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SRAPFTGRIARFDEPGKPFDIETVTLPEVGPGEILIKVTRANICGSDVHAWHGTFATRGLGGQLPTVLGH EMVGAVEELGAGVTADSNGKPLELGTRVVFPYFFCCHTCRNCLAGRRNACLNLKMAMLGRADEPPYFVGG YADYFVLPAGAVVYTVPDAVSDDIAAGANCALSQVMYGLERVDQQLGEYVVVQGAGALGLYAVAVAKARG AAKVIAIDGVPERLELATAFGADAVIDITATTDKDRAKIVRSLTDGQGADVVVEVVGHPSAIDEGLKLLG QFGRYVEIGNINIGRTFEFDPSRFVFANKTMVGVSLYDPSVLSRALAFLEEYQHRLPFDRLAAARYSLDD INEAFAAAEDKRDVRASIVP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2879 | - | - | 100% (371) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2907 | - | 2e-37 | 32.30% (356) | alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_3767 | - | 1e-32 | 30.25% (367) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0167c | adhE1 | 3e-30 | 30.16% (368) | putative zinc-type alcohol dehydrogenase (e subunit) adhE |
| M. gilvum PYR-GCK | Mflv_2766 | - | 4e-31 | 30.94% (362) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | 3e-30 | 30.16% (368) | zinc-type alcohol dehydrogenase E subunit |
| M. leprae Br4923 | MLBr_01784 | adhE2 | 8e-29 | 27.87% (366) | putative alcohol dehydrogenase (Zn dependent) |
| M. abscessus ATCC 19977 | MAB_1869c | - | 2e-28 | 28.22% (365) | zinc-dependent alcohol dehydrogenase AdhE2 |
| M. marinum M | MMAR_0405 | adhE | 6e-29 | 29.73% (370) | zinc-type alcohol dehydrogenase (E subunit) AdhE |
| M. avium 104 | MAV_5022 | - | 9e-27 | 29.54% (369) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_2882 | - | 0.0 | 88.49% (365) | 5-exo-alcohol dehydrogenase |
| M. thermoresistible (build 8) | TH_4627 | - | 3e-33 | 29.76% (373) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_1292 | adhE2 | 7e-29 | 28.61% (367) | zinc-dependent alcohol dehydrogenase AdhE2 |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_01784|M.leprae_Br4923 -------------------MSQTVRGVISRKKDEPVELVDIVIPDPGPGE
MUL_1292|M.ulcerans_Agy99 -------------------MSQTVRGVISRKKGEPVELVDIVVPDPGPGE
Mflv_2766|M.gilvum_PYR-GCK -------------------MTQTVRGVIARAKGRPVEVVDVVIPDPGPGE
TH_4627|M.thermoresistible__bu -------------------MSQSVRGVIARKKDEPVEVVDIVIPDPGPGE
MAB_1869c|M.abscessus_ATCC_199 -----------------------------------MELVDIVIPDPGPGE
Mb0167c|M.bovis_AF2122/97 -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
Rv0162c|M.tuberculosis_H37Rv -MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISVVELHLDPPDRGE
MMAR_0405|M.marinum_M MELGLQPWLYSNMIHIRGAVLERIGSPRPYAQSRPISVVDLDLDPPGDDE
MAV_5022|M.avium_104 -------------------MLQRIGAPRPYARSRPISITDVELAPPGRDE
Mvan_2879|M.vanbaalenii_PYR-1 ----------------MSRAPFTGRIARFDEPGKPFDIETVTLPEVGPGE
MSMEG_2882|M.smegmatis_MC2_155 ----------------MTLASGTGRIARFDEPGKPFEIQTVPVPQVGPGE
..: : : . .*
