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MFDQISSFRNPSMEQKTLTEAIQQPGFATEQPYLARRQNWTNQLARHALMQPDQPALRFLGNTTTWGELD RRVSALAGALHKRGVGFGDRVLILMLNRTEFIEAVLATNKLGAIAVPVNFRMTPAEIAFLVSDCEAKAII TEAVLANVATAVRDIDPTLATVISAGGSGDDVLDYDDVLAENAPCPVVDIPNDAPALIMYTSGTTGRPKG AVLTHTNLTGQVMTLLFTNGADINHDIGFIGVPFFHIAGVGSSVSGLLLGRPTVLYPVGAFDPNELLDVL EAEKVTGIFLVPAQWQAVCAAQKARPRDLKLRFLSWGAAPASDTLLREMAETFPGAQILAAFGQTEMSPV TCMLLGDDAIRKLGSVGKVIPTVSARIVDEDMNDVPVGQVGEIVYRAPTLMAGYWNNPKATAEAFAGGWF HSGDLVRQDEEGYIWVVDRKKDMIISGGENIYCAEVENVLAAHPEIVEVAVIGRAHEKWGEVPVAVAVVR SSLEATPGAGIELADLEQFLTERLARYKHPKALEIVDALPRNPAGKVLKTELRIRYSAASFADAGESSTP PTISTAPQRN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0131 | - | - | 100% (570) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_4008 | - | e-137 | 51.16% (516) | AMP-dependent synthetase and ligase |
| M. vanbaalenii PYR-1 | Mvan_3993 | - | 4e-82 | 36.05% (527) | AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0172 | fadD5 | 0.0 | 74.38% (523) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_0714 | - | 0.0 | 83.51% (564) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv0166 | fadD5 | 0.0 | 74.57% (523) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 1e-46 | 29.90% (515) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4569c | - | 0.0 | 71.59% (535) | fatty-acid-CoA ligase FadD |
| M. marinum M | MMAR_0409 | fadD5 | 0.0 | 72.91% (539) | fatty-acid-CoA ligase FadD5 |
| M. avium 104 | MAV_5018 | - | 0.0 | 78.63% (524) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_0131 | - | 0.0 | 78.44% (538) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2878 | - | 0.0 | 75.79% (541) | PUTATIVE AMP-binding enzyme, putative |
| M. ulcerans Agy99 | MUL_0650 | fadD8 | 2e-60 | 32.20% (528) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_0131|M.vanbaalenii_PYR-1 -------MFDQISSFRNPSMEQKTLTEAIQQPGFATEQPYLARRQNWTNQ
Mflv_0714|M.gilvum_PYR-GCK MTRTTSCLIKCHTSANPSTMERKTLTDPTGLSGSATEQPNLARRRNWANQ
MSMEG_0131|M.smegmatis_MC2_155 ----------------------------MTAEPSQIEQPYLARRQNWVNQ
TH_2878|M.thermoresistible__bu -----------------------------------LQQPYLARRQNWVNH
Mb0172|M.bovis_AF2122/97 -------------------MTAQLASHLTRALTLAQQQPYLARRQNWVNQ
Rv0166|M.tuberculosis_H37Rv -------------------MTAQLASHLTRALTLAQQQPYLARRQNWVNQ
MMAR_0409|M.marinum_M -------------------MTAELASHLPQAA-HALEQPYLARRQNWVNQ
MAV_5018|M.avium_104 --------------------MLSLTAQLAHHPTQANEQPYLSRRQNWVNQ
MAB_4569c|M.abscessus_ATCC_199 ----------------------MTDTIDATVQSAGLAQPYRARRQNWCNQ
MUL_0650|M.ulcerans_Agy99 ------------------------------------MSDDLLRNPTHNGH
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
*.
