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TFLSPFPEVDIPTASVYDYLFSGLAGPEDSVLDRVALIDAKSGRQTTYREMVARIDSFAGALAARGIGVG DVVALLAPNSSVFAVAFHGILRAGATATTVNALFTAKDIAKQLTDSKATMLVTVAALLPQAKAGAAAAGL SDEDVVVLDGAGRDGSGEGAGHPNAADLLAAGTPAPQVDFAPSSHLAVLPYSSGTTGNPKGVMLTHRNLV ANVAQIRPLHGMVADDVVLAVLPFFHIYGMTVLLNAALHARARLVIMPSFDLGEFLGNIAEHRCTIAFIA PPVAVALAKHPLVDEHDLSSLNVVMSGAAPLDADLGHAVAKRLGCKVVQGYGMSELSPVSHITPFDGGLV DMHEDAPLSSVGWTVSNAASKLVDPETGDEIPIPEEGLSKTGELWFKGPNVMAGYLNNDEATRSTIDEDG WLHTGDLAQVDARGLVYIVDRLKELIKYKGYQVPPAELEALLLSHPGIADAAVVGVHDEEGEEVPKAFVV RQASTDADGGAALTEADVIEFVAGQVAPYKKVRQVEFIDAIPKSASGKILRKDLRNGG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_2110 | - | - | 100% (549) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 6e-65 | 35.25% (505) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_0131 | - | 8e-65 | 32.61% (506) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 1e-61 | 31.48% (521) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4250 | - | 0.0 | 89.05% (548) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 1e-61 | 31.48% (521) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_01051 | xclC | 1e-47 | 31.42% (487) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4055c | - | 1e-171 | 59.52% (546) | putative acyl-CoA synthetase |
| M. marinum M | MMAR_1606 | - | 4e-72 | 36.27% (499) | fatty-acid-CoA ligase |
| M. avium 104 | MAV_3523 | - | 1e-64 | 35.11% (507) | acyl-CoA synthase |
| M. smegmatis MC2 155 | MSMEG_2360 | - | 0.0 | 72.94% (547) | 4-coumarate:CoA ligase |
| M. thermoresistible (build 8) | TH_2068 | fadD3 | 1e-63 | 34.28% (528) | PROBABLE FATTY-ACID-CoA LIGASE FADD3 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_0362 | - | 1e-56 | 32.19% (494) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_2110|M.vanbaalenii_PYR-1 ----MTFLSPFPEVDIPTASVYDYLFSGLAGPEDSV-------LDRVALI
Mflv_4250|M.gilvum_PYR-GCK ----MTFSSPFPEVDIPTASVYDYLFSGLSDPDDPV-------LDRVALI
MSMEG_2360|M.smegmatis_MC2_155 ----MSFASPFPDVTIPPVSVHDFLFAGLDDAD----------AGRVALV
MAB_4055c|M.abscessus_ATCC_199 ----MTFRSPLPDVSIPDCSVYEYVFGDTGAED-----------SRIALI
Mb2533c|M.bovis_AF2122/97 ----MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALV
Rv2505c|M.tuberculosis_H37Rv ----MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALV
TH_2068|M.thermoresistible__bu ----MRTIPAVLDR--AAERLPDHDALVTAATGG----------------
MMAR_1606|M.marinum_M ------MTSLAGNLIEGARRHPNRIALR----------------------
MLBr_01051|M.leprae_Br4923 ----MLLASLNPSVVTATDIADAVCVDGVVLS------------------
MAV_3523|M.avium_104 ----MPAAETRETLAGIVERHAQRRPDAIAIR------------------
MUL_0362|M.ulcerans_Agy99 MPGSAMTALPAPPLMYFRSSLLRILFASGDRIFSDCRDRREGRDVTEPAA
Mvan_2110|M.vanbaalenii_PYR-1 DAKSGRQTTYREMVARIDSFAGALAARGIGVGDVVALLAPNSSVFAVAFH
Mflv_4250|M.gilvum_PYR-GCK DAKSGRQTTYREMVARIDSFAGALAARGVGVGDVVGLLAPNSSAFAVAFH
MSMEG_2360|M.smegmatis_MC2_155 DSRTGAETTYGELIGRIEEFAGALAARGIGVGDVVALLSPNSSAFAVAFH
MAB_4055c|M.abscessus_ATCC_199 DGLTGAQTTLGELRSQIDATAAGLAERGFGIGDVAAVFLPNCSAFAVVLH
Mb2533c|M.bovis_AF2122/97 DMVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQY
Rv2505c|M.tuberculosis_H37Rv DMVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQY
TH_2068|M.thermoresistible__bu --AEARRFSYAELRAEVRRAAAAMIAAGIAPGDRVALWAPNTWHWVVACL
MMAR_1606|M.marinum_M --LDEIEIPYGALDAASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYY
MLBr_01051|M.leprae_Br4923 --RSG------------LVGAATSVAERVGGARLVAVLATPTASTVLAIT
MAV_3523|M.avium_104 --YGERQWSWAEWSSRIRRAAGALRGDGIERGQCVAFLDKNHPACLEVLI
MUL_0362|M.ulcerans_Agy99 LVFEDRGFSLPGLGAMADGLAAALRKQGVVAGDRVAVMSSNRPEFVAVLN
* . . ... .
Mvan_2110|M.vanbaalenii_PYR-1 GILRAGATATTVNALFTAKDIAKQLTDSKATMLVTVAALLPQAKAGAAAA
Mflv_4250|M.gilvum_PYR-GCK GILRAGATATTINALFTAKDIAKQLTDSRARTLITVTPLLAQAREGAALA
MSMEG_2360|M.smegmatis_MC2_155 GILRAGATATTVNALFTARDIAKQLTDSKAKLLLTVNALAPQSREAAAAV
MAB_4055c|M.abscessus_ATCC_199 GILRAGGTASTVNVLYTAEELAKQLIDSKAQLIFTVSPLLSRALEAAEIA
Mb2533c|M.bovis_AF2122/97 ATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAE
Rv2505c|M.tuberculosis_H37Rv ATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAE
TH_2068|M.thermoresistible__bu ATHYAGAVMVPLNTRYTASEAADVLARTGAPLLVAAGEFLGADKTADLDR
MMAR_1606|M.marinum_M GVLRAGGVVVPMNVLLKERETSFYLTDSEAKAIIAWHEFAPAAQAGADEA
MLBr_01051|M.leprae_Br4923 GCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWLG---PGPSADSAPDGL
MAV_3523|M.avium_104 GGASVGAVTTVVNWRVIGDELVHVLADSGARVLVVGAELRPAAEAAARRV
MUL_0362|M.ulcerans_Agy99 VIWCLGASAVLISPAWKRAEVDHALALTGPAHAAGDHPVLAGLMPMLHLD
* : : * :
Mvan_2110|M.vanbaalenii_PYR-1 G----LSDEDVVVLDGAGRDGSGEGAGHPNAADLLAAGTPAPQVDFAPSS
Mflv_4250|M.gilvum_PYR-GCK G----LSDEDVIVLDGPGRDGSGDGAGHPNAADILAPGTPAPQVNFAPSS
MSMEG_2360|M.smegmatis_MC2_155 G----LTDDAVVLLDG----------------ESLPTGHAAPQVTFDPAT
MAB_4055c|M.abscessus_ATCC_199 G----IDAAGVITVDP--------VEGRLSLADIARPDLAPPQVTFDPAT
Mb2533c|M.bovis_AF2122/97 VGPRCPDLADVILLESDR----WDALAG----AEPDLPALQQTAARLDGS
Rv2505c|M.tuberculosis_H37Rv VGPRCPDLADVILLESDR----WDALAG----AEPDLPALQQTAARLDGS
TH_2068|M.thermoresistible__bu D--ALPALRRIVRIPVDKPDGTWDEFIAGGSMSGAALAEVDARAAAVRPD
MMAR_1606|M.marinum_M G-------AECILVKPGE----FEELIQ--------AAEPLEEAAVREDD
MLBr_01051|M.leprae_Br4923 P---------HIPVQLDA-----RSWNR--------YPEPSP-------D
MAV_3523|M.avium_104 PS-----LERIIEVGDEY-----ESLLA--------AAEPAPSDAGVDTD
MUL_0362|M.ulcerans_Agy99 EP----------------------------------ITPAAPLPGAPRRA
Mvan_2110|M.vanbaalenii_PYR-1 HLAVLPYSSGTTGNPKGVMLTHRNLVANVAQIRPLHGMVADDVVLAVLPF
Mflv_4250|M.gilvum_PYR-GCK HLAVLPYSSGTTGNPKGVMLTHRNLVANVAQIRPLHGMEPDDVVLAVLPF
MSMEG_2360|M.smegmatis_MC2_155 HLAVLPYSSGTTANPKGVMLTHRNLVANVAQIRPLQGMRRDDRLLAVLPF
MAB_4055c|M.abscessus_ATCC_199 HLAVLPYSSGTTGKAKGVMLTHHNLVANIAQAKHLYGVQRGDRVLAVLPF
Mb2533c|M.bovis_AF2122/97 DPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIPVPF
Rv2505c|M.tuberculosis_H37Rv DPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIPVPF
TH_2068|M.thermoresistible__bu DVSDILFTSGTTGRSKGALCAHRQSLDASAAWAECGRLSSDDRYLCINPF
MMAR_1606|M.marinum_M DTAVILYTSGTTGKPKGAELTHANLRRNVEVIVQMLQVGPDDVILGALPL
MLBr_01051|M.leprae_Br4923 ATAMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTADDVLVHGLPL
MAV_3523|M.avium_104 ETALVIYSSGTTGRPKGVLLSQRALVNHAANLAPAFPFGDGDANLVAMPL
MUL_0362|M.ulcerans_Agy99 GDALLVFSSGTTGLPKAVRHTHASLNAAIGHWRDALGLTERDRIQIVTPP
: ::****. .*.. :: * *
Mvan_2110|M.vanbaalenii_PYR-1 FHIYGMTVLLNAALHAR-ARLVIMPSFDLGEFLGNIAEHRCTIAFIAPPV
Mflv_4250|M.gilvum_PYR-GCK FHIYGMTVLLNAALHAR-ARLVIMPSFDLGDFLGNIAEHRCTIAFIAPPV
MSMEG_2360|M.smegmatis_MC2_155 FHIYGMTVLLNAALHAR-AQLVVMPSFDLAEFLGNIAERRCTYAYIAPPV
MAB_4055c|M.abscessus_ATCC_199 FHIYGLVVLLNVQLKLG-AELVILPRFELDTFLGSIANYRVDHVFVAPPV
Mb2533c|M.bovis_AF2122/97 YHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTM
Rv2505c|M.tuberculosis_H37Rv YHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTM
TH_2068|M.thermoresistible__bu FHNFGYKAGILACIQTG-ATLYPQLTFDPEQAMRAVAEHRITVLPGPPTI
MMAR_1606|M.marinum_M FHAFGQTAGLNAAVAAG-ACLTLIPRFSPEKALQIIERDRVTVFEGVPTM
MLBr_01051|M.leprae_Br4923 FHVHGLVLGLLGSLRIGNRFVHTGK-PTPTAYAQACSEAGGSLYFGVPTV
MAV_3523|M.avium_104 FHVGGIGYALFG-IRAGAPTIMTRE-PDAAALIGAVRAGATHAFFVPPVI
MUL_0362|M.ulcerans_Agy99 SHILGLLN-IVAALRTG-VRVRLHRRFDIDQMLAHIESDRITVEMAVAPI
* * : . :
Mvan_2110|M.vanbaalenii_PYR-1 AVALAKHPLVDEHDLSSLNVVMSGAAPLDADLGHAVAKRLGC-KVVQGYG
Mflv_4250|M.gilvum_PYR-GCK AVALAKHPLVDDHDLSSLQVVMSGAAPLDADLGHAVAKRLDC-KVVQGYG
MSMEG_2360|M.smegmatis_MC2_155 AVALAKHPMVDSYDLSALEGIMSGAASLDAELGLAVARRLDC-RVVQGYG
MAB_4055c|M.abscessus_ATCC_199 AVVLAKHPDVDKYDVSCLRSVFSGAAPLDEQLGNAVAARLNC-RVSQGYG
Mb2533c|M.bovis_AF2122/97 FIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYG
Rv2505c|M.tuberculosis_H37Rv FIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYG
TH_2068|M.thermoresistible__bu YQTILDHPKRGEYDLSSLRFAVTGAAVVPVVLIERMQSELDIDIVLTAYG
MMAR_1606|M.marinum_M FAAMLHSTERP--DTGSLRLCVSGGAAMPVEVMRGFEQAFGT-MVLEGYG
MLBr_01051|M.leprae_Br4923 WS-RLVADEAVARALRPARLLVSGSASLPVPVFDR-LAHLTGHRPIERYG
MAV_3523|M.avium_104 AR-FLDAGEAARASIAGLRYIVYGAAPMPLPLLHRALSTWPGTKFVQVYG
MUL_0362|M.ulcerans_Agy99 ALAMASHPNLESYDLSSLRFIMWGATPVSAGIAETVTNRTGI-GWVPAYG
. . ..: : **
Mvan_2110|M.vanbaalenii_PYR-1 MSELSPVSHITPFDGGLVDMHEDAPLSSVGWTVSNAASKLVDPETGDEIP
Mflv_4250|M.gilvum_PYR-GCK MSELSPVSHITPFDGGRLNMHDDAPLASVGWTVSNAASKLVDPETGAEIE
MSMEG_2360|M.smegmatis_MC2_155 MSELSPVSHVTPKDGGLSTVGTVAPLDSCGWTVPNSESKIVDPETGAEIE
MAB_4055c|M.abscessus_ATCC_199 MTELSPVSHLIPPD------RPDIPLNSVGIPVPNSENKIIDTETGDEIE
Mb2533c|M.bovis_AF2122/97 MTETSPVSTQTRADDSVDRRVG-----TVGRVGPHLEIKVVDPATGETVP
Rv2505c|M.tuberculosis_H37Rv MTETSPVSTQTRADDSVDRRVG-----TVGRVGPHLEIKVVDPATGETVP
TH_2068|M.thermoresistible__bu LTEASGFGTMCRPEDDAVTVAT-----TCGRPIAGFELRIDNPAEDG---
MMAR_1606|M.marinum_M LSETSPTASFNHPDR--ERKPG-----SIGTPIAGVQMKLLEVDTHG---
MLBr_01051|M.leprae_Br4923 STESLITLSTLADGERRAG--------WVGLPLAGVQTRLVDESGGPVPY
MAV_3523|M.avium_104 QTELCGAVTALSDDDHRDAARPQL-QLSAGKAVQGCEIRIVDPNNCAELP
MUL_0362|M.ulcerans_Agy99 TTELPVIACSPLRGARLDT---------VGRVLPGVDLRVVSTETGERVG
:* * :: .
Mvan_2110|M.vanbaalenii_PYR-1 IPEEGLSKTGELWFKGPNVMAGYLNNDEATRSTIDEDGWLHTGDLAQVDA
Mflv_4250|M.gilvum_PYR-GCK IPDEGLSKTGELWFKGPNVMAGYLNNEEATKETIDEDGWLHTGDLAQIDD
MSMEG_2360|M.smegmatis_MC2_155 VPAEGLSETGELWFKGPNVMAGYLNNERATRETIDDDGFLHTGDLARVDA
MAB_4055c|M.abscessus_ATCC_199 IPAEGESAPGELLVRGPNVMAGYLGNEEATAATIEPDGFLHTGDIAVVRA
Mb2533c|M.bovis_AF2122/97 RGV-----VGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDP
Rv2505c|M.tuberculosis_H37Rv RGV-----VGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDP
TH_2068|M.thermoresistible__bu --------TGEVLLRGPNVMLGYLDDPEATAAAIDADGWLHTGDVGKVDE
MMAR_1606|M.marinum_M --------IGEIAIRGHNVMKGYWNRPDATAAAIDAEGWFRTGDLARIDE
MLBr_01051|M.leprae_Br4923 DGET----VGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDS
MAV_3523|M.avium_104 AGR-----SGEVWVRSNQNMSGYLNRAEATAETITADGWVRTGDVGRLDA
MUL_0362|M.ulcerans_Agy99 PGE-----VGEIQARSHLLMAGYLP--AAATAEVMSQGWYRTGDIGSLDA
*.. :. : ** : . :*: :***:. :
Mvan_2110|M.vanbaalenii_PYR-1 RGLVYIVDR-LKELIKYKGYQVPPAELEALLLSHPGIADAAVVGVHD-EE
Mflv_4250|M.gilvum_PYR-GCK RGLVYIVDR-LKELIKYKGYQVPPAELEAVLLSHPDIADAAVVGVRD-EE
MSMEG_2360|M.smegmatis_MC2_155 TGCVYIVDR-LKELIKYKGYQVPPAELEALLLTHPGIADAAVIGVQDPES
MAB_4055c|M.abscessus_ATCC_199 DGVVTIVDR-LKELIKYKGYQVPPAELEALLLTHPGIGDAAVIGVPDPSS
Mb2533c|M.bovis_AF2122/97 SGYVRIAGR-IKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKY
Rv2505c|M.tuberculosis_H37Rv SGYVRIAGR-IKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKY
TH_2068|M.thermoresistible__bu RGNLTITDR-LKDMYICGGFNVYPAEVEQVLARLDGVAEAAVIGVPDQRL
MMAR_1606|M.marinum_M DGYYFIVDR-SKDMIIRGGYNVYPREIEEVLYEHPEVREAAVVAVPDDML
MLBr_01051|M.leprae_Br4923 GGMHRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDL
MAV_3523|M.avium_104 DGYVYIEDR-LKDMIITGGENVYGPEVESVLIEHPAVVDAAVIGVPDDFW
MUL_0362|M.ulcerans_Agy99 AGWLRVTDR-LKEMIKVRGFQVAPTEIEAVLHGHPAVRDCAVFGVPDGAN
* : .* :: * .: *:* * : : *..: *
Mvan_2110|M.vanbaalenii_PYR-1 GEEVPKAFVVRQASTDADGGAALTEADVIEFVAGQVAPYKKVRQVEFIDA
Mflv_4250|M.gilvum_PYR-GCK GEEVPKAFVVTQAN------SELTETDVIEFVAGQVAPYKKVRKVEFIDA
MSMEG_2360|M.smegmatis_MC2_155 GEEVPKAFVVRQPG------IDLGADEVMAFVAGQVAPYKKVRQVEFIEA
MAB_4055c|M.abscessus_ATCC_199 GE-IPKAFVVRTDD-------DLTDEAVMAFVEQKVAPHKRIRQVEFIDA
Mb2533c|M.bovis_AF2122/97 GEELMAVVKLRNDA------PELTIERLREYCMGRIARFKIPRYLWIVDE
Rv2505c|M.tuberculosis_H37Rv GEELMAVVKLRNDA------PELTIERLREYCMGRIARFKIPRYLWIVDE
TH_2068|M.thermoresistible__bu GEVGKAFVVRR-PG------ATLDEQAVIAYCKQHLANFKVPRSVEFLDA
MMAR_1606|M.marinum_M GEEVGAAIALI-PG------ATSDAAALSDFVKERVAAYKYPRRIWFVDE
MLBr_01051|M.leprae_Br4923 GQRIVAFVVGA---------EALDADELINYVAQQLSIHKRPREVRFVDA
MAV_3523|M.avium_104 GESVKAIVVAD---------GDVDAADVIEFCRRHLAGFKCPRTVDFVAE
MUL_0362|M.ulcerans_Agy99 GEAVVVAVAAR---------TPVDAAELRARVAASLASYKRLSRIVFVPD
*: . : :: .* : ::
Mvan_2110|M.vanbaalenii_PYR-1 IPKSASGKILRKDLRNGG--------
Mflv_4250|M.gilvum_PYR-GCK IPKSASGKILRKDLRTG---------
MSMEG_2360|M.smegmatis_MC2_155 VPKSAAGKILRKELRTR---------
MAB_4055c|M.abscessus_ATCC_199 IPKSAAGKILRKDLRARI--------
Mb2533c|M.bovis_AF2122/97 FPMTVTGKVRKVEMRQQALEYLRGQQ
Rv2505c|M.tuberculosis_H37Rv FPMTVTGKVRKVEMRQQALEYLRGQQ
TH_2068|M.thermoresistible__bu LPRNPGGKVVKPLLRERA--------
MMAR_1606|M.marinum_M LPKGPTGKILKRDITVPQASPAQQ--
MLBr_01051|M.leprae_Br4923 LPRNAMGKVLKKQLLFEG--------
MAV_3523|M.avium_104 LPRNASGKILKTQLREPFWRDRDRRV
MUL_0362|M.ulcerans_Agy99 IPRLPSGKVLRRALKELYGCTSDS--
.* **: : :