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MTQTLANPGATQATETLRAAVVTGFGEPLQIKELALPTPGYGEALVKLETSGVCHTDLHAAHGDWPVKPA PPFVPGHEGCGTVVALGDGVTDLKVGDKVGNAWLWSACGSCEQCRTGWETLCENQRNGGYTVNGSFGTYM LVNADYAARIPDGADPLEVAPILCAGVTVYKGLKVTDTRPGQWVAISGIGGLGHVAVQYARAMGLRVVAI DIDDDKLALAARLGAELVVNARTSDVVAQVQEATGGVHGVLVTAVHPQAFGQAIGLARRGGTIVFNGLPP GDFPAPIFVIVLKGLTIRGSIVGTRQDMAEALDFYARGLIHPTVEGAALEDINHVFERMERGQIDGRVVI DYR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0495 | adhX | - | 100% (353) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. ulcerans Agy99 | MUL_2965 | adhC | 5e-48 | 33.13% (335) | NADP-dependent alcohol dehydrogenase AdhC |
| M. ulcerans Agy99 | MUL_1885 | adh | 3e-43 | 31.50% (346) | NADP-dependent alcohol dehydrogenase Adh |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3071 | adhC | 5e-42 | 31.59% (345) | NADP-dependent alcohol dehydrogenase ADHC |
| M. gilvum PYR-GCK | Mflv_4951 | - | 1e-169 | 84.27% (337) | alcohol dehydrogenase |
| M. tuberculosis H37Rv | Rv3045 | adhC | 5e-42 | 31.59% (345) | NADP-dependent alcohol dehydrogenase ADHC |
| M. leprae Br4923 | MLBr_01730 | adhA | 8e-44 | 29.97% (347) | alcohol dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3400 | - | 1e-41 | 30.23% (344) | NADP-dependent alcohol dehydrogenase C |
| M. marinum M | MMAR_4911 | adhX | 0.0 | 99.43% (353) | Zn-dependent alcohol dehydrogenase, AdhX |
| M. avium 104 | MAV_2812 | - | 3e-43 | 32.30% (322) | aldehyde dehydrogenase family protein |
| M. smegmatis MC2 155 | MSMEG_6833 | - | 4e-52 | 35.71% (336) | alcohol dehydrogenase |
| M. thermoresistible (build 8) | TH_2673 | - | 2e-44 | 35.49% (324) | PUTATIVE Alcohol dehydrogenase GroES domain protein |
| M. vanbaalenii PYR-1 | Mvan_5450 | - | 5e-46 | 35.31% (354) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0495|M.ulcerans_Agy99 -----MTQTLANPGATQATETLRAAVVTGFG----EPLQIKELALPTPGY
MMAR_4911|M.marinum_M -----MTQTLANPGATQATETLCAAVVTGFG----EPLQIKELALPTPGY
Mflv_4951|M.gilvum_PYR-GCK ---------------------MQAAVVTAFG----EPLVVEERDLPAPGP
TH_2673|M.thermoresistible__bu ---LWTTGAVARDDDRMSASMMSAWRVREPGPMRTRPLEWVRTPVPEPGP
Mvan_5450|M.vanbaalenii_PYR-1 -------------------MKMRAARMYGYK----QPLRLEEVDVPSPGP
Mb3071|M.bovis_AF2122/97 --------------------MSTVAAYAAMSA--TEPLTKTTITRRDPGP
Rv3045|M.tuberculosis_H37Rv --------------------MSTVAAYAAMSA--TEPLTKTTITRRDPGP
MLBr_01730|M.leprae_Br4923 ----MKSHVSKHRRKRRLGAMTTVSAYAATSA--TEPLTKVTINRRAPGP
MAB_3400|M.abscessus_ATCC_1997 --------------------MVTVSAYAATSG--KDPLVPTTIERREVGP
MAV_2812|M.avium_104 -------------------------------------MELVDTETRPPGR
MSMEG_6833|M.smegmatis_MC2_155 MGRLMVITPIPHPWLIWCRDLMSSYRAYQVTG--RRKFELVQREIRDPAE
: .
MUL_0495|M.ulcerans_Agy99 GEALVKLETSGVCHTDLHAAHGDWP--VKPAPPFVPGHEGCGTVVALGDG
MMAR_4911|M.marinum_M GEALVKLETSGVCHTDLHAAHGDWP--VKPAPPFVPGHEGCGTVVALGDG
Mflv_4951|M.gilvum_PYR-GCK GEALVKLVTSGVCHTDLHAAHGDWP--VKPSPPFIPGHEGYGTVVAVGDG
TH_2673|M.thermoresistible__bu GELLVAVRACGVCRTDLHVAEGDLP--VHR-PGVTPGHEVVGEVVATADG
Mvan_5450|M.vanbaalenii_PYR-1 EEVLVRVGGAGMCRTDFQLIDGYFDNGLSMDFPITPGHEVAGWVDGVGSA
Mb3071|M.bovis_AF2122/97 HDVAIDIKFAGICHSDIHTVKAEWG---QPNYPVVPGHEIAGVVTAVGSE
Rv3045|M.tuberculosis_H37Rv HDVAIDIKFAGICHSDIHTVKAEWG---QPNYPVVPGHEIAGVVTAVGSE
MLBr_01730|M.leprae_Br4923 HDVAIQIKFAGICHSDIHTVKAEWG---QPNYPVVPGHEIAGVVTAVGTE
MAB_3400|M.abscessus_ATCC_1997 HDVFIDIKFAGICHSDIHTVRDEWG---RANYPIVPGHEIAGVITEVGSE
MAV_2812|M.avium_104 DEVRLTVGACGICGTDAHFVNGAFP---GLSWPLTPGHEIAGRIAELGEG
MSMEG_6833|M.smegmatis_MC2_155 EQVRIRTLACGVCHSDALAVEGQRP---NPEEPVVPGHEVVGVVDAVGSG
: : .*:* :* . **** * : .
MUL_0495|M.ulcerans_Agy99 V---TD-LKVGDKVGNAWLWSACGSCEQCRTGWETLCENQR--------N
MMAR_4911|M.marinum_M V---TD-LKVGDKVGNAWLWSACGSCEQCRTGWETLCENQR--------N
Mflv_4951|M.gilvum_PYR-GCK V---DD-LSVGDMVGNAWLWSSCGRCEYCRTGWETLCEQQR--------N
TH_2673|M.thermoresistible__bu ----TD-FRVGDRVGIAWLRHTCGQCRYCRRGQENLCPESR--------Y
Mvan_5450|M.vanbaalenii_PYR-1 VPKSAG-LAEGDQVVVFGSWGDG-ACRQCHEGNEQLCAHGV--------W
Mb3071|M.bovis_AF2122/97 VTK----YRQGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGK
Rv3045|M.tuberculosis_H37Rv VTK----YRQGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGK
MLBr_01730|M.leprae_Br4923 VTK----HKVGDRVGVGCMVGSCGECSSCLAGIEQYCKRGATFTYNSIGT
MAB_3400|M.abscessus_ATCC_1997 VTK----FKPGDHAGVGCFVNSCRECPSCLAGLEQFCERGMVGTYGAKDR
MAV_2812|M.avium_104 VEG----FAVGQRVAVGWFGGCCYRCDPCRAGLFIHCVNGK--------V
MSMEG_6833|M.smegmatis_MC2_155 IQE---RWRIGERVGVGFLGGQCGHCDYCRRGDFVNCLDQP--------L
*: . * * * *
MUL_0495|M.ulcerans_Agy99 GGYTVNGSFGTYMLVNADYAARIPDG--ADPLEVAPILCAGVTVYKGLKV
MMAR_4911|M.marinum_M GGYTVNGSFGTYMLVNADYAARIPDG--ADPLEVAPILCAGVTVYKGLKV
Mflv_4951|M.gilvum_PYR-GCK GGYSVDGSFGTYMLVDAAYAARIPDG--VDPVEVAPILCAGVTVYKGLKV
TH_2673|M.thermoresistible__bu TGWDADGGYAEFATVPAAYAHRLPAG--YSDAELAPLLCAGIIGYRALRR
Mvan_5450|M.vanbaalenii_PYR-1 AGFGRHGGYQEYLPVNYRYLIKIPGGGELSPDNLAPLTDAGLTPYRGLKK
