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PKREPLAPMATSQNNGAVRSPKTAEIVADTLRRMIVEGQLKDGDFLPYEAELMDHFQVSRPSLREAVRVL ESDRLVEVRRGSRTGARVRVPGPEIVARPAGFLLEMAGTTLADVMTARMGIEPYAARLLAEDGTAAAHRE LRELIEEIPAAWETGKLGAASTALHRRLVELSGNATLTVIVGMLHEIFERHMTAAFLSVQNVVPKAQYNK LMRSYTRLADLVAARDGAEAEAHWRRHMENASAELLKGHEKTKVRDIMH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2542 | - | - | 100% (260) | regulatory protein GntR, HTH |
| M. avium 104 | MAV_2560 | - | 3e-38 | 35.95% (242) | regulatory protein GntR, HTH |
| M. avium 104 | MAV_1821 | - | 1e-37 | 36.36% (242) | regulatory protein GntR, HTH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3086c | - | 4e-16 | 29.36% (235) | GntR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_2114 | - | 2e-82 | 62.79% (258) | GntR domain-containing protein |
| M. tuberculosis H37Rv | Rv3060c | - | 4e-16 | 29.36% (235) | GntR family transcriptional regulator |
| M. leprae Br4923 | MLBr_01188 | - | 3e-09 | 34.88% (86) | hypothetical protein MLBr_01188 |
| M. abscessus ATCC 19977 | MAB_4411c | - | 1e-08 | 27.31% (227) | GntR family transcriptional regulator |
| M. marinum M | MMAR_3975 | - | 1e-26 | 31.54% (241) | FadR family transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5201 | - | 5e-82 | 62.02% (258) | regulatory protein GntR, HTH |
| M. thermoresistible (build 8) | TH_0491 | - | 5e-43 | 78.90% (109) | regulatory protein GntR, HTH |
| M. ulcerans Agy99 | MUL_3832 | - | 3e-27 | 31.95% (241) | FadR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_4590 | - | 5e-81 | 60.08% (263) | GntR domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2114|M.gilvum_PYR-GCK MARSTPLAPMIGPDAVASRTAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
Mvan_4590|M.vanbaalenii_PYR-1 MTRNTPLAPMIGPDAVASRAAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
MSMEG_5201|M.smegmatis_MC2_155 MAGSTPLAPMIGPDAITPRAAVRSPKTAELVAGTLRRMVVEGQLKDGDFL
TH_0491|M.thermoresistible__bu ---------MIGPGSTPG-ASVRSPKTAELVAGTLRRMVVDGTLKDGDFL
MAV_2542|M.avium_104 MPKREPLAPMATS---QNNGAVRSPKTAEIVADTLRRMIVEGQLKDGDFL
MMAR_3975|M.marinum_M --------MTALGIGPDPRRRLSAPRIAEIVADELRRQIIDGELADGDLL
MUL_3832|M.ulcerans_Agy99 --------MTALGIGPDPRRRLSAPRIAEIVADELRRQIIDGELADGDLL
MLBr_01188|M.leprae_Br4923 -------------------------------------------------M
Mb3086c|M.bovis_AF2122/97 --------------MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASL
Rv3060c|M.tuberculosis_H37Rv --------------MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASL
MAB_4411c|M.abscessus_ATCC_199 ----------MTTLVPEEFAPLERQSTAELIAERLRIAIMRGVLAPGAQL
:
Mflv_2114|M.gilvum_PYR-GCK PNEAELMAHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
Mvan_4590|M.vanbaalenii_PYR-1 PNEAELMAHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
MSMEG_5201|M.smegmatis_MC2_155 PNEAELMSHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
TH_0491|M.thermoresistible__bu PNEAELMAHFGVSRPTLREAVRVLESERLVEVRRGSRTGARVRVPGPEIV
MAV_2542|M.avium_104 PYEAELMDHFQVSRPSLREAVRVLESDRLVEVRRGSRTGARVRVPGPEIV
MMAR_3975|M.marinum_M PRQEVLVEQFNVSLVSLREALRILETEGLVSVRRGNRGGAVVHAPAKTSA
MUL_3832|M.ulcerans_Agy99 PRQEVLVEQFNVSLVSLREALRILETEGLVSVRRGNRGGAVVHAPAKASA
MLBr_01188|M.leprae_Br4923 PRQEALVEPLNVSLLSFREALQIMDTERLISLRRGNRGSVVVHTPTRTSA
Mb3086c|M.bovis_AF2122/97 GSESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPA
Rv3060c|M.tuberculosis_H37Rv GSESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPA
MAB_4411c|M.abscessus_ATCC_199 G-EASLAAQFAVSRGPLREAMQRLVSEGLLRSERNRG-------------
: * : ** :***:: : . : .*.
Mflv_2114|M.gilvum_PYR-GCK ARPAGLLLELSGATIADLLTAKSAIEPMAARLLAESGSAAA--FDELEQL
Mvan_4590|M.vanbaalenii_PYR-1 ARPAGLLLELSGATIADLLTAKSGIEPMAARLLAESGSPEA--FDELERM
MSMEG_5201|M.smegmatis_MC2_155 ARPVGLLLELSGADIADLLVARSAIEPMAARLLAENGTEEQ--FAELDRM
TH_0491|M.thermoresistible__bu ARPAALLLELSGATVADVMVARSGTGSAGPPCAKRCG-------------
MAV_2542|M.avium_104 ARPAGFLLEMAGTTLADVMTARMGIEPYAARLLAEDGTAAA--HRELREL
MMAR_3975|M.marinum_M AYMLGLLLQSESVAVSDLGAALQELEPACAALAAQRPDRADTLVPELKRV
MUL_3832|M.ulcerans_Agy99 AYMLGLLLQSESVAVSDLGAALQELEPACAALAAQRPDRADTLVPELKRV
MLBr_01188|M.leprae_Br4923 AYMLGLLLQSKSIALADLGAALQELEPACAALAAQ---------------
Mb3086c|M.bovis_AF2122/97 TRAVVIYLEYLGTTIGDLLGARLVLEPLAASLAAEHIDEPG-----IERL
Rv3060c|M.tuberculosis_H37Rv TRAVVIYLEYLGTTIGDLLGARLVLEPLAASLAAEHIDEPG-----IERL
MAB_4411c|M.abscessus_ATCC_199 ----IFVIELTDDDVLDVYRSRSAIERAALECIMTGDTVTAYRRLLVPVA
: :: . : *: :
Mflv_2114|M.gilvum_PYR-GCK LEELVADSHQSPRLAEATGAFHLRVVQLSGNATLSIVAGMLHEITVRHTA
Mvan_4590|M.vanbaalenii_PYR-1 LEELAADSHKSSRLAEATGLFHLRVVQLSGNATLSIVAGMLHEITVRHTA
MSMEG_5201|M.smegmatis_MC2_155 LEEHIPSDWQSDRLAETTGDFHRRVVELSGNATLGIIAGMLHEITVRHHQ
TH_0491|M.thermoresistible__bu -------CWSPSGWSRCG----------AG--------------------
MAV_2542|M.avium_104 IEEIP-AAWETGKLGAASTALHRRLVELSGNATLTVIVGMLHEIFERHMT
MMAR_3975|M.marinum_M NEAMSEHLDDGAMFTEIGRQFHDLIVRGCGNHTIIAVVGSLETLWTSHEQ
MUL_3832|M.ulcerans_Agy99 NEAMSEHLDDGAMFTEIGRQFHDLIVRGCGNHTIIAVVGSLETLWTSHEQ
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 RAVLRAEERWRPGLPPPPEQFYRVLAEQSKNPVLQLFIDILMRLTKRYVQ
Rv3060c|M.tuberculosis_H37Rv RAVLRAEERWRPGLPPPPEQFYRVLAEQSKNPVLQLFIDILMRLTKRYVQ
MAB_4411c|M.abscessus_ATCC_199 VMTEAAARGDVVAVTDADQDFHEVLVDCSGSPRLRRAMRTLLLETRMLLG
Mflv_2114|M.gilvum_PYR-GCK FVFN----ERRPVSKADYETLLRSYRRLLQFLRSRDADGAEAHWRRHLDK
Mvan_4590|M.vanbaalenii_PYR-1 FVFN----ERRPVSKADYDTLLRSYRKLMQFLRAGDAVGAEAHWRKHLDT
MSMEG_5201|M.smegmatis_MC2_155 FLFR----EHRPVSKSDYDKLMRSYRKLMQIMRSGDGDAAEAHWRTHLDT
TH_0491|M.thermoresistible__bu ---------RAPARGSG----CRARRSWLARPR--------CCWNCPARR
MAV_2542|M.avium_104 AAFLS---VQNVVPKAQYNKLMRSYTRLADLVAARDGAEAEAHWRRHMEN
MMAR_3975|M.marinum_M QWADESAARGTYPSLTKRRAVLNTHIKLTETIAEGDVDRARRIAGRHLAD
MUL_3832|M.ulcerans_Agy99 QWADESAARGTYPSLAKRRAVLNAHIKLTETIAEGDVDRARRIAGRHLAD
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 KSGT----QSAGEAVEAAGQVHNEHSDIVAAVTAGDSAWAKTLSERHVEA
Rv3060c|M.tuberculosis_H37Rv KSGT----QSAGEAVEAAGQVHNEHSDIVAAVTAGDSAWAKTLSERHVEA
MAB_4411c|M.abscessus_ATCC_199 ELQG---------AYPDLSEQVREHEVLCAAIGAGDAPAAYRLIDEHMHD
Mflv_2114|M.gilvum_PYR-GCK TRELLLAGLESVPVRDVMG-------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 TRELLLTGLESVPVRDVMG-------------------------------
MSMEG_5201|M.smegmatis_MC2_155 ARALMLQGLESVKVRDVMG-------------------------------
TH_0491|M.thermoresistible__bu SPT-----------------------------------------------
MAV_2542|M.avium_104 ASAELLKGHEKTKVRDIMH-------------------------------
MMAR_3975|M.marinum_M TQTYVLSGRAEQRIYALSPQALSRPRDMRRP-------------------
MUL_3832|M.ulcerans_Agy99 TQTYVLSGRAEQRIYALSPQALSRPRDMRRP-------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 VAGWLQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAATIGD
Rv3060c|M.tuberculosis_H37Rv VAGWLQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAATIGD
MAB_4411c|M.abscessus_ATCC_199 AVTRLMARRDPGSVE-----------------------------------
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
TH_0491|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 DIAASGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMRRGPG
Rv3060c|M.tuberculosis_H37Rv DIAASGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMRRGPG
MAB_4411c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
TH_0491|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 GGLVVTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKVVKRR
Rv3060c|M.tuberculosis_H37Rv GGLVVTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKVVKRR
MAB_4411c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
TH_0491|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 SEPEVASFLDTLGRPRLDNPTDDVRAAAVEEFRFHVGLARAAGNTMLDLF
Rv3060c|M.tuberculosis_H37Rv SEPEVASFLDTLGRPRLDNPTDDVRAAAVEEFRFHVGLARAAGNTMLDLF
MAB_4411c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2114|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4590|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5201|M.smegmatis_MC2_155 --------------------------------------------------
TH_0491|M.thermoresistible__bu --------------------------------------------------
MAV_2542|M.avium_104 --------------------------------------------------
MMAR_3975|M.marinum_M --------------------------------------------------
MUL_3832|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01188|M.leprae_Br4923 --------------------------------------------------
Mb3086c|M.bovis_AF2122/97 LLILVELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSLARCR
Rv3060c|M.tuberculosis_H37Rv LLILVELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSLARCR
MAB_4411c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2114|M.gilvum_PYR-GCK -------------
Mvan_4590|M.vanbaalenii_PYR-1 -------------
MSMEG_5201|M.smegmatis_MC2_155 -------------
TH_0491|M.thermoresistible__bu -------------
MAV_2542|M.avium_104 -------------
MMAR_3975|M.marinum_M -------------
MUL_3832|M.ulcerans_Agy99 -------------
MLBr_01188|M.leprae_Br4923 -------------
Mb3086c|M.bovis_AF2122/97 TRRHLDAAASWWL
Rv3060c|M.tuberculosis_H37Rv TRRHLDAAASWWL
MAB_4411c|M.abscessus_ATCC_199 -------------