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NAEPRTGPAKTLASALARDIEAEIVRRGWAVGESLGSEPALQQRFGVSRSVLREAVRLVEHHQVARMRRG PNGGLYICEPDAGPATRAVVIYLEYLGTTLADLLNARLVLEPLAASLAAERIDEAGIARLRAVLHAEQQW RPGLPMPRDEFHIALAEQSKNPVLQLFIKVLMRLTTRYALQSRTDSETEALEAVDHLHTHHSRIVAAVTA GDPARAKTLSERHVEAVTAWLQRHHAGDRNRGRTPRRPLNSEVPQGKLAEMLAATIGDDIAADGWRVGSV FGTETALLQRYRVSRAVFREAVRLLEYHSIAHMRRGPGGGLVIAEPAAQASIDTIALYLQYRDPSREDLR CVRDAIEIDNVAKVVKRLAEPQVAAFVASRRSGLPDDSRQTPDDVRRAIAEEFDFHVGLAQLAGNAPLDL FLRIIVELFRRHWSSTGQALPTWSDVRAVHHAHLRIADAVAAGDLSVASYRLRRHLDAAASWWL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3932 | - | - | 100% (485) | transcriptional regulator, GntR family protein |
| M. avium 104 | MAV_1821 | - | 6e-21 | 29.60% (223) | regulatory protein GntR, HTH |
| M. avium 104 | MAV_2560 | - | 1e-20 | 30.41% (217) | regulatory protein GntR, HTH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3086c | - | 0.0 | 72.82% (493) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2114 | - | 1e-17 | 28.24% (216) | GntR domain-containing protein |
| M. tuberculosis H37Rv | Rv3060c | - | 0.0 | 72.82% (493) | GntR family transcriptional regulator |
| M. leprae Br4923 | MLBr_01188 | - | 4e-05 | 31.40% (86) | hypothetical protein MLBr_01188 |
| M. abscessus ATCC 19977 | MAB_2272c | - | 4e-14 | 29.15% (223) | putative transcriptional regulator, GntR |
| M. marinum M | MMAR_1630 | - | 0.0 | 71.93% (488) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_5201 | - | 4e-18 | 29.55% (220) | regulatory protein GntR, HTH |
| M. thermoresistible (build 8) | TH_2873 | - | 4e-21 | 30.49% (223) | PUTATIVE regulatory protein GntR, HTH |
| M. ulcerans Agy99 | MUL_3832 | - | 9e-13 | 25.10% (255) | FadR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4590 | - | 9e-17 | 28.44% (218) | GntR domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3086c|M.bovis_AF2122/97 --------------MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASL
Rv3060c|M.tuberculosis_H37Rv --------------MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASL
MMAR_1630|M.marinum_M -----------MGQLSVEPDVIRADKRAARVARHIEAEIVRRGWTVGASL
MAV_3932|M.avium_104 --------------MNAEPRTGPAKTLASALARDIEAEIVRRGWAVGESL
Mflv_2114|M.gilvum_PYR-GCK MARSTPLAPMIGPDAVASRTAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
Mvan_4590|M.vanbaalenii_PYR-1 MTRNTPLAPMIGPDAVASRAAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
MSMEG_5201|M.smegmatis_MC2_155 MAGSTPLAPMIGPDAITPRAAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
TH_2873|M.thermoresistible__bu ----------VEDDMEVT--SLREPKMADRVATVLRRMFIRGEIPEGTML
MLBr_01188|M.leprae_Br4923 -------------------------------------------------M
MUL_3832|M.ulcerans_Agy99 --------MTALGIGPDPRRRLSAPRIAEIVADELRRQIIDGELADGDLL
MAB_2272c|M.abscessus_ATCC_199 ------------------MQPVRRQTLIGQVTEQLREEIVSGRWAIGARI
:
Mb3086c|M.bovis_AF2122/97 GSESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPA
Rv3060c|M.tuberculosis_H37Rv GSESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPA
MMAR_1630|M.marinum_M GSEGALQQRYGVSRSVLREAVRLVEHHQVARMRRGPNGGLLICAPDAGPA
MAV_3932|M.avium_104 GSEPALQQRFGVSRSVLREAVRLVEHHQVARMRRGPNGGLYICEPDAGPA
Mflv_2114|M.gilvum_PYR-GCK PNEAELMAHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
Mvan_4590|M.vanbaalenii_PYR-1 PNEAELMAHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
MSMEG_5201|M.smegmatis_MC2_155 PNEAELMSHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
TH_2873|M.thermoresistible__bu PPESELMERFGVSRPTLREAFRVLESESLIVVQRGVRGGARVTRPRRETL
MLBr_01188|M.leprae_Br4923 PRQEALVEPLNVSLLSFREALQIMDTERLISLRRGNRGSVVVHTPTRTSA
MUL_3832|M.ulcerans_Agy99 PRQEVLVEQFNVSLVSLREALRILETEGLVSVRRGNRGGAVVHAPAKASA
MAB_2272c|M.abscessus_ATCC_199 PTEPELCELTGTSRNTIREAVQALVHAGMLERRQGS--GTYVLSLGG---
: * .* :***.: : : ::* . :
Mb3086c|M.bovis_AF2122/97 TRAVVIYLEYLGTTIGDLLGARLVLEPLAASLAAEHIDEPG-----IERL
Rv3060c|M.tuberculosis_H37Rv TRAVVIYLEYLGTTIGDLLGARLVLEPLAASLAAEHIDEPG-----IERL
MMAR_1630|M.marinum_M TRAVVIYLEYLGITLGELLDARLVFEPLAASLAAEHIDEAG-----IDRL
MAV_3932|M.avium_104 TRAVVIYLEYLGTTLADLLNARLVLEPLAASLAAERIDEAG-----IARL
Mflv_2114|M.gilvum_PYR-GCK ARPAGLLLELSGATIADLLTAKSAIEPMAARLLAE--SGSAAAFDELEQL
Mvan_4590|M.vanbaalenii_PYR-1 ARPAGLLLELSGATIADLLTAKSGIEPMAARLLAE--SGSPEAFDELERM
MSMEG_5201|M.smegmatis_MC2_155 ARPVGLLLELSGADIADLLVARSAIEPMAARLLAE--NGTEEQFAELDRM
TH_2873|M.thermoresistible__bu ARYAGLILEYEGVTVKDVYEARVALEVPMVVQLAK--DRNPAVIAELERI
MLBr_01188|M.leprae_Br4923 AYMLGLLLQSKSIALADLGAALQELEPACAALAAQ---------------
MUL_3832|M.ulcerans_Agy99 AYMLGLLLQSESVAVSDLGAALQELEPACAALAAQRPDRADTLVPELKRV
MAB_2272c|M.abscessus_ATCC_199 --SSAIADYFAAANNRDLIELRQTLEVTAAGLAAQRRDEDD-----IEQL
: . :: :* . *:
Mb3086c|M.bovis_AF2122/97 RAVLRAE-ERWRPGLPPPPEQFYRVLAEQSKNPVLQLFIDILMRLTKRYV
Rv3060c|M.tuberculosis_H37Rv RAVLRAE-ERWRPGLPPPPEQFYRVLAEQSKNPVLQLFIDILMRLTKRYV
MMAR_1630|M.marinum_M RAVLRAE-EQRKPGLPAVRDEFHVALARQSKNPVLQLFIEILMRLTRRYA
MAV_3932|M.avium_104 RAVLHAE-QQWRPGLPMPRDEFHIALAEQSKNPVLQLFIKVLMRLTTRYA
Mflv_2114|M.gilvum_PYR-GCK LEELVAD-SHQSPRLAEATGAFHLRVVQLSGNATLSIVAGMLHEITVRHT
Mvan_4590|M.vanbaalenii_PYR-1 LEELAAD-SHKSSRLAEATGLFHLRVVQLSGNATLSIVAGMLHEITVRHT
MSMEG_5201|M.smegmatis_MC2_155 LEEHIPS-DWQSDRLAETTGDFHRRVVELSGNATLGIIAGMLHEITVRHH
TH_2873|M.thermoresistible__bu VEAESKL-EPGAETVSQLT-DFHGAIARLSGNKTLQIVTDMLHHVIEKAN
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 NEAMSEH-LDDGAMFTEIGRQFHDLIVRGCGNHTIIAVVGSLETLWTSHE
MAB_2272c|M.abscessus_ATCC_199 RALLVRRNELWAPHHVEPHNVEEAISTDIAVHRAVVAASHNALYLELYDS
Mb3086c|M.bovis_AF2122/97 QKSGTQSAG----EAVEAAGQVHNEHSDIVAAVTAGDSAWAKTLSERHVE
Rv3060c|M.tuberculosis_H37Rv QKSGTQSAG----EAVEAAGQVHNEHSDIVAAVTAGDSAWAKTLSERHVE
MMAR_1630|M.marinum_M LTSRTDTVA----EAFEAVDQMHNDHAAIAAAVTAGDSARAKTLSEQHVQ
MAV_3932|M.avium_104 LQSRTDSET----EALEAVDHLHTHHSRIVAAVTAGDPARAKTLSERHVE
Mflv_2114|M.gilvum_PYR-GCK AFVFNERRP----VSKADYETLLRSYRRLLQFLRSRDADGAEAHWRRHLD
Mvan_4590|M.vanbaalenii_PYR-1 AFVFNERRP----VSKADYDTLLRSYRKLMQFLRAGDAVGAEAHWRKHLD
MSMEG_5201|M.smegmatis_MC2_155 QFLFREHRP----VSKSDYDKLMRSYRKLMQIMRSGDGDAAEAHWRTHLD
TH_2873|M.thermoresistible__bu RSLQPTEGT----RAEQAVKKSTKTHRMVLDYIKAGDAEKAGELWQKHLQ
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 QQWADESAARGTYPSLAKRRAVLNAHIKLTETIAEGDVDRARRIAGRHLA
MAB_2272c|M.abscessus_ATCC_199 LLGLMDHYMRG--NPIGAECSFEHEHTRLVESVIAGDIGGATSATEQLFA
Mb3086c|M.bovis_AF2122/97 AVAGWLQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAATIG
Rv3060c|M.tuberculosis_H37Rv AVAGWLQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAATIG
MMAR_1630|M.marinum_M QVTGWLQQHQPGGDAKL-----AHVPRRSLRLDSETPPGKLAEVLAATIA
MAV_3932|M.avium_104 AVTAWLQRHHAGDRNRG------RTPRR--PLNSEVPQGKLAEMLAATIG
Mflv_2114|M.gilvum_PYR-GCK KTRELLLAG--------------------------LESVPVRDVMG----
Mvan_4590|M.vanbaalenii_PYR-1 TTRELLLTG--------------------------LESVPVRDVMG----
MSMEG_5201|M.smegmatis_MC2_155 TARALMLQG--------------------------LESVKVRDVMG----
TH_2873|M.thermoresistible__bu KAGEYLLSG--------------------------TEMSTVVDLLE----
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 DTQTYVLSG--------------------------RAEQRIYALSPQALS
MAB_2272c|M.abscessus_ATCC_199 ELRLSRDQP----------------------------GRNFPHHPHD---
Mb3086c|M.bovis_AF2122/97 DDIAASGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMRRGP
Rv3060c|M.tuberculosis_H37Rv DDIAASGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMRRGP
MMAR_1630|M.marinum_M DDIAASGWQLDSVFGTETALLQRYRVSRAALREAVRLLEYHSVARMRRGP
MAV_3932|M.avium_104 DDIAADGWRVGSVFGTETALLQRYRVSRAVFREAVRLLEYHSIAHMRRGP
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
TH_2873|M.thermoresistible__bu --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 RPRDMRRP------------------------------------------
MAB_2272c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 GGGLVVTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKVVKR
Rv3060c|M.tuberculosis_H37Rv GGGLVVTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKVVKR
MMAR_1630|M.marinum_M GGGLVVTKPQSQASIDTIALYLQYRQPSREDLRCVRDAIEIANVAKVVEQ
MAV_3932|M.avium_104 GGGLVIAEPAAQASIDTIALYLQYRDPSREDLRCVRDAIEIDNVAKVVKR
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
TH_2873|M.thermoresistible__bu --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MAB_2272c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 RSEPEVASFLDTLGRP---RLDNPTDDVRAAAVEEFRFHVGLARAAGNTM
Rv3060c|M.tuberculosis_H37Rv RSEPEVASFLDTLGRP---RLDNPTDDVRAAAVEEFRFHVGLARAAGNTM
MMAR_1630|M.marinum_M RARPEVASVLDELVVASDFAFEDAADAARKVAVEEFGFHVGLAQLAGNAL
MAV_3932|M.avium_104 LAEPQVAAFVASRRSGLPDDSRQTPDDVRRAIAEEFDFHVGLAQLAGNAP
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
TH_2873|M.thermoresistible__bu --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MAB_2272c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 LDLFLLILVELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSL
Rv3060c|M.tuberculosis_H37Rv LDLFLLILVELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSL
MMAR_1630|M.marinum_M LDLFLRIIVELFQRHWSSTEHQQPTFNDVGAVEHAHQRIREAIIAGDDSL
MAV_3932|M.avium_104 LDLFLRIIVELFRRHWSSTGQALPTWSDVRAVHHAHLRIADAVAAGDLSV
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
TH_2873|M.thermoresistible__bu --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MAB_2272c|M.abscessus_ATCC_199 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 ARCRTRRHLDAAASWWL
Rv3060c|M.tuberculosis_H37Rv ARCRTRRHLDAAASWWL
MMAR_1630|M.marinum_M ARYRIRRHLDAAASWWL
MAV_3932|M.avium_104 ASYRLRRHLDAAASWWL
Mflv_2114|M.gilvum_PYR-GCK -----------------
Mvan_4590|M.vanbaalenii_PYR-1 -----------------
MSMEG_5201|M.smegmatis_MC2_155 -----------------
TH_2873|M.thermoresistible__bu -----------------
MLBr_01188|M.leprae_Br4923 -----------------
MUL_3832|M.ulcerans_Agy99 -----------------
MAB_2272c|M.abscessus_ATCC_199 -----------------