MLBr_01784|M.leprae_Br4923 AVVDVTACGVCHTDLTYREG-----GINDRYPFLLGHEAAGTVEVVGPGV
MUL_1292|M.ulcerans_Agy99 AVVDISACGVCHTDLTYREG-----GINDEYPFLLGHEAAGTVEAVGPGV
Mflv_2766|M.gilvum_PYR-GCK VVVDIQACGVCHTDLTYRDG-----GINDEFPFLLGHEAAGIVETVGQGV
TH_4627|M.thermoresistible__bu VVVKVTACGVCHTDLHYREG-----GINDEFPFLLGHEAAGTVESVGSGV
MAB_1869c|M.abscessus_ATCC_199 VVVKVQACGVCHTDLTYREG-----GINDEFPFLLGHEAAGIVETVGEGV
Mb0167c|M.bovis_AF2122/97 VLVRIEAAGVCHSDLSVVDG-----TRVRPVPILLGHEAAGIVEQVGDGV
Rv0162c|M.tuberculosis_H37Rv VLVRIEAAGVCHSDLSVVDG-----TRVRPVPILLGHEAAGIVEQVGDGV
MMAR_0405|M.marinum_M VLVRIEAAGVCHSDLSVVDG-----NRVRPVPMLLGHEAAGIVERVGDRV
MAV_5022|M.avium_104 VLVRIEAAGICHSDLSVVDG-----NRVRPVPMLLGHEAAGIVERVGPGV
Mvan_2879|M.vanbaalenii_PYR-1 ILIKVTRANICGSDVHAWHGTFATRGLGGQLPTVLGHEMVGAVEELGAGV
MSMEG_2882|M.smegmatis_MC2_155 ILIRVTRANICGSDVHAWHGTFATRGLGGQLPTVLGHEMVGVVAVLGDDV
:: : ..:* :*: .* * :**** .* * :* *
MLBr_01784|M.leprae_Br4923 TA------VEPGDFVILNWRAVCGQCRACKRGRPSYCFDTFNAQQKMTLI
MUL_1292|M.ulcerans_Agy99 TN------VEPGDFVILNWRAVCGQCRACKRGRPSYCFDTFNAEQKMTLT
Mflv_2766|M.gilvum_PYR-GCK TN------VAPGDFVILNWRAVCGQCRACKRGRPHLCFDTHNAAQKMTLT
TH_4627|M.thermoresistible__bu TN------VEPGDFVVLNWRAVCGQCRACKRGRPHLCFDTFNATQKMTLG
MAB_1869c|M.abscessus_ATCC_199 TT------VEPGDFVILNWRAVCGVCRACKRGRPQYCFDTFNAAQKMTLT
Mb0167c|M.bovis_AF2122/97 DG------VAVGQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLL
Rv0162c|M.tuberculosis_H37Rv DG------VAVGQRVVLVFLPRCGQCAACATDGRTPCEPGSAANKAGTLL
MMAR_0405|M.marinum_M DD------LAVGQRVVLVFLPRCGHCPSCATEGITPCAPGSATNAAGTLL
MAV_5022|M.avium_104 AD------LAVGARVVLVFLPRCGRCAACATEGLTPCEPGSAANGAGTLL
Mvan_2879|M.vanbaalenii_PYR-1 TADSNGKPLELGTRVVFPYFFCCHTCRNCLAGRRNACLN-----LKMAML
MSMEG_2882|M.smegmatis_MC2_155 HSDSDGRPLEVGTRVVFPYFFCCHTCRNCLAGRRNACVN-----LKMAML
: * *:: : * * * * ::
MLBr_01784|M.leprae_Br4923 DG--------TELTPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGC
MUL_1292|M.ulcerans_Agy99 DG--------TELTPALGIGAFADKTLVHSGQCTKVDPAADPAVAGLLGC
Mflv_2766|M.gilvum_PYR-GCK DG--------TELTPALGIGAFADKTLVHEGQCTKVDPAADPAAAGLLGC
TH_4627|M.thermoresistible__bu DG--------TELTPALGIGAFAEKTLVHEGQCTKVDPAADPAVAGLLGC
MAB_1869c|M.abscessus_ATCC_199 DG--------TELTPALGIGAFIEKTLVHAGQCTKVDPTADPAVVGLLGC
Mb0167c|M.bovis_AF2122/97 GGGIRLSRGGRPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGC
Rv0162c|M.tuberculosis_H37Rv GGGIRLSRGGRPVYHHLGVSGFATHVVVNRASVVPVPHEVPPTVAALLGC
MMAR_0405|M.marinum_M GGGIRISRSGQPIYHHLGVSGFATHAVVNRASAVAVPDEVPPQVAALLGC
MAV_5022|M.avium_104 GGDIRLSRAGRPVYHHLGVSGFATHAVVNRASAVEVPPDVPAEVAALLGC
Mvan_2879|M.vanbaalenii_PYR-1 GR---------ADEPPYFVGGYADYFVLPAGAVVYTVPDAVSDDIAAGAN
MSMEG_2882|M.smegmatis_MC2_155 GR---------ADEPPHFVGGYADYFLLPAKAVVYTVPDSVSDEIAAGAN
. :..: :: . . . . .
MLBr_01784|M.leprae_Br4923 GVMAGLGAAINTAAVSRDDTVAVIGCGGVGDAAISGAALVGANRIIAVDI
MUL_1292|M.ulcerans_Agy99 GVMAGLGAAVNTGGVTRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDT
Mflv_2766|M.gilvum_PYR-GCK GVMAGLGAAINTGGITRDDTVAVIGCGGVGDAAIAGAALVGAKTIIAVDT
TH_4627|M.thermoresistible__bu GVMAGVGAAINTGAVSRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDT
MAB_1869c|M.abscessus_ATCC_199 GVMAGLGAAVNTGNVGRDDTVAVIGCGGVGDAAIAGARLAGARKIIAIDT
Mb0167c|M.bovis_AF2122/97 AVLTGGGAVLNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQ
Rv0162c|M.tuberculosis_H37Rv AVLTGGGAVLNVGDPQPGQSVAVVGLGGVGMAAVLTALTYTDVRVVAVDQ
MMAR_0405|M.marinum_M AVLTGGGAVLNVGKPVAGQSVAVVGLGGVGMAAVLTALTQDGVAVFGVDQ
MAV_5022|M.avium_104 AVLTGGGAVLNVGRPAPGQTVAVVGLGGVGMAALLTALTYDGVPVVAVDQ
Mvan_2879|M.vanbaalenii_PYR-1 CALSQVMYGLERVDQQLGEYVVVQGAGALGLYAVAVAKARGAAKVIAIDG
MSMEG_2882|M.smegmatis_MC2_155 CALSQVMYGLERVDLQLGETVVVQGAGALGLYAVAVAKARGAKTVIAIDG
.:: :: .: *.* * *.:* *: * :..:*
MLBr_01784|M.leprae_Br4923 DDTKLEWARTFGATHTVNALELE---VVKTIQDLTSGFGVDVVIDTVGRP
MUL_1292|M.ulcerans_Agy99 DNTKLEWARAFGATHTVNARELD---VVETIQDLTGGFGVDVVIDAVGRP
Mflv_2766|M.gilvum_PYR-GCK DNRKLDWARQFGATHTINAKDLD---PVKTIQDLTDGFGTDVVIDAVGRP
TH_4627|M.thermoresistible__bu DAKKLDWAREFGATHTIDASSTD---VVEAIQELTDGFGADVVVDAVGRP
MAB_1869c|M.abscessus_ATCC_199 DDTKLAWAKDFGATDTINARKVDD--VVTAIQELTDEFGADVVIDAVGRP
Mb0167c|M.bovis_AF2122/97 LPEKLSAAKALGAHEIYTPQQAT-----------AGGVKAAVVVEAVGHP
Rv0162c|M.tuberculosis_H37Rv LPEKLSAAKALGAHEIYTPQQAT-----------AGGVKAAVVVEAVGHP
MMAR_0405|M.marinum_M LPQKLSAAEALGASATYTPQQAA-----------AAGVKADVVIEAAGHP
MAV_5022|M.avium_104 LPEKLAAARRLGAHQAYTPQQAV-----------EARVKAAVVIEAVGHP
Mvan_2879|M.vanbaalenii_PYR-1 VPERLELATAFGADAVIDITATTDKDRAKIVRSLTDGQGADVVVEVVGHP
MSMEG_2882|M.smegmatis_MC2_155 VPERLELAKAFGADEVIDITATTDKDRVKIVRRLTDRQGADVVVEVVGHP
:* * :** . **::..*:*
MLBr_01784|M.leprae_Br4923 ETWKQAFYARDLAGTVVLVGVPTPDMRLDMPLLDFFSHGGSLKSSWYGDC
MUL_1292|M.ulcerans_Agy99 ETWKQAFYARDLAGTVVLVGVPTPDMRLDMPLVDFFSRGGALKSSWYGDC
Mflv_2766|M.gilvum_PYR-GCK ETWKQAFYARDLAGTVVLVGVPTPDMTLDMPLIDFFSRGGSLKSSWYGDC
TH_4627|M.thermoresistible__bu ETWEQAFYARDLAGTVVLVGVPTPDMRIDMPLIDFFSRGGSLKSSWYGDC
MAB_1869c|M.abscessus_ATCC_199 ETWKQAFYARDLAGTVVLVGVPTPDMTLEMPLIDFFSRGGSLKSSWYGDC
Mb0167c|M.bovis_AF2122/97 AALHTAIGLTAPGGRTITVGLPPPDVRISLSPLDFVTEGRSLIGSYLGSA
Rv0162c|M.tuberculosis_H37Rv AALHTAIGLTAPGGRTITVGLPPPDVRISLSPLDFVTEGRSLIGSYLGSA
MMAR_0405|M.marinum_M AALETAIGLTAPGGRTITVGLPPPDARISVAPLGFVAEGRSLIGSYLGSA
MAV_5022|M.avium_104 AALQTAIDLTAPGGRTITVGLPPPDARITVSPLGFVAEGRSLIGSYLGSA
Mvan_2879|M.vanbaalenii_PYR-1 SAIDEGLKLLGQFGRYVEIGNINIGRTFEFDPSRFVFANKTMVGVSLYDP
MSMEG_2882|M.smegmatis_MC2_155 SAIDEGLKLLGQFGRYVEIGNINIGKTFEFDPSRFVFANKTMVGVSLYDP
: . .: * : :* . : . *. . :: . .
MLBr_01784|M.leprae_Br4923 LPERDFPTLVDLYLQGRLPLGKFVSERIGLGDVEEAFHKIHGG---KVLR
MUL_1292|M.ulcerans_Agy99 LPERDFPTLIDLYLQGRLPLDKFVSEQIGLGGIEEAFEKMHAG---KVLR
Mflv_2766|M.gilvum_PYR-GCK LPERDFPTLISLYLQGRFPLDKFVSERITLDQIEDAFHKMHAGSDDVVLR
TH_4627|M.thermoresistible__bu LPERDFPTLINLYLQGRLPLEKFVTERIALDEVEGAFEKMQRG---EVLR
MAB_1869c|M.abscessus_ATCC_199 LPERDFPTLVSLYQQGRLPLDRFVSERIGIESIEAAFEKMHHG---EVLR
Mb0167c|M.bovis_AF2122/97 VPSHDIPRFVSLWQSGRLPVESLVTSTIRLDDINEAMDHLADG---IAVR
Rv0162c|M.tuberculosis_H37Rv VPSHDIPRFVSLWQSGRLPVESLVTSTIRLDDINEAMDHLADG---IAVR
MMAR_0405|M.marinum_M VPSRDIPRFVSLWQSGRLPVESLVSATIRLDDLNEAMDHLADG---TAVR
MAV_5022|M.avium_104 VPSRDIPRFVELWRAGRLPVESLVSSTIRLEDINEAMDHLADG---TAVR
Mvan_2879|M.vanbaalenii_PYR-1 SVLSRALAFLEEYQH-RLPFDRLAAARYSLDDINEAFAAAEDK---RDVR
MSMEG_2882|M.smegmatis_MC2_155 AVLSRALTFLAEYQD-RLPFDRLAAACYRLEDINDAFSAAENK---RDVR
:: : *:*. :.: : :: *: :*
MLBr_01784|M.leprae_Br4923 SVVML----
MUL_1292|M.ulcerans_Agy99 SVVVL----
Mflv_2766|M.gilvum_PYR-GCK SVVVL----
TH_4627|M.thermoresistible__bu SVVVLK---
MAB_1869c|M.abscessus_ATCC_199 SVVVL----
Mb0167c|M.bovis_AF2122/97 QLISFTGDL
Rv0162c|M.tuberculosis_H37Rv QLISFTGDL
MMAR_0405|M.marinum_M QIIVF----
MAV_5022|M.avium_104 QLIRFDA--
Mvan_2879|M.vanbaalenii_PYR-1 ASIVP----
MSMEG_2882|M.smegmatis_MC2_155 ASIVP----
: