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TFRSPLPDVSIPDCSVYEYVFGDTGAEDSRIALIDGLTGAQTTLGELRSQIDATAAGLAERGFGIGDVAA VFLPNCSAFAVVLHGILRAGGTASTVNVLYTAEELAKQLIDSKAQLIFTVSPLLSRALEAAEIAGIDAAG VITVDPVEGRLSLADIARPDLAPPQVTFDPATHLAVLPYSSGTTGKAKGVMLTHHNLVANIAQAKHLYGV QRGDRVLAVLPFFHIYGLVVLLNVQLKLGAELVILPRFELDTFLGSIANYRVDHVFVAPPVAVVLAKHPD VDKYDVSCLRSVFSGAAPLDEQLGNAVAARLNCRVSQGYGMTELSPVSHLIPPDRPDIPLNSVGIPVPNS ENKIIDTETGDEIEIPAEGESAPGELLVRGPNVMAGYLGNEEATAATIEPDGFLHTGDIAVVRADGVVTI VDRLKELIKYKGYQVPPAELEALLLTHPGIGDAAVIGVPDPSSGEIPKAFVVRTDDDLTDEAVMAFVEQK VAPHKRIRQVEFIDAIPKSAAGKILRKDLRARI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4055c | - | - | 100% (524) | putative acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4377c | - | 2e-54 | 31.35% (504) | AMP-binding domain protein |
| M. abscessus ATCC 19977 | MAB_4559 | - | 6e-54 | 31.66% (499) | putative long-chain-fatty-acid CoA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3591 | fadD3 | 2e-55 | 32.80% (500) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4250 | - | 1e-170 | 58.52% (540) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3561 | fadD3 | 9e-56 | 32.80% (500) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01051 | xclC | 6e-42 | 30.17% (474) | acyl-CoA synthetase |
| M. marinum M | MMAR_1606 | - | 2e-66 | 36.08% (474) | fatty-acid-CoA ligase |
| M. avium 104 | MAV_0863 | - | 1e-58 | 35.15% (478) | AMP-binding enzyme, putative |
| M. smegmatis MC2 155 | MSMEG_2360 | - | 1e-176 | 61.65% (532) | 4-coumarate:CoA ligase |
| M. thermoresistible (build 8) | TH_2068 | fadD3 | 3e-60 | 32.29% (511) | PROBABLE FATTY-ACID-CoA LIGASE FADD3 (FATTY-ACID-CoA |
| M. ulcerans Agy99 | MUL_4126 | fadD3 | 1e-53 | 31.00% (500) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_2110 | - | 1e-171 | 59.52% (546) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3591|M.bovis_AF2122/97 MINDLRTVPAALDRLVRQLPDHTALIAED-----------------RRFT
Rv3561|M.tuberculosis_H37Rv MINDLRTVPAALDRLVRQLPDHTALIAED-----------------RRFT
MUL_4126|M.ulcerans_Agy99 MTSDPRTVPTALDRLVRRLPNHDALVTDE-----------------RSFT
TH_2068|M.thermoresistible__bu ----MRTIPAVLDRAAERLPDHDALVTAATG-----------GAEARRFS
Mflv_4250|M.gilvum_PYR-GCK --MTFSSPFPEVDIPTASVYDYLFSGLSDPDDPVLDRVALIDAKSGRQTT
Mvan_2110|M.vanbaalenii_PYR-1 --MTFLSPFPEVDIPTASVYDYLFSGLAGPEDSVLDRVALIDAKSGRQTT
MSMEG_2360|M.smegmatis_MC2_155 --MSFASPFPDVTIPPVSVHDFLFAGLDDAD---AGRVALVDSRTGAETT
MAB_4055c|M.abscessus_ATCC_199 --MTFRSPLPDVSIPDCSVYEYVFGDTGAED----SRIALIDGLTGAQTT
MAV_0863|M.avium_104 -----------MTEPAALVFE------------------------ERRFS
MMAR_1606|M.marinum_M MTSLAGNLIEGARRHPN---------------------RIALRLDEIEIP
MLBr_01051|M.leprae_Br4923 --MLLASLNPSVVTATDIAD-------------------------AVCVD
Mb3591|M.bovis_AF2122/97 STELRDAVYGAAAALIALGVEPADRVAIWSPNTWHWVVACLAIHHAGAAV
Rv3561|M.tuberculosis_H37Rv STELRDAVYGAAAALIALGVEPADRVAIWSPNTWHWVVACLAIHHAGAAV
MUL_4126|M.ulcerans_Agy99 VSELNDEVYRAAAALIELGVKPAARVGIWSPNTWHWVVACLAIHHVGAAM
TH_2068|M.thermoresistible__bu YAELRAEVRRAAAAMIAAGIAPGDRVALWAPNTWHWVVACLATHYAGAVM
Mflv_4250|M.gilvum_PYR-GCK YREMVARIDSFAGALAARGVGVGDVVGLLAPNSSAFAVAFHGILRAGATA
Mvan_2110|M.vanbaalenii_PYR-1 YREMVARIDSFAGALAARGIGVGDVVALLAPNSSVFAVAFHGILRAGATA
MSMEG_2360|M.smegmatis_MC2_155 YGELIGRIEEFAGALAARGIGVGDVVALLSPNSSAFAVAFHGILRAGATA
MAB_4055c|M.abscessus_ATCC_199 LGELRSQIDATAAGLAERGFGIGDVAAVFLPNCSAFAVVLHGILRAGGTA
MAV_0863|M.avium_104 VPELDALADGWAAALAKDGVTAGRRVAVMTSNRPEFLAVLLAIWRLAATA
MMAR_1606|M.marinum_M YGALDAASARLAGLLIQRGLRPGDRVGVMLPNVPYFAVAYYGVLRAGGVV
MLBr_01051|M.leprae_Br4923 GVVLSRSGLVGAATSVAERVGGARLVAVLATPTASTVLAITGCLIAGVPV
: *. . . ..: . . . .
Mb3591|M.bovis_AF2122/97 VPLNTRYTATEATDILDRAGAPVLFAAGLFLGADRAAGLDRAALPALRHV
Rv3561|M.tuberculosis_H37Rv VPLNTRYTATEATDILDRAGAPVLFAAGLFLGADRAAGLDRAALPALRHV
MUL_4126|M.ulcerans_Agy99 VPLNTRYTADEAADILARTEAPVLFAMGHFLGSDRVAGLDRKALPALRHI
TH_2068|M.thermoresistible__bu VPLNTRYTASEAADVLARTGAPLLVAAGEFLGADKTADLDRDALPALRRI
Mflv_4250|M.gilvum_PYR-GCK TTINALFTAKDIAKQLTDSRARTLITVTPLLAQAREG--AALAGLSDEDV
Mvan_2110|M.vanbaalenii_PYR-1 TTVNALFTAKDIAKQLTDSKATMLVTVAALLPQAKAG--AAAAGLSDEDV
MSMEG_2360|M.smegmatis_MC2_155 TTVNALFTARDIAKQLTDSKAKLLLTVNALAPQSREA--AAAVGLTDDAV
MAB_4055c|M.abscessus_ATCC_199 STVNVLYTAEELAKQLIDSKAQLIFTVSPLLSRALEA--AEIAGIDAAGV
MAV_0863|M.avium_104 VLISPAWKRDEVEHALALTDPGHAVGDHPVLAGLMPM--LHLD-------
MMAR_1606|M.marinum_M VPMNVLLKERETSFYLTDSEAKAIIAWHEFAPAAQAG--ADEAGAECILV
MLBr_01051|M.leprae_Br4923 VPVPADIGVVERRHMLTDSGAQAWLGPGPSADSAPDG-------------
: : * : . .
Mb3591|M.bovis_AF2122/97 VRVPVEADDGTWDEFIATGAG---ALDAVAARAAAVAPQDVSDILFTSGT
Rv3561|M.tuberculosis_H37Rv VRVPVEADDGTWDEFIATGAG---ALDAVAARAAAVAPQDVSDILFTSGT
MUL_4126|M.ulcerans_Agy99 VRIPIEEPDGTWDEFIETGT----DTGAVTARAAAVSPDDVSDILFTSGT
TH_2068|M.thermoresistible__bu VRIPVDKPDGTWDEFIAGGSMSGAALAEVDARAAAVRPDDVSDILFTSGT
Mflv_4250|M.gilvum_PYR-GCK IVLDGPGRDGSGDGAGHPNAADILAPGTPAPQVNFAPSSHLAVLPYSSGT
Mvan_2110|M.vanbaalenii_PYR-1 VVLDGAGRDGSGEGAGHPNAADLLAAGTPAPQVDFAPSSHLAVLPYSSGT
MSMEG_2360|M.smegmatis_MC2_155 VLLDG----------------ESLPTGHAAPQVTFDPATHLAVLPYSSGT
MAB_4055c|M.abscessus_ATCC_199 ITVDP--------VEGRLSLADIARPDLAPPQVTFDPATHLAVLPYSSGT
MAV_0863|M.avium_104 -----------------------EPVPPAQPTAGAPPRAGDAVLVFSSGT
MMAR_1606|M.marinum_M KPGE---------------FEELIQAAEPLEEAAVREDDDTAVILYTSGT
MLBr_01051|M.leprae_Br4923 -----------------LPHIPVQLDARSWNRYPEPSPDATAMVIYTSGT
: : ::***
Mb3591|M.bovis_AF2122/97 TGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFGYKAGIL
Rv3561|M.tuberculosis_H37Rv TGRSKGVLCAHRQSLSASASWAANGKITSDDRYLCINPFFHNFGYKAGIL
MUL_4126|M.ulcerans_Agy99 TGRSKGVLCAHRQSLSASASWAANGKITADDRHLCINPFFHNFGYKAGIL
TH_2068|M.thermoresistible__bu TGRSKGALCAHRQSLDASAAWAECGRLSSDDRYLCINPFFHNFGYKAGIL
Mflv_4250|M.gilvum_PYR-GCK TGNPKGVMLTHRNLVANVAQIRPLHGMEPDDVVLAVLPFFHIYGMTVLLN
Mvan_2110|M.vanbaalenii_PYR-1 TGNPKGVMLTHRNLVANVAQIRPLHGMVADDVVLAVLPFFHIYGMTVLLN
MSMEG_2360|M.smegmatis_MC2_155 TANPKGVMLTHRNLVANVAQIRPLQGMRRDDRLLAVLPFFHIYGMTVLLN
MAB_4055c|M.abscessus_ATCC_199 TGKAKGVMLTHHNLVANIAQAKHLYGVQRGDRVLAVLPFFHIYGLVVLLN
MAV_0863|M.avium_104 TGLPKAVRHTHASLDEAVRHWREALRLTRRDRIQVATPPSHILGLLNLL-
MMAR_1606|M.marinum_M TGKPKGAELTHANLRRNVEVIVQMLQVGPDDVILGALPLFHAFGQTAGLN
MLBr_01051|M.leprae_Br4923 TGPPKGVLLSRRAIAVDLDALAQAWQWTADDVLVHGLPLFHVHGLVLGLL
*. .*.. :: * * * * :
Mb3591|M.bovis_AF2122/97 ACLQTGATLIPHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHPARKD
Rv3561|M.tuberculosis_H37Rv ACLQTGATLIPHVTFDPLHALRAIERHRITVLPGPPTIYQSLLDHPARKD
MUL_4126|M.ulcerans_Agy99 ACLQTGATLFPHLTFDPLRTLQAIERHRITVLPGPPTIYQTLLDHPARDD
TH_2068|M.thermoresistible__bu ACIQTGATLYPQLTFDPEQAMRAVAEHRITVLPGPPTIYQTILDHPKRGE
Mflv_4250|M.gilvum_PYR-GCK AALHARARLVIMPSFDLGDFLGNIAEHRCTIAFIAPPVAVALAKHPLVDD
Mvan_2110|M.vanbaalenii_PYR-1 AALHARARLVIMPSFDLGEFLGNIAEHRCTIAFIAPPVAVALAKHPLVDE
MSMEG_2360|M.smegmatis_MC2_155 AALHARAQLVVMPSFDLAEFLGNIAERRCTYAYIAPPVAVALAKHPMVDS
MAB_4055c|M.abscessus_ATCC_199 VQLKLGAELVILPRFELDTFLGSIANYRVDHVFVAPPVAVVLAKHPDVDK
MAV_0863|M.avium_104 TALKTGACVRLHPRFDIDKVLHHIESDRVTVEMAVAPIALAIASHPDLES
MMAR_1606|M.marinum_M AAVAAGACLTLIPRFSPEKALQIIERDRVTVFEGVPTMFAAMLHS--TER
MLBr_01051|M.leprae_Br4923 GSLRIGNRFVHTGKPTPTAYAQACSEAGGSLYFGVPTVWSRLVADEAVAR
: . ..: :
Mb3591|M.bovis_AF2122/97 FDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCR
Rv3561|M.tuberculosis_H37Rv FDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCR
MUL_4126|M.ulcerans_Agy99 YDLSSLRFAVTGAATVPVVLVERMQSELDIDIVLTAYGLTEANGMGTMCR
TH_2068|M.thermoresistible__bu YDLSSLRFAVTGAAVVPVVLIERMQSELDIDIVLTAYGLTEASGFGTMCR
Mflv_4250|M.gilvum_PYR-GCK HDLSSLQVVMSGAAPLDADLGHAVAKRLDC-KVVQGYGMSELSPVSHITP
Mvan_2110|M.vanbaalenii_PYR-1 HDLSSLNVVMSGAAPLDADLGHAVAKRLGC-KVVQGYGMSELSPVSHITP
MSMEG_2360|M.smegmatis_MC2_155 YDLSALEGIMSGAASLDAELGLAVARRLDC-RVVQGYGMSELSPVSHVTP
MAB_4055c|M.abscessus_ATCC_199 YDVSCLRSVFSGAAPLDEQLGNAVAARLNC-RVSQGYGMTELSPVSHLIP
MAV_0863|M.avium_104 YDLSSLRYIVWGATPVNAEVAQTVTRRTGV-GWLPAYGTTELPVIACN--
MMAR_1606|M.marinum_M PDTGSLRLCVSGGAAMPVEVMRGFEQAFGT-MVLEGYGLSETSPTASFNH
MLBr_01051|M.leprae_Br4923 A-LRPARLLVSGSASLPVPVFDRLAHLTGH-RPIERYGSTESLITLSTLA
. . *.: : : . . ** :*
Mb3591|M.bovis_AF2122/97 PE-----DDAVTVATTCGRPFADFELRIADD----------------GEV
Rv3561|M.tuberculosis_H37Rv PE-----DDAVTVATTCGRPFADFELRIADD----------------GEV
MUL_4126|M.ulcerans_Agy99 AD-----DDALTVATTCGRPFADFELRIGPDT---------------GEV
TH_2068|M.thermoresistible__bu PE-----DDAVTVATTCGRPIAGFELRIDNPAEDG-----------TGEV
Mflv_4250|M.gilvum_PYR-GCK FDGGRLNMHDDAPLASVGWTVSNAASKLVDPETGAEIEIPDEGLSKTGEL
Mvan_2110|M.vanbaalenii_PYR-1 FDGGLVDMHEDAPLSSVGWTVSNAASKLVDPETGDEIPIPEEGLSKTGEL
MSMEG_2360|M.smegmatis_MC2_155 KDGGLSTVGTVAPLDSCGWTVPNSESKIVDPETGAEIEVPAEGLSETGEL
MAB_4055c|M.abscessus_ATCC_199 PD------RPDIPLNSVGIPVPNSENKIIDTETGDEIEIPAEGESAPGEL
MAV_0863|M.avium_104 -------PIEDARLDTVGRPVPGVEVRVVSLESG-----EPAGAGEVGEI
MMAR_1606|M.marinum_M PD-------RERKPGSIGTPIAGVQMKLLEVDTHG-----------IGEI
MLBr_01051|M.leprae_Br4923 DG--------ERRAGWVGLPLAGVQTRLVDESGGP----VPYDGETVGRL
* .... :: *.:
Mb3591|M.bovis_AF2122/97 LLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLRINDR-LK
Rv3561|M.tuberculosis_H37Rv LLRGPNVMVGYLDDTEATAAAIDADGWLHTGDIGAVDQAGNLRITDR-LK
MUL_4126|M.ulcerans_Agy99 LLRGPNVMLGYLDDPRATAAAIDADGWLHTGDIGVLDEAGNLRITDR-LK
TH_2068|M.thermoresistible__bu LLRGPNVMLGYLDDPEATAAAIDADGWLHTGDVGKVDERGNLTITDR-LK
Mflv_4250|M.gilvum_PYR-GCK WFKGPNVMAGYLNNEEATKETIDEDGWLHTGDLAQIDDRGLVYIVDR-LK
Mvan_2110|M.vanbaalenii_PYR-1 WFKGPNVMAGYLNNDEATRSTIDEDGWLHTGDLAQVDARGLVYIVDR-LK
MSMEG_2360|M.smegmatis_MC2_155 WFKGPNVMAGYLNNERATRETIDDDGFLHTGDLARVDATGCVYIVDR-LK
MAB_4055c|M.abscessus_ATCC_199 LVRGPNVMAGYLGNEEATAATIEPDGFLHTGDIAVVRADGVVTIVDR-LK
MAV_0863|M.avium_104 QARSASLMAGYLPG-EATGEAIR-DGWYRTGDAGWLDTGGWLRITDR-LK
MMAR_1606|M.marinum_M AIRGHNVMKGYWNRPDATAAAIDAEGWFRTGDLARIDEDGYYFIVDR-SK
MLBr_01051|M.leprae_Br4923 QVRSPTMFGGYLNRPEATAEAFDEDGWYRTGDVAVVDSGGMHRIVGRESV
:. .:: ** ** :: :*: :*** . : * * .*
Mb3591|M.bovis_AF2122/97 DMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVVARP
Rv3561|M.tuberculosis_H37Rv DMYICGGFNVYPAEVEQVLARMDGVADAAVIGVPDQRLGEVGRAFVVARP
MUL_4126|M.ulcerans_Agy99 DMYICGGFNVYPAEVEQVLARLDGVADVAVIGIPDHRLGEVGRAFIVARP
TH_2068|M.thermoresistible__bu DMYICGGFNVYPAEVEQVLARLDGVAEAAVIGVPDQRLGEVGKAFVVRRP
Mflv_4250|M.gilvum_PYR-GCK ELIKYKGYQVPPAELEAVLLSHPDIADAAVVGVRD-EEGEEVPKAFVVTQ
Mvan_2110|M.vanbaalenii_PYR-1 ELIKYKGYQVPPAELEALLLSHPGIADAAVVGVHD-EEGEEVPKAFVVRQ
MSMEG_2360|M.smegmatis_MC2_155 ELIKYKGYQVPPAELEALLLTHPGIADAAVIGVQDPESGEEVPKAFVVRQ
MAB_4055c|M.abscessus_ATCC_199 ELIKYKGYQVPPAELEALLLTHPGIGDAAVIGVPDPSSGE-IPKAFVVRT
MAV_0863|M.avium_104 EMIKVRGFQVAPAEIDAVLQGHPAVADCAVFGVPDGLNGEAVVAAVAVSA
MMAR_1606|M.marinum_M DMIIRGGYNVYPREIEEVLYEHPEVREAAVVAVPDDMLGEEVGAAIALIP
MLBr_01051|M.leprae_Br4923 DLIKLGGYRIGAGEIEMALLGHPDVREVAVVGLPDEDLGQRIVAFVVGAE
:: *:.: . *:: * : : **..: * *: ..
Mb3591|M.bovis_AF2122/97 GTG-------LDEASVIAYTREHLANFKTPRSVRFVDVLPRNAAGKVSKP
Rv3561|M.tuberculosis_H37Rv GTG-------LDEASVIAYTREHLANFKTPRSVRFVDVLPRNAAGKVSKP
MUL_4126|M.ulcerans_Agy99 GFN-------LDEKSVIDYTREHLANFKAPRSVRFVDTLPRNAGGKVVKP
TH_2068|M.thermoresistible__bu GAT-------LDEQAVIAYCKQHLANFKVPRSVEFLDALPRNPGGKVVKP
Mflv_4250|M.gilvum_PYR-GCK AN------SELTETDVIEFVAGQVAPYKKVRKVEFIDAIPKSASGKILRK
Mvan_2110|M.vanbaalenii_PYR-1 ASTDADGGAALTEADVIEFVAGQVAPYKKVRQVEFIDAIPKSASGKILRK
MSMEG_2360|M.smegmatis_MC2_155 PG------IDLGADEVMAFVAGQVAPYKKVRQVEFIEAVPKSAAGKILRK
MAB_4055c|M.abscessus_ATCC_199 DD-------DLTDEAVMAFVEQKVAPHKRIRQVEFIDAIPKSAAGKILRK
MAV_0863|M.avium_104 PV---------DVTELTALVRQKLASYKHLSRVVVVPEIPRLPSGKVLRR
MMAR_1606|M.marinum_M GATS-------DAAALSDFVKERVAAYKYPRRIWFVDELPKGPTGKILKR
MLBr_01051|M.leprae_Br4923 ALD---------ADELINYVAQQLSIHKRPREVRFVDALPRNAMGKVLKK
: ::: .* : .: :*: . **: :
Mb3591|M.bovis_AF2122/97 QLRELG------
Rv3561|M.tuberculosis_H37Rv QLRELG------
MUL_4126|M.ulcerans_Agy99 QLRELA------
TH_2068|M.thermoresistible__bu LLRERA------
Mflv_4250|M.gilvum_PYR-GCK DLRTG-------
Mvan_2110|M.vanbaalenii_PYR-1 DLRNGG------
MSMEG_2360|M.smegmatis_MC2_155 ELRTR-------
MAB_4055c|M.abscessus_ATCC_199 DLRARI------
MAV_0863|M.avium_104 VLKERHGCTSDS
MMAR_1606|M.marinum_M DITVPQASPAQQ
MLBr_01051|M.leprae_Br4923 QLLFEG------
: