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VSSLSPLVAAEAPVGRADEIVQRITEAIHLGLLDDGERLPVEVDLAAQFGVAPMTVREALATLREQELVE TRRGRSGGSFVRRPAGPPVDKLTARLAAMSASDLRDLFDEHTAVSGQAARLAAERAAPYAVRRLFALTDQ LGAAATLGDRIRADSRFHIQVAMASQSARLARREANLQAEAAGLVWLPIGPSLDVAAHVEEQHAIAAAVA SEMADEARRLAEAHVMGQLARVTSINLALSTGELSASGSAS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1846 | - | - | 100% (251) | regulatory protein GntR, HTH |
| M. vanbaalenii PYR-1 | Mvan_2282 | - | 6e-18 | 33.78% (222) | regulatory protein GntR, HTH |
| M. vanbaalenii PYR-1 | Mvan_4590 | - | 2e-17 | 31.64% (177) | GntR domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0505 | - | 2e-10 | 34.75% (141) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4061 | - | 2e-18 | 33.78% (222) | regulatory protein GntR, HTH |
| M. tuberculosis H37Rv | Rv0494 | - | 2e-10 | 34.75% (141) | GntR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4411c | - | 2e-11 | 28.81% (236) | GntR family transcriptional regulator |
| M. marinum M | MMAR_4842 | - | 2e-09 | 36.84% (114) | regulatory protein |
| M. avium 104 | MAV_2542 | - | 6e-13 | 31.82% (154) | regulatory protein GntR, HTH |
| M. smegmatis MC2 155 | MSMEG_6700 | - | 1e-113 | 86.72% (241) | regulatory protein |
| M. thermoresistible (build 8) | TH_4465 | - | 8e-14 | 29.06% (234) | PUTATIVE putative hydride transferase 1 |
| M. ulcerans Agy99 | MUL_4564 | - | 6e-09 | 31.88% (138) | GntR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1846|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6700|M.smegmatis_MC2_155 --------------------------------------------------
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4411c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
TH_4465|M.thermoresistible__bu LATIGLSAYGMAGGELVELAACADELGFDTLWLGEHVVRPLTQRSAHPTS
MMAR_4842|M.marinum_M --------------------------------------------------
Mvan_1846|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6700|M.smegmatis_MC2_155 --------------------------------------------------
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4411c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
TH_4465|M.thermoresistible__bu GTRQHHSGPLVAERTELIDPWAVHAAIAAVTTGIKLGTAVYVAALRHPLH
MMAR_4842|M.marinum_M --------------------------------------------------
Mvan_1846|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6700|M.smegmatis_MC2_155 --------------------------------------------------
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4411c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
TH_4465|M.thermoresistible__bu TARTTITVQELSGGRVVFGVGVGWLEEEFDAFDVPFRTRVSRTEECLAIL
MMAR_4842|M.marinum_M --------------------------------------------------
Mvan_1846|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6700|M.smegmatis_MC2_155 --------------------------------------------------
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4411c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
TH_4465|M.thermoresistible__bu RAAWRGEPFSHHGRHFRIDRVQVHSRPVDIPVVLGGNGPKALARAATLGD
MMAR_4842|M.marinum_M --------------------------------------------------
Mvan_1846|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6700|M.smegmatis_MC2_155 --------------------------------------------------
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4411c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
TH_4465|M.thermoresistible__bu GWFTSGTPEFDDALRMVREIRRVREQHGRPGPFTCYVRIPSVDEVGRYRD
MMAR_4842|M.marinum_M --------------------------------------------------
Mvan_1846|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6700|M.smegmatis_MC2_155 --------------------------------------------------
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4411c|M.abscessus_ATCC_199 --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
TH_4465|M.thermoresistible__bu HDMTDLVLWADTVWQGRTLDEKRDRLAAAADRLGLVSRSSGDPPAAAAGR
MMAR_4842|M.marinum_M --------------------------------------------------
Mvan_1846|M.vanbaalenii_PYR-1 ------------------------------------------------MS
MSMEG_6700|M.smegmatis_MC2_155 -------------------------------------------------M
Mb0505|M.bovis_AF2122/97 ---------------------------------------------MVEPM
Rv0494|M.tuberculosis_H37Rv ---------------------------------------------MVEPM
MUL_4564|M.ulcerans_Agy99 -------------------------------------------------M
Mflv_4061|M.gilvum_PYR-GCK ---------------------------------------MAAPDPADSSD
MAB_4411c|M.abscessus_ATCC_199 -----------------------------------------------MTT
MAV_2542|M.avium_104 ----------------------------------------MPKREPLAPM
TH_4465|M.thermoresistible__bu SQRRRSGSALRMGDDVPRRVQNTGARSAGVRDTRPQNSRAGANGARTARD
MMAR_4842|M.marinum_M --------------------------------------------MEGCRV
Mvan_1846|M.vanbaalenii_PYR-1 SLSPLVAAEAPVGRADEIVQRITEAIHLGLLDDGERLPVEVDLAAQFGVA
MSMEG_6700|M.smegmatis_MC2_155 SLSPLVAPEAPVGRADEIVQRITEAIHLGLLDDGERLPVEVDLAAQFGVA
Mb0505|M.bovis_AF2122/97 NQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAERLGVN
Rv0494|M.tuberculosis_H37Rv NQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAERLGVN
MUL_4564|M.ulcerans_Agy99 NQSSILQPPDRQRVDEQIATSIADAILDGVFPPGSALPPERELAEQLGVN
Mflv_4061|M.gilvum_PYR-GCK ASEALLRPVRPLNAFEDTVERLLQTIRLGVLTPGESLPPERELAARLGVS
MAB_4411c|M.abscessus_ATCC_199 LVPEEFAPLERQSTAELIAERLRIAIMRGVLAPGAQLG-EASLAAQFAVS
MAV_2542|M.avium_104 ATSQNNGAVRSPKTAEIVADTLRRMIVEGQLKDGDFLPYEAELMDHFQVS
TH_4465|M.thermoresistible__bu EHRGEVSLLRPLKAAESVARMIVDEIKTKGLQPGDSLPLEATMLKQYGVS
MMAR_4842|M.marinum_M LQLGQIDRTDDKPPYRQIASMLREAISSSRFPPGERLPSEAELIEHFGVA
. : * : * * * : : *
Mvan_1846|M.vanbaalenii_PYR-1 PMTVREALATLREQELVETRRGRSGGSFVR-RPAGPPVDKLTARLAAMSA
MSMEG_6700|M.smegmatis_MC2_155 PMTVREALATLRELELVETRRGRSGGSFVR-RPAGPPVEKLTARLAAMSA
Mb0505|M.bovis_AF2122/97 RTSLRQGLARLQQMGLIEVRHG--SGSVVR-DPEGLTHPAVVEALVRKLG
Rv0494|M.tuberculosis_H37Rv RTSLRQGLARLQQMGLIEVRHG--SGSVVR-DPEGLTHPAVVEALVRKLG
MUL_4564|M.ulcerans_Agy99 RTSLRQGLARLQQMGLIETRQG--SGNVVR-DPQSLTHPAVVEALVRKLG
Mflv_4061|M.gilvum_PYR-GCK RDTVREAIKSLADAGYLVSRRGRYGGTFLA-DALPAPRADGTEMHR----
MAB_4411c|M.abscessus_ATCC_199 RGPLREAMQRLVSEGLLRSERN--RGIFVI-ELT----------------
MAV_2542|M.avium_104 RPSLREAVRVLESDRLVEVRRGSRTGARVR-VPGPEIVARPAGFLLEMAG
TH_4465|M.thermoresistible__bu RESLREGLRLLEVQGMISIRRGPGGGPVVG-TVDAGHLGRVSALFYNMAD
MMAR_4842|M.marinum_M RMTVRQAMQELRSDGLVISQHG--RGVFVRPTPPIRRLASDRFARQHRAE
.:*:.: * : .:. * :
Mvan_1846|M.vanbaalenii_PYR-1 SD-LRDLFDEHTAVSGQAARLAAERAAPY--AVRRLFALTDQLGAAAT--
MSMEG_6700|M.smegmatis_MC2_155 SD-LRDLFDEHTAIAGQAARLAAERAAPS--TVRRLFALTDQLDTATS--
Mb0505|M.bovis_AF2122/97 PDFLVELLEIRAALGPLIGRLAAARSTPE--DAEALCAALEVVQQADT--
Rv0494|M.tuberculosis_H37Rv PDFLVELLEIRAALGPLIGRLAAARSTPE--DAEALCAALEVVQQADT--
MUL_4564|M.ulcerans_Agy99 PDFLVEVLEIRAALGPLIGRLAAERNSSE--DAEALRAALAEVADADT--
Mflv_4061|M.gilvum_PYR-GCK -DDIDDAVRLREILEVGAARMAAVRTLAA--VEREALRSRLTDVRGAD--
MAB_4411c|M.abscessus_ATCC_199 DDDVLDVYRSRSAIERAALECIMTGDTVT--AYRRLLVPVAVMTEAAARG
MAV_2542|M.avium_104 TT-LADVMTARMGIEPYAARLLAEDGTAA--AHRELRELIEEIPAAWE--
TH_4465|M.thermoresistible__bu ATYEELLEAWVWAEGELAERAARNPDAQL--RSARMTPYLTDHDGSAEG-
MMAR_4842|M.marinum_M GKAAFSVEAEKSGYSPQVDNIAVSREKPNSFIAEQLRISADDDIVVRSRR
.
