGSLLDTQVNLNLAMLTLMQKNLQGTIFGGGNPQYDIPHLL
* : ..: * : : .: .: *. . *:* ::
Rv0162c|M.tuberculosis_H37Rv SLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL-
Mb0167c|M.bovis_AF2122/97 SLWQSGRLPVESLVTSTIRLDDINEAMDHLADGIAVRQLISFTGDL-
MMAR_0405|M.marinum_M SLWQSGRLPVESLVSATIRLDDLNEAMDHLADGTAVRQIIVF-----
MAV_5022|M.avium_104 ELWRAGRLPVESLVSSTIRLEDINEAMDHLADGTAVRQLIRFDA---
MSMEG_0127|M.smegmatis_MC2_155 ELWRAGRLPVESLVSSTIALDDINAGMDELAEGRAVRQVIDFA----
TH_3466|M.thermoresistible__bu DLWRSGRLPVEQLVSSTITLDELNEGLDRLADGAAVRQLITLPG---
MAB_0983c|M.abscessus_ATCC_199 ALWRAGRLPVEKLKSDDLPLSDINIALDALAEGQAVRQILRPGVSA-
MLBr_01784|M.leprae_Br4923 DLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGGKVLRSVVML-----
Mvan_3767|M.vanbaalenii_PYR-1 SLYLQGRFPLDKFVSERIGLDQIEDAFDKMHAGEVLRSVVVL-----
Mflv_4588|M.gilvum_PYR-GCK ELYNSGQLKLDELITREYTLDEINEGYDDMRSGRNIRGLIRF-----
MUL_0470|M.ulcerans_Agy99 SMYKARNLNIDDMITRQYRLEQINEGYQDMIDGKNIRGVIRFTDADR
:: .: : .: : * ::: . . : * :* ::