For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TAERPSALSPVRQIPAHELVVDQMRRALELGQFRPGDRLPTERELSEMLDVSRTTVRTAVAVLERDGLIA VRRGRGGGFTVQAPPVDPAEMRRELRRNKRAIRDAFDYRIIVETGATRLAAERRRAIELADLRKLLVGME AALDAALKDQSAQRTTEFQTLDTAFHMGIAQAAQNDRLLDAVADARRRMWLPVGAIFGRLEPNANDYHES ILEAIENRDPELAGSRMEAHINDTRNTLESWLKR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0606 | - | - | 100% (245) | GntR domain-containing protein |
| M. vanbaalenii PYR-1 | Mvan_2282 | - | 1e-23 | 34.27% (248) | regulatory protein GntR, HTH |
| M. vanbaalenii PYR-1 | Mvan_1846 | - | 4e-17 | 30.93% (236) | regulatory protein GntR, HTH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3086c | - | 2e-10 | 29.36% (218) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4061 | - | 4e-24 | 34.02% (241) | regulatory protein GntR, HTH |
| M. tuberculosis H37Rv | Rv3060c | - | 2e-10 | 29.36% (218) | GntR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4644c | - | 1e-12 | 30.58% (206) | GntR family transcriptional regulator |
| M. marinum M | MMAR_0749 | - | 9e-16 | 31.96% (219) | GntR family transcriptional regulator |
| M. avium 104 | MAV_2542 | - | 5e-14 | 33.14% (172) | regulatory protein GntR, HTH |
| M. smegmatis MC2 155 | MSMEG_3822 | - | 1e-118 | 86.53% (245) | regulatory protein GntR, HTH |
| M. thermoresistible (build 8) | TH_4115 | - | 6e-14 | 29.20% (226) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1381 | - | 8e-16 | 31.96% (219) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0606|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3822|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0749|M.marinum_M --------------------------------------------------
MUL_1381|M.ulcerans_Agy99 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASLGSESALQQRFCVSR
Rv3060c|M.tuberculosis_H37Rv MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASLGSESALQQRFCVSR
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4115|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
Mvan_0606|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3822|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0749|M.marinum_M --------------------------------------------------
MUL_1381|M.ulcerans_Agy99 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 SVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPATRAVVIYLEYLGTT
Rv3060c|M.tuberculosis_H37Rv SVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPATRAVVIYLEYLGTT
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4115|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
Mvan_0606|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3822|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0749|M.marinum_M --------------------------------------------------
MUL_1381|M.ulcerans_Agy99 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 IGDLLGARLVLEPLAASLAAEHIDEPGIERLRAVLRAEERWRPGLPPPPE
Rv3060c|M.tuberculosis_H37Rv IGDLLGARLVLEPLAASLAAEHIDEPGIERLRAVLRAEERWRPGLPPPPE
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4115|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
Mvan_0606|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3822|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0749|M.marinum_M --------------------------------------------------
MUL_1381|M.ulcerans_Agy99 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 QFYRVLAEQSKNPVLQLFIDILMRLTKRYVQKSGTQSAGEAVEAAGQVHN
Rv3060c|M.tuberculosis_H37Rv QFYRVLAEQSKNPVLQLFIDILMRLTKRYVQKSGTQSAGEAVEAAGQVHN
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4115|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
Mvan_0606|M.vanbaalenii_PYR-1 ------------------------------------------MTAERPS-
MSMEG_3822|M.smegmatis_MC2_155 ------------------------------------------MTAAKP--
Mflv_4061|M.gilvum_PYR-GCK ------------------------------------------MAAPDPAD
MMAR_0749|M.marinum_M --------------------------------------------------
MUL_1381|M.ulcerans_Agy99 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 EHSDIVAAVTAGDSAWAKTLSERHVEAVAGWLQQHQRGNDAAVRNGGRAR
Rv3060c|M.tuberculosis_H37Rv EHSDIVAAVTAGDSAWAKTLSERHVEAVAGWLQQHQRGNDAAVRNGGRAR
MAB_4644c|M.abscessus_ATCC_199 --------------------------------------------------
TH_4115|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 -------------------------------------------MPKREPL
Mvan_0606|M.vanbaalenii_PYR-1 -------ALSPVRQIPAHELVVDQMRRALELGQFRPGDRLPTERELSEML
MSMEG_3822|M.smegmatis_MC2_155 -------ALVPVRQIPAHELVVDQMRRALELGQFRPGDRLPTERELSEML
Mflv_4061|M.gilvum_PYR-GCK SSDASEALLRPVRPLNAFEDTVERLLQTIRLGVLTPGESLPPERELAARL
MMAR_0749|M.marinum_M --------MQTVRRRTLIAQVSDQLRDEITSGRWKVGDRIPTEPELCEMT
MUL_1381|M.ulcerans_Agy99 -----------MRRRTLIAQVSDQLRDEITSGRWKVGDRIPTEPELCEMT
Mb3086c|M.bovis_AF2122/97 EPRRAQQLILGAPRGKLAEVLAATIGDDIAASGWQVGSVFGTETALLERY
Rv3060c|M.tuberculosis_H37Rv EPRRAQQLILGAPRGKLAEVLAATIGDDIAASGWQVGSVFGTETALLERY
MAB_4644c|M.abscessus_ATCC_199 -------MHPRLSSQSLAEQVANILAAQIGDGRWSTGAKLPGEVALCEEF
TH_4115|M.thermoresistible__bu -------------VQSSYIQVADQLRDLILRGDLAVGQKLPSEAEMAPLL
MAV_2542|M.avium_104 APMATSQNNGAVRSPKTAEIVADTLRRMIVEGQLKDGDFLPYEAELMDHF
: : . * : * :
Mvan_0606|M.vanbaalenii_PYR-1 DVSRTTVRTAVAVLERDGLIAVRRGRGGGFTVQAPPVDPAEMRRELRRNK
MSMEG_3822|M.smegmatis_MC2_155 DVSRTTVRTAVAVLEREGLIAVRRGRGGGFTVQAPEYDPVEMRREMRRNK
Mflv_4061|M.gilvum_PYR-GCK GVSRDTVREAIKSLADAGYLVSRRGRYGGTFLADALPAPRADGTEMHRDD
MMAR_0749|M.marinum_M GTARNTVREAVQALVHVGILERRQGSGTYVIADVEQGSALAEYFAAARER
MUL_1381|M.ulcerans_Agy99 GTARNTVREAVQALVHVGILERRQGSGTYVIADVEQGSALAEYFAAARER
Mb3086c|M.bovis_AF2122/97 QVSRAVLREAVRLLEYHAIAHMRRGPGGGLVVTTPQPQASIDTIALYLQY
Rv3060c|M.tuberculosis_H37Rv QVSRAVLREAVRLLEYHAIAHMRRGPGGGLVVTTPQPQASIDTIALYLQY
MAB_4644c|M.abscessus_ATCC_199 GVSRATVREAIRDLKTKGLVSTRQG--AGVFVTSDRPLGQWDRVLAAAEI
TH_4115|M.thermoresistible__bu GVSRSTIREALRILTTEHLIETRRGIQGGAFVAVPDSERLEGMFNTSFSM
MAV_2542|M.avium_104 QVSRPSLREAVRVLESDRLVEVRRGSRTGARVRVPGPEIVARPAGFLLEM
.:* :* *: * *:* .
Mvan_0606|M.vanbaalenii_PYR-1 R--AIRDAFDYRIIVETGATRLAAERRRAIELADLRKLLVGMEAALDAAL
MSMEG_3822|M.smegmatis_MC2_155 R--AVRDAFDYRVVVETGATRLAAERRRAADLNDLHKLLNGMDEALKTAL
Mflv_4061|M.gilvum_PYR-GCK ----IDDAVRLREILEVGAARMAAVR----------TLAAVEREALRSRL
MMAR_0749|M.marinum_M ------DLWELREAVEVTAAVLSARRRDAADIEDLRALLARRNELWSREP
MUL_1381|M.ulcerans_Agy99 ------DLWELREAVEVTAAVLSARRRDAADIEDLRVLLARRNELWSREP
Mb3086c|M.bovis_AF2122/97 RKPSREDLRCVRDAIEIDNVAKVVKRRSEPEVASFLDTLGRPR--LDNPT
Rv3060c|M.tuberculosis_H37Rv RKPSREDLRCVRDAIEIDNVAKVVKRRSEPEVASFLDTLGRPR--LDNPT
MAB_4644c|M.abscessus_ATCC_199 D-----AVVEIRRLLEVQAAGLAAERRNRSD-------VAAIRRALVARA
TH_4115|M.thermoresistible__bu L--ALTNQVDARSFLQAMRALEGPAAALAAAARG-----GDQVEELKRTA
MAV_2542|M.avium_104 AGTTLADVMTARMGIEPYAARLLAEDGTAAAHRELRELIEEIPAAWETGK
* :: .
Mvan_0606|M.vanbaalenii_PYR-1 KDQSAQRTTEFQTLDTAFHMGIAQAAQNDRLLDAVADARRRMWLPVG--A
MSMEG_3822|M.smegmatis_MC2_155 DDQSPKHTTDFQTLDSAFHLGIAQAAQNDRLLDAVADARRRMWLPVG--A
Mflv_4061|M.gilvum_PYR-GCK TDVRGADPADYRRLDSRLHLAIAEAAGVPSLVPLVAQNRMRLNELLDRIP
MMAR_0749|M.marinum_M AN--DKERTEMTSADTALHRAIVAASHNEIYLQFYDLLLPTIHRAVEAGP
MUL_1381|M.ulcerans_Agy99 AN--DKERTEMTSADTALHRAIVAASHNETYLQFYDLLLPTIHRAVEAGP
Mb3086c|M.bovis_AF2122/97 DDVRAAAVEEFR-FHVGLARAAGNTMLDLFLLILVELFRRHLSSTEQALP
Rv3060c|M.tuberculosis_H37Rv DDVRAAAVEEFR-FHVGLARAAGNTMLDLFLLILVELFRRHLSSTEQALP
MAB_4644c|M.abscessus_ATCC_199 KAESAGDDIEYVDADLEFHRAVVAAVHNPLLDELFDSFSVRMREAMLALL
TH_4115|M.thermoresistible__bu AMVDPADQEAAMQQSADFHSAILRASGNKLLEAMGRPVSAVARSKFRRTV
MAV_2542|M.avium_104 LG---AASTALHRRLVELSGNATLTVIVGMLHEIFERHMTAAFLSVQN-V
: :
Mvan_0606|M.vanbaalenii_PYR-1 IFGRLEPNANDYHESILEAIENRDPELAGSRMEAHINDTRNTLESWLKR-
MSMEG_3822|M.smegmatis_MC2_155 IFGRLEPNANDYHESILEAIENREPELAAARMEAHINDTRHTIESWLKR-
Mflv_4061|M.gilvum_PYR-GCK LMTRNIAHSDEQHEAIVSAILAGDADTAAQTMAAHVWGSAALLHGFLD--
MMAR_0749|M.marinum_M VGT--CTSYEREHTELVEAIIAGDPQRAEAAAQVFIARLRP---------
MUL_1381|M.ulcerans_Agy99 VGT--CTSYEREHTELVEAIIAGDPQRAEAAAQVFIARLRR---------
Mb3086c|M.bovis_AF2122/97 TWS-DVVAVGHAHVRILEAIGSGDDSLARCRTRRHLDAAASWWL------
Rv3060c|M.tuberculosis_H37Rv TWS-DVVAVGHAHVRILEAIGSGDDSLARCRTRRHLDAAASWWL------
MAB_4644c|M.abscessus_ATCC_199 AGSAERPHDQEHHQWLFDAIVDGSTRRAVELATDQLQHVRMR--------
TH_4115|M.thermoresistible__bu PGLEFWERNQRAHQELLKAILAGDENLAYELATRHIDEDLSPYYLPPEEA
MAV_2542|M.avium_104 VPKAQYNKLMRSYTRLADLVAARDGAEAEAHWRRHMENASAELLKGHEKT
: : . : . * :
Mvan_0606|M.vanbaalenii_PYR-1 -------
MSMEG_3822|M.smegmatis_MC2_155 -------
Mflv_4061|M.gilvum_PYR-GCK -------
MMAR_0749|M.marinum_M -------
MUL_1381|M.ulcerans_Agy99 -------
Mb3086c|M.bovis_AF2122/97 -------
Rv3060c|M.tuberculosis_H37Rv -------
MAB_4644c|M.abscessus_ATCC_199 -------
TH_4115|M.thermoresistible__bu DRDGAGA
MAV_2542|M.avium_104 KVRDIMH