Mvan_1846|M.vanbaalenii_PYR-1 -LGDRIRADSRFHIQVAMASQSARLARREA---NLQAEAAGLVWLPIGPS
MSMEG_6700|M.smegmatis_MC2_155 -LRDRIRADSRFHIQVAVAAQSARLARREA---NLQAEVSGLIWLPIGPP
Mb0505|M.bovis_AF2122/97 -AAARQAADLAYFRVLIHSTRNRALGLLYR---WVEHAFGGREHALTGAY
Rv0494|M.tuberculosis_H37Rv -AAARQAADLAYFRVLIHSTRNRALGLLYR---WVEHAFGGREHALTGAY
MUL_4564|M.ulcerans_Agy99 -APARQAADLAYFRVLIHGTRNRALGLLYR---WVEQAFGGREHDLTGAY
Mflv_4061|M.gilvum_PYR-GCK -PADYRRLDSRLHLAIAEAAGVPSLVPLVA---QNRMRLNELLDRIPLMT
MAB_4411c|M.abscessus_ATCC_199 DVVAVTDADQDFHEVLVDCSGSPRLRRAMR---TLLLETRMLLGELQGAY
MAV_2542|M.avium_104 -TGKLGAASTALHRRLVELSGNATLTVIVG---MLHEIFERHMTAAFLSV
TH_4465|M.thermoresistible__bu -LAPYLEGHTAFHRAVADLSNNRVLALSLQ---TYGQIVSHHVAVLSDPR
MMAR_4842|M.marinum_M YLANGRPVETAVSYIPAAFAEGTRIEQVDTGPGGIYARLEEHGHVLARFT
: :
Mvan_1846|M.vanbaalenii_PYR-1 LDVAAHVEE------QHAIAAAVASEMADEARRLAEAHVMGQLARVTSIN
MSMEG_6700|M.smegmatis_MC2_155 IDVAAYVEE------KHAISAAIAAENAQEARQLAEAHVMGQLARLTQIN
Mb0505|M.bovis_AF2122/97 DDADPVLTD------LRAINGAVLAGDPAAAAATVEAYLNASALRMVKSY
Rv0494|M.tuberculosis_H37Rv DDADPVLTD------LRAINGAVLAGDPAAAAATVEAYLNASALRMVKSY
MUL_4564|M.ulcerans_Agy99 EDADPVIAD------LTAINDAVLAGDPETAAAAVEGYLNASALRMIMCY
Mflv_4061|M.gilvum_PYR-GCK RNIAHSDEQ------HEAIVSAILAGDADTAAQTMAAHVWGSAALLHGFL
MAB_4411c|M.abscessus_ATCC_199 PDLSEQVRE------HEVLCAAIGAGDAPAAYRLIDEHMHDAVTRLMARR
MAV_2542|M.avium_104 QNVVPKAQYNKLMRSYTRLADLVAARDGAEAEAHWRRHMENASAELLKGH
TH_4465|M.thermoresistible__bu SLRDVLVDE------HRHIAEAVISGHARRARALMRSHLEGVTAFVRENI
MMAR_4842|M.marinum_M EEVAARMPTP-----EERRQLELDSGVPVLTVLRTAYDTNDVAVEVCDTV
: : : :
Mvan_1846|M.vanbaalenii_PYR-1 LALSTGELSASGSAS
MSMEG_6700|M.smegmatis_MC2_155 LDLTTKEAGR-----
Mb0505|M.bovis_AF2122/97 RDRA-----------
Rv0494|M.tuberculosis_H37Rv RDRA-----------
MUL_4564|M.ulcerans_Agy99 RAAYAGEDPER----
Mflv_4061|M.gilvum_PYR-GCK D--------------
MAB_4411c|M.abscessus_ATCC_199 DPGSVE---------
MAV_2542|M.avium_104 EKTKVRDIMH-----
TH_4465|M.thermoresistible__bu PVPLDQPIEWL----
MMAR_4842|M.marinum_M KVASAYLLEYEFPAR