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SLSPLVAPEAPVGRADEIVQRITEAIHLGLLDDGERLPVEVDLAAQFGVAPMTVREALATLRELELVETR RGRSGGSFVRRPAGPPVEKLTARLAAMSASDLRDLFDEHTAIAGQAARLAAERAAPSTVRRLFALTDQLD TATSLRDRIRADSRFHIQVAVAAQSARLARREANLQAEVSGLIWLPIGPPIDVAAYVEEKHAISAAIAAE NAQEARQLAEAHVMGQLARLTQINLDLTTKEAGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6700 | - | - | 100% (245) | regulatory protein |
| M. smegmatis MC2 155 | MSMEG_1117 | - | 2e-26 | 38.39% (211) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_2682 | - | 6e-20 | 35.19% (216) | transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0505 | - | 4e-12 | 27.15% (221) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_4061 | - | 2e-19 | 32.89% (228) | regulatory protein GntR, HTH |
| M. tuberculosis H37Rv | Rv0494 | - | 4e-12 | 27.15% (221) | GntR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4571 | - | 1e-09 | 31.61% (155) | GntR family transcriptional regulatory protein |
| M. marinum M | MMAR_0820 | - | 1e-09 | 25.00% (216) | GntR family transcriptional regulator |
| M. avium 104 | MAV_2542 | - | 4e-11 | 29.87% (154) | regulatory protein GntR, HTH |
| M. thermoresistible (build 8) | TH_4465 | - | 7e-12 | 25.45% (220) | PUTATIVE putative hydride transferase 1 |
| M. ulcerans Agy99 | MUL_4564 | - | 1e-09 | 25.00% (216) | GntR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_1846 | - | 1e-113 | 86.72% (241) | regulatory protein GntR, HTH |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0820|M.marinum_M --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6700|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4571|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
TH_4465|M.thermoresistible__bu LATIGLSAYGMAGGELVELAACADELGFDTLWLGEHVVRPLTQRSAHPTS
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0820|M.marinum_M --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6700|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4571|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
TH_4465|M.thermoresistible__bu GTRQHHSGPLVAERTELIDPWAVHAAIAAVTTGIKLGTAVYVAALRHPLH
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0820|M.marinum_M --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6700|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4571|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
TH_4465|M.thermoresistible__bu TARTTITVQELSGGRVVFGVGVGWLEEEFDAFDVPFRTRVSRTEECLAIL
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0820|M.marinum_M --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6700|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4571|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
TH_4465|M.thermoresistible__bu RAAWRGEPFSHHGRHFRIDRVQVHSRPVDIPVVLGGNGPKALARAATLGD
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0820|M.marinum_M --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6700|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4571|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
TH_4465|M.thermoresistible__bu GWFTSGTPEFDDALRMVREIRRVREQHGRPGPFTCYVRIPSVDEVGRYRD
Mb0505|M.bovis_AF2122/97 --------------------------------------------------
Rv0494|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_0820|M.marinum_M --------------------------------------------------
MUL_4564|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_6700|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_1846|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4061|M.gilvum_PYR-GCK --------------------------------------------------
MAB_4571|M.abscessus_ATCC_1997 --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
TH_4465|M.thermoresistible__bu HDMTDLVLWADTVWQGRTLDEKRDRLAAAADRLGLVSRSSGDPPAAAAGR
Mb0505|M.bovis_AF2122/97 ---------------------------------------------MVEPM
Rv0494|M.tuberculosis_H37Rv ---------------------------------------------MVEPM
MMAR_0820|M.marinum_M -------------------------------------------------M
MUL_4564|M.ulcerans_Agy99 -------------------------------------------------M
MSMEG_6700|M.smegmatis_MC2_155 -------------------------------------------------M
Mvan_1846|M.vanbaalenii_PYR-1 ------------------------------------------------MS
Mflv_4061|M.gilvum_PYR-GCK ---------------------------------------MAAPDPADSSD
MAB_4571|M.abscessus_ATCC_1997 ------------------------------------------------MN
MAV_2542|M.avium_104 ----------------------------------------MPKREPLAPM
TH_4465|M.thermoresistible__bu SQRRRSGSALRMGDDVPRRVQNTGARSAGVRDTRPQNSRAGANGARTARD
Mb0505|M.bovis_AF2122/97 NQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAERLGVN
Rv0494|M.tuberculosis_H37Rv NQSSVFQPPDRQRVDERIATTIADAILDGVFPPGSTLPPERDLAERLGVN
MMAR_0820|M.marinum_M NQSSILQPPDRQRVDEQIATSIADAILDGVFPPGSALPPERELAEQLGVN
MUL_4564|M.ulcerans_Agy99 NQSSILQPPDRQRVDEQIATSIADAILDGVFPPGSALPPERELAEQLGVN
MSMEG_6700|M.smegmatis_MC2_155 SLSPLVAPEAPVGRADEIVQRITEAIHLGLLDDGERLPVEVDLAAQFGVA
Mvan_1846|M.vanbaalenii_PYR-1 SLSPLVAAEAPVGRADEIVQRITEAIHLGLLDDGERLPVEVDLAAQFGVA
Mflv_4061|M.gilvum_PYR-GCK ASEALLRPVRPLNAFEDTVERLLQTIRLGVLTPGESLPPERELAARLGVS
MAB_4571|M.abscessus_ATCC_1997 APRARTREIRRPQLSEEVAGRLRAAIMTGDLRPGEYIRMD-ETAAQLGVS
MAV_2542|M.avium_104 ATSQNNGAVRSPKTAEIVADTLRRMIVEGQLKDGDFLPYEAELMDHFQVS
TH_4465|M.thermoresistible__bu EHRGEVSLLRPLKAAESVARMIVDEIKTKGLQPGDSLPLEATMLKQYGVS
: . : * : *. : : : *
Mb0505|M.bovis_AF2122/97 RTSLRQGLARLQQMGLIEVRHG--SGSVVRDPEGLTHPAVVEALVRKLGP
Rv0494|M.tuberculosis_H37Rv RTSLRQGLARLQQMGLIEVRHG--SGSVVRDPEGLTHPAVVEALVRKLGP
MMAR_0820|M.marinum_M RTSLRQGLARLQQMGLIETRQG--SGNVVRDPQSLTHPAVVEALVRKLGP
MUL_4564|M.ulcerans_Agy99 RTSLRQGLARLQQMGLIETRQG--SGNVVRDPQSLTHPAVVEALVRKLGP
MSMEG_6700|M.smegmatis_MC2_155 PMTVREALATLRELELVETRRGRSGGSFVRRPAGPPVEKLTARLAAMSAS
Mvan_1846|M.vanbaalenii_PYR-1 PMTVREALATLREQELVETRRGRSGGSFVRRPAGPPVDKLTARLAAMSAS
Mflv_4061|M.gilvum_PYR-GCK RDTVREAIKSLADAGYLVSRRGRYGGTFLADALPAPRADGTEMHR-----
MAB_4571|M.abscessus_ATCC_1997 VTPVREALLTLRGEGMVDAVPHR--GYAVAALS----------------R
MAV_2542|M.avium_104 RPSLREAVRVLESDRLVEVRRGSRTGARVRVPGPEIVARPAGFLLEMAGT
TH_4465|M.thermoresistible__bu RESLREGLRLLEVQGMISIRRGPGGGPVVGTVDAGHLGRVSALFYNMADA
.:*:.: * : * :
Mb0505|M.bovis_AF2122/97 DFLVELLEIRAALGPLIGRLAAA--RSTPEDAEALCAALEVVQQADTAAA
Rv0494|M.tuberculosis_H37Rv DFLVELLEIRAALGPLIGRLAAA--RSTPEDAEALCAALEVVQQADTAAA
MMAR_0820|M.marinum_M DFLVEVLEIRAALGPLIGRLAAE--RNSSEDAEALRAALAEVADADTAPA
MUL_4564|M.ulcerans_Agy99 DFLVEVLEIRAALGPLIGRLAAE--RNSSEDAEALRAALAEVADADTAPA
MSMEG_6700|M.smegmatis_MC2_155 D-LRDLFDEHTAIAGQAARLAAE--RAAPSTVRRLFALTDQLDTATSLRD
Mvan_1846|M.vanbaalenii_PYR-1 D-LRDLFDEHTAVSGQAARLAAE--RAAPYAVRRLFALTDQLGAAATLGD
Mflv_4061|M.gilvum_PYR-GCK DDIDDAVRLREILEVGAARMAAV--RTLAAVEREALRSRLTDVRGADPAD
MAB_4571|M.abscessus_ATCC_1997 KDVEDIFALQSHLAVELAKAAAA--RITPEQADALAELNDALRNATSPDQ
MAV_2542|M.avium_104 T-LADVMTARMGIEPYAARLLAE--DGTAAAHRELRELIEEIPAAWETGK
TH_4465|M.thermoresistible__bu T-YEELLEAWVWAEGELAERAARNPDAQLRSARMTPYLTDHDGSAEGLAP
: . .. * .
Mb0505|M.bovis_AF2122/97 RQAADLAYFRVLIHSTRNRALGLLYRWVEHAFGGREHALTGAYDDADPVL
Rv0494|M.tuberculosis_H37Rv RQAADLAYFRVLIHSTRNRALGLLYRWVEHAFGGREHALTGAYDDADPVL
MMAR_0820|M.marinum_M RQAADLAYFRVLIHGTRNRALGLLYRWVEQAFGGREHELTGAYEDADPVI
MUL_4564|M.ulcerans_Agy99 RQAADLAYFRVLIHGTRNRALGLLYRWVEQAFGGREHDLTGAYEDADPVI
MSMEG_6700|M.smegmatis_MC2_155 RIRADSRFHIQVAVAAQSARLARREANLQAEVSGLIWLPIGPPIDVAAYV
Mvan_1846|M.vanbaalenii_PYR-1 RIRADSRFHIQVAMASQSARLARREANLQAEAAGLVWLPIGPSLDVAAHV
Mflv_4061|M.gilvum_PYR-GCK YRRLDSRLHLAIAEAAGVPSLVPLVAQNRMRLNELLDRIPLMTRNIAHSD
MAB_4571|M.abscessus_ATCC_1997 VIWAEFEFHRLLNHVADRPKLAWFLLQAVRYTP--HQLFAEDASWIVPTT
MAV_2542|M.avium_104 LGAASTALHRRLVELSGNATLTVIVGMLHEIFERHMTAAFLSVQNVVPKA
TH_4465|M.thermoresistible__bu YLEGHTAFHRAVADLSNNRVLALSLQTYGQIVSHHVAVLSDPRSLRDVLV
. : : *
Mb0505|M.bovis_AF2122/97 TD------LRAINGAVLAGDPAAAAATVEAYLNASALRMVKSYRDRA---
Rv0494|M.tuberculosis_H37Rv TD------LRAINGAVLAGDPAAAAATVEAYLNASALRMVKSYRDRA---
MMAR_0820|M.marinum_M AD------LTAINDAVLAGDPETAAAAVEGYLNASALRMIMCYRAAYAGE
MUL_4564|M.ulcerans_Agy99 AD------LTAINDAVLAGDPETAAAAVEGYLNASALRMIMCYRAAYAGE
MSMEG_6700|M.smegmatis_MC2_155 EE------KHAISAAIAAENAQEARQLAEAHVMGQLARLTQINLDLTTKE
Mvan_1846|M.vanbaalenii_PYR-1 EE------QHAIAAAVASEMADEARRLAEAHVMGQLARVTSINLALSTGE
Mflv_4061|M.gilvum_PYR-GCK EQ------HEAIVSAILAGDADTAAQTMAAHVWGSAALLHGFLD------
MAB_4571|M.abscessus_ATCC_1997 ET------HDKLIAALRAGDIAEVIAQTEVQFIDGARRLIEYLDRTGMWS
MAV_2542|M.avium_104 QYNKLMRSYTRLADLVAARDGAEAEAHWRRHMENASAELLKGHEKTKVRD
TH_4465|M.thermoresistible__bu DE------HRHIAEAVISGHARRARALMRSHLEGVTAFVRENIPVPLDQP
: : : . . :
Mb0505|M.bovis_AF2122/97 --------
Rv0494|M.tuberculosis_H37Rv --------
MMAR_0820|M.marinum_M DPER----
MUL_4564|M.ulcerans_Agy99 DPER----
MSMEG_6700|M.smegmatis_MC2_155 AGR-----
Mvan_1846|M.vanbaalenii_PYR-1 LSASGSAS
Mflv_4061|M.gilvum_PYR-GCK --------
MAB_4571|M.abscessus_ATCC_1997 QD------
MAV_2542|M.avium_104 IMH-----
TH_4465|M.thermoresistible__bu IEWL----