Mvan_0131|M.vanbaalenii_PYR-1 LARHALMQPDQPALRFLG-NTTTWGELDRRVSALAGALHKRGVGFGDRVL
Mflv_0714|M.gilvum_PYR-GCK LSRHALMQPDTVALRFLG-RSTTWGELDRRVTALAGALHERGVGFGDRVL
MSMEG_0131|M.smegmatis_MC2_155 LTRHAMMQPDKTALRFLG-RTTTWRELDDRVTRLAGALNRRGVGFGDRVL
TH_2878|M.thermoresistible__bu LARHALMQPDATALRFMG-QTTTWADLHHRVNRLAGALRRRGVEFGDRVL
Mb0172|M.bovis_AF2122/97 LERHAMMQPDAPALRFVG-NTMTWADLRRRVAALAGALSGRGVGFGDRVM
Rv0166|M.tuberculosis_H37Rv LERHAMMQPDAPALRFVG-NTMTWADLRRRVAALAGALSGRGVGFGDRVM
MMAR_0409|M.marinum_M LERHAMMQPRATAIRYLG-HTVTWADLRYRVAALAGSLSRRGVGFGDRVM
MAV_5018|M.avium_104 LERHALMQPNATALRFLG-KGLTWGELHGRVRALADALSRRGVGFGDRVM
MAB_4569c|M.abscessus_ATCC_199 LARHALMQPDATAIRYLG-HSISWAELHQRVQALADALSRRGVGFGDRVL
MUL_0650|M.ulcerans_Agy99 LLVGALERHKNRPVLFLGDTTLTGGQLAERISQYIQAFEALGAGTGVTVG
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGGDGIA
* . : . : :* .: *. * :
Mvan_0131|M.vanbaalenii_PYR-1 ILMLNRTEFIEAVLATNKLGAIAVPVNFRMTPAEIAFLVSDCEAKAIITE
Mflv_0714|M.gilvum_PYR-GCK ILMLNRTEFMESVLAVNKLGGIAVPVNFRMTPSEIAFLVSDCAAEVVITE
MSMEG_0131|M.smegmatis_MC2_155 ILMLNRTEFVEAMLAANRLGAIAVPVNFRMTPPEIAYLVSDCEAHVVVTE
TH_2878|M.thermoresistible__bu ILMLNRTEFIETMLAANRLGAIAVPVNFRMTPPEIAFLAKDCEAKVIATE
Mb0172|M.bovis_AF2122/97 ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCAAHVMLTE
Rv0166|M.tuberculosis_H37Rv ILMLNRTEFVESVLAANMIGAIAVPLNFRLTPTEIAVLVEDCVAHVMLTE
MMAR_0409|M.marinum_M ILMLNRTEFVESVLAANMLGAIAVPLNFRLTPSEIAFLVEDCAPRLVITE
MAV_5018|M.avium_104 VLMLNRPEFMESVLAINMLGAIAVPLNFRLTAAEIAFLVQDCQARVVITE
MAB_4569c|M.abscessus_ATCC_199 ILMLNRPEYVESWLAINELGAIAIPVNFRMTPPEVAFLVENSGAKVAITE
MUL_0650|M.ulcerans_Agy99 LLSLNRPEVLMILGASQARGYRRTALHPLGSLDDHAYVLYDAGASALIID
MLBr_02546|M.leprae_Br4923 ILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVSEREGAKVIIYD
:* *: : . * :: : : : . :
Mvan_0131|M.vanbaalenii_PYR-1 A--VLANVATAVRDIDPTLATVISAG---GSG-DDVLDYDDVLAENA-PC
Mflv_0714|M.gilvum_PYR-GCK S--VLENVATAVRDIDPKLATVIVAG---GTSRDNVLDYDDVLASTT-AA
MSMEG_0131|M.smegmatis_MC2_155 P--VLAGVATAVRDLDATLQTVIVAGGATEDG---VLGYDDLIAEEG-EP
TH_2878|M.thermoresistible__bu P--VLAGVATAVRDLAPSLSSVIVAGAADGSDTPDVLDYEALIAEPG-ED
Mb0172|M.bovis_AF2122/97 A--ALAPVAIGVRNIQPLLSVIVVAG---GSSQDSVFGYEDLLNEAG-DV
Rv0166|M.tuberculosis_H37Rv A--ALAPVAIGVRNIQPLLSVIVVAG---GSSQDSVFGYEDLLNEAG-DV
MMAR_0409|M.marinum_M E--VLAQVAVGVREIAPALSTIVVAG---GASDPTVVGYDELISETG-DP
MAV_5018|M.avium_104 A--VLAPVATGVRDIESLLDTVVVAG---GSSDDAVLGYDDLIDETG-AA
MAB_4569c|M.abscessus_ATCC_199 T--VLAPVAAAVRQQAPALETVIVAG---SASENGVLGYEEVIAEPG-EP
MUL_0650|M.ulcerans_Agy99 PNPMFVERALGLLEKVDSLEQVLTIGPVPEALEDRAVDLSAEAAKYQPKP
MLBr_02546|M.leprae_Br4923 D-----EYTKVVSKAEPALGKLRALGVNPDEEEPPGSTDETLAELIARSS
: : . * : * .
Mvan_0131|M.vanbaalenii_PYR-1 P-VVDIPNDAPALIMYTSGTTGRPKGAVLTHTNLTGQVMTLLFTNGADIN
Mflv_0714|M.gilvum_PYR-GCK PPLVDIPDDSPALIMYTSGTTGRPKGAVLTHNNLAGQAMTLLFTNGADIN
MSMEG_0131|M.smegmatis_MC2_155 PAPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLSAQAMMHLFTTGADLN
TH_2878|M.thermoresistible__bu PPPVDIPDDSPALIMYTSGTTGNPKGAVLTHSNLTGQAMTNLFTIGVDLA
Mb0172|M.bovis_AF2122/97 HEPVDIPNDSPALIMYTAGTTGRPKGAVLTHANLTGQAMTALYTSGANIN
Rv0166|M.tuberculosis_H37Rv HEPVDIPNDSPALIMYTSGTTGRPKGAVLTHANLTGQAMTALYTSGANIN
MMAR_0409|M.marinum_M PEPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLTGQVMTALYTGGANIN
MAV_5018|M.avium_104 HQPVDIPNDAAALIMYTSGTTGRPKGAVLTHTNLTGQTMTGLYTNGADIN
MAB_4569c|M.abscessus_ATCC_199 HAEVDLPGDTPALIMYTSGTTGRPKGAVLTHLNLSGQAMTYLLSTTVDLN
MUL_0650|M.ulcerans_Agy99 LVVADLPPNHIGGLTYTGGTTGKPKGVIGTAGNIT--AMTSIQLAEWEWP
MLBr_02546|M.leprae_Br4923 SAPAPKVRKRASIIILTSGTTGTPKGANR-NTPASLAPLGGILSKVPFRA
. . . : *.**** ***. : : :
Mvan_0131|M.vanbaalenii_PYR-1 HDIGFIGVPFFHIAGVG-SSVSGLLLGRPTVLYPVGAFDPNELLDVLEAE
Mflv_0714|M.gilvum_PYR-GCK HDIGFIGVPFFHIAGVG-SIVSGMMLGRPTVIYPLGAFDPNELLDVLEAE
MSMEG_0131|M.smegmatis_MC2_155 SDVGFVGVPLFHIAGVAGSVLSGVTLGVPTVLYPLGAFDPDGLLDVLESE
TH_2878|M.thermoresistible__bu NDVGFIGVPLFHIAGIAGNVLSGLTLGLPTVLYPLGAFDPGGLLDVLEAE
Mb0172|M.bovis_AF2122/97 SDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAE
Rv0166|M.tuberculosis_H37Rv SDVGFVGVPLFHIAGIG-NMLTGLLLGLPTVIYPLGAFDPGQLLDVLEAE
MMAR_0409|M.marinum_M SDVGFIGVPFFHIAGIG-NMLSGMLLGVPTVIYPLGAFNPGQLLDVLEAE
MAV_5018|M.avium_104 NDVGFIGVPFFHIAGIG-NMLTGLLLGIPTVIYPLGAFEPGQLLDVLAAE
MAB_4569c|M.abscessus_ATCC_199 SDVGFIGVPMFHIAGVG-NMITGLLLGLPTVIHPLGAFDPGALLDVLESE
MUL_0650|M.ulcerans_Agy99 EHPRFLMCTPLSHAGAAFFTPTLVKGGE---MIVLAKFDPGEVLRVIEEQ
MLBr_02546|M.leprae_Br4923 HEVTLLPAPMFHALGYLHATLAMFLGST---LVLRRRFKPATVLEDIEKH
. :: . : * : . . : *.* :* : .
Mvan_0131|M.vanbaalenii_PYR-1 KVTGIFLVPAQWQAVCAAQK--ARPRDLK-LRFLSWGAAPASDTLLREMA
Mflv_0714|M.gilvum_PYR-GCK KVTGIFLVPAQWQAVCAAQK--ANPRNLK-LRFLSWGAAPASDTLLRQMS
MSMEG_0131|M.smegmatis_MC2_155 QVTGIFLVPAQWQAVCAAQR--ARPRNLK-LRALSWGAAPASDTLLREMN
TH_2878|M.thermoresistible__bu KVTGIFLVPAQWQAVCAEQR--ARPRDLR-LRALSWGAAPASDTLLQEMT
Mb0172|M.bovis_AF2122/97 KVTGIFLVPAQWQAVCTEQQ--ARPRDLR-LRVLSWGAAPAPDALLRQMS
Rv0166|M.tuberculosis_H37Rv KVTGIFLVPAQWQAVCTEQQ--ARPRDLR-LRVLSWGAAPAPDALLRQMS
MMAR_0409|M.marinum_M RVSGIFLVPAQWQAVCAEQQ--ARPRELS-LRVMSWGAAPAPDALLRQMS
MAV_5018|M.avium_104 KVTGIFLVPAQWQAVCAEQR--ARPRDLK-LRVISWGAAPAPDALLREMS
MAB_4569c|M.abscessus_ATCC_199 GVTGIFLVPAQWQAVCAAQQ--ANPRKVR-LKTLSWGAAPATDVLLRTMS
MUL_0650|M.ulcerans_Agy99 RITATMLVPSMLYALMDHPD--PHTRDLSSLETVYYGASAINPVRLAEAI
MLBr_02546|M.leprae_Br4923 QATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGSQLGAELATRAL
:. .:** : .: *. : ..:
Mvan_0131|M.vanbaalenii_PYR-1 ETFPGAQILAAFGQTEMSPVTCMLLGDDAIRKLGSVGKVIPTVSARIVDE
Mflv_0714|M.gilvum_PYR-GCK ETFPGAQILAAFGQTEMSPVTCMLLGDDALRKLGSVGKVIPTVSARIVDE
MSMEG_0131|M.smegmatis_MC2_155 EVFPDAQIFAAFGQTEMSPVTCMLLGDDAIRKLGSVGRVIPTVSARVVDD
TH_2878|M.thermoresistible__bu EVFPGTKIFAAFGQTEMSPVTCMLLAEDAVRKLGSVGKVIPTVAARIVDD
Mb0172|M.bovis_AF2122/97 ATFPETQILAAFGQTEMSPVTCMLLGEDAIAKRGSVGRVIPTVAARVVDQ
Rv0166|M.tuberculosis_H37Rv ATFPETQILAAFGQTEMSPVTCMLLGEDAIAKRGSVGRVIPTVAARVVDQ
MMAR_0409|M.marinum_M EVFPGTQIMAAFGQTEMSPVTCMLLGEDAIRKRGSVGKVIPTVSARVVDD
MAV_5018|M.avium_104 AMFPGTQILAAFGQTEMSPVTCMLLGEDAIRKRGSVGKVIPTVAARVVDE
MAB_4569c|M.abscessus_ATCC_199 ETFPDARILAAFGQTEMSPVTCMLMGDDAIRKMGSVGRVIPTVSARVVDD
MUL_0650|M.ulcerans_Agy99 DRFGPIFAQYYGQSEAPMVITYLPKADHDEKRLTSCGRPTLFARVALLGE
MLBr_02546|M.leprae_Br4923 EELG-PVIYNMYGSTEIAFATIAGPKDLQINS-ATVGPVVKGVKVKILDD
: . * : : * . . ::.:
Mvan_0131|M.vanbaalenii_PYR-1 DMNDVPVGQVGEIVYRAPTLMAGYWNNPKATAEAFAGGWFHSGDLVRQDE
Mflv_0714|M.gilvum_PYR-GCK DMNDVPIGQVGEIVYRAPTLMTGYWNNPTATAEAFAGGWFHSGDLVRQDE
MSMEG_0131|M.smegmatis_MC2_155 NMNDVPVGEVGEIVYRGPNLMVGYWNNPKATAEAFAGGWFHSGDLVRQDE
TH_2878|M.thermoresistible__bu TMNDVPVGEVGEIVYRAPTLMAGYWNNPQATAEAFAGGWFHSGDLVRQDE
Mb0172|M.bovis_AF2122/97 NMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGGWFHSGDLVRMDS
Rv0166|M.tuberculosis_H37Rv NMNDVPVGEVGEIVYRAPTLMSCYWNNPEATAEAFAGGWFHSGDLVRMDS
MMAR_0409|M.marinum_M EMNDVPIGQVGEIVYRAPTLMSGYWNNPDATAEAFAGGWFHSGDLVRMDE
MAV_5018|M.avium_104 NMNDVPVGEVGEIVYRAPTLMSGYWNNPEATAEAFAGGWFHSGDLVRMDE
MAB_4569c|M.abscessus_ATCC_199 NMNDVPVGEVGEIVYRAPTLMQGYWNNPEATADAFAGGWFHSGDLVRQDE
MUL_0650|M.ulcerans_Agy99 DGKPVPQGEPGEICVSGPLLAGGYWNKPDDTAQTFRDGWLHTGDMAREDE
MLBr_02546|M.leprae_Br4923 SGKEVPRGQVGRIFVGNAFPFEGYTG---GGGKQIIDGLLSSGDVGYFDE
: ** *: *.* . * . .. : .* : :**: *.
Mvan_0131|M.vanbaalenii_PYR-1 EGYIWVVDRKKDMIISGGENIYCAEVENVLAAHPEIVEVAVIGRAHEKWG
Mflv_0714|M.gilvum_PYR-GCK EGYIWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRSHRKWG
MSMEG_0131|M.smegmatis_MC2_155 EGYVWVVDRKKDMIISGGENIYCAEVENVLAAHPAIMEVAVIGRPHEKWG
TH_2878|M.thermoresistible__bu EGYIWVVDRKKDMIISGGENIYCAEVENVLAAHPAVAEVAVVGRPHEKWG
Mb0172|M.bovis_AF2122/97 DGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEKWG
Rv0166|M.tuberculosis_H37Rv DGYVWVVDRKKDMIISGGENIYCAELENVLASHPDIAEVAVIGRADEKWG
MMAR_0409|M.marinum_M DGYVWVVDRKKDMIISGGENVYCAEVENVLASHPSIVEVAVIGRADEKWG
MAV_5018|M.avium_104 DGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRAHEKWG
MAB_4569c|M.abscessus_ATCC_199 DGFVWVVDRKKDMIISGGENIYCAEVENALAEHEQIAEVAVIGRPHEKWG
MUL_0650|M.ulcerans_Agy99 DGFYFIVDRVKDMIVTGGFNVFPREVEDVVAEHSAVAQVCVVGAPDEKWG
MLBr_02546|M.leprae_Br4923 HDLLYISGRDDEMIVSGGENVFPAEVEDLISGHPEVVEATAIGVDDKEWG
.. :: .* .:**::** *:: *:*: :: * : :. .:* ..:**
Mvan_0131|M.vanbaalenii_PYR-1 EVPVAVAVVRSSLE-ATPGAGIELADLEQFLTERLARYKHPKALEIVDAL
Mflv_0714|M.gilvum_PYR-GCK EVPVAVAVLRSSLN-STGSGRLELTDLEQFLGDRLARYKHPKAIEIVEAL
MSMEG_0131|M.smegmatis_MC2_155 EVPVAVVALNS-----ATAESISLGELDSFLTERLARYKHPKALEVVDAL
TH_2878|M.thermoresistible__bu EVPVAVVALN-------PDAELTMAELEEFLADRLARYKHPKVLEIVDAL
Mb0172|M.bovis_AF2122/97 EVPIAVAAVTN--------DDLRIEDLGEFLTDRLARYKHPKALEIVDAL
Rv0166|M.tuberculosis_H37Rv EVPIAVAAVTN--------DDLRIEDLGEFLTDRLARYKHPKALEIVDAL
MMAR_0409|M.marinum_M EVPIAVAAVTK--------DHLRIEDLDEYLTERLARYKHPKALEIVDAL
MAV_5018|M.avium_104 EVPIAVAAVAN--------DNLALEDLDEFLTERLARYKHPKALEIVDAL
MAB_4569c|M.abscessus_ATCC_199 EVPVAVAAIHG--------AALTLAELDGFLTARLARYKHPKDLVIVDAL
MUL_0650|M.ulcerans_Agy99 EAVTAVVVLRADAARDDAAIETMTAEIQAAVKQRKGSVQSPKQVVVVDSL
MLBr_02546|M.leprae_Br4923 ARLRAFVVKKQ-------DATIDEDAIKAYVRDHLARYKVPREVIFLEEL
*... : : : . : *: : .:: *
Mvan_0131|M.vanbaalenii_PYR-1 PRNPAGKVLKTELRIRYSAASFADAGESSTPPTISTAPQRN-
Mflv_0714|M.gilvum_PYR-GCK PRNPAGKVLKTELRVRFGSEESVDAGESATAATSSAAAPKD-
MSMEG_0131|M.smegmatis_MC2_155 PRNPSGKVLKTELRERFGRATSLDGGESNSATTVSAG-----
TH_2878|M.thermoresistible__bu PRNPAGKVLKTELRARFAAGPSAEKEQSSSGATTSAGSS---
Mb0172|M.bovis_AF2122/97 PRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
Rv0166|M.tuberculosis_H37Rv PRNPAGKVLKTELRLRYGACVNVERRSASAGFTERRENRQKL
MMAR_0409|M.marinum_M PRNPSGKVLKTELRLRYGVGVYSESRSVSRSFEFREGS----
MAV_5018|M.avium_104 PRNPAGKVLKTELRIRYGGG----------------------
MAB_4569c|M.abscessus_ATCC_199 PRNPSGKVLKTELRQRFGIAD---------------------
MUL_0650|M.ulcerans_Agy99 PLTGLGKPDKKAVRARFWEGAGRAVG----------------
MLBr_02546|M.leprae_Br4923 PRNPTGKVLKRELRDFEVH-----------------------
* . ** * :*