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MPAAETRETLAGIVERHAQRRPDAIAIRYGERQWSWAEWSSRIRRAAGALRGDGIERGQCVAFLDKNHPA CLEVLIGGASVGAVTTVVNWRVIGDELVHVLADSGARVLVVGAELRPAAEAAARRVPSLERIIEVGDEYE SLLAAAEPAPSDAGVDTDETALVIYSSGTTGRPKGVLLSQRALVNHAANLAPAFPFGDGDANLVAMPLFH VGGIGYALFGIRAGAPTIMTREPDAAALIGAVRAGATHAFFVPPVIARFLDAGEAARASIAGLRYIVYGA APMPLPLLHRALSTWPGTKFVQVYGQTELCGAVTALSDDDHRDAARPQLQLSAGKAVQGCEIRIVDPNNC AELPAGRSGEVWVRSNQNMSGYLNRAEATAETITADGWVRTGDVGRLDADGYVYIEDRLKDMIITGGENV YGPEVESVLIEHPAVVDAAVIGVPDDFWGESVKAIVVADGDVDAADVIEFCRRHLAGFKCPRTVDFVAEL PRNASGKILKTQLREPFWRDRDRRV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3523 | - | - | 100% (515) | acyl-CoA synthase |
| M. avium 104 | MAV_1899 | - | 1e-79 | 36.38% (503) | feruloyl-CoA synthetase |
| M. avium 104 | MAV_5018 | - | 2e-77 | 34.94% (518) | acyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0172 | fadD5 | 2e-78 | 35.08% (516) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_5271 | - | 1e-152 | 52.02% (496) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 2e-78 | 35.27% (516) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 2e-54 | 37.16% (409) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 6e-86 | 37.94% (514) | putative long-chain-fatty-acid CoA ligase |
| M. marinum M | MMAR_0409 | fadD5 | 1e-76 | 34.11% (516) | fatty-acid-CoA ligase FadD5 |
| M. smegmatis MC2 155 | MSMEG_4065 | - | 3e-87 | 38.33% (514) | feruloyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2878 | - | 3e-79 | 35.50% (524) | PUTATIVE AMP-binding enzyme, putative |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 2e-56 | 33.14% (513) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0970 | - | 1e-155 | 51.80% (500) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_5271|M.gilvum_PYR-GCK MSRGKRANPASGSGSRGTLLGMAELTEPRFLDERLAHWATVNPDGEAMDY
Mvan_0970|M.vanbaalenii_PYR-1 ---------------------MADLPEPRFLDERIAHWAQVKPDDEAMDY
MAV_3523|M.avium_104 ---------------------MPAAETRETLAGIVERHAQRRPDAIAIRY
MAB_4559|M.abscessus_ATCC_1997 ----------------------------MQFTQWLHRALQQYPDRLITID
MSMEG_4065|M.smegmatis_MC2_155 --------------------------MTMYLTQGLHRAVQQTPGATMTVF
Mb0172|M.bovis_AF2122/97 ---MTAQLASHLTRALTLAQQQPYLARRQNWVNQLERHAMMQPDAPALRF
Rv0166|M.tuberculosis_H37Rv ---MTAQLASHLTRALTLAQQQPYLARRQNWVNQLERHAMMQPDAPALRF
MMAR_0409|M.marinum_M ---MTAELASHLPQAA-HALEQPYLARRQNWVNQLERHAMMQPRATAIRY
TH_2878|M.thermoresistible__bu -------------------LQQPYLARRQNWVNHLARHALMQPDATALRF
MUL_4126|M.ulcerans_Agy99 -----------------------MTSDPRTVPTALDRLVRRLPNHDALVT
MLBr_01051|M.leprae_Br4923 ----------------------------MLLASLNPSVVTATDIADAVCV
Mflv_5271|M.gilvum_PYR-GCK LERSWTWSQWNDRVRRLAGALTERGISRGDVVAFLDKNHPACVELTFAAA
Mvan_0970|M.vanbaalenii_PYR-1 LDRSWTWSQWNDRVRRLAGALTDRGVKRGDVVAFLDKNHPACVELTFAAA
MAV_3523|M.avium_104 GERQWSWAEWSSRIRRAAGALRGDGIERGQCVAFLDKNHPACLEVLIGGA
MAB_4559|M.abscessus_ATCC_1997 QGREHTVEQFADRVARLSAGLRANGVRPGDRVGMLSLNSDRYIEYLTAVP
MSMEG_4065|M.smegmatis_MC2_155 GERRRTFLEVADRVARLAGALRALGVRAGDRVAMLAQNSDRYHEYLLAVP
Mb0172|M.bovis_AF2122/97 VGNTMTWADLRRRVAALAGALSGRGVGFGDRVMILMLNRTEFVESVLAAN
Rv0166|M.tuberculosis_H37Rv VGNTMTWADLRRRVAALAGALSGRGVGFGDRVMILMLNRTEFVESVLAAN
MMAR_0409|M.marinum_M LGHTVTWADLRYRVAALAGSLSRRGVGFGDRVMILMLNRTEFVESVLAAN
TH_2878|M.thermoresistible__bu MGQTTTWADLHHRVNRLAGALRRRGVEFGDRVLILMLNRTEFIETMLAAN
MUL_4126|M.ulcerans_Agy99 DERSFTVSELNDEVYRAAAALIELGVKPAARVGIWSPNTWHWVVACLAIH
MLBr_01051|M.leprae_Br4923 DGVVLSRSGLVGAATSVAERVGG-----ARLVAVLATPTASTVLAITGCL
: : : . * . .
Mflv_5271|M.gilvum_PYR-GCK SLGAATAIVNCRLAPDELDYVLNDSGAKLLIVGEEFTG---SIDKIRDKL
Mvan_0970|M.vanbaalenii_PYR-1 SLGAANAIINFRLAADELDYVLNDSGAKLLIVGEEFKP---SIDKIRDRL
MAV_3523|M.avium_104 SVGAVTTVVNWRVIGDELVHVLADSGARVLVVGAELRP---AAEAAARRV
MAB_4559|M.abscessus_ATCC_1997 WLGAALNAVNIRWSLAEIGYSLRESGTRVLLVDDTFKA---AAAPLRAAC
MSMEG_4065|M.smegmatis_MC2_155 WANGVLNPVNIRWTPAEIAYSLEDSGTKVMFVDDSFAR---MLPAIKDAW
Mb0172|M.bovis_AF2122/97 MIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLTEAALAP---VAIGVRNIQ
Rv0166|M.tuberculosis_H37Rv MIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLTEAALAP---VAIGVRNIQ
MMAR_0409|M.marinum_M MLGAIAVPLNFRLTPSEIAFLVEDCAPRLVITEEVLAQ---VAVGVREIA
TH_2878|M.thermoresistible__bu RLGAIAVPVNFRMTPPEIAFLAKDCEAKVIATEPVLAG---VATAVRDLA
MUL_4126|M.ulcerans_Agy99 HVGAAMVPLNTRYTADEAADILARTEAPVLFAMGHFLGSDRVAGLDRKAL
MLBr_01051|M.leprae_Br4923 IAGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPSAD------SAPDGL
. : * .
Mflv_5271|M.gilvum_PYR-GCK GRVEHVISVKP------DGDDEYEAMLEASSPVDRADDVEPGDVCIIMYS
Mvan_0970|M.vanbaalenii_PYR-1 EHIEHVISVKP------EGDDEYEAMLEASSPVGRSADVEPGDVCIIMYS
MAV_3523|M.avium_104 PSLERIIEVG----------DEYESLLAAAEPAPSDAGVDTDETALVIYS
MAB_4559|M.abscessus_ATCC_1997 ACLETVIYCG--AGPAPQDMIGYEDLLASH-EPIDDTRTGGDSLLGVFYT
MSMEG_4065|M.smegmatis_MC2_155 AELSTVIYAG--EASPPAGTLAYEELIDKS-DPVDDARRGGDELAGLFYT
Mb0172|M.bovis_AF2122/97 PLLSVIVVAG---GSSQDSVFGYEDLLNEAGDVHEPVDIPNDSPALIMYT
Rv0166|M.tuberculosis_H37Rv PLLSVIVVAG---GSSQDSVFGYEDLLNEAGDVHEPVDIPNDSPALIMYT
MMAR_0409|M.marinum_M PALSTIVVAG---GASDPTVVGYDELISETGDPPEPVDIPNDSPALIMYT
TH_2878|M.thermoresistible__bu PSLSSVIVAGAADGSDTPDVLDYEALIAEPGEDPPPVDIPDDSPALIMYT
MUL_4126|M.ulcerans_Agy99 PALRHIVRIP-IEEPDGTWDEFIETGTDTGAVTARAAAVSPDDVSDILFT
MLBr_01051|M.leprae_Br4923 PHIPVQLDAR---------------------SWNRYPEPSPDATAMVIYT
: : . ::::
Mflv_5271|M.gilvum_PYR-GCK SGTTGRPKGVELTQANIIAHTVN-AHEGFEFDEGDKNMVSMPLFHVGGSS
Mvan_0970|M.vanbaalenii_PYR-1 SGTTGRPKGVELTQANIIAHTVN-AHEGFEFDEGDKNMVSMPLFHVGGSS
MAV_3523|M.avium_104 SGTTGRPKGVLLSQRALVNHAAN-LAPAFPFGDGDANLVAMPLFHVGGIG
MAB_4559|M.abscessus_ATCC_1997 GGTTGNPKGVMLSHNNVLASAMGSLSTGNFLTRGGRLLHSAPMFHMADFS
MSMEG_4065|M.smegmatis_MC2_155 GGTTGFPKGVMLSHANLLTSTYGLLTPGFAFRPGGICLHAAPMFHLADLM
Mb0172|M.bovis_AF2122/97 AGTTGRPKGAVLTHANLTGQAMTALYTSGANINSDVGFVGVPLFHIAGIG
Rv0166|M.tuberculosis_H37Rv SGTTGRPKGAVLTHANLTGQAMTALYTSGANINSDVGFVGVPLFHIAGIG
MMAR_0409|M.marinum_M SGTTGRPKGAVLTHTNLTGQVMTALYTGGANINSDVGFIGVPFFHIAGIG
TH_2878|M.thermoresistible__bu SGTTGNPKGAVLTHSNLTGQAMTNLFTIGVDLANDVGFIGVPLFHIAGIA
MUL_4126|M.ulcerans_Agy99 SGTTGRSKGVLCAHRQSLSASASWAANG-KITADDRHLCINPFFHNFGYK
MLBr_01051|M.leprae_Br4923 SGTTGPPKGVLLSRR-AIAVDLDALAQAWQWTADDVLVHGLPLFHVHGLV
.**** .**. :: .. . *:** .
Mflv_5271|M.gilvum_PYR-GCK -YVQFGIHDGFPSVMTRD--VDGMTLAGAILKG-ANRTFLVPAVLAKVLD
Mvan_0970|M.vanbaalenii_PYR-1 -YVQFGIHDGVPSVMTRD--VDGMTLAGAILKG-ANRTFLVPAVLAKVLE
MAV_3523|M.avium_104 -YALFGIRAGAPTIMTRE--PDAAALIGAVRAG-ATHAFFVPPVIARFLD
MAB_4559|M.abscessus_ATCC_1997 -AVLAGNLSGSTHVIVPS--FSPQGVLDAIVAHDVQDMLLVPTMIQMLVD
MSMEG_4065|M.smegmatis_MC2_155 -SWSAGLLQGGRHVFIPS--FEPVTVMQAIAQHQVTDALLVPTMIQKLID
Mb0172|M.bovis_AF2122/97 -NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEKVTGIFLVPAQWQAVCT
Rv0166|M.tuberculosis_H37Rv -NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAEKVTGIFLVPAQWQAVCT
MMAR_0409|M.marinum_M -NMLSGMLLGVPTVIYPLGAFNPGQLLDVLEAERVSGIFLVPAQWQAVCA
TH_2878|M.thermoresistible__bu GNVLSGLTLGLPTVLYPLGAFDPGGLLDVLEAEKVTGIFLVPAQWQAVCA
MUL_4126|M.ulcerans_Agy99 AGILACLQTG--ATLFPHLTFDPLRTLQAIERHRITVLPGPPTIYQTLLD
MLBr_01051|M.leprae_Br4923 LGLLGSLRIGNRFVHTGKP--TPTAYAQACSEAGGSLYFGVPTVWSRLVA
* . *. .
Mflv_5271|M.gilvum_PYR-GCK AGEDAVKLFGSLKTFAYGASPMPLPLLRQALEAWPNTDFMQAYGLTELCG
Mvan_0970|M.vanbaalenii_PYR-1 AGEDAVKLFGSLKTFAYGASPMPLPLLRQALQAWPNTDFMQAYGLTELCG
MAV_3523|M.avium_104 AGEAARASIAGLRYIVYGAAPMPLPLLHRALSTWPGTKFVQVYGQTELCG
MAB_4559|M.abscessus_ATCC_1997 HPGAAQLDLSGIRSITYGASVISEAVLQRATRVFPNARFTQAYGMTEVSP
MSMEG_4065|M.smegmatis_MC2_155 HPDINRYDLTSFRALFYAASAIPQALLERAMKVFPNAEFVQGYGMTELSP
Mb0172|M.bovis_AF2122/97 EQQARPRDLR-LRVLSWGAAPAPDALLRQMSATFPETQILAAFGQTEMSP
Rv0166|M.tuberculosis_H37Rv EQQARPRDLR-LRVLSWGAAPAPDALLRQMSATFPETQILAAFGQTEMSP
MMAR_0409|M.marinum_M EQQARPRELS-LRVMSWGAAPAPDALLRQMSEVFPGTQIMAAFGQTEMSP
TH_2878|M.thermoresistible__bu EQRARPRDLR-LRALSWGAAPASDTLLQEMTEVFPGTKIFAAFGQTEMSP
MUL_4126|M.ulcerans_Agy99 HPARDDYDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANG
MLBr_01051|M.leprae_Br4923 DEAVAR-ALRPARLLVSGSASLPVPVFDRLAHLTG-HRPIERYGSTESLI
: : .:: . :. . :* **
Mflv_5271|M.gilvum_PYR-GCK VISHLLPEAHRDPGREERLSSAGTLVPNAELRVVDPDT-LKDVPTGEQGE
Mvan_0970|M.vanbaalenii_PYR-1 VISHLLPEAHRDPGREERLSSAGTLVPNAELRVVDPDT-LEDVPTGEQGE
MAV_3523|M.avium_104 AVTALSDDDHRDAARPQLQLSAGKAVQGCEIRIVDPNN-CAELPAGRSGE
MAB_4559|M.abscessus_ATCC_1997 VATLLLPDDHDDPA---LLRSAGRAAPHCEVRIVDPD--DNEVPRGEIGE
MSMEG_4065|M.smegmatis_MC2_155 LATLLSPDDHQKPR---LLRSAGRAAPSAEVRIVDPD--GNEVPRRTVGE
Mb0172|M.bovis_AF2122/97 VTCMLLGEDAIAK-----RGSVGRVIPTVAARVVDQN--MNDVPVGEVGE
Rv0166|M.tuberculosis_H37Rv VTCMLLGEDAIAK-----RGSVGRVIPTVAARVVDQN--MNDVPVGEVGE
MMAR_0409|M.marinum_M VTCMLLGEDAIRK-----RGSVGKVIPTVSARVVDDE--MNDVPIGQVGE
TH_2878|M.thermoresistible__bu VTCMLLAEDAVRK-----LGSVGKVIPTVAARIVDDT--MNDVPVGEVGE
MUL_4126|M.ulcerans_Agy99 MGTMCRADDDALT----VATTCGRPFADFELRIGPDT-----------GE
MLBr_01051|M.leprae_Br4923 TLSTLADGERRAG-------WVGLPLAGVQTRLVDESGGPVPYDGETVGR
* *: *.
Mflv_5271|M.gilvum_PYR-GCK LWFRSPQLMKGYHNKPEATAESITEDGWFRTGDVGRVDDGGYIFVEDR-L
Mvan_0970|M.vanbaalenii_PYR-1 LWFRSPQLMKGYHNKPEATAEAITEDGWFRTGDVGRVDDGGYIFVEDR-L
MAV_3523|M.avium_104 VWVRSNQNMSGYLNRAEATAETITADGWVRTGDVGRLDADGYVYIEDR-L
MAB_4559|M.abscessus_ATCC_1997 VIVKGDNVMLGYWELPEESAAAIRD-GWMHTGDAGRMDDRGYVYIVDR-I
MSMEG_4065|M.smegmatis_MC2_155 VAVRGGNVMLGYWNKPQETAAAIRD-GWMHTGDAAYMDDDGYIYVVDR-I
Mb0172|M.bovis_AF2122/97 IVYRAPTLMSCYWNNPEATAEAFAG-GWFHSGDLVRMDSDGYVWVVDR-K
Rv0166|M.tuberculosis_H37Rv IVYRAPTLMSCYWNNPEATAEAFAG-GWFHSGDLVRMDSDGYVWVVDR-K
MMAR_0409|M.marinum_M IVYRAPTLMSGYWNNPDATAEAFAG-GWFHSGDLVRMDEDGYVWVVDR-K
TH_2878|M.thermoresistible__bu IVYRAPTLMAGYWNNPQATAEAFAG-GWFHSGDLVRQDEEGYIWVVDR-K
MUL_4126|M.ulcerans_Agy99 VLLRGPNVMLGYLDDPRATAAAIDADGWLHTGDIGVLDEAGNLRITDR-L
MLBr_01051|M.leprae_Br4923 LQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIVGRES
: :. : * : . :* :: ** ::** * * : .*
Mflv_5271|M.gilvum_PYR-GCK KDMIISGGENIYSIEVERVLAEHDAVVEVAVIGVPDDKWGEVVKAVVVIE
Mvan_0970|M.vanbaalenii_PYR-1 KDMIISGGENIYSIEVERVLAEHEAVVEVAVIGIPDDRWGEVVKAVVVLE
MAV_3523|M.avium_104 KDMIITGGENVYGPEVESVLIEHPAVVDAAVIGVPDDFWGESVKAIVVAD
MAB_4559|M.abscessus_ATCC_1997 KDMVVTGGENVYSAEVENALAKHPAVAACAVIGIPDEQWGERVHAVVVKQ
MSMEG_4065|M.smegmatis_MC2_155 KDMIITGGENVYSAEVENAVVQHPSVAACAVIGVPDADWGERVHAVVVLQ
Mb0172|M.bovis_AF2122/97 KDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEKWGEVPIAVAAVT
Rv0166|M.tuberculosis_H37Rv KDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEKWGEVPIAVAAVT
MMAR_0409|M.marinum_M KDMIISGGENVYCAEVENVLASHPSIVEVAVIGRADEKWGEVPIAVAAVT
TH_2878|M.thermoresistible__bu KDMIISGGENIYCAEVENVLAAHPAVAEVAVVGRPHEKWGEVPVAVVALN
MUL_4126|M.ulcerans_Agy99 KDMYICGGFNVYPAEVEQVLARLDGVADVAVIGIPDHRLGEVGRAFIVAR
MLBr_01051|M.leprae_Br4923 VDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQRIVAFVVGA
*: ** .: *:* .: : **:* .. *: *. .
Mflv_5271|M.gilvum_PYR-GCK --GETSESELIAFARERLAAYKCPKSVDITDELPRKPTGKILKKELRKPH
Mvan_0970|M.vanbaalenii_PYR-1 --REVTETELIAFARERLAAYKCPKTVDITDELPRNPTGKILKKELRKPH
MAV_3523|M.avium_104 --GDVDAADVIEFCRRHLAGFKCPRTVDFVAELPRNASGKILKTQLREPF
MAB_4559|M.abscessus_ATCC_1997 AQSECCDGDLQEHCREHIANYKVPRSFEFVDELPLSGAGKILKRVLRQKY
MSMEG_4065|M.smegmatis_MC2_155 PGAELAACQIREHAKRLIAGYKCPRSIEFVNALPLSGAGKVLKRELRERH
Mb0172|M.bovis_AF2122/97 -NDDLRIEDLGEFLTDRLARYKHPKALEIVDALPRNPAGKVLKTELRLRY
Rv0166|M.tuberculosis_H37Rv -NDDLRIEDLGEFLTDRLARYKHPKALEIVDALPRNPAGKVLKTELRLRY
MMAR_0409|M.marinum_M -KDHLRIEDLDEYLTERLARYKHPKALEIVDALPRNPSGKVLKTELRLRY
TH_2878|M.thermoresistible__bu PDAELTMAELEEFLADRLARYKHPKVLEIVDALPRNPAGKVLKTELRARF
MUL_4126|M.ulcerans_Agy99 PGFNLDEKSVIDYTREHLANFKAPRSVRFVDTLPRNAGGKVVKPQLRELA
MLBr_01051|M.leprae_Br4923 --EALDADELINYVAQQLSIHKRPREVRFVDALPRNAMGKVLKKQLLFEG
.: . :: .* *: . :. ** . **::* *
Mflv_5271|M.gilvum_PYR-GCK WDGRDRATV----------------
Mvan_0970|M.vanbaalenii_PYR-1 WEGRDRANV----------------
MAV_3523|M.avium_104 WRDRDRRV-----------------
MAB_4559|M.abscessus_ATCC_1997 WESRDAGVS----------------
MSMEG_4065|M.smegmatis_MC2_155 LGARERDRGSLP-------------
Mb0172|M.bovis_AF2122/97 GACVNVERRSASAGFTERRENRQKL
Rv0166|M.tuberculosis_H37Rv GACVNVERRSASAGFTERRENRQKL
MMAR_0409|M.marinum_M GVGVYSESRSVSRSFEFREGS----
TH_2878|M.thermoresistible__bu AAGPSAEKEQSSSGATTSAGSS---
MUL_4126|M.ulcerans_Agy99 -------------------------
MLBr_01051|M.leprae_Br4923 -------------------------