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EENATTFTELSHTRAAIWRGGGDVVIESVPLPVLQTGEVLVRVRLATVCGSDRHTVTGRRPQPCPSVLGH ETVGEIVALGDGEPLAVDGNPLGKGRRVVWSVTLPCGTCDRCVAGVTAKCRTLRKAGHESLYSAWPLSGG YAEHVVLPRGMPVAVVADDIADALAAPAACATATVMAVIERALPVGGRRVVVIGAGMLGLTALAAAADLG ASTVTAVDPSAERREIAAHFGAEVTAESVNEIEECDVLLEFSGKSAALQAGLRTLDVSGVAVFAGSVAPD GDIAVDPEAVVRRHLTLVGVHNYEPRHLLQALNFLQRTKDRFPWADLVADPVPLDRIAGLLLDAPGPKPR YAVAP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4400 | - | - | 100% (356) | alcohol dehydrogenase, zinc-containing |
| M. smegmatis MC2 155 | MSMEG_2882 | - | 3e-45 | 37.46% (323) | 5-exo-alcohol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_6296 | - | 5e-36 | 31.14% (350) | 5-exo-alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0167c | adhE1 | 5e-23 | 30.52% (344) | putative zinc-type alcohol dehydrogenase (e subunit) adhE |
| M. gilvum PYR-GCK | Mflv_0660 | - | 1e-23 | 29.64% (334) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv0162c | adhE1 | 5e-23 | 30.52% (344) | zinc-type alcohol dehydrogenase E subunit |
| M. leprae Br4923 | MLBr_02053 | - | 7e-16 | 27.95% (297) | putative alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0983c | - | 4e-25 | 30.37% (326) | zinc-containing alcohol dehydrogenase |
| M. marinum M | MMAR_0405 | adhE | 1e-24 | 30.00% (320) | zinc-type alcohol dehydrogenase (E subunit) AdhE |
| M. avium 104 | MAV_5022 | - | 2e-22 | 30.41% (296) | oxidoreductase, zinc-binding dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3514 | - | 1e-27 | 55.45% (110) | PUTATIVE putative hypothetical protein Mflv_4945 |
| M. ulcerans Agy99 | MUL_2965 | adhC | 4e-22 | 29.29% (297) | NADP-dependent alcohol dehydrogenase AdhC |
| M. vanbaalenii PYR-1 | Mvan_2907 | - | 1e-94 | 52.19% (343) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_4400|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_2907|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0167c|M.bovis_AF2122/97 --------------------------------------------------
Rv0162c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_5022|M.avium_104 --------------------------------------------------
MMAR_0405|M.marinum_M --------------------------------------------------
MAB_0983c|M.abscessus_ATCC_199 --------------------------------------------------
TH_3514|M.thermoresistible__bu VTGGLDVAARLADGLPAVRAAQEYLSACESLGYRQPDLSGRPGQVFDWYR
MUL_2965|M.ulcerans_Agy99 --------------------------------------------------
MLBr_02053|M.leprae_Br4923 --------------------------------------------------
Mflv_0660|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_4400|M.smegmatis_MC2_155 -----------------------MEENATTFTELSHTRAAIWRGGGDVVI
Mvan_2907|M.vanbaalenii_PYR-1 -----------------------------------MTRAAVWEG-SAIAV
Mb0167c|M.bovis_AF2122/97 -------------MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISV
Rv0162c|M.tuberculosis_H37Rv -------------MPAVQPWLYSNMPAIRGAVLDQIGVPRPYWRSKPISV
MAV_5022|M.avium_104 -------------------------------MLQRIGAPRPYARSRPISI
MMAR_0405|M.marinum_M ------------MELGLQPWLYSNMIHIRGAVLERIGSPRPYAQSRPISV
MAB_0983c|M.abscessus_ATCC_199 -------------------------MRIRSAVLHAAPIERPYRDTHPLKV
TH_3514|M.thermoresistible__bu SEDGLDLGALADDSAALDRAAARAAEVLELQDRQSAALGAGWRGVGGTAA
MUL_2965|M.ulcerans_Agy99 --------------------------------MATHKAVQIGAAGGPLQL
MLBr_02053|M.leprae_Br4923 -------------------------------MHAWRVRRPGPIQTSPLEW
Mflv_0660|M.gilvum_PYR-GCK ------------------------------------MEAIVLNGTNDVGL
MSMEG_4400|M.smegmatis_MC2_155 ESVPLPV-----LQTGEVLVRVRLATVCGSDRHTVTGRRP-QPCPSVLG-
Mvan_2907|M.vanbaalenii_PYR-1 REVRLPE-----PGPGETLIRISAATVCGSDLHTVSGRRP-APCPSILG-
Mb0167c|M.bovis_AF2122/97 VELHLDP-----PDRGEVLVRIEAAGVCHSDLSVVDGTRV-RPVPILLG-
Rv0162c|M.tuberculosis_H37Rv VELHLDP-----PDRGEVLVRIEAAGVCHSDLSVVDGTRV-RPVPILLG-
MAV_5022|M.avium_104 TDVELAP-----PGRDEVLVRIEAAGICHSDLSVVDGNRV-RPVPMLLG-
MMAR_0405|M.marinum_M VDLDLDP-----PGDDEVLVRIEAAGVCHSDLSVVDGNRV-RPVPMLLG-
MAB_0983c|M.abscessus_ATCC_199 IELELDP-----PGPGEVLVRIEAAGLCHSDLSVVDGNRI-RPVPMALG-
TH_3514|M.thermoresistible__bu AELLRRHGAASAAATAALRTAADALTTLRTELWQLVDRKV-TATQGIDGG
MUL_2965|M.ulcerans_Agy99 VDVDTAP-----PADGEVRISVSACGICGTDRAFVHGAFPGLDWPLTPG-
MLBr_02053|M.leprae_Br4923 VTTEVPC-----PEPSELLVAVRACGVCRTDLHVAEGDLPVHREHVTPG-
Mflv_0660|M.gilvum_PYR-GCK TSVPDPA-----PQDGEVIIEVAATGLCGTDLHEYVAGPTFSQPPVVLG-
:: *
MSMEG_4400|M.smegmatis_MC2_155 ----HETVGEIVALGDGEPLAVDGNPLGKGRRVVWSVTL-PCGTCDRCVA
Mvan_2907|M.vanbaalenii_PYR-1 ----HEAVGVVVATGADSPVSV-------GDRVVWSVTV-SCGECPRCRA
Mb0167c|M.bovis_AF2122/97 ----HEAAGIVEQVGDGVDGVA------VGQRVVLVFLP-RCGQCAACAT
Rv0162c|M.tuberculosis_H37Rv ----HEAAGIVEQVGDGVDGVA------VGQRVVLVFLP-RCGQCAACAT
MAV_5022|M.avium_104 ----HEAAGIVERVGPGVADLA------VGARVVLVFLP-RCGRCAACAT
MMAR_0405|M.marinum_M ----HEAAGIVERVGDRVDDLA------VGQRVVLVFLP-RCGHCPSCAT
MAB_0983c|M.abscessus_ATCC_199 ----HEAAGVIAAVGPGVRDVS------PGDHVVLVYVP-SCGACRYCSS
TH_3514|M.thermoresistible__bu GRTDWQAAAHTVLTGAGDRSVAS----ELVDAEVKPFVD-EAIGCEWLTV
MUL_2965|M.ulcerans_Agy99 ----HEIAGRIAEIGNGVEDFA------VGDRVAVGWFGGNCNHCDPCRK
MLBr_02053|M.leprae_Br4923 ----HEVVGEVLGVGSDVDAAAG---FDVGDRVGIAWLRYTCGVCNYCRS
Mflv_0660|M.gilvum_PYR-GCK ----HEVSGRIVEVGAGVDQSR------IGEGAAVIPMD-FCGSCHYCHR
: . * . *
MSMEG_4400|M.smegmatis_MC2_155 GVTAKCRTLRKAGHES--LYSAWPLS-------------GGYAEHVVLPR
Mvan_2907|M.vanbaalenii_PYR-1 GLSAKCCSVRKVGHES--FAGDWPLS-------------GGYAEHILLPA
Mb0167c|M.bovis_AF2122/97 DGRTPCEPGSAANKAGTLLGGGIRLS-RGGRPVYHHLGVSGFATHVVVNR
Rv0162c|M.tuberculosis_H37Rv DGRTPCEPGSAANKAGTLLGGGIRLS-RGGRPVYHHLGVSGFATHVVVNR
MAV_5022|M.avium_104 EGLTPCEPGSAANGAGTLLGGDIRLS-RAGRPVYHHLGVSGFATHAVVNR
MMAR_0405|M.marinum_M EGITPCAPGSATNAAGTLLGGGIRIS-RSGQPIYHHLGVSGFATHAVVNR
MAB_0983c|M.abscessus_ATCC_199 GRPALCPDAAAANGRGDLIRGGTRLHDLDGTEVRHHLGVSGFADHAVVDR
TH_3514|M.thermoresistible__bu MNQTLTSIEEKFDAAIAELTGSAAVPDFGAGEGEAPPWAANWGPPWAANW
MUL_2965|M.ulcerans_Agy99 GMFIHCSKMKVP---------GWQYP-------------GGYAESVTVPA
MLBr_02053|M.leprae_Br4923 GTENLCVQSRYT---------GWDVD-------------GGYAEFTTVPA
Mflv_0660|M.gilvum_PYR-GCK SLYHLCQRPGWIG---------FTRN-------------GGLANYVAVPS
.. .
MSMEG_4400|M.smegmatis_MC2_155 G---------------MPVAVVADDIADALAAPAACATATVMAVIERALP
Mvan_2907|M.vanbaalenii_PYR-1 G---------------TAFARVPESMPDVVAAPAACATATVMATLEAAGP
Mb0167c|M.bovis_AF2122/97 A---------------SVVPVPHEVPPTVAALLGCAVLTGGGAVLNVGDP
Rv0162c|M.tuberculosis_H37Rv A---------------SVVPVPHEVPPTVAALLGCAVLTGGGAVLNVGDP
MAV_5022|M.avium_104 A---------------SAVEVPPDVPAEVAALLGCAVLTGGGAVLNVGRP
MMAR_0405|M.marinum_M A---------------SAVAVPDEVPPQVAALLGCAVLTGGGAVLNVGKP
MAB_0983c|M.abscessus_ATCC_199 N---------------SVVVIDENVPLDTAALFGCAMLTGFGAVTHTASV
TH_3514|M.thermoresistible__bu GQPGAASWGSPPVADGAASAIGADPAPAEAAAPGVPPPAVPPTGPGGGLP
MUL_2965|M.ulcerans_Agy99 T---------------ALARIPAELSDAEAAPMGCAGVTTYNALRHTR-A
MLBr_02053|M.leprae_Br4923 A---------------FAHHLPSGYSDCELAPLLCAGIIGYRSLLRSELP
Mflv_0660|M.gilvum_PYR-GCK R---------------LAVRVPDVVDLEEAALTEPTAVAFHAVR--RAEL
*
MSMEG_4400|M.smegmatis_MC2_155 VGGRRVVVIG----------AGMLGLTALAAAADLGASTVTAVDPSAERR
Mvan_2907|M.vanbaalenii_PYR-1 VTGRRVLILG----------AGMLGVTAVAACS-VADADVRVVDLDEQRA
Mb0167c|M.bovis_AF2122/97 QPGQSVAVVG----------LGGVGMAAVLTALTYTDVRVVAVDQLPEKL
Rv0162c|M.tuberculosis_H37Rv QPGQSVAVVG----------LGGVGMAAVLTALTYTDVRVVAVDQLPEKL
MAV_5022|M.avium_104 APGQTVAVVG----------LGGVGMAALLTALTYDGVPVVAVDQLPEKL
MMAR_0405|M.marinum_M VAGQSVAVVG----------LGGVGMAAVLTALTQDGVAVFGVDQLPQKL
MAB_0983c|M.abscessus_ATCC_199 RPGDSVAVLG----------LGGVGLAVVMSAAAAGAGEVLAIDPVPAKR
TH_3514|M.thermoresistible__bu DPGAGLSTVGRQLVDLLGGLLGPVGEALGNGVGAAGVDPMGGEDAGGEDA
MUL_2965|M.ulcerans_Agy99 RPGDRVAVLG----------VGGLGHLGLQFCRAMGFETVAIARG-SAKA
MLBr_02053|M.leprae_Br4923 PGG-RLGIYG----------FGGSAHIAAQVALVQGAEVHVMTRG-ARAQ
Mflv_0660|M.gilvum_PYR-GCK LLGETVMVLG----------AGALGLTVIQCARAAGAARIFVTEPSGVRA
* : * * .
MSMEG_4400|M.smegmatis_MC2_155 EIAAHFGAEVT---AESVNEIE----------------------------
Mvan_2907|M.vanbaalenii_PYR-1 DSATGFGARPD---DGGP--------------------------------
Mb0167c|M.bovis_AF2122/97 SAAKALGAHEIYTPQQATAGGV----------------------------
Rv0162c|M.tuberculosis_H37Rv SAAKALGAHEIYTPQQATAGGV----------------------------
MAV_5022|M.avium_104 AAARRLGAHQAYTPQQAVEARV----------------------------
MMAR_0405|M.marinum_M SAAEALGASATYTPQQAAAAGV----------------------------
MAB_0983c|M.abscessus_ATCC_199 ELALELGATSACAPDEAPGG------------------------------
TH_3514|M.thermoresistible__bu GTEERDGASDADTDAEDDDRGDDTPEDDTPDDGDPDAGGSPGEDPQEAPD
MUL_2965|M.ulcerans_Agy99 EDARQLGAHHYIDSTTGDVAEG----------------------------
MLBr_02053|M.leprae_Br4923 ELALELGAASAQGVADLPPVPL----------------------------
Mflv_0660|M.gilvum_PYR-GCK SLARDLGATLVLDPHDPGTTACILEETRG---------------------
**
MSMEG_4400|M.smegmatis_MC2_155 --------------------ECDVLLEFSGKSAALQAGLRTLDVSGVAVF
Mvan_2907|M.vanbaalenii_PYR-1 ---------------------ADVVIDFTGSTPAIAAALGRLDVGATMVL
Mb0167c|M.bovis_AF2122/97 --------------------KAAVVVEAVGHPAALHTAIGLTAPGGRTIT
Rv0162c|M.tuberculosis_H37Rv --------------------KAAVVVEAVGHPAALHTAIGLTAPGGRTIT
MAV_5022|M.avium_104 --------------------KAAVVIEAVGHPAALQTAIDLTAPGGRTIT
MMAR_0405|M.marinum_M --------------------KADVVIEAAGHPAALETAIGLTAPGGRTIT
MAB_0983c|M.abscessus_ATCC_199 ---------------------HDWVFEVVGSAAVLEQAYALTGRGGGTVS
TH_3514|M.thermoresistible__bu PEHDPDPAPGEPETHXXXAGPGDVAIDFSGSTEALGEALDRLDVGGVLVL
MUL_2965|M.ulcerans_Agy99 ---------------LRRIGGAAVVLATAGNSAAMAETVGGLLPRGELVV
MLBr_02053|M.leprae_Br4923 --------------------DAAIVFAPVG--DLVLPACEALNRGGTLAI
Mflv_0660|M.gilvum_PYR-GCK -------------------VGVDVVFHVAGSAEAFTQGLDCLRKQGRFME
. * . .
MSMEG_4400|M.smegmatis_MC2_155 AGSVAPDGDIAVDPEAVVRRHLTLVGVHNYEPRHLLQALNFLQRTKD-RF
Mvan_2907|M.vanbaalenii_PYR-1 AGSVLPAPPLAVDPETVVRRWLTLTGVHNYEPRHLTRAVEFLETTQA-DF
Mb0167c|M.bovis_AF2122/97 VGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFVSLWQSGRL
Rv0162c|M.tuberculosis_H37Rv VGLPPPDVRISLSPLDFVTEGRSLIGSYLGSAVPSHDIPRFVSLWQSGRL
MAV_5022|M.avium_104 VGLPPPDARITVSPLGFVAEGRSLIGSYLGSAVPSRDIPRFVELWRAGRL
MMAR_0405|M.marinum_M VGLPPPDARISVAPLGFVAEGRSLIGSYLGSAVPSRDIPRFVSLWQSGRL
MAB_0983c|M.abscessus_ATCC_199 VGLPHPDARISLPALNIVAEGRSILGSYMGSAQPQQDIPAMLALWRAGRL
TH_3514|M.thermoresistible__bu AGSVSPAPALPVDPELIVRRWLTLTGVHNYEPQHLRDAVAFLRHSRD-RF
MUL_2965|M.ulcerans_Agy99 IGVTADP--LPISPVQLINPGLSVTGHPSGTAKDVEDTMHFAVLSGVRAW
MLBr_02053|M.leprae_Br4923 AGIHLSD----IPQLNYQRHLFQERQIRSVTSNTRADARAFLDFAAQHHI
Mflv_0660|M.gilvum_PYR-GCK MSSWAGAASLDVNRHLLKEIQLRMVFGYD----MFDDFPAVLALIADGKL
. : .
MSMEG_4400|M.smegmatis_MC2_155 PWADLVADPVPLDR-IAGLLLDAPGPKPRYAVAP----------------
Mvan_2907|M.vanbaalenii_PYR-1 DWAELVGSPVPLER-ISSVMSPPGSGRLRSAVAP----------------
Mb0167c|M.bovis_AF2122/97 PVESLVTSTIRLDD-INEAMDHLADGIAVRQLISFTGDL-----------
Rv0162c|M.tuberculosis_H37Rv PVESLVTSTIRLDD-INEAMDHLADGIAVRQLISFTGDL-----------
MAV_5022|M.avium_104 PVESLVSSTIRLED-INEAMDHLADGTAVRQLIRFDA-------------
MMAR_0405|M.marinum_M PVESLVSATIRLDD-LNEAMDHLADGTAVRQIIVF---------------
MAB_0983c|M.abscessus_ATCC_199 PVEKLKSDDLPLSD-INIALDALAEGQAVRQILRPGVSA-----------
TH_3514|M.thermoresistible__bu DWPALVDDPVGLDD-IAAALMPAPTGRLRKAVSPGLPPRTAARNSPGSRP
MUL_2965|M.ulcerans_Agy99 IEE------RPLAQ-AADGYEAMEQGRTRYRTVLAM--------------
MLBr_02053|M.leprae_Br4923 AVTTP---EYPLEQ-ADQALTDLSVGRISGAAVLLA--------------
Mflv_0660|M.gilvum_PYR-GCK ALAPQITARVPLDRAVKEGLGGLLEGREGLVKVLVKP-------------
*
MSMEG_4400|M.smegmatis_MC2_155 ---
Mvan_2907|M.vanbaalenii_PYR-1 ---
Mb0167c|M.bovis_AF2122/97 ---
Rv0162c|M.tuberculosis_H37Rv ---
MAV_5022|M.avium_104 ---
MMAR_0405|M.marinum_M ---
MAB_0983c|M.abscessus_ATCC_199 ---
TH_3514|M.thermoresistible__bu PDS
MUL_2965|M.ulcerans_Agy99 ---
MLBr_02053|M.leprae_Br4923 ---
Mflv_0660|M.gilvum_PYR-GCK ---