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MSAVPEPTDERLREEQTASDERLREEQTASDERLREEQTASDGADATAEQIAADALLRPVRPLNAFEDTV ERLLQTIRLGVLRPGESLPPERELATRLGVSRDTVREAIKSLADAGYLVSRRGRYGGTFIADALPAPRTG DVAFSRTDIDDALRLREILETGAARMAACRTLSATEREALWSRLLDVRGAAPQDYRRLDSRLHLAITEAA GVPSLVPLVAQNRMRLNEMLDCIPLLPRNIAHSDEQHEAIVMAILAGDADGAAQTMAAHVWGSAALLHGF LD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2282 | - | - | 100% (282) | regulatory protein GntR, HTH |
| M. vanbaalenii PYR-1 | Mvan_0606 | - | 1e-23 | 34.27% (248) | GntR domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_1846 | - | 7e-18 | 33.78% (222) | regulatory protein GntR, HTH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0601 | - | 1e-09 | 33.33% (138) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4061 | - | 1e-109 | 84.77% (243) | regulatory protein GntR, HTH |
| M. tuberculosis H37Rv | Rv0586 | - | 1e-09 | 33.33% (138) | GntR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4644c | - | 1e-11 | 30.05% (183) | GntR family transcriptional regulator |
| M. marinum M | MMAR_0749 | - | 4e-10 | 26.11% (226) | GntR family transcriptional regulator |
| M. avium 104 | MAV_3932 | - | 1e-09 | 31.22% (205) | transcriptional regulator, GntR family protein |
| M. smegmatis MC2 155 | MSMEG_2599 | - | 2e-96 | 77.55% (245) | GntR-family protein transcriptional regulator |
| M. thermoresistible (build 8) | TH_4115 | - | 2e-12 | 27.52% (218) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1381 | - | 2e-10 | 26.46% (223) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2282|M.vanbaalenii_PYR-1 MSAVPEPTDERLREEQTASDERLREEQTASDERLREEQTASDGADATAEQ
Mflv_4061|M.gilvum_PYR-GCK -MAAPDPADS------------------------------SD--------
MSMEG_2599|M.smegmatis_MC2_155 MSADPDPQPT------------------------------AE--------
MMAR_0749|M.marinum_M --------------------------------------------------
MUL_1381|M.ulcerans_Agy99 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0601|M.bovis_AF2122/97 --------------------------------------------------
Rv0586|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3932|M.avium_104 --------------------------------------------------
TH_4115|M.thermoresistible__bu --------------------------------------------------
Mvan_2282|M.vanbaalenii_PYR-1 IAADALLRPVRPLNAFEDTVERLLQTIRLGVLRPGESLPPERELATRLGV
Mflv_4061|M.gilvum_PYR-GCK -ASEALLRPVRPLNAFEDTVERLLQTIRLGVLTPGESLPPERELAARLGV
MSMEG_2599|M.smegmatis_MC2_155 -AADALLRPVRLGNAFEDTVGRLLETIRLGVLGPGESLPPERELATRLGV
MMAR_0749|M.marinum_M ------MQTVRRRTLIAQVSDQLRDEITSGRWKVGDRIPTEPELCEMTGT
MUL_1381|M.ulcerans_Agy99 ---------MRRRTLIAQVSDQLRDEITSGRWKVGDRIPTEPELCEMTGT
MAB_4644c|M.abscessus_ATCC_199 -----MHPRLSSQSLAEQVANILAAQIGDGRWSTGAKLPGEVALCEEFGV
Mb0601|M.bovis_AF2122/97 ----MALQPVTRRSVPEEVFEQIATDVLTGEMPPGEALPSERRLAELLGV
Rv0586|M.tuberculosis_H37Rv ----MALQPVTRRSVPEEVFEQIATDVLTGEMPPGEALPSERRLAELLGV
MAV_3932|M.avium_104 --MNAEPRTGPAKTLASALARDIEAEIVRRGWAVGESLGSEPALQQRFGV
TH_4115|M.thermoresistible__bu -----------VQSSYIQVADQLRDLILRGDLAVGQKLPSEAEMAPLLGV
. : : * : * : *.
Mvan_2282|M.vanbaalenii_PYR-1 SRDTVREAIKSLADAGYLVSRRGRYGGTFIADALPAPRTGDVAFSRTDI-
Mflv_4061|M.gilvum_PYR-GCK SRDTVREAIKSLADAGYLVSRRGRYGGTFLADALPAPRADGTEMHRDDI-
MSMEG_2599|M.smegmatis_MC2_155 SRDTVREAIKSLADAGYLVSRRGRYGGTFLADELPSHTADTPRPTHEEI-
MMAR_0749|M.marinum_M ARNTVREAVQALVHVGILERRQG--SGTYVIADVEQGSALAEYFAAARE-
MUL_1381|M.ulcerans_Agy99 ARNTVREAVQALVHVGILERRQG--SGTYVIADVEQGSALAEYFAAARE-
MAB_4644c|M.abscessus_ATCC_199 SRATVREAIRDLKTKGLVSTRQG--AGVFVTSDRPLG-QWDRVLAAAEI-
Mb0601|M.bovis_AF2122/97 SRPAVREALKRLSAAGLVEVRQGDVTTVRDFRRHAGLDLLPRLLFRNGE-
Rv0586|M.tuberculosis_H37Rv SRPAVREALKRLSAAGLVEVRQGDVTTVRDFRRHAGLDLLPRLLFRNGE-
MAV_3932|M.avium_104 SRSVLREAVRLVEHHQVARMRRGPNGGLYICEPDAGPATRAVVIYLEYLG
TH_4115|M.thermoresistible__bu SRSTIREALRILTTEHLIETRRGIQGGAFVAVPDSERLEGMFNTSFSMLA
:* .:***:: : *:*
Mvan_2282|M.vanbaalenii_PYR-1 -------DDALRLREILETGAARMAACR---TLSATEREALWSR----LL
Mflv_4061|M.gilvum_PYR-GCK -------DDAVRLREILEVGAARMAAVR---TLAAVEREALRSR----LT
MSMEG_2599|M.smegmatis_MC2_155 -------DDALRLREILEVGAARMAAGR---TLSAAERDGLWSR----LA
MMAR_0749|M.marinum_M -------RDLWELREAVEVTAAVLSARRRDAADIEDLRALLARRNELWSR
MUL_1381|M.ulcerans_Agy99 -------RDLWELREAVEVTAAVLSARRRDAADIEDLRVLLARRNELWSR
MAB_4644c|M.abscessus_ATCC_199 -------DAVVEIRRLLEVQAAGLAAERRNRSDVAAIRRALVAR-----A
Mb0601|M.bovis_AF2122/97 -------LDISVVRSILEARLRNFPKVAELAAERNEPELAELLQDS--LR
Rv0586|M.tuberculosis_H37Rv -------LDISVVRSILEARLRNFPKVAELAAERNEPELAELLQDS--LR
MAV_3932|M.avium_104 TT----LADLLNARLVLEPLAASLAAERIDEAGIARLRAVLHAE------
TH_4115|M.thermoresistible__bu LTNQVDARSFLQAMRALEGPAAALAAAARGGDQVEELKRTAAMVDP----
:* :. .
Mvan_2282|M.vanbaalenii_PYR-1 DVRGAA-PQDYRRLDSRLHLAITEAAGVPSLVPLVAQNR-----MRLNEM
Mflv_4061|M.gilvum_PYR-GCK DVRGAD-PADYRRLDSRLHLAIAEAAGVPSLVPLVAQNR-----MRLNEL
MSMEG_2599|M.smegmatis_MC2_155 DVRAAEGTDDYRRLDSRLHLAIAEAAGSPSLVPLIAENR-----MRINGL
MMAR_0749|M.marinum_M EPANDKERTEMTSADTALHRAIVAASHNEIYLQFYDLLL-----PTIHRA
MUL_1381|M.ulcerans_Agy99 EPANDKERTEMTSADTALHRAIVAASHNETYLQFYDLLL-----PTIHRA
MAB_4644c|M.abscessus_ATCC_199 KAESAGDDIEYVDADLEFHRAVVAAVHNPLLDELFDSFS-----VRMREA
Mb0601|M.bovis_AF2122/97 ALDTEEDPIVWQRHTLDFWDHVVDSAGSIVDRLMYNAFR-----AAYEPT
Rv0586|M.tuberculosis_H37Rv ALDTEEDPIVWQRHTLDFWDHVVDSAGSIVDRLMYNAFR-----AAYEPT
MAV_3932|M.avium_104 ----QQWRPGLPMPRDEFHIALAEQSKNPVLQLFIKVLMRLTTRYALQSR
TH_4115|M.thermoresistible__bu -----ADQEAAMQQSADFHSAILRASGNKLLEAMGRPVS-----AVARSK
: : : .
Mvan_2282|M.vanbaalenii_PYR-1 LDCIPLLPRNIAHSDEQHEAIVMAILAGDADGAAQTMAAHVWGSAALLHG
Mflv_4061|M.gilvum_PYR-GCK LDRIPLMTRNIAHSDEQHEAIVSAILAGDADTAAQTMAAHVWGSAALLHG
MSMEG_2599|M.smegmatis_MC2_155 LDRIPLLPRNIAHSDDQHEAIVMAILAGDADRAATAMLDHVSGSAALLHG
MMAR_0749|M.marinum_M VEAGPVGTCTS--YEREHTELVEAIIAGDPQRAEAAAQVFIARLRP----
MUL_1381|M.ulcerans_Agy99 VEAGPVGTCTS--YEREHTELVEAIIAGDPQRAEAAAQVFIARLRR----
MAB_4644c|M.abscessus_ATCC_199 MLALLAGSAERPHDQEHHQWLFDAIVDGSTRRAVELATDQLQHVRMR---
Mb0601|M.bovis_AF2122/97 LAALTTTMTAAAKRPSDYRKLADAICSGDPTGAKKAAQDLLELANTSLMA
Rv0586|M.tuberculosis_H37Rv LAALTTTMTAAAKRPSDYRKLADAICSGDPTGAKKAAQDLLELANTSLMA
MAV_3932|M.avium_104 TDSETEALEAVDHLHTHHSRIVAAVTAGDPARAKTLSERHVEAVTAWLQR
TH_4115|M.thermoresistible__bu FRRTVPGLEFWERNQRAHQELLKAILAGDENLAYELATRHIDEDLSPYYL
: : *: *. * :
Mvan_2282|M.vanbaalenii_PYR-1 FLD-----------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK FLD-----------------------------------------------
MSMEG_2599|M.smegmatis_MC2_155 FLD-----------------------------------------------
MMAR_0749|M.marinum_M --------------------------------------------------
MUL_1381|M.ulcerans_Agy99 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0601|M.bovis_AF2122/97 VLVSQASRQ-----------------------------------------
Rv0586|M.tuberculosis_H37Rv VLVSQASRQ-----------------------------------------
MAV_3932|M.avium_104 HHAGDRNRGRTPRRPLNSEVPQGKLAEMLAATIGDDIAADGWRVGSVFGT
TH_4115|M.thermoresistible__bu PPEEADRDGAGA--------------------------------------
Mvan_2282|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2599|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0749|M.marinum_M --------------------------------------------------
MUL_1381|M.ulcerans_Agy99 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0601|M.bovis_AF2122/97 --------------------------------------------------
Rv0586|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3932|M.avium_104 ETALLQRYRVSRAVFREAVRLLEYHSIAHMRRGPGGGLVIAEPAAQASID
TH_4115|M.thermoresistible__bu --------------------------------------------------
Mvan_2282|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2599|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0749|M.marinum_M --------------------------------------------------
MUL_1381|M.ulcerans_Agy99 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0601|M.bovis_AF2122/97 --------------------------------------------------
Rv0586|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3932|M.avium_104 TIALYLQYRDPSREDLRCVRDAIEIDNVAKVVKRLAEPQVAAFVASRRSG
TH_4115|M.thermoresistible__bu --------------------------------------------------
Mvan_2282|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2599|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0749|M.marinum_M --------------------------------------------------
MUL_1381|M.ulcerans_Agy99 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0601|M.bovis_AF2122/97 --------------------------------------------------
Rv0586|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3932|M.avium_104 LPDDSRQTPDDVRRAIAEEFDFHVGLAQLAGNAPLDLFLRIIVELFRRHW
TH_4115|M.thermoresistible__bu --------------------------------------------------
Mvan_2282|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_2599|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_0749|M.marinum_M --------------------------------------------------
MUL_1381|M.ulcerans_Agy99 --------------------------------------------------
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
Mb0601|M.bovis_AF2122/97 --------------------------------------------------
Rv0586|M.tuberculosis_H37Rv --------------------------------------------------
MAV_3932|M.avium_104 SSTGQALPTWSDVRAVHHAHLRIADAVAAGDLSVASYRLRRHLDAAASWW
TH_4115|M.thermoresistible__bu --------------------------------------------------
Mvan_2282|M.vanbaalenii_PYR-1 -
Mflv_4061|M.gilvum_PYR-GCK -
MSMEG_2599|M.smegmatis_MC2_155 -
MMAR_0749|M.marinum_M -
MUL_1381|M.ulcerans_Agy99 -
MAB_4644c|M.abscessus_ATCC_199 -
Mb0601|M.bovis_AF2122/97 -
Rv0586|M.tuberculosis_H37Rv -
MAV_3932|M.avium_104 L
TH_4115|M.thermoresistible__bu -