Mb3071|M.bovis_AF2122/97 DGQPTQGGYSEAIVVDENYVLRIPDV--LPLDVAAPLLCAGITLYSPLRH
Rv3045|M.tuberculosis_H37Rv DGQPTQGGYSEAIVVDENYVLRIPDV--LPLDVAAPLLCAGITLYSPLRH
MLBr_01730|M.leprae_Br4923 DGQSTQGGYSQAIVVDENFVVHIPDA--LPLDAAAPLLCAGITLYSPLRH
MAB_3400|M.abscessus_ATCC_1997 DGTQTQGGYSQAIVVDENYVLRIPDS--LPLDAAAPLLCAGITTFSPLRH
MAV_2812|M.avium_104 PSWHYPGGYAESVTVPTSALARIPEE--LTDAEAAPMGCAGVTTYNALRH
MSMEG_6833|M.smegmatis_MC2_155 TGTTVDGGYSEMLYVRESALVRVPEG--FDALTAAPLLCAGVTVFNALRA
. *.: * ::* **: **: : *:
MUL_0495|M.ulcerans_Agy99 TDTR----PGQWVAISGIGGLGHVAVQYARAMG--LRVVAIDIDDDKLAL
MMAR_4911|M.marinum_M TDTR----PGQWVAISGIGGLGHVAVQYARAMG--LRVVAIDIDDDKLAL
Mflv_4951|M.gilvum_PYR-GCK TDTR----PGQWVAISGIGGLGHVAVQYARAMG--LRVVAIDVDDSKLDL
TH_2673|M.thermoresistible__bu AELP----PGGRLGIYGFGGSAHLTAQVALAQG--AEVHVMTRGAQAREL
Mvan_5450|M.vanbaalenii_PYR-1 LRNAGHLGPGRTVAVSGIGGLGSYATQYAKLLGGGAEVVAFARSDEKLKI
Mb3071|M.bovis_AF2122/97 WNAG----ANTRVAIIGLGGLGHMGVKLGAAMG--ADVTVLSQSLKKMED
Rv3045|M.tuberculosis_H37Rv WNAG----ANTRVAIIGLGGLGHMGVKLGAAMG--ADVTVLSQSLKKMED
MLBr_01730|M.leprae_Br4923 WNAK----PGTRLAIIGLGGLGHMGVKLGRKMG--CEVTVLSQSLKKMED
MAB_3400|M.abscessus_ATCC_1997 WNAG----PGKRVAVVGLGGLGHMAVKLGKAMG--AEVTVLSQSLKKMED
MAV_2812|M.avium_104 TKAL----PGDRVAILGVGGLGHLGVQFAAAMG--FETIAINRGTGKADD
MSMEG_6833|M.smegmatis_MC2_155 GDAP----PNTLVAVQGLGGLGHLGVQYAKKLG--YEVAAIARGTDKADL
.. :.: *.** . .: . * . .: .
MUL_0495|M.ulcerans_Agy99 AARLGAELVVNARTSD-----VVAQVQEATGGVHGVLVTAVHPQAFGQAI
MMAR_4911|M.marinum_M AARLGAELVVNARTSD-----VVAQVQEATGGVHGVLVTAVHPQAFGQAI
Mflv_4951|M.gilvum_PYR-GCK ATGLGAEVVVNARTAD-----VVAEVHRATGGVHGVLVTAVHRDAFGQAI
TH_2673|M.thermoresistible__bu ALALGAASAQGAADPP-----PVP--------LDAAILFAPVGHLVLPAL
Mvan_5450|M.vanbaalenii_PYR-1 AKDNGADHVVNVRDKDTEDVRAELESATGRTELDAVIECAGSEDSIRLAF
Mb3071|M.bovis_AF2122/97 GLRLGAKSYYATADPD------TFRKLR--GGFDLILNTVSANLDLGQYL
Rv3045|M.tuberculosis_H37Rv GLRLGAKSYYATADPD------TFRKLR--GGFDLILNTVSANLDLGQYL
MLBr_01730|M.leprae_Br4923 GLQLGASNYYATADPD------TFRKLR--GSFDLILNTVSANLDLGKYL
MAB_3400|M.abscessus_ATCC_1997 GLRLGASHYYATADPD------TFKSLR--NSFDLILNTVSSNLDMGKYL
MAV_2812|M.avium_104 ARKLGAHHYIDSTAED------PAEALRALGGAAVVLATAGNSQAMAATV
MSMEG_6833|M.smegmatis_MC2_155 AATLGADHYIDSATED------VAAGLTRLGGAAAVVATASSGQSMAGLV
. ** : . . .
MUL_0495|M.ulcerans_Agy99 GLARRGGTIVFNGLPPGDFPAPIFVIVLKG-LTIRGSIVGTRQDMAEALD
MMAR_4911|M.marinum_M GLARRGGTIVFNGLPPGDFPAPIFDIVLKG-LTIRGSIVGTRQDMAEALD
Mflv_4951|M.gilvum_PYR-GCK GLARRGGTIVFVGLPPGDFPAPIFDIVLKG-LTIRGSIVGTRQDMVEAID
TH_2673|M.thermoresistible__bu EALDRGGTLSIAGIHLTDIPTLDYQRHLFQERQVRSVTANTRDDARAFLD
Mvan_5450|M.vanbaalenii_PYR-1 SLLAAEGAVASVGLIGNRVDIPLFPLVARE-YTFYGSFWGNYNDLTEVLA
Mb3071|M.bovis_AF2122/97 NLLDVDGTLVELGIPEHPMAVPAFALALMR-RSLAGSNIGGIAETQEMLN
Rv3045|M.tuberculosis_H37Rv NLLDVDGTLVELGIPEHPMAVPAFALALMR-RSLAGSNIGGIAETQEMLN
MLBr_01730|M.leprae_Br4923 NLLDVNGTLVELGIPEHPMLVPAFALALMR-RSLAGSNIGGITETQEMMN
MAB_3400|M.abscessus_ATCC_1997 GLLGVDGTLVELGLPENPIEVPGFPLLTNR-RSISGSLIGGIPETQEMLD
MAV_2812|M.avium_104 GGLAPQGELVTIGVTPEPLPISPLQLITPG-LSIVGHPSGTAKDVEDTMQ
MSMEG_6833|M.smegmatis_MC2_155 AGLRPRGRLVVVGAAPDPIPVQTPDLIFGG-RTIVGSLTGSAIDNEDNLA
* : * . . . . : :
MUL_0495|M.ulcerans_Agy99 FYARGLIHPTVEGAALEDINHVFERMERGQIDGRVVIDYR--
MMAR_4911|M.marinum_M FYARGLIHPTVEGAALEDINHVFERMERGQIDGRVVIDYR--
Mflv_4951|M.gilvum_PYR-GCK FFARGLVHPTVHTTRLDDINDVFDRMERGQIDGRVVIDYR--
TH_2673|M.thermoresistible__bu FAAQHRIEVTTPEYPLDRADDALTDLSEGRIAGAAVLRV---
Mvan_5450|M.vanbaalenii_PYR-1 LARTGQLKHSVTRVRFDDVNETLEAIARGDVLGRAVIVYD--
Mb3071|M.bovis_AF2122/97 FCAEHGVTPEIELIEPDYINDAYERVLASDVRYRFVIDISAL
Rv3045|M.tuberculosis_H37Rv FCAEHGVTPEIELIEPDYINDAYERVLASDVRYRFVIDISAL
MLBr_01730|M.leprae_Br4923 FSAEHSVTPEIELIEPDYINEAYERVLASDVRYRFVINISSL
MAB_3400|M.abscessus_ATCC_1997 FCAKHGIGSEIEVIDASYINEAYERVVASDVRYRFVIDTQTL
MAV_2812|M.avium_104 FAVLSGVRAWIEELPLSRAADGYAALEGGRAHYRTVLTM---
MSMEG_6833|M.smegmatis_MC2_155 FSLNHQIAPMIERMPFTEAPQAYERMMSGHARFRVVLDFS--
: : . : . *: