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SFASPFPDVTIPPVSVHDFLFAGLDDADAGRVALVDSRTGAETTYGELIGRIEEFAGALAARGIGVGDVV ALLSPNSSAFAVAFHGILRAGATATTVNALFTARDIAKQLTDSKAKLLLTVNALAPQSREAAAAVGLTDD AVVLLDGESLPTGHAAPQVTFDPATHLAVLPYSSGTTANPKGVMLTHRNLVANVAQIRPLQGMRRDDRLL AVLPFFHIYGMTVLLNAALHARAQLVVMPSFDLAEFLGNIAERRCTYAYIAPPVAVALAKHPMVDSYDLS ALEGIMSGAASLDAELGLAVARRLDCRVVQGYGMSELSPVSHVTPKDGGLSTVGTVAPLDSCGWTVPNSE SKIVDPETGAEIEVPAEGLSETGELWFKGPNVMAGYLNNERATRETIDDDGFLHTGDLARVDATGCVYIV DRLKELIKYKGYQVPPAELEALLLTHPGIADAAVIGVQDPESGEEVPKAFVVRQPGIDLGADEVMAFVAG QVAPYKKVRQVEFIEAVPKSAAGKILRKELRTR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2360 | - | - | 100% (524) | 4-coumarate:CoA ligase |
| M. smegmatis MC2 155 | MSMEG_5649 | - | 6e-64 | 32.74% (504) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4065 | - | 5e-62 | 34.68% (496) | feruloyl-CoA synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 1e-64 | 33.73% (510) | AMP-binding domain protein |
| M. gilvum PYR-GCK | Mflv_4250 | - | 0.0 | 72.14% (542) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 1e-64 | 33.73% (510) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_01051 | xclC | 2e-42 | 30.08% (512) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4055c | - | 1e-176 | 61.65% (532) | putative acyl-CoA synthetase |
| M. marinum M | MMAR_1606 | - | 7e-66 | 34.85% (482) | fatty-acid-CoA ligase |
| M. avium 104 | MAV_0600 | fadD | 2e-57 | 33.07% (499) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2068 | fadD3 | 3e-61 | 33.15% (537) | PROBABLE FATTY-ACID-CoA LIGASE FADD3 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_0362 | - | 2e-57 | 34.12% (466) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_2110 | - | 0.0 | 72.94% (547) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4250|M.gilvum_PYR-GCK -------MTFSSPFPEVDIPTASVYDYLFSGLSDPDDPVLDRVALIDAK-
Mvan_2110|M.vanbaalenii_PYR-1 -------MTFLSPFPEVDIPTASVYDYLFSGLAGPEDSVLDRVALIDAK-
MSMEG_2360|M.smegmatis_MC2_155 -------MSFASPFPDVTIPPVSVHDFLFAGLDDAD---AGRVALVDSR-
MAB_4055c|M.abscessus_ATCC_199 -------MTFRSPLPDVSIPDCSVYEYVFGDTGAED----SRIALIDGL-
Mb2533c|M.bovis_AF2122/97 MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVD---
Rv2505c|M.tuberculosis_H37Rv MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVD---
MAV_0600|M.avium_104 --------------------MTTDPRTVPAALDRLARRLPDHDALIT---
TH_2068|M.thermoresistible__bu ------------------------MRTIPAVLDRAAERLPDHDALVTAAT
MMAR_1606|M.marinum_M ------------------------MTSLAGNLIEGARRHPNRIALRL---
MLBr_01051|M.leprae_Br4923 --------------------------MLLASLNPSVVTATDIADAVCVDG
MUL_0362|M.ulcerans_Agy99 ---MPGSAMTALPAPPLMYFRSSLLRILFASGDRIFSDCRDRREGRDVTE
: .
Mflv_4250|M.gilvum_PYR-GCK ------SGRQTTYREMVARIDSFAGALAARGVGVGDVVGLLAPNSSAFAV
Mvan_2110|M.vanbaalenii_PYR-1 ------SGRQTTYREMVARIDSFAGALAARGIGVGDVVALLAPNSSVFAV
MSMEG_2360|M.smegmatis_MC2_155 ------TGAETTYGELIGRIEEFAGALAARGIGVGDVVALLSPNSSAFAV
MAB_4055c|M.abscessus_ATCC_199 ------TGAQTTLGELRSQIDATAAGLAERGFGIGDVAAVFLPNCSAFAV
Mb2533c|M.bovis_AF2122/97 ----MVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVL
Rv2505c|M.tuberculosis_H37Rv ----MVARRRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVL
MAV_0600|M.avium_104 ------EDRSFTAAALRDEVHRAAAALIELGVRAGDRVAIWSPNTWHWVV
TH_2068|M.thermoresistible__bu ---GGAEARRFSYAELRAEVRRAAAAMIAAGIAPGDRVALWAPNTWHWVV
MMAR_1606|M.marinum_M ------DEIEIPYGALDAASARLAGLLIQRGLRPGDRVGVMLPNVPYFAV
MLBr_01051|M.leprae_Br4923 -------------VVLSRSGLVGAATSVAERVGGARLVAVLATPTASTVL
MUL_0362|M.ulcerans_Agy99 PAALVFEDRGFSLPGLGAMADGLAAALRKQGVVAGDRVAVMSSNRPEFVA
: * . . ..: . .
Mflv_4250|M.gilvum_PYR-GCK AFHGILRAGATATTINALFTAKDIAKQLTDSRARTLITVTPLLAQAREGA
Mvan_2110|M.vanbaalenii_PYR-1 AFHGILRAGATATTVNALFTAKDIAKQLTDSKATMLVTVAALLPQAKAGA
MSMEG_2360|M.smegmatis_MC2_155 AFHGILRAGATATTVNALFTARDIAKQLTDSKAKLLLTVNALAPQSREAA
MAB_4055c|M.abscessus_ATCC_199 VLHGILRAGGTASTVNVLYTAEELAKQLIDSKAQLIFTVSPLLSRALEAA
Mb2533c|M.bovis_AF2122/97 VQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAM
Rv2505c|M.tuberculosis_H37Rv VQYATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAM
MAV_0600|M.avium_104 ACLAIHHAGAAMVPLNTRYTAAEAGDILARVGAPVLFGMGRFLGHDRLAD
TH_2068|M.thermoresistible__bu ACLATHYAGAVMVPLNTRYTASEAADVLARTGAPLLVAAGEFLGADKTAD
MMAR_1606|M.marinum_M AYYGVLRAGGVVVPMNVLLKERETSFYLTDSEAKAIIAWHEFAPAAQAG-
MLBr_01051|M.leprae_Br4923 AITGCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWLGPGPSADSAPDGL
MUL_0362|M.ulcerans_Agy99 VLNVIWCLGASAVLISPAWKRAEVDHALALTGPAHAAGDHPVLAGLMPML
. * : : *
Mflv_4250|M.gilvum_PYR-GCK ALAGLS-----DEDVIVLDGPGRDGSGDGAGHPNAADILAPGTPAPQVNF
Mvan_2110|M.vanbaalenii_PYR-1 AAAGLS-----DEDVVVLDGAGRDGSGEGAGHPNAADLLAAGTPAPQVDF
MSMEG_2360|M.smegmatis_MC2_155 AAVGLT-----DDAVVLLDG----------------ESLPTGHAAPQVTF
MAB_4055c|M.abscessus_ATCC_199 EIAGID-----AAGVITVDP--------VEGRLSLADIARPDLAPPQVTF
Mb2533c|M.bovis_AF2122/97 LAEVGPRCPDLADVILLESDR-----WDALAGAEP----DLPALQQTAAR
Rv2505c|M.tuberculosis_H37Rv LAEVGPRCPDLADVILLESDR-----WDALAGAEP----DLPALQQTAAR
MAV_0600|M.avium_104 LDRAALPALRHIVRIPIETDDPVPGSWDEFIAHG----TDLGAVAERAAA
TH_2068|M.thermoresistible__bu LDRDALPALRRIVRIPVDKPD---GTWDEFIAGGSMSGAALAEVDARAAA
MMAR_1606|M.marinum_M ADEAG------AECILVKPGE-----FEELIQAAEP--------LEEAAV
MLBr_01051|M.leprae_Br4923 PHIPVQLDAR---------------------------------SWNRYPE
MUL_0362|M.ulcerans_Agy99 HLDEPITP-----------------------------------AAPLPGA
Mflv_4250|M.gilvum_PYR-GCK APSSHLAVLPYSSGTTGNPKGVMLTHRNLVANVAQIRPLHGMEPDDVVLA
Mvan_2110|M.vanbaalenii_PYR-1 APSSHLAVLPYSSGTTGNPKGVMLTHRNLVANVAQIRPLHGMVADDVVLA
MSMEG_2360|M.smegmatis_MC2_155 DPATHLAVLPYSSGTTANPKGVMLTHRNLVANVAQIRPLQGMRRDDRLLA
MAB_4055c|M.abscessus_ATCC_199 DPATHLAVLPYSSGTTGKAKGVMLTHHNLVANIAQAKHLYGVQRGDRVLA
Mb2533c|M.bovis_AF2122/97 LDGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICI
Rv2505c|M.tuberculosis_H37Rv LDGSDPVNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICI
MAV_0600|M.avium_104 VTSDDVSDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITSDDRYLC
TH_2068|M.thermoresistible__bu VRPDDVSDILFTSGTTGRSKGALCAHRQSLDASAAWAECGRLSSDDRYLC
MMAR_1606|M.marinum_M REDDDTAVILYTSGTTGKPKGAELTHANLRRNVEVIVQMLQVGPDDVILG
MLBr_01051|M.leprae_Br4923 PSPDATAMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTADDVLVH
MUL_0362|M.ulcerans_Agy99 PRRAGDALLVFSSGTTGLPKAVRHTHASLNAAIGHWRDALGLTERDRIQI
: ::****. .*.. :: *
Mflv_4250|M.gilvum_PYR-GCK VLPFFHIYGMTVLLNAALHAR-ARLVIMPSFDLGDFLGNIAEHRCTIAFI
Mvan_2110|M.vanbaalenii_PYR-1 VLPFFHIYGMTVLLNAALHAR-ARLVIMPSFDLGEFLGNIAEHRCTIAFI
MSMEG_2360|M.smegmatis_MC2_155 VLPFFHIYGMTVLLNAALHAR-AQLVVMPSFDLAEFLGNIAERRCTYAYI
MAB_4055c|M.abscessus_ATCC_199 VLPFFHIYGLVVLLNVQLKLG-AELVILPRFELDTFLGSIANYRVDHVFV
Mb2533c|M.bovis_AF2122/97 PVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYG
Rv2505c|M.tuberculosis_H37Rv PVPFYHCFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYG
MAV_0600|M.avium_104 INPFFHNFGYKAGILACLQTG-ATLIPHLTFDPLRALQAIEQHRITVLPG
TH_2068|M.thermoresistible__bu INPFFHNFGYKAGILACIQTG-ATLYPQLTFDPEQAMRAVAEHRITVLPG
MMAR_1606|M.marinum_M ALPLFHAFGQTAGLNAAVAAG-ACLTLIPRFSPEKALQIIERDRVTVFEG
MLBr_01051|M.leprae_Br4923 GLPLFHVHGLVLGLLGSLRIG-NRFVHTGKPTPTAYAQACSEAGGSLYFG
MUL_0362|M.ulcerans_Agy99 VTPPSHILGLLN-IVAALRTG-VRVRLHRRFDIDQMLAHIESDRITVEMA
* * * .
Mflv_4250|M.gilvum_PYR-GCK APPVAVALAKHPLVDDHDLSSLQVVMSGAAPLDADLGHAVAKRLDC-KVV
Mvan_2110|M.vanbaalenii_PYR-1 APPVAVALAKHPLVDEHDLSSLNVVMSGAAPLDADLGHAVAKRLGC-KVV
MSMEG_2360|M.smegmatis_MC2_155 APPVAVALAKHPMVDSYDLSALEGIMSGAASLDAELGLAVARRLDC-RVV
MAB_4055c|M.abscessus_ATCC_199 APPVAVVLAKHPDVDKYDVSCLRSVFSGAAPLDEQLGNAVAARLNC-RVS
Mb2533c|M.bovis_AF2122/97 VPTMFIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVS
Rv2505c|M.tuberculosis_H37Rv VPTMFIAELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVS
MAV_0600|M.avium_104 PPTIYQTLLDHPARRDYDLSSLRFAVTGAATVPVVLVERMQSELDIDIVL
TH_2068|M.thermoresistible__bu PPTIYQTILDHPKRGEYDLSSLRFAVTGAAVVPVVLIERMQSELDIDIVL
MMAR_1606|M.marinum_M VPTMFAAMLHSTERP--DTGSLRLCVSGGAAMPVEVMRGFEQAFGT-MVL
MLBr_01051|M.leprae_Br4923 VPTVWSRLVADEAVAR-ALRPARLLVSGSASLPVPVFDRLAHLTGH-RPI
MUL_0362|M.ulcerans_Agy99 VAPIALAMASHPNLESYDLSSLRFIMWGATPVSAGIAETVTNRTGI-GWV
..: . . ..: : .
Mflv_4250|M.gilvum_PYR-GCK QGYGMSELSPVSHITPFDGGRLNMHDDAPLASVGWTVSNAASKLVDPETG
Mvan_2110|M.vanbaalenii_PYR-1 QGYGMSELSPVSHITPFDGGLVDMHEDAPLSSVGWTVSNAASKLVDPETG
MSMEG_2360|M.smegmatis_MC2_155 QGYGMSELSPVSHVTPKDGGLSTVGTVAPLDSCGWTVPNSESKIVDPETG
MAB_4055c|M.abscessus_ATCC_199 QGYGMTELSPVSHLIPPD------RPDIPLNSVGIPVPNSENKIIDTETG
Mb2533c|M.bovis_AF2122/97 ICYGMTETSPVSTQTRADDS-----VDRRVGTVGRVGPHLEIKVVDPATG
Rv2505c|M.tuberculosis_H37Rv ICYGMTETSPVSTQTRADDS-----VDRRVGTVGRVGPHLEIKVVDPATG
MAV_0600|M.avium_104 TAYGLTEANGMGTMCRADDD-----AVTVATTCGRPFADFELRIDD----
TH_2068|M.thermoresistible__bu TAYGLTEASGFGTMCRPEDD-----AVTVATTCGRPIAGFELRIDNPAE-
MMAR_1606|M.marinum_M EGYGLSETSPTASFNHPDR-------ERKPGSIGTPIAGVQMKLLEVDT-
MLBr_01051|M.leprae_Br4923 ERYGSTES--LITLSTLADG------ERRAGWVGLPLAGVQTRLVDESGG
MUL_0362|M.ulcerans_Agy99 PAYGTTELPVIACSPLRGAR---------LDTVGRVLPGVDLRVVSTETG
** :* * . :: .
Mflv_4250|M.gilvum_PYR-GCK AEIEIPDEGLSKTGELWFKGPNVMAGYLNNEEATKETIDEDGWLHTGDLA
Mvan_2110|M.vanbaalenii_PYR-1 DEIPIPEEGLSKTGELWFKGPNVMAGYLNNDEATRSTIDEDGWLHTGDLA
MSMEG_2360|M.smegmatis_MC2_155 AEIEVPAEGLSETGELWFKGPNVMAGYLNNERATRETIDDDGFLHTGDLA
MAB_4055c|M.abscessus_ATCC_199 DEIEIPAEGESAPGELLVRGPNVMAGYLGNEEATAATIEPDGFLHTGDIA
Mb2533c|M.bovis_AF2122/97 ETVPR-----GVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLA
Rv2505c|M.tuberculosis_H37Rv ETVPR-----GVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLA
MAV_0600|M.avium_104 ------------SGEVLLRGPNVMLGYLDDPDATAAAIDADGWLHTGDIG
TH_2068|M.thermoresistible__bu ----------DGTGEVLLRGPNVMLGYLDDPEATAAAIDADGWLHTGDVG
MMAR_1606|M.marinum_M ----------HGIGEIAIRGHNVMKGYWNRPDATAAAIDAEGWFRTGDLA
MLBr_01051|M.leprae_Br4923 PVPYDG----ETVGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVA
MUL_0362|M.ulcerans_Agy99 ERVGP-----GEVGEIQARSHLLMAGYLP--AAATAEVMSQGWYRTGDIG
*.. :. :: ** : . :*: :***:.
Mflv_4250|M.gilvum_PYR-GCK QIDDRGLVYIVDR-LKELIKYKGYQVPPAELEAVLLSHPDIADAAVVGVR
Mvan_2110|M.vanbaalenii_PYR-1 QVDARGLVYIVDR-LKELIKYKGYQVPPAELEALLLSHPGIADAAVVGVH
MSMEG_2360|M.smegmatis_MC2_155 RVDATGCVYIVDR-LKELIKYKGYQVPPAELEALLLTHPGIADAAVIGVQ
MAB_4055c|M.abscessus_ATCC_199 VVRADGVVTIVDR-LKELIKYKGYQVPPAELEALLLTHPGIGDAAVIGVP
Mb2533c|M.bovis_AF2122/97 EMDPSGYVRIAGR-IKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVP
Rv2505c|M.tuberculosis_H37Rv EMDPSGYVRIAGR-IKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVP
MAV_0600|M.avium_104 VLDEAGNLRITDR-LKDMYICGGFNVYPAEVEQVLARMEGVADAAVIGVP
TH_2068|M.thermoresistible__bu KVDERGNLTITDR-LKDMYICGGFNVYPAEVEQVLARLDGVAEAAVIGVP
MMAR_1606|M.marinum_M RIDEDGYYFIVDR-SKDMIIRGGYNVYPREIEEVLYEHPEVREAAVVAVP
MLBr_01051|M.leprae_Br4923 VVDSGGMHRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLP
MUL_0362|M.ulcerans_Agy99 SLDAAGWLRVTDR-LKEMIKVRGFQVAPTEIEAVLHGHPAVRDCAVFGVP
: * :..* :: * .: . *:* * : : *..:
Mflv_4250|M.gilvum_PYR-GCK D-EEGEEVPKAFVVTQAN------SELTETDVIEFVAGQVAPYKKVRKVE
Mvan_2110|M.vanbaalenii_PYR-1 D-EEGEEVPKAFVVRQASTDADGGAALTEADVIEFVAGQVAPYKKVRQVE
MSMEG_2360|M.smegmatis_MC2_155 DPESGEEVPKAFVVRQPG------IDLGADEVMAFVAGQVAPYKKVRQVE
MAB_4055c|M.abscessus_ATCC_199 DPSSGE-IPKAFVVRTDD-------DLTDEAVMAFVEQKVAPHKRIRQVE
Mb2533c|M.bovis_AF2122/97 DAKYGEELMAVVKLRNDAPELT------IERLREYCMGRIARFKIPRYLW
Rv2505c|M.tuberculosis_H37Rv DAKYGEELMAVVKLRNDAPELT------IERLREYCMGRIARFKIPRYLW
MAV_0600|M.avium_104 DERLGEVGRAFVVPR-PGAQLD------EQSVIAYTRDHLANFKAPRSVR
TH_2068|M.thermoresistible__bu DQRLGEVGKAFVVRR-PGATLD------EQAVIAYCKQHLANFKVPRSVE
MMAR_1606|M.marinum_M DDMLGEEVGAAIALI-PGATSD------AAALSDFVKERVAAYKYPRRIW
MLBr_01051|M.leprae_Br4923 DEDLGQRIVAFVVGAEALD---------ADELINYVAQQLSIHKRPREVR
MUL_0362|M.ulcerans_Agy99 DGANGEAVVVAVAARTPVD---------AAELRARVAASLASYKRLSRIV
* *: . : :: .* :
Mflv_4250|M.gilvum_PYR-GCK FIDAIPKSASGKILRKDLRTG---------
Mvan_2110|M.vanbaalenii_PYR-1 FIDAIPKSASGKILRKDLRNGG--------
MSMEG_2360|M.smegmatis_MC2_155 FIEAVPKSAAGKILRKELRTR---------
MAB_4055c|M.abscessus_ATCC_199 FIDAIPKSAAGKILRKDLRARI--------
Mb2533c|M.bovis_AF2122/97 IVDEFPMTVTGKVRKVEMRQQALEYLRGQQ
Rv2505c|M.tuberculosis_H37Rv IVDEFPMTVTGKVRKVEMRQQALEYLRGQQ
MAV_0600|M.avium_104 FVDALPRNSGGKVVKPQLRELD--------
TH_2068|M.thermoresistible__bu FLDALPRNPGGKVVKPLLRERA--------
MMAR_1606|M.marinum_M FVDELPKGPTGKILKRDITVPQASPAQQ--
MLBr_01051|M.leprae_Br4923 FVDALPRNAMGKVLKKQLLFEG--------
MUL_0362|M.ulcerans_Agy99 FVPDIPRLPSGKVLRRALKELYGCTSDS--
:: .* **: : :