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MTFSSPFPEVDIPTASVYDYLFSGLSDPDDPVLDRVALIDAKSGRQTTYREMVARIDSFAGALAARGVGV GDVVGLLAPNSSAFAVAFHGILRAGATATTINALFTAKDIAKQLTDSRARTLITVTPLLAQAREGAALAG LSDEDVIVLDGPGRDGSGDGAGHPNAADILAPGTPAPQVNFAPSSHLAVLPYSSGTTGNPKGVMLTHRNL VANVAQIRPLHGMEPDDVVLAVLPFFHIYGMTVLLNAALHARARLVIMPSFDLGDFLGNIAEHRCTIAFI APPVAVALAKHPLVDDHDLSSLQVVMSGAAPLDADLGHAVAKRLDCKVVQGYGMSELSPVSHITPFDGGR LNMHDDAPLASVGWTVSNAASKLVDPETGAEIEIPDEGLSKTGELWFKGPNVMAGYLNNEEATKETIDED GWLHTGDLAQIDDRGLVYIVDRLKELIKYKGYQVPPAELEAVLLSHPDIADAAVVGVRDEEGEEVPKAFV VTQANSELTETDVIEFVAGQVAPYKKVRKVEFIDAIPKSASGKILRKDLRTG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4250 | - | - | 100% (542) | AMP-dependent synthetase and ligase |
| M. gilvum PYR-GCK | Mflv_0027 | - | 2e-64 | 34.30% (519) | AMP-dependent synthetase and ligase |
| M. gilvum PYR-GCK | Mflv_4616 | - | 2e-62 | 33.20% (509) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2533c | fadD35 | 2e-61 | 32.17% (516) | AMP-binding domain protein |
| M. tuberculosis H37Rv | Rv2505c | fadD35 | 2e-61 | 32.17% (516) | AMP-binding domain protein |
| M. leprae Br4923 | MLBr_01051 | xclC | 4e-46 | 30.52% (485) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4055c | - | 1e-170 | 58.52% (540) | putative acyl-CoA synthetase |
| M. marinum M | MMAR_1606 | - | 4e-71 | 35.50% (493) | fatty-acid-CoA ligase |
| M. avium 104 | MAV_3523 | - | 1e-61 | 34.81% (497) | acyl-CoA synthase |
| M. smegmatis MC2 155 | MSMEG_2360 | - | 0.0 | 72.14% (542) | 4-coumarate:CoA ligase |
| M. thermoresistible (build 8) | TH_2068 | fadD3 | 3e-64 | 33.53% (519) | PROBABLE FATTY-ACID-CoA LIGASE FADD3 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 2e-57 | 32.10% (539) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_2110 | - | 0.0 | 89.05% (548) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4250|M.gilvum_PYR-GCK -------MTFSSPFPEVDIPTASVYDYLFSGLSDPDDPVLDRVALIDAKS
Mvan_2110|M.vanbaalenii_PYR-1 -------MTFLSPFPEVDIPTASVYDYLFSGLAGPEDSVLDRVALIDAKS
MSMEG_2360|M.smegmatis_MC2_155 -------MSFASPFPDVTIPPVSVHDFLFAGLDDAD---AGRVALVDSRT
MAB_4055c|M.abscessus_ATCC_199 -------MTFRSPLPDVSIPDCSVYEYVFGDTGAED----SRIALIDGLT
Mb2533c|M.bovis_AF2122/97 MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMVA
Rv2505c|M.tuberculosis_H37Rv MAAAEVVDPNRLSYDRGPSAPSLLESTIGANLAATAARYGHREALVDMVA
TH_2068|M.thermoresistible__bu ------------------------MRTIPAVLDRAAERLPDHDALVTAAT
MUL_4126|M.ulcerans_Agy99 --------------------MTSDPRTVPTALDRLVRRLPNHDALVTDE-
MMAR_1606|M.marinum_M ------------------------MTSLAGNLIEGARRHPNRIALRLDEI
MLBr_01051|M.leprae_Br4923 ------------------MLLASLNPSVVTATDIADAVCVDGVVLSRSG-
MAV_3523|M.avium_104 ------------------MPAAETRETLAGIVERHAQRRPDAIAIRYGER
: .:
Mflv_4250|M.gilvum_PYR-GCK G----RQTTYREMVARIDSFAGALAARGVGVGDVVGLLAPNSSAFAVAFH
Mvan_2110|M.vanbaalenii_PYR-1 G----RQTTYREMVARIDSFAGALAARGIGVGDVVALLAPNSSVFAVAFH
MSMEG_2360|M.smegmatis_MC2_155 G----AETTYGELIGRIEEFAGALAARGIGVGDVVALLSPNSSAFAVAFH
MAB_4055c|M.abscessus_ATCC_199 G----AQTTLGELRSQIDATAAGLAERGFGIGDVAAVFLPNCSAFAVVLH
Mb2533c|M.bovis_AF2122/97 R----RRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQY
Rv2505c|M.tuberculosis_H37Rv R----RRFNYSELLTDVHRLATGLVRAGIGPGDRVGIWAPNRWEWVLVQY
TH_2068|M.thermoresistible__bu GGAEARRFSYAELRAEVRRAAAAMIAAGIAPGDRVALWAPNTWHWVVACL
MUL_4126|M.ulcerans_Agy99 -----RSFTVSELNDEVYRAAAALIELGVKPAARVGIWSPNTWHWVVACL
MMAR_1606|M.marinum_M E------IPYGALDAASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYY
MLBr_01051|M.leprae_Br4923 -----------------LVGAATSVAERVGGARLVAVLATPTASTVLAIT
MAV_3523|M.avium_104 Q------WSWAEWSSRIRRAAGALRGDGIERGQCVAFLDKNHPACLEVLI
* . . ... .
Mflv_4250|M.gilvum_PYR-GCK GILRAGATATTINALFTAKDIAKQLTDSRARTLITVTPLLAQAREGAALA
Mvan_2110|M.vanbaalenii_PYR-1 GILRAGATATTVNALFTAKDIAKQLTDSKATMLVTVAALLPQAKAGAAAA
MSMEG_2360|M.smegmatis_MC2_155 GILRAGATATTVNALFTARDIAKQLTDSKAKLLLTVNALAPQSREAAAAV
MAB_4055c|M.abscessus_ATCC_199 GILRAGGTASTVNVLYTAEELAKQLIDSKAQLIFTVSPLLSRALEAAEIA
Mb2533c|M.bovis_AF2122/97 ATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAE
Rv2505c|M.tuberculosis_H37Rv ATAEIGAILVTINPAYRVREVEYALRQSGVAMVIAVASFKDADYAAMLAE
TH_2068|M.thermoresistible__bu ATHYAGAVMVPLNTRYTASEAADVLARTGAPLLVAAGEFLGADKTADLDR
MUL_4126|M.ulcerans_Agy99 AIHHVGAAMVPLNTRYTADEAADILARTEAPVLFAMGHFLGSDRVAGLDR
MMAR_1606|M.marinum_M GVLRAGGVVVPMNVLLKERETSFYLTDSEAKAIIAWHEFAPAAQAGADEA
MLBr_01051|M.leprae_Br4923 GCLIAGVPVVPVPADIGVVERRHMLTDSGAQAWLG---PGPSADSAPDGL
MAV_3523|M.avium_104 GGASVGAVTTVVNWRVIGDELVHVLADSGARVLVVGAELRPAAEAAARRV
. * : : * : . . .
Mflv_4250|M.gilvum_PYR-GCK GLSDEDVIVLDGPGRDGSGDGAGHPNAADILAPG--TPAPQVNFAPSSHL
Mvan_2110|M.vanbaalenii_PYR-1 GLSDEDVVVLDGAGRDGSGEGAGHPNAADLLAAG--TPAPQVDFAPSSHL
MSMEG_2360|M.smegmatis_MC2_155 GLTDDAVVLLDG----------------ESLPTG--HAAPQVTFDPATHL
MAB_4055c|M.abscessus_ATCC_199 GIDAAGVITVDP--------VEGRLSLADIARPD--LAPPQVTFDPATHL
Mb2533c|M.bovis_AF2122/97 VGPRCPDLADVILLE--SDRWDALAGAEPDLPA----LQQTAARLDGSDP
Rv2505c|M.tuberculosis_H37Rv VGPRCPDLADVILLE--SDRWDALAGAEPDLPA----LQQTAARLDGSDP
TH_2068|M.thermoresistible__bu DALPALRRIVRIPVDKPDGTWDEFIAGGSMSGAALAEVDARAAAVRPDDV
MUL_4126|M.ulcerans_Agy99 KALPALRHIVRIPIEEPDGTWDEFIETGTDTGA----VTARAAAVSPDDV
MMAR_1606|M.marinum_M G-------AECILVK--PGEFEELIQAAEPLEE--------AAVREDDDT
MLBr_01051|M.leprae_Br4923 P----HIPVQLDARS--------WNRYPEPSP---------------DAT
MAV_3523|M.avium_104 PSLERIIEVGDEYES--------LLAAAEPAPSD--------AGVDTDET
Mflv_4250|M.gilvum_PYR-GCK AVLPYSSGTTGNPKGVMLTHRNLVANVAQIRPLHGMEPDDVVLAVLPFFH
Mvan_2110|M.vanbaalenii_PYR-1 AVLPYSSGTTGNPKGVMLTHRNLVANVAQIRPLHGMVADDVVLAVLPFFH
MSMEG_2360|M.smegmatis_MC2_155 AVLPYSSGTTANPKGVMLTHRNLVANVAQIRPLQGMRRDDRLLAVLPFFH
MAB_4055c|M.abscessus_ATCC_199 AVLPYSSGTTGKAKGVMLTHHNLVANIAQAKHLYGVQRGDRVLAVLPFFH
Mb2533c|M.bovis_AF2122/97 VNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIPVPFYH
Rv2505c|M.tuberculosis_H37Rv VNIQYTSGTTAYPKGVTLSHRNILNNGYLVGELLGYTAQDRICIPVPFYH
TH_2068|M.thermoresistible__bu SDILFTSGTTGRSKGALCAHRQSLDASAAWAECGRLSSDDRYLCINPFFH
MUL_4126|M.ulcerans_Agy99 SDILFTSGTTGRSKGVLCAHRQSLSASASWAANGKITADDRHLCINPFFH
MMAR_1606|M.marinum_M AVILYTSGTTGKPKGAELTHANLRRNVEVIVQMLQVGPDDVILGALPLFH
MLBr_01051|M.leprae_Br4923 AMVIYTSGTTGPPKGVLLSRRAIAVDLDALAQAWQWTADDVLVHGLPLFH
MAV_3523|M.avium_104 ALVIYSSGTTGRPKGVLLSQRALVNHAANLAPAFPFGDGDANLVAMPLFH
: ::****. .**. :: * *::*
Mflv_4250|M.gilvum_PYR-GCK IYGMTVLLNAALHAR-ARLVIMPSFDLGDFLGNIAEHRCTIAFIAPPVAV
Mvan_2110|M.vanbaalenii_PYR-1 IYGMTVLLNAALHAR-ARLVIMPSFDLGEFLGNIAEHRCTIAFIAPPVAV
MSMEG_2360|M.smegmatis_MC2_155 IYGMTVLLNAALHAR-AQLVVMPSFDLAEFLGNIAERRCTYAYIAPPVAV
MAB_4055c|M.abscessus_ATCC_199 IYGLVVLLNVQLKLG-AELVILPRFELDTFLGSIANYRVDHVFVAPPVAV
Mb2533c|M.bovis_AF2122/97 CFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFI
Rv2505c|M.tuberculosis_H37Rv CFGMVMGNLAATSHGAAMVIPAPGFDPAATLRAVQDERCTSLYGVPTMFI
TH_2068|M.thermoresistible__bu NFGYKAGILACIQTG-ATLYPQLTFDPEQAMRAVAEHRITVLPGPPTIYQ
MUL_4126|M.ulcerans_Agy99 NFGYKAGILACLQTG-ATLFPHLTFDPLRTLQAIERHRITVLPGPPTIYQ
MMAR_1606|M.marinum_M AFGQTAGLNAAVAAG-ACLTLIPRFSPEKALQIIERDRVTVFEGVPTMFA
MLBr_01051|M.leprae_Br4923 VHGLVLGLLGSLRIG-NRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWS
MAV_3523|M.avium_104 VGGIGYALFG-IRAG-APTIMTREPDAAALIGAVRAGATHAFFVPPVIAR
* * :
Mflv_4250|M.gilvum_PYR-GCK ALAKHPLVDDHDLSSLQVVMSGAAPLDADLGHAVAKRLDC-KVVQGYGMS
Mvan_2110|M.vanbaalenii_PYR-1 ALAKHPLVDEHDLSSLNVVMSGAAPLDADLGHAVAKRLGC-KVVQGYGMS
MSMEG_2360|M.smegmatis_MC2_155 ALAKHPMVDSYDLSALEGIMSGAASLDAELGLAVARRLDC-RVVQGYGMS
MAB_4055c|M.abscessus_ATCC_199 VLAKHPDVDKYDVSCLRSVFSGAAPLDEQLGNAVAARLNC-RVSQGYGMT
Mb2533c|M.bovis_AF2122/97 AELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMT
Rv2505c|M.tuberculosis_H37Rv AELGLPDFTDYELGSLRTGIMAGAACPVEVMRKVISRMHMPGVSICYGMT
TH_2068|M.thermoresistible__bu TILDHPKRGEYDLSSLRFAVTGAAVVPVVLIERMQSELDIDIVLTAYGLT
MUL_4126|M.ulcerans_Agy99 TLLDHPARDDYDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLT
MMAR_1606|M.marinum_M AMLHSTERP--DTGSLRLCVSGGAAMPVEVMRGFEQAFGT-MVLEGYGLS
MLBr_01051|M.leprae_Br4923 RLVAD-EAVARALRPARLLVSGSASLPVPVFDR-LAHLTGHRPIERYGST
MAV_3523|M.avium_104 FLDAG-EAARASIAGLRYIVYGAAPMPLPLLHRALSTWPGTKFVQVYGQT
. . ..* : ** :
Mflv_4250|M.gilvum_PYR-GCK ELSPVSHITPFDGGRLNMHDDAPLASVGWTVSNAASKLVDPETGAEIEIP
Mvan_2110|M.vanbaalenii_PYR-1 ELSPVSHITPFDGGLVDMHEDAPLSSVGWTVSNAASKLVDPETGDEIPIP
MSMEG_2360|M.smegmatis_MC2_155 ELSPVSHVTPKDGGLSTVGTVAPLDSCGWTVPNSESKIVDPETGAEIEVP
MAB_4055c|M.abscessus_ATCC_199 ELSPVSHLIPPD------RPDIPLNSVGIPVPNSENKIIDTETGDEIEIP
Mb2533c|M.bovis_AF2122/97 ETSPVSTQTRADDS-----VDRRVGTVGRVGPHLEIKVVDPATGETVPR-
Rv2505c|M.tuberculosis_H37Rv ETSPVSTQTRADDS-----VDRRVGTVGRVGPHLEIKVVDPATGETVPR-
TH_2068|M.thermoresistible__bu EASGFGTMCRPEDD-----AVTVATTCGRPIAGFELRIDNPAE-------
MUL_4126|M.ulcerans_Agy99 EANGMGTMCRADDD-----ALTVATTCGRPFADFELRIG-----------
MMAR_1606|M.marinum_M ETSPTASFNHPDR-------ERKPGSIGTPIAGVQMKLLEVDT-------
MLBr_01051|M.leprae_Br4923 ESLITLSTLADGER-RAG-------WVGLPLAGVQTRLVDESGGPVPYDG
MAV_3523|M.avium_104 ELCGAVTALSDDDH-RDAARPQLQLSAGKAVQGCEIRIVDPNNCAELPAG
* * ::
Mflv_4250|M.gilvum_PYR-GCK DEGLSKTGELWFKGPNVMAGYLNNEEATKETIDEDGWLHTGDLAQIDDRG
Mvan_2110|M.vanbaalenii_PYR-1 EEGLSKTGELWFKGPNVMAGYLNNDEATRSTIDEDGWLHTGDLAQVDARG
MSMEG_2360|M.smegmatis_MC2_155 AEGLSETGELWFKGPNVMAGYLNNERATRETIDDDGFLHTGDLARVDATG
MAB_4055c|M.abscessus_ATCC_199 AEGESAPGELLVRGPNVMAGYLGNEEATAATIEPDGFLHTGDIAVVRADG
Mb2533c|M.bovis_AF2122/97 ----GVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSG
Rv2505c|M.tuberculosis_H37Rv ----GVVGEFCTRGYSVMAGYWNDPQKTAEVIDADGWMHTGDLAEMDPSG
TH_2068|M.thermoresistible__bu ----DGTGEVLLRGPNVMLGYLDDPEATAAAIDADGWLHTGDVGKVDERG
MUL_4126|M.ulcerans_Agy99 ----PDTGEVLLRGPNVMLGYLDDPRATAAAIDADGWLHTGDIGVLDEAG
MMAR_1606|M.marinum_M ----HGIGEIAIRGHNVMKGYWNRPDATAAAIDAEGWFRTGDLARIDEDG
MLBr_01051|M.leprae_Br4923 ET----VGRLQVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGG
MAV_3523|M.avium_104 R-----SGEVWVRSNQNMSGYLNRAEATAETITADGWVRTGDVGRLDADG
*.. :. : ** . * .: :*: :***:. : *
Mflv_4250|M.gilvum_PYR-GCK LVYIVDR-LKELIKYKGYQVPPAELEAVLLSHPDIADAAVVGVRD-EEGE
Mvan_2110|M.vanbaalenii_PYR-1 LVYIVDR-LKELIKYKGYQVPPAELEALLLSHPGIADAAVVGVHD-EEGE
MSMEG_2360|M.smegmatis_MC2_155 CVYIVDR-LKELIKYKGYQVPPAELEALLLTHPGIADAAVIGVQDPESGE
MAB_4055c|M.abscessus_ATCC_199 VVTIVDR-LKELIKYKGYQVPPAELEALLLTHPGIGDAAVIGVPDPSSGE
Mb2533c|M.bovis_AF2122/97 YVRIAGR-IKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGE
Rv2505c|M.tuberculosis_H37Rv YVRIAGR-IKDLVVRGGENISPREIEELLHTHPDIVDGHVIGVPDAKYGE
TH_2068|M.thermoresistible__bu NLTITDR-LKDMYICGGFNVYPAEVEQVLARLDGVAEAAVIGVPDQRLGE
MUL_4126|M.ulcerans_Agy99 NLRITDR-LKDMYICGGFNVYPAEVEQVLARLDGVADVAVIGIPDHRLGE
MMAR_1606|M.marinum_M YYFIVDR-SKDMIIRGGYNVYPREIEEVLYEHPEVREAAVVAVPDDMLGE
MLBr_01051|M.leprae_Br4923 MHRIVGRESVDLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQ
MAV_3523|M.avium_104 YVYIEDR-LKDMIITGGENVYGPEVESVLIEHPAVVDAAVIGVPDDFWGE
* .* :: * .: *:* * : : *:.: * *:
Mflv_4250|M.gilvum_PYR-GCK EVPKAFVVTQAN------SELTETDVIEFVAGQVAPYKKVRKVEFIDAIP
Mvan_2110|M.vanbaalenii_PYR-1 EVPKAFVVRQASTDADGGAALTEADVIEFVAGQVAPYKKVRQVEFIDAIP
MSMEG_2360|M.smegmatis_MC2_155 EVPKAFVVRQPG------IDLGADEVMAFVAGQVAPYKKVRQVEFIEAVP
MAB_4055c|M.abscessus_ATCC_199 -IPKAFVVRTDD-------DLTDEAVMAFVEQKVAPHKRIRQVEFIDAIP
Mb2533c|M.bovis_AF2122/97 ELMAVVKLRNDAPELT------IERLREYCMGRIARFKIPRYLWIVDEFP
Rv2505c|M.tuberculosis_H37Rv ELMAVVKLRNDAPELT------IERLREYCMGRIARFKIPRYLWIVDEFP
TH_2068|M.thermoresistible__bu VGKAFVVRR-PGATLD------EQAVIAYCKQHLANFKVPRSVEFLDALP
MUL_4126|M.ulcerans_Agy99 VGRAFIVAR-PGFNLD------EKSVIDYTREHLANFKAPRSVRFVDTLP
MMAR_1606|M.marinum_M EVGAAIALI-PGATSD------AAALSDFVKERVAAYKYPRRIWFVDELP
MLBr_01051|M.leprae_Br4923 RIVAFVVGAEALD---------ADELINYVAQQLSIHKRPREVRFVDALP
MAV_3523|M.avium_104 SVKAIVVADGDVD---------AADVIEFCRRHLAGFKCPRTVDFVAELP
. : : ::: .* * : :: .*
Mflv_4250|M.gilvum_PYR-GCK KSASGKILRKDLRTG---------
Mvan_2110|M.vanbaalenii_PYR-1 KSASGKILRKDLRNGG--------
MSMEG_2360|M.smegmatis_MC2_155 KSAAGKILRKELRTR---------
MAB_4055c|M.abscessus_ATCC_199 KSAAGKILRKDLRARI--------
Mb2533c|M.bovis_AF2122/97 MTVTGKVRKVEMRQQALEYLRGQQ
Rv2505c|M.tuberculosis_H37Rv MTVTGKVRKVEMRQQALEYLRGQQ
TH_2068|M.thermoresistible__bu RNPGGKVVKPLLRERA--------
MUL_4126|M.ulcerans_Agy99 RNAGGKVVKPQLRELA--------
MMAR_1606|M.marinum_M KGPTGKILKRDITVPQASPAQQ--
MLBr_01051|M.leprae_Br4923 RNAMGKVLKKQLLFEG--------
MAV_3523|M.avium_104 RNASGKILKTQLREPFWRDRDRRV
**: : :